Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.

abstract：BACKGROUND:Hepatocytes are polarized epithelial cells with three morphologically and functionally distinct membrane surfaces: the sinusoidal, lateral and canalicular surface domains. These domains differ from each other in the expression of integral proteins, which concur to their polarized functions. We hypothesize th...

journal_title：European journal of clinical investigation

authors： Liquori GE,Mastrodonato M,Rossi R,Scillitani G,Gena P,Portincasa P,Calamita G,Ferri D

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Experimental and clinical studies have suggested that inhibitors of the renin angiotensin system (RAS) might be useful to slow the progression of valvular calcification in patients with aortic stenosis (AS). OBJECTIVES:The aim of this study was to evaluate the relationships between the weight and tissue rem...

journal_title：European journal of clinical investigation

authors： Côté N,Couture C,Pibarot P,Després JP,Mathieu P

更新日期：2011-11-01 00:00:00

abstract：:The concentrations of gastrins containing the active C-terminal tetrapeptide amide (mainly gastrin-34 and gastrin-17) and the N-terminal tridecapeptide fragment of gastrin-17 were measured in antral and duodenal biopsy specimens. The antral concentration of the N-terminal gastrin fragment was much higher in patients w...

journal_title：European journal of clinical investigation

authors： Petersen B,Andersen BN

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Although the association between chronic Helicobacter pylori infection and type 2 diabetes has been suggested, findings have been inconsistent. This study evaluated the association between chronic H. pylori infection and glucose regulation. MATERIALS AND METHODS:We evaluated H. pylori infection status of pa...

journal_title：European journal of clinical investigation

authors： Hsieh MC,Wang SS,Hsieh YT,Kuo FC,Soon MS,Wu DC

更新日期：2013-09-01 00:00:00

abstract：:Activities of urea cycle enzymes were measured in the liver of starved rats 12 and 48 h after bilateral nephrectomy. Control experiments (sham-operated, starved rats) revealed that the activities of only two enzymes of the cycle are altered in the uraemic state: argininosuccinic acid synthetase (EC 6.3.4.5.), which is...

journal_title：European journal of clinical investigation

authors： Hoppe-Seyler G

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:The pathogenesis of atherosclerosis and acute coronary syndromes involves inflammation and immunological mechanisms. We hypothesized that patients with unstable angina may have an imbalance between inflammatory and anti-inflammatory cytokines. DESIGN:Plasma levels of tumour necrosis factor (TNF)alpha and in...

journal_title：European journal of clinical investigation

authors： Waehre T,Halvorsen B,Damås JK,Yndestad A,Brosstad F,Gullestad L,Kjekshus J,Frøland SS,Aukrust P

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have...

journal_title：European journal of clinical investigation

authors： MacLeod MJ,De Lange RP,Breen G,Meiklejohn D,Lemmon H,Clair DS

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:A total of 30 subjects with type 2 diabetes were incl...

journal_title：European journal of clinical investigation

authors： Heinisch BB,Francesconi M,Mittermayer F,Schaller G,Gouya G,Wolzt M,Pleiner J

更新日期：2010-02-01 00:00:00

abstract：:Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being elucidated. This study was carried out to investigate the relationship between serum leptin, plasma insulin, insulin sensitivity and free testosterone in 46 men ...

journal_title：European journal of clinical investigation

authors： Vettor R,De Pergola G,Pagano C,Englaro P,Laudadio E,Giorgino F,Blum WF,Giorgino R,Federspil G

更新日期：1997-12-01 00:00:00

abstract：:Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, n...

journal_title：European journal of clinical investigation

authors： Jaschonek K,Muller CP

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Fat tissue is a common material for autologous transplantation in plastic and reconstructive surgery. Basic fibroblast growth factor (bFGF) ameliorates the fat graft survival. A transplantation model has shown the gene expression of matrix metalloproteinases (MMPs) to increase in adipocytes. The aim of this ...

journal_title：European journal of clinical investigation

authors： Kuramochi D,Unoki H,Bujo H,Kubota Y,Jiang M,Rikihisa N,Udagawa A,Yoshimoto S,Ichinose M,Saito Y

