当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL INVESTIGATION期刊下所有文献 > Renal impairment and all-cause mortality in cardiovascular disease: effect modification by type 2 diabetes mellitus.

Renal impairment and all-cause mortality in cardiovascular disease: effect modification by type 2 diabetes mellitus.

Abstract：

BACKGROUND:Renal impairment and type 2 diabetes mellitus (DM) are well-known independent risk factors for mortality. The evidence of their combined effects on mortality is unclear, but of importance because it may determine aggressiveness of treatment. This study sought to assess and quantify the effect modification of diabetes on renal impairment in its association with mortality. MATERIALS AND METHODS:Patients with cardiovascular disease or at high risk, recruited in the Second Manifestations of ARTerial disease cohort study, were selected. A total of 7135 patients were enrolled with 33 198 person-years of follow-up. Renal impairment was defined by albuminuria status and estimated glomerular filtration rate (eGFR). Outcome was all-cause mortality. RESULTS:Mortality increased progressively with each stage of renal impairment, for both albuminuria status and eGFR, for diabetics and non-diabetics. There was no effect modification by diabetes on mortality risk due to renal impairment. The relative excess risk due to interaction (RERI) for DM and microalbuminuria was 0·21 (-0·11, 0·52), for overt proteinuria -1·12 (-2·83, 0·59) and for end-stage renal failure (ESRF) 0·32 (-3·65, 4·29). The RERI for DM with eGFR of 60-89 mL/min/1·73 m(2) was -0·31(-0·92, 0·32), for eGFR of 30-59 mL/min/1·73 m(2) -0·07 (-0·76, 0·62) and for eGFR of < 30 mL/min/1·73 m(2) 0·38 (-0·85, 1·61). CONCLUSIONS:Type 2 diabetes mellitus does not modify nor increase the risk relation between all-cause mortality and renal impairment. These findings suggest that the hallmark for survival is the prevention and delay in progression of renal impairment in patients with cardiovascular disease.

journal_name

Eur J Clin Invest

journal_title

European journal of clinical investigation

authors

Selvarajah S,Uiterwaal CS,Haniff J,van der Graaf Y,Visseren FL,Bots ML,SMART study group.

doi

10.1111/eci.12035

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

198-207

issue

2

eissn

0014-2972

issn

1365-2362

journal_volume

43

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION文献大全
  • A critical update on the immunopathogenesis of Stiff Person Syndrome.

    abstract：BACKGROUND:Stiff Person Syndrome (SPS) is a relatively rare but often overlooked autoimmune neurological disorder that targets antigens within the brain's inhibitory pathways resulting in incapacitating stiffness and spasms that impact on the patients' quality of life. Although a number of immunomodulating therapies si...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.2010.02340.x

    authors： Alexopoulos H,Dalakas MC

    更新日期：2010-11-01 00:00:00

  • Neuropsychological impairment in auto-immune disease.

    abstract：:Estimations of the prevalence of central nervous system involvement in patients with systemic lupus erythematosus (SLE) vary from 25 to 75%. In order to assess possible deficits in memory, attention, and/or reaction time, a battery of neuropsychological tests was administered to 15 patients with SLE and to two matched...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：

    authors： Ferstl R,Niemann T,Biehl G,Hinrichsen H,Kirch W

    更新日期：1992-10-01 00:00:00

  • Amadori-albumin correlates with microvascular complications and precedes nephropathy in type 1 diabetic patients.

    abstract：BACKGROUND:Amadori-albumin, a major glycated protein, is involved in experimental hyperglycaemia-induced microvascular complications, and is associated with advanced nephropathy in Type I diabetic patients in humans. Our aim was to assess the association of Amadori-albumin with early nephropathy and with retinopathy in...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2362.2002.01011.x

    authors： Schalkwijk CG,Chaturvedi N,Twaafhoven H,van Hinsbergh VW,Stehouwer CD,EUCLID Study Group.

    更新日期：2002-07-01 00:00:00

  • Anabolic effects of rhIGF-I/IGFBP-3 in vivo are influenced by thyroid status.

    abstract：BACKGROUND:There are close interrelationships between hormones that regulate bone formation and protein biosynthesis. For example, growth hormone and thyroid hormones can influence plasma levels of insulin-like growth factor-I (IGF-I). A patient's status regarding hormones other than IGF-I may thus indirectly modify th...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2362.2001.00793.x

    authors： Svanberg E,Healey J,Mascarenhas D

    更新日期：2001-04-01 00:00:00

  • Preconception folic acid use influences the follicle fluid proteome.

