当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL INVESTIGATION期刊下所有文献 > Nontransferrin-bound iron in the plasma of haemodialysis patients after intravenous iron saccharate infusion.

Nontransferrin-bound iron in the plasma of haemodialysis patients after intravenous iron saccharate infusion.

Abstract：

BACKGROUND:Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis. It has been shown previously that this may result in a transient "oversaturation" of transferrin. METHODS:Ten stable haemodialysis patients on r-HuEPO treatment received 100 mg iron saccharate in 60 min, and 1 week later 100 mg in 6 min. Conventional iron metabolism parameters and nontransferrin-bond iron, detected with HPLC after addition of nitrilotriacetate and pretreatment with cobalt, were measured. Also, iron was measured in dialysate. RESULTS:Serum iron increased from 9.6 +/- 6.2 to 213.7 +/- 49.4 micromol L(-1) (P < 0.001) when iron was given in 60 min, and from 11.1 +/- 4.7 to 219.3 +/- 43.7 micromol L(-1) (P < 0.001) when iron was given in 6 min. Transferrin saturation increased from 0.22 +/- 0.18 to 4.75 +/- 1.35 in protocol 1 and 0.26 +/- 0.16 to 4.91 +/- 1.38 in protocol 2. Nontransferrin-bound iron increased from 0.74 +/- 0.69 to 3.79 +/- 1.41 micromol L(-1) in protocol 1, and from 0.90 +/- 0.92 to 2.90 +/- 0.96 micromol L(-1) in protocol 2. No significant iron concentrations were found in dialysate before or during the iron saccharate infusion. CONCLUSION:Nontransferrin-bound iron exists in plasma of dialysis patients after infusion of iron saccharate. There was no difference when 100 mg iron was given in 60 min or in 6 min. Before iron infusion, appreciable concentrations of nontransferrin-bound iron could already be detected. The clinical significance is not clear, but the findings may be important since nontransferrin-bound iron can act as a catalytic agent in the formation of hydroxyl radicals, thus potentially inducing cell damage and atherosclerosis.

journal_name

Eur J Clin Invest

journal_title

European journal of clinical investigation

authors

Kooistra MP,Kersting S,Gosriwatana I,Lu S,Nijhoff-Schutte J,Hider RC,Marx JJ

doi

10.1046/j.1365-2362.2002.0320s1036.x

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

36-41

eissn

0014-2972

issn

1365-2362

pii

043

journal_volume

32 Suppl 1

pub_type

临床试验,杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION文献大全
  • Impact of T-inversion on the outcome of Takotsubo syndrome as compared to acute coronary syndrome.

    abstract：BACKGROUND:Previous studies revealed that patients with Takotsubo syndrome (TTS) have a higher mortality rate than the general population and a comparable mortality to acute coronary syndrome (ACS). Repolarisation abnormalities, namely T-wave amplitude, may provide incremental prognostic information, in addition to tra...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13078

    authors： Gietzen T,El-Battrawy I,Lang S,Zhou XB,Ansari U,Behnes M,Borggrefe M,Akin I

    更新日期：2019-04-01 00:00:00

  • Prognostic value of serum lactic dehydrogenase (S-LDH) in multiple myeloma.

    abstract：:Serum lactic dehydrogenase (S-LDH) was analysed at diagnosis in ninety-three patients with multiple myeloma. The patients were then followed up after a mean observation period of 39 months (SD 29). Serum lactic dehydrogenase was elevated in twenty-seven out of ninety-three patients and found to correlate with the seru...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1987.tb02197.x

    authors： Simonsson B,Brenning G,Källander C,Ahre A

    更新日期：1987-08-01 00:00:00

  • Effect of indomethacin upon angiotensin-induced changes in blood pressure and plasma aldosterone in normal man.

    abstract：:The effect of indomethacin (75 mg/day for 3 days) on the response to i.v. angiotensin II was investigated in eight healthy, sodium-repleted, male subjects. Indomethacin reduced the release of aldosterone during the i.v. administration of angiotensin II (5, 10 and 20 ng kg-1 min-1), whereas the pressor response to angi...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1981.tb02044.x

    authors： Vierhapper H,Waldhäusl W,Nowotny P

    更新日期：1981-04-01 00:00:00

  • Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.

    abstract：:Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2004.01304.x

    authors： Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

    更新日期：2004-02-01 00:00:00

  • The influence of sorafenib on hepatic encephalopathy and the mechanistic survey in cirrhotic rats.

    abstract：BACKGROUND:Sorafenib, a multikinase inhibitor that inhibits angiogenesis and carcinogenesis, has been used for patients with advanced hepatocellular carcinoma. However, sporadic cases have been reported with the development of hepatic encephalopathy (HE) after sorafenib treatment, mostly in those with cirrhosis. Liver ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12006

    authors： Hsu SJ,Hsin IF,Lin YL,Chen YC,Huang HC,Lee FY,Lin HC,Chang CC,Lee SD

    更新日期：2012-12-01 00:00:00

  • Na+/H+ antiporter activity in peripheral blood lymphocytes of obese and type 2 diabetic patients is increased only in the presence of arterial hypertension.

