Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling.

abstract：BACKGROUND:Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis. It has been shown previously that this may result in a transient "oversaturation" of transferrin. METHODS:Ten stable haemodialysis patients on r-HuEPO treatment re...

journal_title：European journal of clinical investigation

authors： Kooistra MP,Kersting S,Gosriwatana I,Lu S,Nijhoff-Schutte J,Hider RC,Marx JJ

更新日期：2002-03-01 00:00:00

abstract：:N-3 fatty acids were supplied to a 36-year-old female patient suffering from ulcerative colitis and severe steroid side-effects, in a sequence of parenteral and enteral administration. During a moderately active period of disease, 200 ml d-1 fish oil-derived lipid emulsion (eicosapentaenoic acid [EPA], 4.2 g; docosahe...

journal_title：European journal of clinical investigation

authors： Grimminger F,Führer D,Papavassilis C,Schlotzer E,Mayer K,Heuer KU,Kiss L,Walmrath D,Piberhofer S,Lübbecke F

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:We investigated whether plasma ferritin levels through the pro-inflammatory effects of free iron are associated with adipose tissue dysfunction in a relevant population of patients with manifest vascular disease who would potentially benefit the most from further aetiological insights. MATERIALS AND METHODS...

journal_title：European journal of clinical investigation

authors： Westerink J,Olijhoek JK,Koppen A,Faber DR,Kalkhoven E,Monajemi H,van Asbeck BS,van der Graaf Y,Visseren FL

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cardiovascular patients suffer from reduced blood flow leading to ischaemia and impaired tissue metabolism. Unfortunately, an increasing group of elderly patients cannot be treated with current revascularization methods. Thus, new treatment strategies are urgently needed. Hypoxia-inducible factors (HIFs) upr...

journal_title：European journal of clinical investigation

authors： Niemi H,Honkonen K,Korpisalo P,Huusko J,Kansanen E,Merentie M,Rissanen TT,André H,Pereira T,Poellinger L,Alitalo K,Ylä-Herttuala S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Soluble TWEAK (sTWEAK) and asymmetric dimethyl arginine (ADMA) concentrations have been associated with endothelial function in patients with chronic kidney disease (CKD). We tested the hypothesis that the improvement in endothelial function observed after renal transplantation is directly linked to the norm...

journal_title：European journal of clinical investigation

authors： Yilmaz MI,Sonmez A,Saglam M,Yaman H,Unal HU,Gok M,Cetinkaya H,Eyileten T,Oguz Y,Sari S,Yildirim AO,Vural A,Carrero JJ,Blanco-Colio LM

更新日期：2013-12-01 00:00:00

abstract：:After feeding intact conscious dogs 1000 g mashed meat, peripheral venous immunoreactive insulin activity (IRI) increases before any enhancement of amino nitrogen concentration. This course of IRI is paralleled by a decrease of free fatty acids. Meal feeding in dogs, whose pancreatic juice is completely diverted from ...

journal_title：European journal of clinical investigation

authors： Fischer U,Hommel H,Gottschling HD,Nowak W

更新日期：1976-11-30 00:00:00

abstract：BACKGROUND:Increased production of chemokines by adipose tissue and defective adipose tissue oxygenation as a result of obesity may induce leucocyte infiltration and subsequent systemic inflammation. OBJECTIVES:1-To determine the relation between the amount of visceral and subcutaneous adipose tissue and the chemokine...

journal_title：European journal of clinical investigation

authors： Faber DR,van der Graaf Y,Westerink J,Kanhai DA,Monajemi H,Visseren FL,SMART study Group.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Renal cyclooxygenases (COX) produce the prostaglandins (PG) E2, I2 and thromboxane (TxA2), which interact with distinct G protein-coupled receptors. We investigated the expression of the three EP receptors EP2, EP3 and EP4 and the receptors for PGI2 (IP) and TxA2 (TP) in rats with passive Heymann nephritis (...

journal_title：European journal of clinical investigation

authors： Waldner C,Heise G,Schrör K,Heering P

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Platelets are involved in the pathogenesis of bronchial asthma, including aspirin-sensitive asthma (ASA). The pineal hormone melatonin (MT) has been described as inhibiting several physiological processes in platelets. The MT metabolite - N-acetyl-5-methoxy-kynurenamine - has a chemical structure similar to ...

