Abstract:
:In a retrospectively analyzed series of 441 patients operated for primary hyperparathyroidism (HPT), the prevalence of diabetes mellitus was 8.2%, which was three times higher than in the unselected age-matched population. Following parathyroid surgery, the need for antidiabetic treatment was unchanged. The insulin response to an intravenous glucose load was enhanced preoperatively [95 mU/1 +/- 41 (SD)] in twenty-six prospectively studied patients compared to postoperative (65 +/- 41 mU/1) investigations (P less than 0.01). This response was inversely correlated (r = 2, P less than 0.01) to the serum phosphate concentrations but not related to calcium or parathyroid hormone levels. Postoperatively, most HPT patients experienced a deterioration of their glucose tolerance (t 1/2 for i.v. glucose 54 +/- 12 and 64 +/- 21 min, respectively, P less than 0.05), and one-third of them had pathological values at follow-up. Despite this, neither the fasting blood glucose levels nor the values for haemoglobin A1c were significantly affected.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Ljunghall S,Palmér M,Akerström G,Wide Ldoi
10.1111/j.1365-2362.1983.tb00116.xsubject
Has Abstractpub_date
1983-10-01 00:00:00pages
373-7issue
5eissn
0014-2972issn
1365-2362journal_volume
13pub_type
杂志文章abstract:BACKGROUND:The pathogenesis of atherosclerosis and acute coronary syndromes involves inflammation and immunological mechanisms. We hypothesized that patients with unstable angina may have an imbalance between inflammatory and anti-inflammatory cytokines. DESIGN:Plasma levels of tumour necrosis factor (TNF)alpha and in...
journal_title:European journal of clinical investigation
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更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Several clinical trials have suggested that a metabolic cocktail of glucose-insulin-potassium (GIK) decreases mortality rates in patients with acute myocardial infarction (AMI). It has also been reported that Fas-mediated apoptosis plays an important role in ischaemic/reperfusion injury in the rat model. Thi...
journal_title:European journal of clinical investigation
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更新日期:2005-03-01 00:00:00
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更新日期:2019-07-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Patients with continuous ambulatory peritoneal dialysis (CAPD) have high all-cause mortality risk that varies extensively among different conditions. The objective of this study was to develop and validate risk models to predict the 2-year all-cause mortality risks of CAPD patients. MATERIAL AND METHODS:A t...
journal_title:European journal of clinical investigation
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更新日期:2014-11-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1986.tb01334.x
更新日期:1986-06-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,多中心研究
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更新日期:2018-08-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2004-09-01 00:00:00
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更新日期:2018-02-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:1998-05-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章
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更新日期:1985-12-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1988.tb01023.x
更新日期:1988-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1046/j.1365-2362.2002.00987.x
更新日期:2002-05-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,随机对照试验
doi:10.1111/eci.13035
更新日期:2019-01-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1990.tb01908.x
更新日期:1990-12-01 00:00:00
abstract::In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinol...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1985.tb00277.x
更新日期:1985-12-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.1986.tb01322.x
更新日期:1986-04-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2016-05-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.2010.02396.x
更新日期:2011-03-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2021-02-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-02-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,多中心研究
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更新日期:2015-07-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.2010.02273.x
更新日期:2010-05-01 00:00:00
abstract::Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, n...
journal_title:European journal of clinical investigation
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2362.1988.tb01157.x
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Bleeding time has been reported to increase during gaseous nitric oxide (NO) inhalation in healthy volunteers and patients, and it has been speculated that inhaled NO inhibits platelet function. However, results have not been unanimous, and we have been unable to document any effects of inhaled NO on circula...
journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-2362.1999.00560.x
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To investigate alterations in endothelial nitric oxide synthase and inducible nitric oxide synthase mRNA expressions and nitric oxide release in the myocardium during ischaemia/reperfusion and determine whether these changes are ischaemic and/or reperfusion dependent. MATERIALS AND METHODS:Isolated rat heart...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.2005.01553.x
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:We have investigated the potential for using antisense technology as a means of delivering treatment for acute myeloblastic leukaemia (FAB-M2) by gene therapy. MATERIALS AND METHODS:A test recombinant adenovirus vector was constructed containing human c-myc antisense fragments to study the effects of alteri...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.2006.01589.x
更新日期:2006-01-01 00:00:00