The regulation of megakaryocyte polyploidization and its implications for coronary artery occlusion.

abstract：:Two methods of measurement of fractional calcium absorption have been compared in the same individuals. There is a significant correlation between fractional 47Ca absorption as measured with a blood counting method and with an external counting method after intravenous and oral administration of 47Ca (P less than 0.00...

journal_title：European journal of clinical investigation

authors： Juttmann JR,Ruis AM,Hagenouw-Taal JC,Lockefeer JH,Birkenhäger JC

更新日期：1978-06-01 00:00:00

abstract：:In eleven patients with chronic renal insufficiency treated by intermittent haemodialysis and in ten normal subjects, hepatic and extrahepatic triglyceride lipase activity of post heparin plasma was selectively measured, utilizing the different sensitivity of both enzymes to inhibition by protamine sulphate. In uraemi...

journal_title：European journal of clinical investigation

authors： Bolzano K,Krempler F,Sandhofer F

更新日期：1978-10-01 00:00:00

abstract：:Metabolic alterations related to resting energy expenditure (REE) and fat metabolism have been noted during sepsis, and often depend on the causative agent and the stage and severity of the illness. We studied the effect of IL-1, the protein mediator of the 'acute phase' response during infection, on REE, respiratory ...

journal_title：European journal of clinical investigation

authors： Tocco-Bradley R,Georgieff M,Jones CT,Moldawer LL,Dinarello CA,Blackburn GL,Bistrian BR

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Analytical statistics revealed a variety of risk factors for hypertension, but the complex interplay between different factors remains to be determined by more powerful statistical techniques. METHODS:Analytical as well as new, explorative statistical methods such as natural segmentation (k-means) and predi...

journal_title：European journal of clinical investigation

authors： Lukas A,Kumbein F,Temml C,Mayer B,Oberbauer R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Most of the previous reports found cirrhosis patients with a high risk of subsequent tuberculosis (TB). However, data about the risk of developing liver cirrhosis in TB patients are limited. As a hepatitis endemic area, the risk of liver cirrhosis in patients with TB should be elucidated in Taiwan. METHODS:...

journal_title：European journal of clinical investigation

authors： Peng YC,Lin CL,Hsu WY,Chang CS,Yeh HZ,Kao CH

更新日期：2015-07-01 00:00:00

abstract：:The ATP-binding cassette transporter P-glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P-glycoprotein-expressing cell lines, the generation of P-glycoprotein knockout mice as well as studies in animals and humans contributed to a better understanding on the role...

journal_title：European journal of clinical investigation

authors： Fromm MF

更新日期：2003-11-01 00:00:00

abstract：:Nitrogen load can be reduced by substituting dietary protein intake with keto or hydroxy analogues of amino acids. To investigate their intestinal absorption, human jejunal brush border membrane vesicles were used to measure uptake of L-leucine hydroxy analogue (L-LHA) and L-lactate. Uptake assays were performed under...

journal_title：European journal of clinical investigation

authors： Friedrich M,Murer H,Sterchi E,Berger EG

更新日期：1992-02-01 00:00:00

abstract：:Deficiency of apolipoprotein C-II (apo C-II), the cofactor for lipoprotein lipase, results in the familial chylomicronaemia syndrome characterized by severe hypertriglyceridaemia and fasting chylomicronaemia. To investigate the biochemical features of the heterozygous state for apo C-II deficiency, we characterized th...

journal_title：European journal of clinical investigation

authors： Gabelli C,Bilato C,Santamarina-Fojo S,Martini S,Brewer HB Jr,Crepaldi G,Baggio G

更新日期：1993-09-01 00:00:00

abstract：:Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, n...

journal_title：European journal of clinical investigation

authors： Jaschonek K,Muller CP

更新日期：1988-02-01 00:00:00

abstract：:The saphenous vein is the most commonly used graft for revascularization procedures in patients with coronary artery disease and critical limb ischaemia. However, the patency rate of this vessel is poor, with a high proportion of patients requiring further surgery. Early graft occlusion is caused by vasoconstriction o...

journal_title：European journal of clinical investigation

authors： Dashwood MR

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Alcohol may have a cardioprotective effect. One possible mechanism is by modifying insulin resistance/secretion. The aims of this study were: (i) to examine the effect of short-term alcohol consumption on the metabolic control of glucose tolerance; (ii) to study the influence of short-term alcohol consumptio...