journal_title：European journal of clinical investigation

authors： Evsyukova HV

更新日期：1999-06-01 00:00:00

abstract：:To determine the comparative value of serum Type III procollagen peptide (PIIIP) in paediatric and adult liver disease we have measured PIIIP in 201 healthy subjects (aged 1 day-77 years) and twenty-one children and five adults with chronic active hepatitis (CAH). Healthy children had significantly higher PIIIP levels...

journal_title：European journal of clinical investigation

authors： Trivedi P,Cheeseman P,Portmann B,Hegarty J,Mowat AP

更新日期：1985-04-01 00:00:00

abstract：:Proliferation of smooth muscle cells (SMCs) plays an important role in vascular pathobiology by being involved in the development of coronary atherosclerosis and restenosis. Competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase have shown antiproliferative properties on different cell typ...

journal_title：European journal of clinical investigation

authors： Martínez-González J,Badimon L

更新日期：1996-11-01 00:00:00

abstract：:It has been shown that the detection of tuberculostearic acid (TBSA) with gas chromatography-mass-spectrometry provides a highly specific, sensitive and rapid method for the diagnosis of various forms of tuberculosis. However, the need for complex and expensive equipment prevented the more widespread use of this metho...

journal_title：European journal of clinical investigation

authors： Herz A,Leichsenring M,Felten M,Oosthuizen OJ,Mayatepek E,Haas W,Bremer HJ

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) is a well-documented predictor of cardiovascular diseases and mortality. We aimed to better understand the distribution and determinants of CRP in the population. MATERIALS AND METHODS:Study participants were men and women aged 40-79 in the UK-based EPIC-Norfolk population-based coh...

journal_title：European journal of clinical investigation

authors： Ahmadi-Abhari S,Luben RN,Wareham NJ,Khaw KT

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumours with a strong genetic background. DESIGN:We searched the PubMed database through February 2015 to identify studies characterizing metastatic PCs/PGLs as well as currently established and evolving therapies. RESULTS...

journal_title：European journal of clinical investigation

authors： Angelousi A,Kassi E,Zografos G,Kaltsas G

更新日期：2015-09-01 00:00:00

abstract：:To understand better impairment of glucose utilization in diabetics during a hyperosmolal state, in vitro models were established to evaluate the effects of hyperosmolality on basal glucose uptake as well as glucagon dependent glucose release by isolated hepatocytes. In these studies simulating a hyperglycaemic (40 mm...

journal_title：European journal of clinical investigation

authors： Komjati M,Kastner G,Waldhäusl W,Bratusch-Marrain P

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:In the 13C-octanoate breath test, the shape of the 13CO2 excretion curve in the ascending portion reflects a pattern of gastric emptying (GE). Recent scintigraphic studies have revealed an overall delay in solid GE in fertile women compared with men. However, it remains unknown whether women have a different...

journal_title：European journal of clinical investigation

authors： Sanaka M,Yamamoto T,Anjiki H,Osaki Y,Kuyama Y

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:EPB4.1 has been previously mapped to human chromosome 1p33-p34.2. In contradiction to this chromosomal location, we have mapped EPB4.1-1p36 by using fluorescence in situ hybridization and radiation hybrid mapping. In neuroblastomas, deletions of the telomeric end of chromosome 1 (1p36) are the most common ge...

journal_title：European journal of clinical investigation

authors： Huang S,Lichtenauer UD,Pack S,Wang C,Kim AC,Lutchman M,Koch CA,Torres-Cruz J,Huang SC,Benz EJ Jr,Christiansen H,Dockhorn-Dworniczak B,Poremba C,Vortmeyer AO,Chishti AH,Zhuang Z

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Infiltration of white adipose tissue (WAT) by inflammatory cells in obesity is considered to be a key event in the development of insulin resistance. Recently, mast cells (MCs) have been identified as new players in the pathogenesis of obesity. We aimed to investigate the relationship between MCs and various...

journal_title：European journal of clinical investigation

authors： Einwallner E,Kiefer FW,Di Caro G,Orthofer M,Witzeneder N,Hörmann G,Itariu B,Zeyda M,Penninger JM,Stulnig TM,Esterbauer H,Todoric J

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Several studies have suggested that chronic obstructive pulmonary disease (COPD) could be predictive of the prognosis in patients with heart failure (HF), but yield conflicting findings. Therefore, we conducted a meta-analysis to examine the impact of COPD on adverse outcomes in patients with HF. METHODS:We...