    abstract：BACKGROUND:The investigation of the human follicle fluid proteome has gained much interest in the search of new markers as predictors for in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatment outcome. Follicular fluid folate, as substrate of one carbon (1-C) metabolism, affects follicular met...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12478

    authors： Twigt JM,Bezstarosti K,Demmers J,Lindemans J,Laven JS,Steegers-Theunissen RP

    更新日期：2015-08-01 00:00:00

  • Changes in energy expenditure and fat metabolism in rats infused with interleukin-1.

    abstract：:Metabolic alterations related to resting energy expenditure (REE) and fat metabolism have been noted during sepsis, and often depend on the causative agent and the stage and severity of the illness. We studied the effect of IL-1, the protein mediator of the 'acute phase' response during infection, on REE, respiratory ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1987.tb01149.x

    authors： Tocco-Bradley R,Georgieff M,Jones CT,Moldawer LL,Dinarello CA,Blackburn GL,Bistrian BR

    更新日期：1987-12-01 00:00:00

  • Metastatic pheochromocytoma and paraganglioma.

    abstract：BACKGROUND:Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumours with a strong genetic background. DESIGN:We searched the PubMed database through February 2015 to identify studies characterizing metastatic PCs/PGLs as well as currently established and evolving therapies. RESULTS...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/eci.12495

    authors： Angelousi A,Kassi E,Zografos G,Kaltsas G

    更新日期：2015-09-01 00:00:00

  • Congestive heart failure: involvement of perivascular peptides reflecting activity in sympathetic, parasympathetic and afferent fibres.

    abstract：:In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1990.tb01796.x

    authors： Edvinsson L,Ekman R,Hedner P,Valdemarsson S

    更新日期：1990-02-01 00:00:00

  • The glomerular sieving of pepsinogen A and C in man.

    abstract：:Pepsinogen A (PGA) and pepsinogen C (PGC) are negatively charged, low molecular weight (LMW) proteins with a striking difference in renal handling: PGA (molecular weight 43,500 daltons) shows a high fractional excretion while the fractional excretion of PGC (molecular weight 40,500 daltons) is low, presumably due to t...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1989.tb00234.x

    authors： ten Kate RW,Pals G,Res JC,van Kamp GJ,Verheugt FW,Pronk JC,Donker AJ,Eriksson AW,Meuwissen SG

    更新日期：1989-06-01 00:00:00

  • Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyunsaturated fatty acids.

    abstract：BACKGROUND:Diets and Omega-3 polyunsaturated fatty acids have been considered as important factors to reduce the risk of cardiovascular and inflammatory diseases, but there are few details on the effects on healthy subjects. The aim of the present study was to examine the variation of several physiological parameters i...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.2005.01540.x

    authors： Fontani G,Corradeschi F,Felici A,Alfatti F,Bugarini R,Fiaschi AI,Cerretani D,Montorfano G,Rizzo AM,Berra B

    更新日期：2005-08-01 00:00:00

  • H2 S donor improves heart function and vascular relaxation in diabetes.

    abstract：BACKGROUND AND AIMS:Diabetes dramatically increases the risk of cardiovascular complications and mortality. Hydrogen sulphide plays an important role in reducing oxidative stress. Several studies demonstrated that hydrogen sulphide protects islet beta cells from oxidant stress damage and decreases apoptosis. The aim of...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13354

    authors： Dorofeyeva N,Drachuk K,Rajkumar R,Sabnis O,Sagach V

    更新日期：2021-01-01 00:00:00

  • Liraglutide relieves cardiac dilated function than DPP-4 inhibitors.

    abstract：INTRODUCTION:Diabetes mellitus is a progressive disease with cardiovascular complications. This study evaluated the effects of liraglutide, a glucagon-like peptide-1 analogue and the dipeptidyl peptidase 4 inhibitors sitagliptin and linagliptin on cardiac function in type 2 diabetes patients with renal impairment. MAT...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/eci.13007

    authors： Hiramatsu T,Asano Y,Mabuchi M,Imai K,Iguchi D,Furuta S

    更新日期：2018-10-01 00:00:00

  • Effect of low protein diet on the renal response to meat ingestion in diabetic nephropathy.

    abstract：:We measured the renal haemodynamic and proteinuric response to a meat meal (MM) in ten persistently proteinuric insulin-dependent diabetic patients in a randomized cross-over study of 3 weeks on low protein diet (LPD) or normal protein intake (NPD). On LPD, protein intake (0.64 +/- 0.05 vs 1.15 +/- 0.09 g kg-1 body we...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1991.tb01807.x

    authors： Pinto JR,Bending JJ,Dodds RA,Viberti GC

    更新日期：1991-04-01 00:00:00

  • HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.

