The glomerular sieving of pepsinogen A and C in man.

abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...

journal_title：European journal of clinical investigation

authors： Turan RG,Brehm M,Koestering M,Tobias Z,Bartsch T,Steiner S,Picard F,Ebner P,Schannwell CM,Strauer BE

更新日期：2007-11-01 00:00:00

abstract：:The capillary permeability in human skeletal muscle, expressed as capillary diffusion capacity (CDC) for 51Cr-EDTA, was determined during exercise with a local clearance method in two groups of healthy male subjects: a younger group with a mean age of 30 years and an older one with a mean age of 58 years. The main fin...

journal_title：European journal of clinical investigation

authors： Berglund B,Efendić S,Strandell T,Luft R

更新日期：1979-10-01 00:00:00

abstract：:Eur J Clin Invest 2012; 42 (6): 579-588 ABSTRACT: Glucose-based methods are currently gold standards for identifying individuals at risk of type 2 diabetes. Obviously, these methods only consider one of many pathologies of impaired glucose metabolism and they all suffer from a poor specificity as type 2 diabetes risk ...

journal_title：European journal of clinical investigation

authors： Gjesing AP,Pedersen O

更新日期：2012-06-01 00:00:00

abstract：:Endothelin-1 is a recently described endothelium-derived vasoconstricting peptide. Plasma concentrations of immunoreactive (IR-) endothelin were investigated in six healthy young men applying a radioimmunoassay after extraction of endothelin from plasma. In venous plasma a mean concentration of 1.3 +/- 0.4 pmol l-1 wa...

journal_title：European journal of clinical investigation

authors： Wagner OF,Nowotny P,Vierhapper H,Waldhäusl W

更新日期：1990-10-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease associated with autoimmune disorders. The aetiology is unknown, although it has been suggested that the disease may be related to infectious agents. Previous studies revealed that sera from patients with PBC react against Mycobacterium gordonae. Th...

journal_title：European journal of clinical investigation

authors： Vilagut L,Parés A,Viñas O,Vila J,Jiménez de Anta MT,Rodés J

更新日期：1997-08-01 00:00:00

abstract：:The siblings presented here are the third family found in Japan with familial LCAT deficiency. Their post-heparin plasma lipoprotein lipase and hepatic triglyceride lipase activities were measured selectively by an immunochemical method. Plasma triglyceride levels were elevated, and post-heparin plasma lipoprotein lip...

journal_title：European journal of clinical investigation

authors： Murayama N,Asano Y,Kato K,Sakamoto Y,Hosoda S,Yamada N,Kodama T,Murase T,Akanuma Y

更新日期：1984-04-01 00:00:00

abstract：:We have examined the impact of race and positive family history of type 2 diabetes on glucose/insulin dynamics and the two components of glucose disposal in healthy, first-degree relatives of black and white American patients with type 2 diabetes mellitus who are at a greater risk from the disease and their healthy co...

journal_title：European journal of clinical investigation

authors： Osei K,Cottrell DA

更新日期：1994-12-01 00:00:00

abstract：:A haemolytically inactive alpha-mobile complement C8 component was identified by crossed immunoelectrophoresis in a 27-year-old male with recurrent meningococcal infections and absence of complement mediated serum haemolytic activity. The patient's serum/plasma contained no demonstrable normal C8. C8 inhibitor activit...

journal_title：European journal of clinical investigation

authors： Brandslund I,Teisner B,Strate M,Grunnet N,Svehag SE,Isager H,Wang P

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Chronic hyponatremia is common and associated with increased morbidity and mortality. However, whether treatment improves outcome in patients without significant symptoms is unclear. We here assessed the therapeutic outcome on clinical symptoms, neurocognitive and neuromuscular function in patients with chro...

journal_title：European journal of clinical investigation

authors： Refardt J,Kling B,Krausert K,Fassnacht M,von Felten S,Christ-Crain M,Fenske W

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Circulatory dysfunction in portal hypertension is characterized by increased cardiac output, decreased systemic vascular resistance, a fall in mean arterial pressure secondary to splanchnic and systemic vasodilation and hence renal hypoperfusion. Previous studies have disclosed that renal vasculatures of por...

journal_title：European journal of clinical investigation

authors： Chuang CL,Huang HC,Chang CC,Lee FY,Wu JC,Lee SD

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis. It has been shown previously that this may result in a transient "oversaturation" of transferrin. METHODS:Ten stable haemodialysis patients on r-HuEPO treatment re...

