Temporal changes of soluble ST2 after cardiovascular interventions.

Abstract:

BACKGROUND:Soluble ST2 (sST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we studied the effect of cardiovascular interventions and clinical characteristics on plasma sST2 expression levels. MATERIAL AND METHODS:In the current study, sST2 levels were assessed in the plasma of patients scheduled for coronary artery bypass grafting (CABG) (n = 76), percutaneous coronary intervention (PCI) (n = 68) or peripheral vascular surgery (n = 27). RESULTS:Age was the only classical risk factor significantly correlating with sST2 levels. Soluble ST2 levels were significantly increased 1 h after CABG (48 [33-70] vs. 61 [42-89] pg/mL, P = 0·001) and increased even further after 24 h (1116 [578-13 666] pg/mL, P < 0·001). An average threefold increase in sST2 levels was also observed in patients 24 h after peripheral interventions (30 [21-41] vs. 98 [48-211] pg/mL, P < 0·001). Two months after PCI, we found that sST2 levels were significantly higher compared with baseline levels (41 [29-61] vs. 48 [31-80] pg/mL, P = 0·007, n = 52). In addition, we did not observe an association between sST2 and any inflammatory or cardiac-specific markers that were measured in this study. CONCLUSIONS:Soluble ST2 increases significantly following cardiovascular interventions. The notion of a recent cardiovascular intervention is a strong determinant of sST2 levels and therefore needs to be taken into account when exploring sST2 as predictor of future cardiovascular events.

journal_name

Eur J Clin Invest

authors

Willems S,Sels JW,Flier S,Versteeg D,Buhre WF,de Kleijn DP,Hoefer IE,Pasterkamp G

doi

10.1111/eci.12022

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

113-20

issue

2

eissn

0014-2972

issn

1365-2362

journal_volume

43

pub_type

杂志文章
  • Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.

    abstract::• The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice. • The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2011.02493.x

    authors: Janssens AC,Ioannidis JP,Bedrosian S,Boffetta P,Dolan SM,Dowling N,Fortier I,Freedman AN,Grimshaw JM,Gulcher J,Gwinn M,Hlatky MA,Janes H,Kraft P,Melillo S,O'Donnell CJ,Pencina MJ,Ransohoff D,Schully SD,Seminara D,

    更新日期:2011-09-01 00:00:00

  • Effects of glyceryl trinitrate on the pyloric motor response to intraduodenal triglyceride infusion in humans.

    abstract::The retardation of gastric emptying induced by infusion of triglyceride into the small intestine is associated with suppression of antral pressure waves and stimulation of basal pyloric tone in combination with phasic pressure waves localized to the pylorus. The role of nitric oxide (NO) mechanisms in the control of p...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1996.tb02149.x

    authors: Sun WM,Doran S,Lingenfelser T,Hebbard GS,Morley JE,Dent J,Horowitz M

    更新日期:1996-08-01 00:00:00

  • The role of functional thyroid capacity in pituitary thyroid feedback regulation.

    abstract:BACKGROUND:Thyroid feedback regulation and equilibria between thyroid hormones differ in the presence or absence of a functioning thyroid remnant. MATERIALS AND METHODS:This study examines the relationship between the sensitivity of TSH feedback and thyroid capacity in untreated patients with thyroid autoimmune diseas...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13003

    authors: Hoermann R,Midgley JEM,Larisch R,Dietrich JW

    更新日期:2018-10-01 00:00:00

  • Evaluation of antileukaemic effects of rapamycin in patients with imatinib-resistant chronic myeloid leukaemia.

    abstract:BACKGROUND:Recent data suggest that the mammalian target of rapamycin (mTOR) is involved in the regulation of growth of neoplastic cells in chronic myeloid leukaemia (CML). PATIENTS AND METHODS:We treated six patients with imatinib-resistant CML in haematological relapse (leukocytes > 20,000 microL(-1)) with rapamycin...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2007.01892.x

    authors: Sillaber C,Mayerhofer M,Böhm A,Vales A,Gruze A,Aichberger KJ,Esterbauer H,Pfeilstöcker M,Sperr WR,Pickl WF,Haas OA,Valent P

    更新日期:2008-01-01 00:00:00

  • Effect of low protein diet on the renal response to meat ingestion in diabetic nephropathy.

    abstract::We measured the renal haemodynamic and proteinuric response to a meat meal (MM) in ten persistently proteinuric insulin-dependent diabetic patients in a randomized cross-over study of 3 weeks on low protein diet (LPD) or normal protein intake (NPD). On LPD, protein intake (0.64 +/- 0.05 vs 1.15 +/- 0.09 g kg-1 body we...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1991.tb01807.x

    authors: Pinto JR,Bending JJ,Dodds RA,Viberti GC

    更新日期:1991-04-01 00:00:00

  • Italian survey on managing immune checkpoint inhibitors in oncology during COVID-19 outbreak.

