Expression of tenascin is related to angiogenesis in pre-eclampsia.

Abstract:

METHODS:Ten samples of decidua basalis from pre-eclamptic women and 10 from healthy primigravid women subjected to caesarean section (control tissues) were investigated immunohistochemically for changes in angiogenesis and expression of tenascin, an extracellular matrix protein thought to modulate angiogenesis. In addition, pre-eclamptic and control samples were grafted onto the chick embryo chorioallantoic membrane (CAM) to study their possible angiogenic activity in vivo. RESULTS:Although the microvessel area was low in control samples, it increased significantly in the pre-eclamptic decidua. In parallel, the area covered by tenascin staining underwent a significant expansion that was highly correlated with the microvessel area. Angiogenic activity was assessed both macroscopically and microscopically on histological sections 4 days after grafting. In contrast to control samples, pre-eclamptic decidua induced an intense capillary growth, and numerous capillaries converging towards the implant and forming a spoke-wheel pattern were evident. Histological examination using a planimetric point-count method showed that microvessel counts in the CAM area under and around the pre-eclamptic implants were significantly higher than those of control samples. Again, the extracellular matrix of nearby microvessels was strongly immunoreactive with tenascin. CONCLUSION:It is suggested that, unlike normal decidua, pre-eclamptic decidua displays an intense, autonomous angiogenic activity, probably mediated by tenascin in addition to its own angiogenic factors.

journal_name

Eur J Clin Invest

authors

Ribatti D,Loverro G,Vacca A,Greco P,Roncali L,Selvaggi L

doi

10.1046/j.1365-2362.1998.00294.x

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

373-8

issue

5

eissn

0014-2972

issn

1365-2362

journal_volume

28

pub_type

杂志文章
  • Immunopathogenesis of cholestatic autoimmune liver diseases.

    abstract::Primary biliary cirrhosis and primary sclerosing cholangitis are well recognized chronic cholestatic liver diseases that are considered to have an autoimmune basis. Recent progress in the study of autoimmune liver diseases has improved the recognition and characterization of these conditions. An important component of...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2362.2001.00765.x

    authors: Medina J,Jones EA,García-Monzón C,Moreno-Otero R

    更新日期:2001-01-01 00:00:00

  • Transport of L-leucine hydroxy analogue and L-lactate in human small intestinal brush border membrane vesicles.

    abstract::Nitrogen load can be reduced by substituting dietary protein intake with keto or hydroxy analogues of amino acids. To investigate their intestinal absorption, human jejunal brush border membrane vesicles were used to measure uptake of L-leucine hydroxy analogue (L-LHA) and L-lactate. Uptake assays were performed under...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1992.tb01939.x

    authors: Friedrich M,Murer H,Sterchi E,Berger EG

    更新日期:1992-02-01 00:00:00

  • Alcohol consumption alters insulin secretion and cardiac autonomic activity.

    abstract:BACKGROUND:Alcohol may have a cardioprotective effect. One possible mechanism is by modifying insulin resistance/secretion. The aims of this study were: (i) to examine the effect of short-term alcohol consumption on the metabolic control of glucose tolerance; (ii) to study the influence of short-term alcohol consumptio...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2362.2002.00970.x

    authors: Flanagan DE,Pratt E,Murphy J,Vaile JC,Petley GW,Godsland IF,Kerr D

    更新日期:2002-03-01 00:00:00

  • Prevalence of coronary atherosclerosis and reclassification of cardiovascular risk in Spanish population by coronary computed tomography angiography: EVA study.

    abstract:BACKGROUND:A more complete assessment of coronary artery disease (CAD) can be performed by coronary computed tomography angiography (CCTA). The aim was to assess the prevalence, distribution and characteristics of coronary artery disease (CAD) and the reclassification of cardiovascular risk by CCTA in an asymptomatic S...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13272

    authors: García-Ortiz L,Barreiro-Perez M,Merchan-Gómez S,Ignacio Recio-Rodriguez J,Sánchez-Aguadero N,Alonso-Dominguez R,Lugones-Sanchez C,Rodríguez-Sanchez E,Sanchez PL,Gómez-Marcos MA,on behalf EVA investigators.

