Abstract:
:The effect of renal function on the cyclic AMP (cAMP) response to exogenous parathyroid hormone (PTH) was examined in patients with chronic renal failure (n = 22) and primary hyperparathyroidism (n = 19). In the patients with chronic renal failure there was marked resistance to the effect of exogenous PTH. In primary hyperparathyroidism the cAMP responses were variable; most of the patients with an abnormally small response having impaired renal function. After parathyroidectomy, responsiveness improved to varying degrees. In three patients repeatedly tested up to several months after parathyroidectomy, the recovery of responsiveness was a gradual process which began within days but did not, however, return to normal. Thus, there was an irreversible component to the resistance to PTH in these patients. A strong negative correlation between plasma creatinine and the cAMP response to PTH (P less than 0.001) was found in a group of patients, some with treated primary hyperparathyroidism and some with chronic renal failure. Thus, renal impairment is an important, but probably not the sole, contributory factor involved in the irreversible resistance to the action of PTH in hyperparathyroidism.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Lewin IG,Hendy GN,Papapoulos SE,Tomlinson S,O'Riordan JLdoi
10.1111/j.1365-2362.1985.tb00141.xsubject
Has Abstractpub_date
1985-02-01 00:00:00pages
38-44issue
1eissn
0014-2972issn
1365-2362journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Different time-concentration profiles of plasma insulin following insulin modification of a frequently sampled intravenous glucose-tolerance-test (FSIVGTT) were observed in a study investigating maternal metabolism and fetal macrosomia. We aimed to investigate whether these differences were related to the vo...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-12-01 00:00:00
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更新日期:2009-05-01 00:00:00
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更新日期:2008-07-01 00:00:00
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更新日期:1980-02-01 00:00:00
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更新日期:2012-08-01 00:00:00
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更新日期:2020-04-01 00:00:00
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