    abstract:BACKGROUND:During COVID-19 outbreak, oncological care has been reorganized. Patients with cancer have been reported to experience a more severe COVID-19 syndrome; moreover, there are concerns of a potential interference between immune checkpoint inhibitors (ICIs) and SARS-CoV-2 pathogenesis. MATERIALS AND METHODS:Betw...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13315

    authors: Tagliamento M,Spagnolo F,Poggio F,Soldato D,Conte B,Ruelle T,Barisione E,De Maria A,Del Mastro L,Di Maio M,Lambertini M

    更新日期:2020-09-01 00:00:00

  • The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia.

    abstract::Disseminated intravascular coagulation (DIC) is a frequently occurring complication of sepsis and may contribute to multiple organ failure. More insight into the pathogenesis of this derangement of the coagulation system is necessary to develop more effective therapeutic strategies for this condition. Recently, more d...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2362.1997.570614.x

    authors: Levi M,van der Poll T,ten Cate H,van Deventer SJ

    更新日期:1997-01-01 00:00:00

  • Postnatal increase of procalcitonin in premature newborns is enhanced by chorioamnionitis and neonatal sepsis.

    abstract:BACKGROUND:To determine the influence of chorioamnionitis and neonatal sepsis on procalcitonin (PCT) levels in very-low-birth-weight (VLBW) infants within the first week of life. DESIGN:PCT serum levels were measured in cord blood 1 h after delivery and on day 3 and day 7 of life. Chorioamnionitis and neonatal sepsis ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2001.00912.x

    authors: Janota J,Stranák Z,Bĕlohlávková S,Mudra K,Simák J

    更新日期:2001-11-01 00:00:00

  • Is the renal kallikrein system relevant to sodium sensitivity in patients with essential hypertension.

    abstract::In twenty-five outpatients with essential hypertension, the relevance of renal kallikrein excretion for inter-individual differences in the blood pressure response to changes in dietary sodium intake was investigated. The patients were studied during 2 weeks of high (300 mmol) and 2 weeks of low (50-100 mmol) sodium i...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1985.tb00160.x

    authors: Koolen MI,Daha MR,van Brummelen P

    更新日期:1985-06-01 00:00:00

  • Effect of heparin and aspirin on platelet and clotting activation during leukapheresis.

    abstract::Beta-thromboglobulin (beta TG), serotonin (5HT) and fibrinopeptide A (FPA) were assessed in twenty-two normal donors before, during, and at the end of leukapheresis. Seven procedures were carried out adding heparin to the circuit, and seven adding acetyl salicylic acid (ASA). The remaining eight procedures were carrie...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1985.tb00166.x

    authors: Fabris F,Casonato A,Randi ML,Belloni M,Quaino V,Ongaro G,Girolami A

    更新日期:1985-08-01 00:00:00

  • Matrix metalloproteinase 2 improves the transplanted adipocyte survival in mice.

    abstract:BACKGROUND:Fat tissue is a common material for autologous transplantation in plastic and reconstructive surgery. Basic fibroblast growth factor (bFGF) ameliorates the fat graft survival. A transplantation model has shown the gene expression of matrix metalloproteinases (MMPs) to increase in adipocytes. The aim of this ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2008.02023.x

    authors: Kuramochi D,Unoki H,Bujo H,Kubota Y,Jiang M,Rikihisa N,Udagawa A,Yoshimoto S,Ichinose M,Saito Y

    更新日期:2008-10-01 00:00:00

  • Immunopathogenesis of cholestatic autoimmune liver diseases.

    abstract::Primary biliary cirrhosis and primary sclerosing cholangitis are well recognized chronic cholestatic liver diseases that are considered to have an autoimmune basis. Recent progress in the study of autoimmune liver diseases has improved the recognition and characterization of these conditions. An important component of...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2362.2001.00765.x

    authors: Medina J,Jones EA,García-Monzón C,Moreno-Otero R

    更新日期:2001-01-01 00:00:00

  • Inhibition of cell proliferation and fibronectin biosynthesis by Na ascorbate.

    abstract:BACKGROUND:The importance of ascorbate on the production of extracellular matrix proteins (as elastin and collagens) is now well documented, but no studies have been published concerning its effects on fibronectin biosynthesis. Fibronectin is important for cell attachment and for proliferation. MATERIALS AND METHODS:T...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2002.00992.x

    authors: Péterszegi G,Dagonet FB,Labat-Robert J,Robert L

    更新日期:2002-05-01 00:00:00

  • Platelet and vessel associated prostacyclin and thromboxane A2/prostaglandin endoperoxide receptors.