    abstract：BACKGROUND:Cardiovascular patients suffer from reduced blood flow leading to ischaemia and impaired tissue metabolism. Unfortunately, an increasing group of elderly patients cannot be treated with current revascularization methods. Thus, new treatment strategies are urgently needed. Hypoxia-inducible factors (HIFs) upr...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12333

    authors： Niemi H,Honkonen K,Korpisalo P,Huusko J,Kansanen E,Merentie M,Rissanen TT,André H,Pereira T,Poellinger L,Alitalo K,Ylä-Herttuala S

    更新日期：2014-10-01 00:00:00

  • Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial.

    abstract：OBJECTIVE:The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:A total of 30 subjects with type 2 diabetes were incl...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.2009.02236.x

    authors： Heinisch BB,Francesconi M,Mittermayer F,Schaller G,Gouya G,Wolzt M,Pleiner J

    更新日期：2010-02-01 00:00:00

  • Evaluation of antileukaemic effects of rapamycin in patients with imatinib-resistant chronic myeloid leukaemia.

    abstract：BACKGROUND:Recent data suggest that the mammalian target of rapamycin (mTOR) is involved in the regulation of growth of neoplastic cells in chronic myeloid leukaemia (CML). PATIENTS AND METHODS:We treated six patients with imatinib-resistant CML in haematological relapse (leukocytes > 20,000 microL(-1)) with rapamycin...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2007.01892.x

    authors： Sillaber C,Mayerhofer M,Böhm A,Vales A,Gruze A,Aichberger KJ,Esterbauer H,Pfeilstöcker M,Sperr WR,Pickl WF,Haas OA,Valent P

    更新日期：2008-01-01 00:00:00

  • High levels of desmosines in urine and plasma of patients with pseudoxanthoma elasticum.

    abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE), a rare heritable disorder caused by mutations of the ABCC6 gene, is characterized by fragmentation and mineralization of elastic fibres. We determined the extent of degradation of elastin by measuring and comparing the amount of desmosines in plasma and urine of PXE patients, ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2004.01306.x

    authors： Annovazzi L,Viglio S,Gheduzzi D,Pasquali-Ronchetti I,Zanone C,Cetta G,Iadarola P

    更新日期：2004-02-01 00:00:00

  • Bosentan for severe pulmonary arterial hypertension related to systemic sclerosis with interstitial lung disease.

    abstract：BACKGROUND:The oral dual endothelin (ET) antagonist bosentan has been established as a cornerstone in the treatment of pulmonary arterial hypertension (PAH). ET is believed to be a key pathogenic mediator in systemic sclerosis (scleroderma, SSc), causing fibrotic, hypertrophic and inflammatory processes. PAH is one of ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2006.01695.x

    authors： Ahmadi-Simab K,Hellmich B,Gross WL

    更新日期：2006-09-01 00:00:00

  • CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils.

    abstract：BACKGROUND:Complement fragment C5a and neutrophils have been implicated in the pathogenesis of renal disease and C5a has also been shown to delay apoptosis of human neutrophils via a transcription-independent pathway. However, transcription-dependent pathways have not been well described. The present study examined whe...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2006.01637.x

    authors： Perianayagam MC,Madias NE,Pereira BJ,Jaber BL

    更新日期：2006-05-01 00:00:00

  • The regulation of megakaryocyte polyploidization and its implications for coronary artery occlusion.

    abstract：:Polyploidization is a distinctive feature of megakaryocyte differentiation. The physiological meaning and the regulation of this process are obscure. Megakaryocyte ploidy varies in normal biology and in disease. Here we review the evidence suggesting that ploidy changes may have a role in the determination of platelet...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.1993.tb00711.x

    authors： Erusalimsky JD,Martin JF

    更新日期：1993-01-01 00:00:00

  • Mild portal endotoxaemia induces subacute hepatic inflammation and pancreatic beta-cell dysfunction in rats.

    abstract：BACKGROUND:Portal endotoxaemia has been speculated to be crucially involved in the pathogenesis of chronic hepatic inflammation, which is highly associated with the development of type 2 diabetes mellitus. This study tests whether portal endotoxaemia is a pathogenic link between chronic subacute hepatic inflammation an...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2008.01991.x

    authors： Hsieh PS,Chan JY,Shyu JF,Chen YT,Loh CH

    更新日期：2008-09-01 00:00:00

  • The 13C/2H-glucose test for determination of small intestinal lactase activity.