    abstract：:The aim of this work is to evaluate whether type 2 diabetes mellitus, obesity and arterial hypertension, three conditions characterized by the presence of insulin resistance, share some common genetic markers. A potential candidate is the Na+/H+ antiporter, the increased activity of which is considered a marker of ess...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1994.tb00983.x

    authors： Ghigo D,Alessio P,Burzacca S,Costamagna C,Anfossi G,Cavalot F,Bosia A,Trovati M

    更新日期：1994-03-01 00:00:00

  • Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2.

    abstract：BACKGROUND:Irisin, a novel myokine, has been shown to increase following vigorous exercise, with studies suggesting that it mediates some of the beneficial effects of exercise. Irisin might play a role in 'browning' of white adipocytes, thus increasing energy expenditure. The role of irisin in exercise and energy expen...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12468

    authors： Al-Daghri NM,Alokail MS,Rahman S,Amer OE,Al-Attas OS,Alfawaz H,Tripathi G,Sabico S,Chrousos GP,McTernan PG,Piya MK

    更新日期：2015-08-01 00:00:00

  • Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice.

    abstract：BACKGROUND/AIMS:Nitric oxide synthase (NOS) 3-deficient (NOS-3 KO) mice have an increased systemic arterial pressure but develop portal hypertension to the same extent as wildtype (WT) mice. We hypothesized that other vasodilators in the portal circulation compensate for the lack in NOS-3 activity. We used quantitative...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2004.01331.x

    authors： Biecker E,Sägesser H,Reichen J

    更新日期：2004-04-01 00:00:00

  • Incomplete suppression of hepatic glucose production in non-insulin dependent diabetes mellitus measured with [6,6-2H2]glucose enriched glucose infusion during hyperinsulinaemic euglycaemic clamps.

    abstract：:We have minimized methodological errors in the isotope dilution technique by using stable isotope, [6,6-2H2]glucose, thus avoiding the problem of contamination of tritiated glucose tracers and, by maintaining a constant plasma tracer enrichment have reduced error due to mixing transients. Using these modifications we ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1992.tb01458.x

    authors： Powrie JK,Smith GD,Hennessy TR,Shojaee-Moradie F,Kelly JM,Sönksen PH,Jones RH

    更新日期：1992-04-01 00:00:00

  • Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cells.

    abstract：:Patients with primary biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver. However, most of the patients with PBC do not show peripheral blood T cells response to PDC. In this study, we re-evaluated the ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2001.00847.x

    authors： Akbar SM,Yamamoto K,Miyakawa H,Ninomiya T,Abe M,Hiasa Y,Masumoto T,Horiike N,Onji M

    更新日期：2001-07-01 00:00:00

  • Regenerative pulmonary medicine: potential and promise, pitfalls and challenges.

    abstract：BACKGROUND:Chronic lung diseases contribute significantly to the morbidity and mortality of the population. There are few effective treatments for many chronic lung diseases, and even fewer therapies that can arrest or reverse the progress of the disease. DESIGN:In this review, we present the current state of regenera...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.2012.02667.x

    authors： Anversa P,Perrella MA,Kourembanas S,Choi AM,Loscalzo J

    更新日期：2012-08-01 00:00:00

  • Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187.

    abstract：:The formation of metabolites of arachidonic acid by the cyclo-oxygenase and lipoxygenase pathways were determined in human lung tissue, obtained from surgery. In this measurement the chopped tissue was incubated with the calcium ionophore A23187. Formation of metabolites from [1-14C] arachidonic acid was also determin...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1987.tb02195.x

    authors： Zijlstra FJ,Naaktgeboren M,Mons H,Vincent JE

    更新日期：1987-08-01 00:00:00

  • Influence of leucine infusion on intracellular amino acids in humans.

    abstract：:A continuous intravenous infusion of L-leucine (300 mumols min-1) was given to 12 healthy females over a 2 1/2 h period. Arterial plasma concentrations of amino acids and the keto acids of the branched-chain amino acids (BCAA) were measured. In six subjects muscle biopsies were taken before and at the end of the infus...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1990.tb01858.x

    authors： Alvestrand A,Hagenfeldt L,Merli M,Oureshi A,Eriksson LS

    更新日期：1990-06-01 00:00:00

  • Reverse iontophoresis of urea in health and chronic kidney disease: a potential diagnostic and monitoring tool?

