Abstract:
BACKGROUND:The pathogenesis of atherosclerosis and acute coronary syndromes involves inflammation and immunological mechanisms. We hypothesized that patients with unstable angina may have an imbalance between inflammatory and anti-inflammatory cytokines. DESIGN:Plasma levels of tumour necrosis factor (TNF)alpha and interleukin (IL)-10 were analyzed in 44 patients with stable angina, 29 patients with unstable angina and 20 controls. mRNA levels of these cytokines were analyzed in peripheral blood mononuclear cells (PBMC). We also studied the in vitro effects of IL-10 in PBMC from unstable angina patients. RESULTS:Our main findings were: (1) the angina patients and particularly those with unstable disease had significantly raised TNFalpha in comparison with the controls, both at the protein and mRNA level; (2) in contrast, the levels of IL-10 were not different in the angina patients in comparison with the healthy controls, resulting in a markedly enhanced TNFalpha:IL-10 ratio, particularly in the unstable angina patients; (3) while exogenously added IL-10 markedly inhibited the release of TNFalpha, IL-8 and tissue factor as well as impairing the gelatinolytic activity and mRNA production of matrix metalloproteinase-9, it enhanced the tissue inhibitor of this metalloproteinase (i.e. TIMP-1) in PBMC from the unstable angina patients. CONCLUSION:Patients with unstable angina appear to have an imbalance between TNFalpha and IL-10, possibly favouring inflammatory net effects. IL-10 may have beneficial effects on mechanisms that are important in plaque rupture and thrombus formation.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Waehre T,Halvorsen B,Damås JK,Yndestad A,Brosstad F,Gullestad L,Kjekshus J,Frøland SS,Aukrust Pdoi
10.1046/j.1365-2362.2002.01069.xkeywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
803-10issue
11eissn
0014-2972issn
1365-2362pii
1069journal_volume
32pub_type
杂志文章abstract::1. The activity of lipoprotein lipase (E.C.3.1.1.3) extracted and released from adipose tissue has been measured in obese subjects with mild or severe hypertriglyceridaemia. The Intralipid tolerance test has been studied as a measure of in vivo clearance of exogenous triglyceride from plasma. 2. Plasma triglyceride cl...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1980.tb02072.x
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:Little is known about gallbladder motility in patients with black pigment stones when compared to cholesterol gallstone patients, or about their relationship to biliary composition, crystallization and stone characteristics. DESIGN:Fasting and postprandial gallbladder volumes were studied by ultrasonography...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1989-02-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:1985-12-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:2012-09-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.1997.1150663.x
更新日期:1997-04-01 00:00:00
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更新日期:2018-08-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.1997.900616.x
更新日期:1997-01-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.1983.tb00098.x
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:BACKGROUND:SOX6 has been recently proposed as a pleiotropic gene for obesity and osteoporosis. The aim of this study was to investigate whether the rs7117858 genetic variant in SOX6 was associated with bone mass assessed by quantitative ultrasound (QUS) and obesity-related measures in a population of young adults. MET...
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更新日期:1997-09-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.1983.tb00084.x
更新日期:1983-04-01 00:00:00
abstract::To determine if the sex differences in clearance of long chain fatty acids by the liver observed in the rat are relevant to humans, the authors isolated hepatocytes from human adult males and females (five per group) and measured the initial (unidirectional) clearance of [3H]-palmitate from buffer containing albumin. ...
journal_title:European journal of clinical investigation
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更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-07-01 00:00:00