journal_title：European journal of clinical investigation

authors： Kooistra MP,Kersting S,Gosriwatana I,Lu S,Nijhoff-Schutte J,Hider RC,Marx JJ

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The platelet-to-lymphocyte ratio (PLR) has been found to predict clinical outcomes in borderline ovarian tumours and the other genital neoplasms. However, its prognostic value in patients with ovarian cancer remains controversial. The aim of this study was to assess its prognostic value in ovarian cancer. M...

journal_title：European journal of clinical investigation

authors： Tian C,Song W,Tian X,Sun Y

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Bezafibrate reportedly lowers serum lipids and plasma fibrinogen in humans and rats, but the mechanism of this process has still to be clarified. We have addressed this problem by investigating the effects of bezafibrate on fibrinogen in the human hepatoma HepG2 cell line. METHODS:In cells cultured with and...

journal_title：European journal of clinical investigation

authors： Binsack R,Stegmeier K,Dörge L,Völkl A

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Neutrophil-mediated inflammation was recently identified as an active contributor to athero-progression. Therapeutic strategies inhibiting neutrophil degranulation or recruitment were hypothesized to positively impact on plaque vulnerability. In this study, we investigated whether treatment with the recently...

journal_title：European journal of clinical investigation

authors： Da Silva AR,Lenglet S,Carbone F,Burger F,Roth A,Liberale L,Bonaventura A,Dallegri F,Stergiopulos N,Santos RA,Mach F,Fraga-Silva RA,Montecucco F

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Differences in lipid parameters between patients with acute coronary syndromes (ACS) and patients with stable coronary artery disease (CAD) are unclear and are addressed in this study. METHODS:We enrolled 582 patients with angiographically proven stable CAD (of whom 26·9% had diabetes mellitus type 2 (T2DM)...

journal_title：European journal of clinical investigation

authors： Vonbank A,Saely CH,Rein P,Drexel H

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to examine the effects of a large dose of slow-release carbohydrates (CHOs) at bedtime on the nocturnal glucose, insulin and free fatty acid (FFA) levels, and to assess the putative effects on morning fasting and post-prandial glucose levels in patients with moderately controlled non-i...

journal_title：European journal of clinical investigation

authors： Axelsen M,Lönnroth P,Arvidsson Lenner R,Smith U

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Irisin, a novel myokine, has been shown to increase following vigorous exercise, with studies suggesting that it mediates some of the beneficial effects of exercise. Irisin might play a role in 'browning' of white adipocytes, thus increasing energy expenditure. The role of irisin in exercise and energy expen...

journal_title：European journal of clinical investigation

authors： Al-Daghri NM,Alokail MS,Rahman S,Amer OE,Al-Attas OS,Alfawaz H,Tripathi G,Sabico S,Chrousos GP,McTernan PG,Piya MK

更新日期：2015-08-01 00:00:00

abstract：:Platelet aggregation induced by collagen, ADP and epinephrine, was monitored in 150 type-II patients (115 type IIA and 35 type IIB) and compared with a reference group of normolipidaemic controls; in addition, malondialydehyde formation and thromboxane B2 were examined in a subsample of the type-IIA patients. Threshol...

journal_title：European journal of clinical investigation

authors： Tremoli E,Maderna P,Colli S,Morazzoni G,Sirtori M,Sirtori CR

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Over the past decades, the prevalence of obesity has markedly increased worldwide. Stress is recognized as a substantial contributor to increased body weight; therefore, stress management interventions, especially cognitive behavioural, are becoming increasingly popular. The impact of stress management on st...

journal_title：European journal of clinical investigation

authors： Simos DS,Kokkinos A,Tentolouris N,Dimosthenopoulos C,Mantzou E,Artemiadis A,Bacopoulou F,Nicolaides NC,Kosta O,Chrousos GP,Darviri C

更新日期：2019-10-01 00:00:00

abstract：METHODS:Ten samples of decidua basalis from pre-eclamptic women and 10 from healthy primigravid women subjected to caesarean section (control tissues) were investigated immunohistochemically for changes in angiogenesis and expression of tenascin, an extracellular matrix protein thought to modulate angiogenesis. In addi...

journal_title：European journal of clinical investigation

authors： Ribatti D,Loverro G,Vacca A,Greco P,Roncali L,Selvaggi L

更新日期：1998-05-01 00:00:00

abstract：:Alpha-naphthyl-isothiocyanate (ANIT)-induced intrahepatic cholangitis was associated with significant polyuria in rats. The urine output in the experimental rats was about two and a half to four fold higher than that in the controls. The polyuria was accompanied by polydypsia and disappeared when water intake was limi...

