Multiple biochemical effects in the pathogenesis of alcoholic fatty liver.

abstract：BACKGROUND:To evaluate the inflammatory axis mediated by tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its scavenger receptor CD163 during pregnancy and their influence on insulin sensitivity in normal pregnancy and in gestational diabetes mellitus (GDM). MATERIALS AND METHODS:One hundred and thirt...

journal_title：European journal of clinical investigation

authors： Simón-Muela I,Llauradó G,Chacón MR,Olona M,Näf S,Maymó-Masip E,Gil P,de la Flor M,Gonzalez Clemente JM,Vendrell J,Megía A

更新日期：2015-01-01 00:00:00

abstract：:The electrical parameters and the unidirectional fluxes of 45Ca and 3H-mannitol were measured in preparations of rat colon descendens freed from the muscularis externa and mounted in a modified Ussing-chamber. Two criteria were used to differentiate between changes in the trans- and the paracellular calcium transport ...

journal_title：European journal of clinical investigation

authors： Karbach U,Rummel W

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis. It has been shown previously that this may result in a transient "oversaturation" of transferrin. METHODS:Ten stable haemodialysis patients on r-HuEPO treatment re...

journal_title：European journal of clinical investigation

authors： Kooistra MP,Kersting S,Gosriwatana I,Lu S,Nijhoff-Schutte J,Hider RC,Marx JJ

更新日期：2002-03-01 00:00:00

abstract：:Changes in blood glucose homeostasis induced by the new somatostatin analogue BIM 23014 (BIM) were studied. Eight normal men (study 1) received either vehicle or 1000, 2000 and 3000 micrograms BIM as a 24 h s.c. infusion. Blood glucose, plasma insulin, C-peptide, glucagon and growth hormone (GH) were measured before t...

journal_title：European journal of clinical investigation

authors： Kuhn JM,Basin C,Mollard M,De Rouge B,Schatz B,Wolf LM

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Buerger's disease (BD) is a segmental occlusive vascular disease. The aim of this study was to detect functional changes in brachial artery and asymptomatic morphological changes in extra-cranial carotid arteries not affected by the disease process and to assess markers of inflammation and endothelial damage...

journal_title：European journal of clinical investigation

authors： Joras M,Poredos P,Fras Z

更新日期：2006-06-01 00:00:00

abstract：:In order to estimate their in-vivo reactivity two antacids of equal theoretical neutralizing capacity (approximately 3.9 mol/l at pH 3.5) but of different chemical composition were employed as intragastric titrant (pH 3.5) following a liquid protein meal (oxo) in two groups of five volunteers each. The two antacids ch...

journal_title：European journal of clinical investigation

authors： Halter F,Huber R,Häcki WH,Varga L,Bachmann C

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Most of the previous reports found cirrhosis patients with a high risk of subsequent tuberculosis (TB). However, data about the risk of developing liver cirrhosis in TB patients are limited. As a hepatitis endemic area, the risk of liver cirrhosis in patients with TB should be elucidated in Taiwan. METHODS:...

journal_title：European journal of clinical investigation

authors： Peng YC,Lin CL,Hsu WY,Chang CS,Yeh HZ,Kao CH

更新日期：2015-07-01 00:00:00

abstract：:Skeletal muscle glycogen deposition, and the activation of muscle glycogen synthase and pyruvate dehydrogenase during a hyerinsulinaemic euglycaemic clamp have been measured in six young and six elderly males matched for body mass index, physical activity and diet. Clamp glucose requirement (insulin, 0.1 U kg-1 h-1) w...

journal_title：European journal of clinical investigation

authors： Kruszynska YT,Petranyi G,Alberti KG

更新日期：1988-10-01 00:00:00

abstract：:The aim of the present study was to examine the effects of a large dose of slow-release carbohydrates (CHOs) at bedtime on the nocturnal glucose, insulin and free fatty acid (FFA) levels, and to assess the putative effects on morning fasting and post-prandial glucose levels in patients with moderately controlled non-i...

journal_title：European journal of clinical investigation

authors： Axelsen M,Lönnroth P,Arvidsson Lenner R,Smith U

更新日期：1997-02-01 00:00:00

abstract：INTRODUCTION:Smoking is associated with dyslipidaemia, particularly raised plasma triglycerides and reduced high-density lipoprotein (HDL)-cholesterol and a delayed clearance of triglyceride in fat tolerance tests. The aim of this study was to investigate whether these phenomena could be explained by a reduced lipoprot...

journal_title：European journal of clinical investigation

authors： Freeman DJ,Caslake MJ,Griffin BA,Hinnie J,Tan CE,Watson TD,Packard CJ,Shepherd J