    abstract：BACKGROUND:Patients with chronic kidney disease (CKD) need regular monitoring, usually by blood urea and creatinine measurements, needing venepuncture, frequent attendances and a healthcare professional, with significant inconvenience. Noninvasive monitoring will potentially simplify and improve monitoring. We tested t...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2012.02657.x

    authors： Ebah LM,Read I,Sayce A,Morgan J,Chaloner C,Brenchley P,Mitra S

    更新日期：2012-08-01 00:00:00

  • Effect of nitroglycerin on pulmonary perfusion distribution and gas exchange of normal subjects.

    abstract：:In eight healthy subjects we assessed the effects of 3 mg sublingual nitroglycerin on lung distribution of ventilation and perfusion using 133Xe (sitting, supine and lateral decubitus) and on alveolo-arterial O2 and CO2 partial pressure differences [(PAO2-PaO2), (PaCO2-PACO2)] and physiological dead space to tidal vol...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1982.tb00956.x

    authors： Nemery B,Vanderlinden-Mahieu S,Piret L,Brasseur L,Frans A

    更新日期：1982-04-01 00:00:00

  • Prevention of age-induced N(ε)-(carboxymethyl)lysine accumulation in the microvasculature.

    abstract：OBJECTIVE:N(ε)-(carboxymethyl)lysine (CML) is one of the major advanced glycation end products in both diabetics and nondiabetics. CML depositions in the microvasculature have recently been linked to the aetiology of acute myocardial infarction and cognitive impairment in Alzheimer's disease, possibly related to local ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12599

    authors： Fuijkschot WW,de Graaff HJ,Berishvili E,Kakabadze Z,Kupreishvili K,Meinster E,Houtman M,van Broekhoven A,Schalkwijk CG,Vonk AB,Krijnen PA,Smulders YM,Niessen HW

    更新日期：2016-04-01 00:00:00

  • Implementation of proteomic biomarkers: making it work.

    abstract：:While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implement...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2012.02674.x

    authors： Mischak H,Ioannidis JP,Argiles A,Attwood TK,Bongcam-Rudloff E,Broenstrup M,Charonis A,Chrousos GP,Delles C,Dominiczak A,Dylag T,Ehrich J,Egido J,Findeisen P,Jankowski J,Johnson RW,Julien BA,Lankisch T,Leung HY,Maahs

    更新日期：2012-09-01 00:00:00

  • The improvement of renal concentration capacity after surgery for primary hyperparathyroidism.

    abstract：BACKGROUND:Improvement of renal concentration capacity was long ago shown to occur after surgery for primary hyperparathyroidism (pHPT). Study of concentration capacity is of interest, as it was also shown to be a predictive factor for the risk of death in patients with pHPT, and it affected the risk of death independe...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2001.00926.x

    authors： Hedbäck G,Abrahamsson K,Odén A

    更新日期：2001-12-01 00:00:00

  • Affinity of LDL to a human arterial proteoglycan among male survivors of myocardial infarction.

    abstract：:In the present study, the hypothesis that the affinity of LDL to arterial proteoglycans might discriminate myocardial infarction patients from controls were tested. The patients were 52 men who had sustained a myocardial infarction at an age of 50 years or less and the controls, selected from a random population sampl...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1989.tb00193.x

    authors： Linden T,Bondjers G,Camejo G,Bergstrand R,Wilhelmsen L,Wiklund O

    更新日期：1989-02-01 00:00:00

  • Biocompatibility of coated and uncoated charcoal during haemoperfusion in healthy dogs.

    abstract：:The biocompatibility of two commercially available charcoal columns, one containing coated and the other uncoated but immobilized charcoal, was compared during four haemoperfusions with each in eight healthy greyhounds. Reductions in arterial levels of platelets (49% and 42% respectively) and leucocytes (both 21%) wer...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1977.tb01626.x

    authors： Weston MJ,Hanid A,Rubin MH,Langley PG,Mellon PJ,Williams R

    更新日期：1977-10-01 00:00:00

  • Altered membrane glycoprotein targeting in cholestatic hepatocytes.

    abstract：BACKGROUND:Hepatocytes are polarized epithelial cells with three morphologically and functionally distinct membrane surfaces: the sinusoidal, lateral and canalicular surface domains. These domains differ from each other in the expression of integral proteins, which concur to their polarized functions. We hypothesize th...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02273.x

    authors： Liquori GE,Mastrodonato M,Rossi R,Scillitani G,Gena P,Portincasa P,Calamita G,Ferri D

    更新日期：2010-05-01 00:00:00

  • Plasma vitamin D metabolites in a patient with sporadic hypophosphataemic osteomalacia (adult-onset type).