journal_title：European journal of clinical investigation

authors： Xu S,Ye Z,Ma J,Yuan T

更新日期：2021-01-01 00:00:00

abstract：:The activity of delta-aminolaevulinate synthase was determined in the livers of fed female rats and was found to vary with the phase of their sexual cycle. The highest enzymic activity was obtained during preoestrus (38.0 +/- 3.2 nmol delta-aminolaevulinateg.g liver.-1 hour-1), the lowest during dioestrus (17.4 +/- 3....

journal_title：European journal of clinical investigation

authors： Held H,Przerwa M

更新日期：1976-09-10 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNF) mRNA expression has been reported to be up-regulated in adipose tissue from several rodent models of obesity and diabetes and from obese humans. This elevated expression has been assumed to be associated with the development of insulin resistance. However, the biological si...

journal_title：European journal of clinical investigation

authors： Hube F,Birgel M,Lee YM,Hauner H

更新日期：1999-08-01 00:00:00

abstract：:Deficiency of apolipoprotein C-II (apo C-II), the cofactor for lipoprotein lipase, results in the familial chylomicronaemia syndrome characterized by severe hypertriglyceridaemia and fasting chylomicronaemia. To investigate the biochemical features of the heterozygous state for apo C-II deficiency, we characterized th...

journal_title：European journal of clinical investigation

authors： Gabelli C,Bilato C,Santamarina-Fojo S,Martini S,Brewer HB Jr,Crepaldi G,Baggio G

更新日期：1993-09-01 00:00:00

abstract：:We recently reported that chloride-depletion metabolic alkalosis (CDMA) results in renal losses of Na, K, and water. In these studies we investigated whether CDMA (induced using a new model that avoids external changes in Na and water balance) was also associated with internal Na and water shifts out of the ECF. CDMA ...

journal_title：European journal of clinical investigation

authors： Garella S,Cohen JJ,Northrup TE

更新日期：1991-06-01 00:00:00

abstract：:To assess the degree of immune system activation associated with addiction or hepatotropic viruses infection, we examined 60 HIV-negative heroin addicts for the presence of hepatitis B virus (HBV) infection markers, hepatitis C virus antibodies (anti-HCV), various auto-antibodies, and serum levels of soluble interleuk...

journal_title：European journal of clinical investigation

authors： Dalekos GN,Manoussakis MN,Zervou E,Tsianos EV,Moutsopoulos HM

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called 'vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Altera...

journal_title：European journal of clinical investigation

authors： de Boer MP,Wijnstok NJ,Serné EH,Eringa EC,Stehouwer CD,Flyvbjerg A,Hoekstra T,Heymans MW,Meijer RI,Twisk JW,Smulders YM

更新日期：2014-07-01 00:00:00

abstract：:Fibromuscular dysplasia (FMD) is an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small and medium-sized arteries, mostly involving renal and cervical arteries. As a result of better and more systematic screening, it appears that in...

journal_title：European journal of clinical investigation

authors： Van der Niepen P,van Tussenbroek F,Devos H,Debing E,Di Monaco S,Goffette P,Astarci P,Persu A

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Antihyperglycemic drugs have been linked to new-onset atrial fibrillation (NAF). However, the effect of the different classes of antihyperglycemic drugs on the development of NAF in elderly patients has not been well studied. In this study, we investigated the association between different classes of antihyp...

journal_title：European journal of clinical investigation

authors： Chen HY,Yang FY,Jong GP,Liou YS

更新日期：2017-05-01 00:00:00

abstract：:The studies were designed to explore the effect of the converting enzyme inhibitor captopril on the activity of the sympathetic nervous system during basal conditions and following graded physical exercise in patients with essential hypertension. Seven males and two females, aged 36-59 years, were hospitalized under m...

journal_title：European journal of clinical investigation

authors： Manhem P,Bramnert M,Hulthén UL,Hökfelt B

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:It remains unsettled whether alcoholic cirrhosis is a risk factor for myocardial infarction (MI). METHODS:We used data from nationwide healthcare registries to study all Danes diagnosed with alcoholic cirrhosis in 1996-2014, and five controls were matched to each of them on gender and age. We excluded every...

journal_title：European journal of clinical investigation

authors： Deleuran T,Schmidt M,Vilstrup H,Jepsen P

更新日期：2020-04-01 00:00:00

abstract：:Approximately 20% of monocytes and peritoneal macrophages from renal failure patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were transferrin-receptor (TfR) positive by immunofluorescence, whereas cells from normal controls were generally TfR negative, as were monocytes from rheumatoid arthritis p...

journal_title：European journal of clinical investigation

authors： Moughal NA,McGregor SJ,Brock JH,Briggs JD,Junor BJ

更新日期：1991-12-01 00:00:00