更新日期：1998-07-01 00:00:00

abstract：:In systemic lupus erythematosus (SLE) patients, most of the clinical manifestation share a vascular component triggered by endothelial dysfunction. Endothelial cells (ECs) activation occurs both on the arterial and venous side, and the high vascular density of kidneys accounts for the detrimental outcomes of SLE throu...

journal_title：European journal of clinical investigation

authors： Mancardi D,Arrigo E,Cozzi M,Cecchi I,Radin M,Fenoglio R,Roccatello D,Sciascia S

更新日期：2021-02-01 00:00:00

abstract：:The effect of renal function on the cyclic AMP (cAMP) response to exogenous parathyroid hormone (PTH) was examined in patients with chronic renal failure (n = 22) and primary hyperparathyroidism (n = 19). In the patients with chronic renal failure there was marked resistance to the effect of exogenous PTH. In primary ...

journal_title：European journal of clinical investigation

authors： Lewin IG,Hendy GN,Papapoulos SE,Tomlinson S,O'Riordan JL

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Urotensin II plays a role in myocardial remodelling. Cardiac fibroblasts play a critical role in the development of cardiac fibrosis. The effect of hypoxia on urotensin II expression in cardiac fibroblasts is poorly understood. We sought to investigate the regulation of urotensin II by hypoxia in cardiac fib...

journal_title：European journal of clinical investigation

authors： Shyu KG,Wang BW,Chen WJ,Kuan P,Lin CM

更新日期：2012-01-01 00:00:00

abstract：:Whether leptin levels are related to insulin sensitivity or subject to acute regulation by insulin is not known. In 12 obese [body mass index (BMI) = 34.0 +/- 1.5 kg m-2] and 12 lean (BMI = 22.2 +/- 0.6 kg m-2) non-diabetic subjects, plasma leptin concentrations were measured in the fasting state and during 2 hours of...

journal_title：European journal of clinical investigation

authors： Muscelli E,Camastra S,Masoni A,Baldi S,Sironi AM,Natali A,Ferrannini E

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Morpholinosydnonimine, a nitric oxide (NO) donor, has been reported to inhibit insulin release in isolated pancreatic islets. We studied whether transdermal application of nitroglycerin, another NO donor widely used for angina prophylaxis, influenced glucose-stimulated insulin release in healthy, young, male...

journal_title：European journal of clinical investigation

authors： Kovacs P,Szilvassy Z,Hegyi P,Nemeth J,Ferdinandy P,Tosaki A

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Acute ischaemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing poststroke recovery. In smokers with AIS, inflammation might be further upregulated, increasing ischaemia/reperfusion injury. Here, the predictive value of leucocyte and adhesion molecules levels on poststroke out...

journal_title：European journal of clinical investigation

authors： Liberale L,Montecucco F,Bonaventura A,Casetta I,Seraceni S,Trentini A,Padroni M,Dallegri F,Fainardi E,Carbone F

更新日期：2017-10-01 00:00:00

abstract：:N-3 fatty acids were supplied to a 36-year-old female patient suffering from ulcerative colitis and severe steroid side-effects, in a sequence of parenteral and enteral administration. During a moderately active period of disease, 200 ml d-1 fish oil-derived lipid emulsion (eicosapentaenoic acid [EPA], 4.2 g; docosahe...

journal_title：European journal of clinical investigation

authors： Grimminger F,Führer D,Papavassilis C,Schlotzer E,Mayer K,Heuer KU,Kiss L,Walmrath D,Piberhofer S,Lübbecke F

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Diverticular disease (DD) and irritable bowel syndrome (IBS) share a similar symptom pattern. However, comparative studies are flawed by different age at onset of symptoms. We aimed to verify whether clinical features distinguish DD from IBS. MATERIALS AND METHODS:Patients with DD or IBS, matched for age an...

journal_title：European journal of clinical investigation

authors： Cuomo R,Barbara G,Andreozzi P,Bassotti G,Casetti T,Grassini M,Ierardi E,Maconi G,Marchi S,Sarnelli G,Savarino V,Usai P,Vozzella L,Annibale B

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Passive smoking is a well-known risk factor for both recurrent respiratory infections and disturbed lipid profile. Whether passive smoking problems are related to altered lymphocyte survival and its relation to altered lipid profile are the points of concern in this work. MATERIALS AND METHODS:Urinary cotin...

journal_title：European journal of clinical investigation

authors： El-Hodhod MA,Hamdy AM,Ahmed MB,Youssef SR,Aly SM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:In Western societies colonic cancer most frequently develops in the distal colon, largely as a result of the composition of the diet. Modulation of dietary factors is therefore an attractive modality to reduce colorectal cancer risk. This study aims to evaluate the potentially protective effects of calcium i...