    abstract::Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, n...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2362.1988.tb01157.x

    authors: Jaschonek K,Muller CP

    更新日期:1988-02-01 00:00:00

  • Pythagorean self-awareness intervention: A novel cognitive stress management technique for body weight control.

    abstract:BACKGROUND:Over the past decades, the prevalence of obesity has markedly increased worldwide. Stress is recognized as a substantial contributor to increased body weight; therefore, stress management interventions, especially cognitive behavioural, are becoming increasingly popular. The impact of stress management on st...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/eci.13164

    authors: Simos DS,Kokkinos A,Tentolouris N,Dimosthenopoulos C,Mantzou E,Artemiadis A,Bacopoulou F,Nicolaides NC,Kosta O,Chrousos GP,Darviri C

    更新日期:2019-10-01 00:00:00

  • The influence of ulnar nerve blockade on skin microvascular blood flow.

    abstract::Microvascular research is seriously hampered by the great temporal and spatial variability of the measured skin blood flow and variation in sympathetic vasomotor reflexes within and between persons. Therefore skin vasomotor reflexes were studied before and after ulnar nerve blockade within the same person, resulting i...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1995.tb01738.x

    authors: Netten PM,Wollersheim H,Gielen MJ,Den Arend JA,Lutterman JA,Thien T

    更新日期:1995-07-01 00:00:00

  • Liraglutide relieves cardiac dilated function than DPP-4 inhibitors.

    abstract:INTRODUCTION:Diabetes mellitus is a progressive disease with cardiovascular complications. This study evaluated the effects of liraglutide, a glucagon-like peptide-1 analogue and the dipeptidyl peptidase 4 inhibitors sitagliptin and linagliptin on cardiac function in type 2 diabetes patients with renal impairment. MAT...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/eci.13007

    authors: Hiramatsu T,Asano Y,Mabuchi M,Imai K,Iguchi D,Furuta S

    更新日期:2018-10-01 00:00:00

  • Use of an artificial neural network to predict Graves' disease outcome within 2 years of drug withdrawal.

    abstract:BACKGROUND:Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, which can relapse in many patients after antithyroid drug treatment withdrawal. Several studies have been performed to predict the clinical course of GD in patients treated with antithyroid drugs, without conclusive results. The...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2004.01318.x

    authors: Orunesu E,Bagnasco M,Salmaso C,Altrinetti V,Bernasconi D,Del Monte P,Pesce G,Marugo M,Mela GS

    更新日期:2004-03-01 00:00:00

  • In vitro immune modulation of polymorphonuclear leukocyte adhesiveness by sodium fluoride.

    abstract::We investigated the influence of sodium fluoride on polymorphonuclear leukocyte (PMN) adhesiveness in a healthy subject with low serum levels of fluoride. The PMN were separated from venous blood, and the percentages of adhered and unadhered cells were determined in vitro in plastic culture plates. The cells were cult...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1992.tb01426.x

    authors: Gómez-Ubric JL,Liébana J,Gutiérrez J,Castillo A

    更新日期:1992-10-01 00:00:00

  • Soluble TWEAK plasma levels increase after renal transplantation and associate with the improvement of endothelial function.

    abstract:BACKGROUND:Soluble TWEAK (sTWEAK) and asymmetric dimethyl arginine (ADMA) concentrations have been associated with endothelial function in patients with chronic kidney disease (CKD). We tested the hypothesis that the improvement in endothelial function observed after renal transplantation is directly linked to the norm...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12166

    authors: Yilmaz MI,Sonmez A,Saglam M,Yaman H,Unal HU,Gok M,Cetinkaya H,Eyileten T,Oguz Y,Sari S,Yildirim AO,Vural A,Carrero JJ,Blanco-Colio LM

    更新日期:2013-12-01 00:00:00

  • Aortic distensibility is reduced in subjects with type 2 diabetes and cardiac autonomic neuropathy.

    abstract:BACKGROUND:Reduced aortic distensibility predicts cardiovascular mortality in patients with type 2 diabetes and impaired glucose tolerance. Cardiac autonomic neuropathy is common in subjects with diabetes. However, the relationship between the elastic properties of the aorta and autonomic neuropathy has not been studie...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2003.01279.x

    authors: Tentolouris N,Liatis S,Moyssakis I,Tsapogas P,Psallas M,Diakoumopoulou E,Voteas V,Katsilambros N

    更新日期:2003-12-01 00:00:00

  • Effect of lactose on oro-cecal transit in lactose digesters and maldigesters.

