Abstract:
:N-3 fatty acids were supplied to a 36-year-old female patient suffering from ulcerative colitis and severe steroid side-effects, in a sequence of parenteral and enteral administration. During a moderately active period of disease, 200 ml d-1 fish oil-derived lipid emulsion (eicosapentaenoic acid [EPA], 4.2 g; docosahexaenoic acid [DHA], 4.2 g) was infused for 9 days, in parallel with rapid tapering of the steroid dose. Disease activity declined rapidly, and the patient was subsequently provided with 16 fish oil capsules per day (EPA, 2.9 g; DHA, 1.9 g) for 2 months. At the end of this period of therapy, severe colitis recurred with intestinal and extraintestinal manifestations. The n-3 lipid emulsion was then used for intravenous alimentation (29 days, maximum dose 300 ml per day); during this time, marked improvement of the inflammatory bowel disease was noted. During both periods of parenteral n-3 lipid administration, total plasma EPA and DHA contents increased several-fold, surpassing that of arachidonic acid; this plasma n-3 fatty acid enrichment was only maintained to a minor extent during the intermediate period of dietary fish oil supplementation. The intravenously administered EPA-containing triglycerides were rapidly hydrolyzed, as evidenced by the appearance of substantial quantities of EPA in the plasma free fatty acid fraction. Platelet and neutrophil total membrane content of EPA and DHA as well as n-3 fatty acid/AA membrane ratios similarly increased during the periods of intravenous n-3 lipid administration and declined during oral fish oil uptake.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Grimminger F,Führer D,Papavassilis C,Schlotzer E,Mayer K,Heuer KU,Kiss L,Walmrath D,Piberhofer S,Lübbecke Fdoi
10.1111/j.1365-2362.1993.tb01290.xsubject
Has Abstract,Author List Incompletepub_date
1993-11-01 00:00:00pages
706-15issue
11eissn
0014-2972issn
1365-2362journal_volume
23pub_type
杂志文章abstract:BACKGROUND:Smoking remains the most important avoidable cause of global mortality. Even though the number of cigarette smokers declines in first world countries, the uses of alternative nicotine delivery products increase and may even surpass the sells of cigarettes. In this light, the explicit role of nicotine in the ...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:1985-12-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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更新日期:1997-01-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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