    更新日期:2020-09-01 00:00:00

  • Strategies used by individuals to prevent burnout.

    abstract:BACKGROUND:Burnout represents a syndrome that is related to demanding job characteristics combined with the absence of resources or motivational job characteristics. The aim of this position study was to present strategies that individuals use to minimize burnout and its unfavourable effects. MATERIALS AND METHODS:The...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/eci.12494

    authors: Demerouti E

    更新日期:2015-10-01 00:00:00

  • The lymphocyte Na+/H+ antiport: activation in primary hypertension and during chronic NaCl-loading.

    abstract::Increased activity of the Na+/H+ antiport may be a major abnormality in essential hypertension. The activity of this transport system was investigated in lymphocytes from 13 patients with untreated essential hypertension (Ht) and 13 normotensive control subjects (Nt) on an ad libitum (130-170 mmol d-1) NaCl intake. Fu...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1994.tb01103.x

    authors: Göbel BO,Hoffmann G,Ruppert M,Stumpe KO,Vetter H,Siffert W,Düsing R

    更新日期:1994-08-01 00:00:00

  • The effect of antacids on the occurrence of bile acid and aspirin-induced gastric lesions in rats.

    abstract::Taurodeoxycholic acid increases the incidence of aspirin induced gastric bleeding in rats and in vitro is well bound by Aludrox (aluminium hydroxide) and poorly bound by Maalox (aluminium hydroxide and magnesium hydroxide). We studied the relevance of this binding, as demonstrated in vitro, by observing the effect of ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1980.tb02080.x

    authors: Morgan RJ,Nelson LM,Russell RI,Plevin T

    更新日期:1980-12-01 00:00:00

  • DALI-the first human whole-blood low-density lipoprotein and lipoprotein (a) apheresis system in clinical use: procedure and clinical results.

    abstract:BACKGROUND:The DALI low-density lipoprotein (LDL) apheresis system is the first whole-blood apheresis system in regular clinical use. DALI stands for direct adsorption of lipoproteins, which describes the basic principle of operation of this newly developed LDL apheresis procedure. METHODS:The selective removal of LDL...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1365-2362.1998.00395.x

    authors: Dräger LJ,Julius U,Kraenzle K,Schaper J,Toepfer M,Zygan K,Otto V,Steinhagen-Thiessen E

    更新日期:1998-12-01 00:00:00

  • Influence of leucine infusion on intracellular amino acids in humans.

    abstract::A continuous intravenous infusion of L-leucine (300 mumols min-1) was given to 12 healthy females over a 2 1/2 h period. Arterial plasma concentrations of amino acids and the keto acids of the branched-chain amino acids (BCAA) were measured. In six subjects muscle biopsies were taken before and at the end of the infus...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1990.tb01858.x

    authors: Alvestrand A,Hagenfeldt L,Merli M,Oureshi A,Eriksson LS

    更新日期:1990-06-01 00:00:00

  • Plasmacytoid dendritic cells, a role in neoplastic prevention and progression.

    abstract:BACKGROUND:Plasmacytoid dendritic cells (pDCs) are multifunctional bone-marrow-derived immune cells that are key players in bridging the innate and adaptive immune systems. Activation of pDCs through toll-like receptor agonists has proven to be an effective treatment for some neoplastic disorders. MATERIALS AND METHOD...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/eci.12363

    authors: Lombardi VC,Khaiboullina SF,Rizvanov AA

    更新日期:2015-01-01 00:00:00

  • Randomized placebo controlled trial of furosemide on subjective perception of dyspnoea in patients with pulmonary oedema because of hypertensive crisis.