    abstract:BACKGROUND:The transit time of the small intestine, in addition to lactase activity, may influence lactose digestion and thus play a role in the occurrence of lactose intolerance. The objectives of this study were to investigate the effect of lactose on the oro-cecal transit time (OCTT) in lactose digesters and maldige...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2006.01713.x

    authors: He T,Priebe MG,Welling GW,Vonk RJ

    更新日期:2006-10-01 00:00:00

  • Decision shaping neutrophil-platelet interplay in inflammation: From physiology to intervention.

    abstract::Inflammation is a well-coordinated process in response to tissue injury or infection aimed at restoration of tissue homoeostasis. Platelets and neutrophils are typically viewed important in the context of haemostasis and bacterial killing, respectively. However, as these cells are equipped with readily available armou...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/eci.12871

    authors: Soehnlein O

    更新日期:2018-02-01 00:00:00

  • Autonomic cardiovascular regulation in quiescent ulcerative colitis and Crohn's disease.

    abstract:BACKGROUND:In inflammatory bowel diseases, changes in autonomic enteric regulation may also affect neural cardiovascular control. However, while cardiac autonomic modulation has been shown to be impaired in active ulcerative colitis, the occurrence of cardiovascular autonomic alterations, also in the quiescent phase of...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2007.01887.x

    authors: Coruzzi P,Castiglioni P,Parati G,Brambilla V,Brambilla L,Gualerzi M,Cademartiri F,Franzè A,De Angelis G,Di Rienzo M,Di Mario F

    更新日期:2007-12-01 00:00:00

  • Serum prolactin levels in eighty patients with sarcoidosis.

    abstract::Serum prolactin levels were measured by radioimmunoassay in eighty patients (thirty-four males, forty-six females) with sarcoidosis before treatment. In twelve patients (15%) serum prolactin levels were more than two standard deviations above the mean of normal subjects. Hyperprolactinaemia was found most frequently (...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1978.tb00806.x

    authors: Nakao K,Noma K,Sato B,Yano S,Yamamura Y,Tachibana T

    更新日期:1978-02-01 00:00:00

  • The effect of pegylated granulocyte colony-stimulating factor on collateral function and myocardial ischaemia in chronic coronary artery disease: A randomized controlled trial.

    abstract:OBJECTIVE:To test the effect of long-term pegfilgrastim on collateral function and myocardial ischaemia in patients with chronic stable coronary artery disease (CAD). METHODS:This was a prospective clinical trial with randomized 2:1 allocation to pegfilgrastim or placebo for 6 months. The primary study endpoint was co...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/eci.13035

    authors: Traupe T,Stoller M,Gloekler S,Meier P,Seiler C

    更新日期:2019-01-01 00:00:00

  • SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.

    abstract:BACKGROUND:Angiotensin converting enzyme 2 (ACE2), a monocarboxylase that degrades angiotensin II to angiotensin 1-7, is also the functional receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and is highly expressed in the lungs and heart. Patients with SARS also suffered from cardiac disease ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2009.02153.x

    authors: Oudit GY,Kassiri Z,Jiang C,Liu PP,Poutanen SM,Penninger JM,Butany J

    更新日期:2009-07-01 00:00:00

  • Antitumour and toxic effects on Wistar rats of two new platinum complexes.

    abstract:BACKGROUND:Cancer chemotherapy in humans based on metal complexes started at the clinical level in the late 1970s with the use of cisplatin, which forms intra-strand cross-links with DNA. METHODS:Two new platinum complexes of cis-geometry with the amino acids inosine (ino) and l-alanine (ala), Pt(ino)2Cl2 and cis-[Pt(...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2002.00932.x

    authors: Charalabopoulos K,Karkabounas S,Ioachim E,Papalimneou V,Syrigos K,Evangelou A,Agnantis N,Hadjiliadis N

    更新日期:2002-02-01 00:00:00

  • Decreased insulin sensitivity and muscle enzyme activity in elderly subjects.

    abstract::Skeletal muscle glycogen deposition, and the activation of muscle glycogen synthase and pyruvate dehydrogenase during a hyerinsulinaemic euglycaemic clamp have been measured in six young and six elderly males matched for body mass index, physical activity and diet. Clamp glucose requirement (insulin, 0.1 U kg-1 h-1) w...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1988.tb01045.x

    authors: Kruszynska YT,Petranyi G,Alberti KG

    更新日期:1988-10-01 00:00:00

  • The effect of antacids on the occurrence of bile acid and aspirin-induced gastric lesions in rats.

    abstract::Taurodeoxycholic acid increases the incidence of aspirin induced gastric bleeding in rats and in vitro is well bound by Aludrox (aluminium hydroxide) and poorly bound by Maalox (aluminium hydroxide and magnesium hydroxide). We studied the relevance of this binding, as demonstrated in vitro, by observing the effect of ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1980.tb02080.x

    authors: Morgan RJ,Nelson LM,Russell RI,Plevin T

    更新日期:1980-12-01 00:00:00