journal_title：European journal of clinical investigation

authors： Flanagan DE,Pratt E,Murphy J,Vaile JC,Petley GW,Godsland IF,Kerr D

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Right ventricular (RV) dysfunction in heart failure (HF) with reduced left ventricular ejection fraction (LVEF) is associated with a poorer prognosis. No studies to date have investigated the prognostic utility of RV isovolumic acceleration (IVA) measured at tissue Doppler imaging (TDI) in HF. RV strain inst...

journal_title：European journal of clinical investigation

authors： Sciatti E,Vizzardi E,Bonadei I,Curnis A,D'Aloia A,Metra M

更新日期：2015-10-01 00:00:00

abstract：:In a retrospectively analyzed series of 441 patients operated for primary hyperparathyroidism (HPT), the prevalence of diabetes mellitus was 8.2%, which was three times higher than in the unselected age-matched population. Following parathyroid surgery, the need for antidiabetic treatment was unchanged. The insulin re...

journal_title：European journal of clinical investigation

authors： Ljunghall S,Palmér M,Akerström G,Wide L

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...

journal_title：European journal of clinical investigation

authors： Turan RG,Brehm M,Koestering M,Tobias Z,Bartsch T,Steiner S,Picard F,Ebner P,Schannwell CM,Strauer BE

更新日期：2007-11-01 00:00:00

abstract：:beta-Adrenoceptor binding on peripheral blood mononuclear cells (PBMC) of healthy adult volunteers was investigated using the radioligand 125iodo-cyanopindolol (ICYP). Saturation binding studies were performed with nine different concentrations of ICYP. Receptor density and affinity were calculated by Scatchard plots....

journal_title：European journal of clinical investigation

authors： Griese M,Körholz U,Körholz D,Seeger K,Wahn V,Reinhardt D

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss of higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques (SPs) of aggregated amyloid-beta peptide (Abeta) and intracellular neurofibrillary tangles ...

journal_title：European journal of clinical investigation

authors： Yokota T,Mishra M,Akatsu H,Tani Y,Miyauchi T,Yamamoto T,Kosaka K,Nagai Y,Sawada T,Heese K

更新日期：2006-11-01 00:00:00

abstract：:The effect of the potent specific cholecystokinin (CCK) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of CCK, gastrin, pancreatic polypeptide (PP), neurotensin, glucose-dependent insulinotropic polypeptide (GIP), insulin and C peptide was investigated in a placebo-controlled study in 10 heal...

journal_title：European journal of clinical investigation

authors： Schmidt WE,Creutzfeldt W,Höcker M,Nustede R,Choudhury AR,Schleser A,Rovati LC,Fölsch UR

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Patients with continuous ambulatory peritoneal dialysis (CAPD) have high all-cause mortality risk that varies extensively among different conditions. The objective of this study was to develop and validate risk models to predict the 2-year all-cause mortality risks of CAPD patients. MATERIAL AND METHODS:A t...

journal_title：European journal of clinical investigation

authors： Zhao C,Luo Q,Xia X,He F,Peng F,Yu X,Huang F

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnoea (OSA) is a common complication of obesity and can have a substantial negative impact on a patient's quality of life and risk of cardiovascular disease. The aim of this case-control study was to undertake discovery profiling of urinary peptides using capillary electrophoresis-mass spe...

journal_title：European journal of clinical investigation

authors： Seetho IW,Siwy J,Albalat A,Mullen W,Mischak H,Parker RJ,Craig S,Duffy N,Hardy KJ,Burniston JG,Wilding JP

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The Treating to New Targets (TNT) study has recently provided evidence that reduction in LDL-C levels below 2·6 mmol L⁻¹ lowers the risk of cerebrovascular events by an additional 20% to 25%, thereby confirming the value of statin therapy in preventing transient ischaemic attacks and stroke. Despite the prot...

journal_title：European journal of clinical investigation

authors： van den Bogaard B,van den Born BJ,Fayyad R,Waters DD,DeMicco DA,LaRosa JC,Kastelein JJ,Holme I,Treating to New Targets investigators.