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Mucosal-associated invariant T (MAIT) cells play an important role in innate host defence. MAIT cells appear to undergo exhaustion and are functionally weakened in chronic viral infections. However, their role in chronic hepatitis C virus (HCV) infection remains unclear. MATERIALS AND METHODS:We investigate...

journal_title：European journal of clinical investigation

authors： Barathan M,Mohamed R,Vadivelu J,Chang LY,Saeidi A,Yong YK,Ravishankar Ram M,Gopal K,Velu V,Larsson M,Shankar EM

更新日期：2016-02-01 00:00:00

abstract：:In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and ...

journal_title：European journal of clinical investigation

authors： Edvinsson L,Ekman R,Hedner P,Valdemarsson S

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the syndrome. The aim of this study was to provide an overview of existing literature around determinants of...

journal_title：European journal of clinical investigation

authors： van Osch D,Nathoe HM,Jacob KA,Doevendans PA,van Dijk D,Suyker WJ,Dieleman JM

更新日期：2017-06-01 00:00:00

abstract：METHODS:Ten samples of decidua basalis from pre-eclamptic women and 10 from healthy primigravid women subjected to caesarean section (control tissues) were investigated immunohistochemically for changes in angiogenesis and expression of tenascin, an extracellular matrix protein thought to modulate angiogenesis. In addi...

journal_title：European journal of clinical investigation

authors： Ribatti D,Loverro G,Vacca A,Greco P,Roncali L,Selvaggi L

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Over the past decades, the prevalence of obesity has markedly increased worldwide. Stress is recognized as a substantial contributor to increased body weight; therefore, stress management interventions, especially cognitive behavioural, are becoming increasingly popular. The impact of stress management on st...

journal_title：European journal of clinical investigation

authors： Simos DS,Kokkinos A,Tentolouris N,Dimosthenopoulos C,Mantzou E,Artemiadis A,Bacopoulou F,Nicolaides NC,Kosta O,Chrousos GP,Darviri C

更新日期：2019-10-01 00:00:00

abstract：:In the present study, the hypothesis that the affinity of LDL to arterial proteoglycans might discriminate myocardial infarction patients from controls were tested. The patients were 52 men who had sustained a myocardial infarction at an age of 50 years or less and the controls, selected from a random population sampl...

journal_title：European journal of clinical investigation

authors： Linden T,Bondjers G,Camejo G,Bergstrand R,Wilhelmsen L,Wiklund O

更新日期：1989-02-01 00:00:00

abstract：:The permeability of the gastrointestinal tract was investigated by means of polyethylene glycol (PEG), given orally. The PEG solutions contained oligomers with molecular weights from 414 to 1206. The urinary recovery of ingested PEG was determined by high performance liquid chromatography (HPLC). Considerable inter- a...

journal_title：European journal of clinical investigation

authors： Philipsen EK,Batsberg W,Christensen AB

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Insulin resistance significantly correlated with a non-dipper type of essential hypertension. Thiazolidinediones (TZD), oral hypoglycaemic agents that act as insulin sensitizers, have been demonstrated in multiple in vivo and in vitro studies to possess antihypertensive properties. This study examined the ef...

journal_title：European journal of clinical investigation

authors： Anan F,Masaki T,Fukunaga N,Teshima Y,Iwao T,Kaneda K,Umeno Y,Okada K,Wakasugi K,Yonemochi H,Eshima N,Saikawa T,Yoshimatsu H

更新日期：2007-09-01 00:00:00

abstract：:Eur J Clin Invest 2012; 42 (6): 579-588 ABSTRACT: Glucose-based methods are currently gold standards for identifying individuals at risk of type 2 diabetes. Obviously, these methods only consider one of many pathologies of impaired glucose metabolism and they all suffer from a poor specificity as type 2 diabetes risk ...

journal_title：European journal of clinical investigation

authors： Gjesing AP,Pedersen O

更新日期：2012-06-01 00:00:00

abstract：:Pulmonary plasma kinetics of endogenous noradrenaline (NA) and tritium labelled L-noradrenaline (3H-NA) was studied in fifteen subjects during pulmonary arterial catheterization. Plasma NA concentration in femoral artery ranged from 0.5 to 8.2 nmol l-1, mean 2.3 nmol l-1, which was not significantly different from tha...

