Abstract:
:1. The activity of lipoprotein lipase (E.C.3.1.1.3) extracted and released from adipose tissue has been measured in obese subjects with mild or severe hypertriglyceridaemia. The Intralipid tolerance test has been studied as a measure of in vivo clearance of exogenous triglyceride from plasma. 2. Plasma triglyceride clearance was reduced in patients with severe hypertriglyceridaemia (> 4 mmol/l) and this was associated with reduced activities of extracted lipoprotein lipase in adipose tissue compared to patients with mild hypertriglyceridaemia (2--4 mmol/l). 3. A course of insulin therapy (20 u/day) for 1 week increased the extracted, but not the released component of the enzyme from adipose tissue of hypertriglyceridaemic patients. 4. Serum (25% v/v) potentiated the release of lipoprotein lipase from adipose tissue of normo- but not hypertriglyceridaemic patients. 5. The effect of serum on enzyme release was abolished if lipoprotein-deficient serum was used. Addition of very low density lipoprotein (VLDL) or high density lipoprotein (HDL) restored the ability of delipidated serum to augment release of enzyme from adipose tissue, but this was not observed with low density lipoprotein (LDL). 6. It is suggested that a defect in the release of lipoprotein lipase activity in adipose tissue may contribute to the development of hypertriglyceridaemia in this group of patients.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Taylor KG,Holdsworth G,Galton DJdoi
10.1111/j.1365-2362.1980.tb02072.xsubject
Has Abstractpub_date
1980-04-01 00:00:00pages
133-8issue
2 Pt 1eissn
0014-2972issn
1365-2362journal_volume
10pub_type
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:1997-09-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1994.tb02373.x
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Although the incidence of co-existent pulmonary tuberculosis (PTB) and lung cancer in China is increasing, risk factors related to its development are still poorly understood. We aimed to investigate which clinical factors were associated with the odds of co-existent PTB and lung cancer (PTB-lung cancer) cas...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:2016-02-01 00:00:00