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Recent data suggest that the mammalian target of rapamycin (mTOR) is involved in the regulation of growth of neoplastic cells in chronic myeloid leukaemia (CML). PATIENTS AND METHODS:We treated six patients with imatinib-resistant CML in haematological relapse (leukocytes > 20,000 microL(-1)) with rapamycin...

journal_title：European journal of clinical investigation

authors： Sillaber C,Mayerhofer M,Böhm A,Vales A,Gruze A,Aichberger KJ,Esterbauer H,Pfeilstöcker M,Sperr WR,Pickl WF,Haas OA,Valent P

更新日期：2008-01-01 00:00:00

abstract：:The biocompatibility of two commercially available charcoal columns, one containing coated and the other uncoated but immobilized charcoal, was compared during four haemoperfusions with each in eight healthy greyhounds. Reductions in arterial levels of platelets (49% and 42% respectively) and leucocytes (both 21%) wer...

journal_title：European journal of clinical investigation

authors： Weston MJ,Hanid A,Rubin MH,Langley PG,Mellon PJ,Williams R

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Previous studies revealed that patients with Takotsubo syndrome (TTS) have a higher mortality rate than the general population and a comparable mortality to acute coronary syndrome (ACS). Repolarisation abnormalities, namely T-wave amplitude, may provide incremental prognostic information, in addition to tra...

journal_title：European journal of clinical investigation

authors： Gietzen T,El-Battrawy I,Lang S,Zhou XB,Ansari U,Behnes M,Borggrefe M,Akin I

更新日期：2019-04-01 00:00:00

abstract：:The developmental aspects of characteristic intestinal lipoprotein synthesis, chlomicrons (CM), very low density lipoproteins (VLDL) and high density lipoproteins (HDL), are unknown. Our objective was to determine the ontogeny of intestinal lipid and lipoprotein synthesis in both the jejunum and the ileum. Explants of...

journal_title：European journal of clinical investigation

authors： Mehran M,Thibault L,Russo P,Garofalo C,Levy E

更新日期：1992-02-01 00:00:00

abstract：:The concentration in serum of cathodal trypsinogen has been studied in certain clinical and experimental situations. The concentration correlated with pancreatic amylase activity. Low levels were found in patients with malabsorption due to exocrine pancreatic insufficiency. The concentration rose after endoscopic retr...

journal_title：European journal of clinical investigation

authors： Borgström A,Ohlsson K

更新日期：1978-12-01 00:00:00

abstract：:Three different types of cardiovascular sequelae attributed to interferon therapy have been reported: arrhythmia, ischaemic heart disease and cardiomyopathy. We evaluated the left ventricular ejection fraction (LVEF) during alpha interferon therapy (3 MU administered subcutaneously three times a week for 6 months) in ...

journal_title：European journal of clinical investigation

authors： Sartori M,Andorno S,La Terra G,Pozzoli G,Rudoni M,Sacchetti GM,Inglese E,Aglietta M

更新日期：1995-01-01 00:00:00

abstract：:The permeability of the gastrointestinal tract was investigated by means of polyethylene glycol (PEG), given orally. The PEG solutions contained oligomers with molecular weights from 414 to 1206. The urinary recovery of ingested PEG was determined by high performance liquid chromatography (HPLC). Considerable inter- a...

journal_title：European journal of clinical investigation

authors： Philipsen EK,Batsberg W,Christensen AB

更新日期：1988-04-01 00:00:00

abstract：:The release of PGI2-like activity into the circulation in response to cholinergic agonists and modification of this response by beta-adrenergic antagonists was investigated in anaesthetized cats and healthy humans. Antiaggregatory activity in the arterial blood was continuously assayed by measuring platelet aggregatio...

journal_title：European journal of clinical investigation

authors： Swies J,Radomski M,Dembińska-Kieć A,Korbut R,Gryglewski RJ,Brandt R,Nowak J

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Cardiovascular patients suffer from reduced blood flow leading to ischaemia and impaired tissue metabolism. Unfortunately, an increasing group of elderly patients cannot be treated with current revascularization methods. Thus, new treatment strategies are urgently needed. Hypoxia-inducible factors (HIFs) upr...

journal_title：European journal of clinical investigation

authors： Niemi H,Honkonen K,Korpisalo P,Huusko J,Kansanen E,Merentie M,Rissanen TT,André H,Pereira T,Poellinger L,Alitalo K,Ylä-Herttuala S

更新日期：2014-10-01 00:00:00

abstract：:The siblings presented here are the third family found in Japan with familial LCAT deficiency. Their post-heparin plasma lipoprotein lipase and hepatic triglyceride lipase activities were measured selectively by an immunochemical method. Plasma triglyceride levels were elevated, and post-heparin plasma lipoprotein lip...

journal_title：European journal of clinical investigation

authors： Murayama N,Asano Y,Kato K,Sakamoto Y,Hosoda S,Yamada N,Kodama T,Murase T,Akanuma Y

更新日期：1984-04-01 00:00:00