journal_title：European journal of clinical investigation

authors： Henriksen JH,Christensen NJ,Ring-Larsen H

更新日期：1986-10-01 00:00:00

abstract：:Propranolol is used clinically as a prophylactic drug to prevent oesophageal variceal bleeding in cirrhotic patients with portal hypertension. Vascular hyporesponsiveness is a common characteristic of the portal hypertensive state. The present study aimed to investigate whether chronic administration of propranolol co...

journal_title：European journal of clinical investigation

authors： Huang YT,Lin HC,Tsai JF,Hou MC,Hong CY

更新日期：1997-07-01 00:00:00

abstract：:A kindred in which several members have otherwise typical acute intermittent porphyria but normal erythrocyte uroporphyrinogen-I-synthase activity has been described from Finland. We studied two porphyric members of this kindred, two patients with typical acute intermittent porphyria, and two healthy controls using th...

journal_title：European journal of clinical investigation

authors： Mustajoki P,Tenhunen R

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Diacylglycerols (DAGs), which are well-known components of insect lipophorins, have been recently recognized as a major glyceride of human high-density lipoprotein (HDL). Moreover, DAGs are good substrates for hepatic lipase and for the phospholipid transfer protein (PLTP). The present work was undertaken to...

journal_title：European journal of clinical investigation

authors： Lalanne F,Pruneta V,Bernard S,Ponsin G

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Although the incidence of co-existent pulmonary tuberculosis (PTB) and lung cancer in China is increasing, risk factors related to its development are still poorly understood. We aimed to investigate which clinical factors were associated with the odds of co-existent PTB and lung cancer (PTB-lung cancer) cas...

journal_title：European journal of clinical investigation

authors： Zheng L,Yin J,Wang S,Jiang H,Hu P,Kang Z,Lv P,Li W,Cai C

更新日期：2020-10-14 00:00:00

abstract：:The collagenolytic activities were assayed in fibroblast cultures established from ten keratoconus and six control corneal explants. The assays included those for both type I and type IV collagenase. The amount of free, directly assayable type I collagenase was highly increased in the media of keratoconus primary cell...

journal_title：European journal of clinical investigation

authors： Ihalainen A,Salo T,Forsius H,Peltonen L

更新日期：1986-02-01 00:00:00

abstract：:Lactose malabsorption, by the breath hydrogen test, and lactose intolerance (presence of symptoms) were studied in twenty healthy Italian subjects after intake of 12.5, 25 and 50 g lactose, whole milk and low-lactose milk. A rise in respiratory concentration of hydrogen (greater than 20 ppm) (malabsorption) was found ...

journal_title：European journal of clinical investigation

authors： Zuccato E,Andreoletti M,Bozzani A,Marcucci F,Velio P,Bianchi P,Mussini E

更新日期：1983-06-01 00:00:00

abstract：:The work was designed to study the effects of a meat meal on glomerular filtration rate (GFR), renal plasma flow (RPF), and plasma concentrations of glucagon, insulin, growth hormone, renin, aldosterone, total amino acids, and NH3 in healthy humans (H) as well as in patients with Child A liver cirrhosis (LC). The meat...

journal_title：European journal of clinical investigation

authors： De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Although several lines of evidence suggest that hypomagnesaemia is a risk factor for developing type 2 diabetes, there are no studies regarding the association between hypomagnesaemia and the risk for developing impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). Our objective was to examine ...

journal_title：European journal of clinical investigation

authors： Guerrero-Romero F,Rascón-Pacheco RA,Rodríguez-Morán M,de la Peña JE,Wacher N

更新日期：2008-06-01 00:00:00

abstract：:We have reported that the disorder of lipoprotein metabolism in hyperalphalipoproteinaemic patients with a deficiency of cholesteryl ester transfer protein (CETP) is characterized by the polydisperse low density lipoprotein (LDL) particles and the accumulation of cholesteryl ester (CE) in high density lipoprotein (HDL...

journal_title：European journal of clinical investigation

authors： Sakai N,Yamashita S,Hirano K,Ishigami M,Arai T,Kobayashi K,Funahashi T,Matsuzawa Y

更新日期：1995-05-01 00:00:00