    abstract:BACKGROUND:To compare the administration of furosemide with placebo on the subjective perception of dyspnoea in patients with acute pulmonary oedema because of hypertensive crisis. Design  Randomized, controlled and double-blinded clinical trial. SETTING:Municipal emergency medical service system and university-based ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.2010.02450.x

    authors: Holzer-Richling N,Holzer M,Herkner H,Riedmüller E,Havel C,Kaff A,Malzer R,Schreiber W

    更新日期:2011-06-01 00:00:00

  • Lipid parameters in patients with acute coronary syndromes versus stable coronary artery disease.

    abstract:BACKGROUND:Differences in lipid parameters between patients with acute coronary syndromes (ACS) and patients with stable coronary artery disease (CAD) are unclear and are addressed in this study. METHODS:We enrolled 582 patients with angiographically proven stable CAD (of whom 26·9% had diabetes mellitus type 2 (T2DM)...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12513

    authors: Vonbank A,Saely CH,Rein P,Drexel H

    更新日期:2015-10-01 00:00:00

  • Prognostic evaluation of the elastic properties of the ascending aorta in dilated cardiomyopathy.

    abstract:BACKGROUND:Nowadays there is an increased interest in the role of aortic stiffness in the pathophysiology of heart failure (HF), as it is a major determinant of left ventricular (LV) performance. We aimed at assessing the predictive value of the aortic stiffness parameters, measured by echocardiography, in patients aff...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12950

    authors: Sciatti E,Vizzardi E,Bonadei I,Fabbricatore D,Prati F,Pagnoni M,Metra M

    更新日期:2018-07-01 00:00:00

  • Variant of acute intermittent porphyria with normal erythrocyte uroporphyrinogen-I-synthase activity.

    abstract::A kindred in which several members have otherwise typical acute intermittent porphyria but normal erythrocyte uroporphyrinogen-I-synthase activity has been described from Finland. We studied two porphyric members of this kindred, two patients with typical acute intermittent porphyria, and two healthy controls using th...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1985.tb00185.x

    authors: Mustajoki P,Tenhunen R

    更新日期:1985-10-01 00:00:00

  • Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas.

    abstract:OBJECTIVES:EPB4.1 has been previously mapped to human chromosome 1p33-p34.2. In contradiction to this chromosomal location, we have mapped EPB4.1-1p36 by using fluorescence in situ hybridization and radiation hybrid mapping. In neuroblastomas, deletions of the telomeric end of chromosome 1 (1p36) are the most common ge...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2001.00892.x

    authors: Huang S,Lichtenauer UD,Pack S,Wang C,Kim AC,Lutchman M,Koch CA,Torres-Cruz J,Huang SC,Benz EJ Jr,Christiansen H,Dockhorn-Dworniczak B,Poremba C,Vortmeyer AO,Chishti AH,Zhuang Z

    更新日期:2001-10-01 00:00:00

  • The improvement of renal concentration capacity after surgery for primary hyperparathyroidism.

    abstract:BACKGROUND:Improvement of renal concentration capacity was long ago shown to occur after surgery for primary hyperparathyroidism (pHPT). Study of concentration capacity is of interest, as it was also shown to be a predictive factor for the risk of death in patients with pHPT, and it affected the risk of death independe...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2001.00926.x

    authors: Hedbäck G,Abrahamsson K,Odén A

    更新日期:2001-12-01 00:00:00

  • Gender dimorphic increase in RBP-4 and NGAL in children born after IVF: an epigenetic phenomenon?

    abstract:BACKGROUND:In vitro fertilisation (IVF) has been widely used during the last decades. Recent studies demonstrated some alterations in IVF children's metabolic profile compared with controls. The recently reported lipocalins retinol-binding protein 4 (RBP-4) and neutrophil gelatinase-associated lipocalin (NGAL), as well...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12066

    authors: Sakka SD,Margeli A,Loutradis D,Chrousos GP,Papassotiriou I,Kanaka-Gantenbein C

    更新日期:2013-05-01 00:00:00

  • Glucagon-independent renal hyperaemia and hyperfiltration after an oral protein load in Child A liver cirrhosis.