journal_title：European journal of clinical investigation

authors： van Gorkom BA,van der Meer R,Karrenbeld A,van der Sluis T,Zwart N,Termont DS,Boersma-van Ek W,de Vries EG,Kleibeuker JH

更新日期：2002-09-01 00:00:00

abstract：:Many diseases with a major public health impact are the result of complex interactions between environmental factors and multiple genes. In the past decade, methods for genome analysis, in particular quantitative trait locus (QTL) analysis in animal models, were developed to identify and localize the genes responsible...

journal_title：European journal of clinical investigation

authors： Hillebrandt S,Matern S,Lammert F

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Diets and Omega-3 polyunsaturated fatty acids have been considered as important factors to reduce the risk of cardiovascular and inflammatory diseases, but there are few details on the effects on healthy subjects. The aim of the present study was to examine the variation of several physiological parameters i...

journal_title：European journal of clinical investigation

authors： Fontani G,Corradeschi F,Felici A,Alfatti F,Bugarini R,Fiaschi AI,Cerretani D,Montorfano G,Rizzo AM,Berra B

更新日期：2005-08-01 00:00:00

abstract：:Platelet aggregation, which plays an important role in acute myocardial infarction (AMI), is mediated by fibrinogen binding to the platelet membrane glycoprotein (GP)IIb-IIIa (CD41). This study measured the relative number of GPIIb-IIIa complexes on platelets from patients immediately following AMI (n = 14) compared w...

journal_title：European journal of clinical investigation

authors： Giles H,Smith RE,Martin JF

更新日期：1994-01-01 00:00:00

abstract：:Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being elucidated. This study was carried out to investigate the relationship between serum leptin, plasma insulin, insulin sensitivity and free testosterone in 46 men ...

journal_title：European journal of clinical investigation

authors： Vettor R,De Pergola G,Pagano C,Englaro P,Laudadio E,Giorgino F,Blum WF,Giorgino R,Federspil G

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Glomerulonephritis clusters in families. However, infections are common inducers of glomerulonephritis and may also cluster in families. Studies of adoptees and their biological and adoptive parents may disentangle genetic from environmental causes of familial clustering. This is the first adoption study aim...

journal_title：European journal of clinical investigation

authors： Akrawi DS,Zöller B,Fjellstedt E,Sundquist J,Sundquist K,PirouziFard M

更新日期：2019-08-01 00:00:00

abstract：:Primary biliary cirrhosis and primary sclerosing cholangitis are well recognized chronic cholestatic liver diseases that are considered to have an autoimmune basis. Recent progress in the study of autoimmune liver diseases has improved the recognition and characterization of these conditions. An important component of...

journal_title：European journal of clinical investigation

authors： Medina J,Jones EA,García-Monzón C,Moreno-Otero R

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Chronic hyperglycaemia in diabetes is suggested to be a major cause of diabetic angiopathy. Up until now, the effects of acutely induced hyperglycaemia in non-diabetic subjects as well as hyperglycaemic effects in early diabetes, on mesenteric microcirculation and leucocyte endothelial cell interaction have ...

journal_title：European journal of clinical investigation

authors： Schäffler A,Arndt H,Schölmerich J,Palitzsch K

更新日期：1998-11-01 00:00:00

abstract：:The effect of the potent specific cholecystokinin (CCK) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of CCK, gastrin, pancreatic polypeptide (PP), neurotensin, glucose-dependent insulinotropic polypeptide (GIP), insulin and C peptide was investigated in a placebo-controlled study in 10 heal...

journal_title：European journal of clinical investigation

authors： Schmidt WE,Creutzfeldt W,Höcker M,Nustede R,Choudhury AR,Schleser A,Rovati LC,Fölsch UR

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Angiogenesis is essential for tumour growth and metastasis, and is coordinated by several classes of growth factors mediating their effect through receptors linked, in turn, to tyrosine kinase. These growth factors include angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and vascular endothelial growth factor ...

journal_title：European journal of clinical investigation

authors： Caine GJ,Blann AD,Stonelake PS,Ryan P,Lip GY

更新日期：2003-10-01 00:00:00

abstract：:The effects of dazoxiben on finger-blood flow in response to cold challenge were studied in normal subjects and patients with Raynaud's phenomenon. In normal subjects concentrations of TXB2 and 6-oxo-PGF1 alpha were measured in blood taken from dorsal hand veins following cold challenge. In a parallel multicentre stud...

journal_title：European journal of clinical investigation

authors： Tindall H,Tooke JE,Menys VC,Martin MF,Davies JA

更新日期：1985-02-01 00:00:00