journal_title：European journal of clinical investigation

authors： Tur-Kaspa R,Adler R,Popovtzer MM,Eliakim M

更新日期：1983-02-01 00:00:00

abstract：:With advancing age both sexes have an increased incidence of osteoporotic fractures, although fractures are more common in women than in men. Whereas in women several potential risk factors have been identified, less is known about osteoporosis in men. A total of 27 Austrian men (mean age: 65 +/- 2 years) with atrauma...

journal_title：European journal of clinical investigation

authors： Resch H,Pietschmann P,Woloszczuk W,Krexner E,Bernecker P,Willvonseder R

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Carotid intima-media thickness and carotid plaque are well-established imaging markers used to capture different stages of the atherosclerotic disease process. We aimed to quantify to which extent carotid intima-media thickness predicts incidence of first-ever carotid plaque. MATERIALS AND METHODS:Two indep...

journal_title：European journal of clinical investigation

authors： Tschiderer L,Klingenschmid G,Seekircher L,Willeit P

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:To reveal detailed histopathological changes, virus distributions, immunologic properties and multi-omic features caused by SARS-CoV-2 in the explanted lungs from the world's first successful lung transplantation of a COVID-19 patient. MATERIALS AND METHODS:A total of 36 samples were collected from the lung...

journal_title：European journal of clinical investigation

authors： Chen XJ,Li K,Xu L,Yu YJ,Wu B,He YL,Zhao WE,Li D,Luan CX,Hu L,Wang J,Ding JJ,Yu YF,Li JX,Tan ZM,Liu XF,Wei D,Zhang ZH,Guo XJ,Su C,Hu ZB,Guo YS,Chen JY,Chen F

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The cholesterol-esterifying enzyme, lecithin:cholesterol acyltransferase (LCAT), is instrumental in high-density lipoprotein (HDL) remodelling. LCAT may also modify oxidative and inflammatory processes, as supported by an inverse relationship with HDL antioxidative functionality and a positive relationship w...

journal_title：European journal of clinical investigation

authors： Gruppen EG,Connelly MA,Otvos JD,Bakker SJ,Dullaart RP

更新日期：2015-08-01 00:00:00

abstract：:Microdialysis was used to selectively assess the effect of the paracrine renin-angiotensin system (RAS) on interstitial glucose and lactate concentration profiles in skeletal muscle of healthy volunteers (n = 8) during basal and insulin-stimulated conditions. Paracrine RAS was selectively inhibited by local retrodialy...

journal_title：European journal of clinical investigation

authors： Müller M,Fasching P,Schmid R,Burgdorff T,Waldhäusl W,Eichler HG

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) represents the most relevant cause of death and morbidity in the adult population of developed and developing countries. During the last decades, a strong research effort has been performed to identify more selective markers and better assess the cardiovascular risk in both prim...

journal_title：European journal of clinical investigation

authors： Quercioli A,Montecucco F,Bertolotto M,Ottonello L,Pende A,Mach F,Dallegri F

更新日期：2010-07-01 00:00:00

abstract：:Polyploidization is a distinctive feature of megakaryocyte differentiation. The physiological meaning and the regulation of this process are obscure. Megakaryocyte ploidy varies in normal biology and in disease. Here we review the evidence suggesting that ploidy changes may have a role in the determination of platelet...

journal_title：European journal of clinical investigation

authors： Erusalimsky JD,Martin JF

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Plasmacytoid dendritic cells (pDCs) are multifunctional bone-marrow-derived immune cells that are key players in bridging the innate and adaptive immune systems. Activation of pDCs through toll-like receptor agonists has proven to be an effective treatment for some neoplastic disorders. MATERIALS AND METHOD...

journal_title：European journal of clinical investigation

authors： Lombardi VC,Khaiboullina SF,Rizvanov AA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Excess of cardiovascular risk among patients with chronic inflammatory diseases has been attributed to increased arterial stiffness. Hypercholesterolaemia has been demonstrated to promote a low-grade inflammatory status. The objective of the present study was to define, in hypercholesterolaemia, the influenc...

journal_title：European journal of clinical investigation

authors： Pirro M,Schillaci G,Savarese G,Gemelli F,Vaudo G,Siepi D,Bagaglia F,Mannarino E

更新日期：2004-05-01 00:00:00