    abstract：:To diagnose hypolactasia, determination of lactase enzyme activity in small intestinal biopsy material is considered to be the golden standard. Because of its strongly invasive character and the sampling problems, alternative methods have been looked for. We analysed the 13C-glucose response in serum after consumption...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2001.00791.x

    authors： Vonk RJ,Stellaard F,Priebe MG,Koetse HA,Hagedoorn RE,De Bruijn S,Elzinga H,Lenoir-Wijnkoop I,Antoine JM

    更新日期：2001-03-01 00:00:00

  • SOX6 rs7117858 polymorphism is associated with osteoporosis and obesity-related phenotypes.

    abstract：BACKGROUND:SOX6 has been recently proposed as a pleiotropic gene for obesity and osteoporosis. The aim of this study was to investigate whether the rs7117858 genetic variant in SOX6 was associated with bone mass assessed by quantitative ultrasound (QUS) and obesity-related measures in a population of young adults. MET...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13011

    authors： Correa-Rodríguez M,Schmidt-RioValle J,Rueda-Medina B

    更新日期：2018-10-01 00:00:00

  • The influence of ulnar nerve blockade on skin microvascular blood flow.

    abstract：:Microvascular research is seriously hampered by the great temporal and spatial variability of the measured skin blood flow and variation in sympathetic vasomotor reflexes within and between persons. Therefore skin vasomotor reflexes were studied before and after ulnar nerve blockade within the same person, resulting i...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1995.tb01738.x

    authors： Netten PM,Wollersheim H,Gielen MJ,Den Arend JA,Lutterman JA,Thien T

    更新日期：1995-07-01 00:00:00

  • Simultaneous assay of noradrenaline and its deaminated metabolite, dihydroxyphenylglycol, in plasma: a simplified approach to the exclusion of phaeochromocytoma in patients with borderline elevation of plasma noradrenaline concentration.

    abstract：:The fate of noradrenaline released from sympathetic endings differs from that of noradrenaline secreted directly into the bloodstream. This has been used to establish a single sample test for the exclusion of phaeochromocytoma in patients with borderline elevation of plasma noradrenaline concentration. This test is ba...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1984.tb00706.x

    authors： Brown MJ

    更新日期：1984-02-01 00:00:00

  • Chronic Q fever associated with systemic sclerosis.

    abstract：BACKGROUND:After the Q fever outbreak in the Netherlands between 2007 and 2010, more than 300 patients with chronic Q fever have been identified. Some patients were also diagnosed with systemic sclerosis, a rare immune-mediated disease. We aimed to increase awareness of concomitant chronic Q fever infection and systemi...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13123

    authors： Jansen AFM,Raijmakers RPH,van Deuren M,Vonk MC,Bleeker-Rovers CP

    更新日期：2019-07-01 00:00:00

  • Pathways of renal injury in systemic gram-negative sepsis.

    abstract：:Acute renal failure is a grave complication of systemic gram-negative sepsis. The pathophysiological mechanisms of sepsis leading to kidney injury result in part from systemic inflammatory and haemodynamic alterations. These are triggered by the interaction of endotoxin with Toll-like receptor 4 (TLR4) on cells of the...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.2008.02007.x

    authors： El-Achkar TM,Hosein M,Dagher PC

    更新日期：2008-10-01 00:00:00

  • Volume regulating hormone responses to repeated head-up tilt and lower body negative pressure.

    abstract：BACKGROUND:We hypothesized the existence of different hormonal response patterns to repeated lower body negative pressure (LBNP) and head-up tilt (HUT) in healthy males. We compared hormonal, cardiovascular and plasma volume changes from rest to stress within- and between-LBNP and HUT applications. Hormones investigate...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2011.02476.x

    authors： Roessler A,Goswami N,Haditsch B,Loeppky JA,Luft FC,Hinghofer-Szalkay H

    更新日期：2011-08-01 00:00:00

  • The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts.

    abstract：:Hyperthyroidism is associated with an increase in both osteoblast and osteoclast activity. We have previously shown that, in vitro, osteoclasts do not respond directly to tri-iodothyronine to increase bone resorption but that the effect is mediated by another bone cell, probably the osteoblast. To investigate this iss...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1996.160289.x

    authors： Allain TJ,Yen PM,Flanagan AM,McGregor AM

    更新日期：1996-05-01 00:00:00

  • Increased thromboxane formation in patients with antiphospholipid syndrome.

    abstract：:Thirty-one patients with IgG antibodies to cardiolipin (ACLA) were studied to determine their in vivo formation of the platelet aggregating and vasoconstricting substance thromboxane A2 (TxA2) and the platelet inhibiting and vasodilating substance prostacyclin (PGI2). This was done by measurements in urine of their en...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1990.tb01908.x

    authors： Arfors L,Vesterqvist O,Johnsson H,Gréen K

    更新日期：1990-12-01 00:00:00