    abstract：:Sporadic hypophosphataemic osteomalacia (adult-onset type) was demonstrated in a 40-year-old man on the basis of severe osteomalacia, hypophosphataemia, hyperphosphaturia and glycinuria. Plasma immunoreactive parathyroid hormone (iPTH) concentration was 9.3 ng prot./ml (normal range: 4-8 ng prot./ml). Plasma 25-hydrox...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1980.tb00047.x

    authors： Ulmann A,Bouchard P,Garabédian M,Bourdeau A,Witmer-Cournot G,Lacour B,Balsan S,Funck-Brentano JL

    更新日期：1980-10-01 00:00:00

  • Antiphospholipid syndrome: pathogenesis and a window of treatment opportunities in the future.

    abstract：BACKGROUND:Antiphospholipid syndrome (APS) is a systemic autoimmune vascular disease characterized by recurrent thrombotic episodes and/or obstetric complications. Management of this disease has been restricted mainly to anticoagulation; however, in recent years, significant advancement has been made in elucidating the...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.2010.02281.x

    authors： Mehdi AA,Uthman I,Khamashta M

    更新日期：2010-05-01 00:00:00

  • Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy.

    abstract：BACKGROUND:Acute hyperglycaemia is known to increase gastrointestinal (GI) sensitivity in healthy subjects and may contribute to the increased prevalence of GI symptoms in diabetes patients. The aim of this study was to evaluate the effect of acute hyperglycaemia on perception and brain responses to painful visceral an...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02335.x

    authors： Frøkjaer JB,Søfteland E,Graversen C,Dimcevski G,Drewes AM

    更新日期：2010-10-01 00:00:00

  • Progressive renovascular hypertension by increasing aortic constriction in rats.

    abstract：:Moderate and progressive hypertension was produced experimentally in rats by progressive aortic constriction. The progression of the stenosis was assessed by the differences of pressure across the stenosis. Haemodynamic studies were performed 15, 30 and 60 days after the ligature was placed or after sham operation. Fi...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1984.tb01178.x

    authors： Martín-Paredero V,Casado S,López-Novoa JM

    更新日期：1984-08-01 00:00:00

  • Platelets from diabetic subjects show diminished sensitivity to prostacyclin.

    abstract：:Prostacyclin, an unstable metabolite of arachidonic acid metabolism, has been shown to have potent platelet antiaggregatory and vasodilator activity. Available evidence suggests that arterial prostacyclin production is diminished in the diabetic state. In this study we have examined the sensitivity of platelets from d...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1982.tb00686.x

    authors： Betteridge DJ,El Tahir KE,Reckless JP,Williams KI

    更新日期：1982-10-01 00:00:00

  • Left ventricular and cardiac autonomic function in survivors of testicular cancer.

    abstract：BACKGROUND:Following cisplatin-based chemotherapy, survivors of testicular cancer have a high prevalence of cardiovascular risk factors and an increased risk of cardiovascular disease. Cardiac function has not been extensively studied and no comparisons have been made with men from the general population. DESIGN:Left ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2005.01460.x

    authors： Nuver J,Smit AJ,Sleijfer DT,van Gessel AI,van Roon AM,van der Meer J,van den Berg MP,Hoekstra HJ,Sluiter WJ,Gietema JA

    更新日期：2005-02-01 00:00:00

  • Risk of liver cirrhosis in patients with tuberculosis: a nationwide cohort study.

    abstract：BACKGROUND:Most of the previous reports found cirrhosis patients with a high risk of subsequent tuberculosis (TB). However, data about the risk of developing liver cirrhosis in TB patients are limited. As a hepatitis endemic area, the risk of liver cirrhosis in patients with TB should be elucidated in Taiwan. METHODS:...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12453

    authors： Peng YC,Lin CL,Hsu WY,Chang CS,Yeh HZ,Kao CH

    更新日期：2015-07-01 00:00:00

  • The effect of smoking on post-heparin lipoprotein and hepatic lipase, cholesteryl ester transfer protein and lecithin:cholesterol acyl transferase activities in human plasma.

    abstract：INTRODUCTION:Smoking is associated with dyslipidaemia, particularly raised plasma triglycerides and reduced high-density lipoprotein (HDL)-cholesterol and a delayed clearance of triglyceride in fat tolerance tests. The aim of this study was to investigate whether these phenomena could be explained by a reduced lipoprot...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1998.00328.x

    authors： Freeman DJ,Caslake MJ,Griffin BA,Hinnie J,Tan CE,Watson TD,Packard CJ,Shepherd J

    更新日期：1998-07-01 00:00:00

  • Corticotropin-releasing hormone binding to the syncytiotrophoblast membranes.

    abstract：:The human placenta secretes large amounts of corticotropin-releasing hormone (CRH) which was thought to exert a paracrine action in the placenta. We have recently characterized high-affinity binding sites for CRH in the human placenta. However, our studies utilized whole placental membranes, which did not identify the...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2001.00770.x

    authors： Saeed B,Fawcett M,Self C

    更新日期：2001-02-01 00:00:00