    abstract::The work was designed to study the effects of a meat meal on glomerular filtration rate (GFR), renal plasma flow (RPF), and plasma concentrations of glucagon, insulin, growth hormone, renin, aldosterone, total amino acids, and NH3 in healthy humans (H) as well as in patients with Child A liver cirrhosis (LC). The meat...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1992.tb01932.x

    authors: De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R

    更新日期:1992-01-01 00:00:00

  • Impaired anti-inflammatory efficacy of n-butyrate in patients with IBD.

    abstract:BACKGROUND:The intestinal mucosa of patients with inflammatory bowel diseases (IBD) characteristically shows a high degree of inflammation when compared to healthy subjects. This appears to be attributable to an imbalance in local reactivity of inflammatory cells. In the present study, we tested the hypothesis that imm...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02407.x

    authors: Kovarik JJ,Tillinger W,Hofer J,Hölzl MA,Heinzl H,Saemann MD,Zlabinger GJ

    更新日期:2011-03-01 00:00:00

  • Inflammation affects lipid metabolism during recovery from hyperinsulinaemia.

    abstract:BACKGROUND:Inflammation is an established contributor in atherosclerosis and several other common diseases including diabetes. Therefore the study was to investigate how inflammatory factors affect lipid metabolism during recovery from hyperinsulinaemia in healthy individuals. MATERIALS AND METHODS:A total of 22 healt...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2006.01730.x

    authors: Heliövaara MK,Teppo AM,Karonen SL,Ebeling P

    更新日期:2006-12-01 00:00:00

  • Hepatic HMGCoA reductase in human cholelithiasis: effects of chenodeoxycholic and ursodeoxycholic acids.

    abstract::To study further the role of hepatic cholesterol synthesis in patients with gallstones, the activity of the rate-limiting step in cholesterogenesis, hydroxymethyl glutaryl co-enzyme A reductase (HMGCoAR), was measured in operative wedge liver biopsies from ten patients with untreated cholesterol gallstones, six with p...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1980.tb00040.x

    authors: Maton PN,Ellis HJ,Higgins MJ,Dowling RH

    更新日期:1980-08-01 00:00:00

  • Multifactorial treatment of hypertensive men at high cardiovascular risk and low-density lipoprotein cholesterol affinity to human arterial proteoglycans.

    abstract::The purpose of this work was to examine in an open, randomized parallel-group study whether an intervention programme directed towards hypercholesterolaemia, smoking and diabetes mellitus in treated hypertensive men was associated with less complex formation between low-density lipoprotein (LDL) and human arterial pro...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2362.1996.2030543.x

    authors: Fagerberg B,Wiklund O,Agewall S,Camejo G,Wikstrand RJ

    更新日期:1996-11-01 00:00:00

  • Angiotensin converting enzyme activity in the serum, lung and kidney of diabetic rats.

    abstract::Diabetes Mellitus in its early stages, is associated with kidney enlargement and increased glomerular filtration rate in humans and in rats. The present study was designed to clarify the direct effect of diabetes on serum and tissue angiotensin converting enzyme (ACE) activity in streptozotocin-induced diabetic rats. ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1993.tb00722.x

    authors: Erman A,van Dyk DJ,Chen-Gal B,Giler ID,Rosenfeld JB,Boner G

    更新日期:1993-10-01 00:00:00

  • A novel protein glycan biomarker and LCAT activity in metabolic syndrome.

    abstract:BACKGROUND:The cholesterol-esterifying enzyme, lecithin:cholesterol acyltransferase (LCAT), is instrumental in high-density lipoprotein (HDL) remodelling. LCAT may also modify oxidative and inflammatory processes, as supported by an inverse relationship with HDL antioxidative functionality and a positive relationship w...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12481

    authors: Gruppen EG,Connelly MA,Otvos JD,Bakker SJ,Dullaart RP

    更新日期:2015-08-01 00:00:00

  • Effect of passive smoking on blood lymphocyte apoptosis in children.

    abstract:BACKGROUND:Passive smoking is a well-known risk factor for both recurrent respiratory infections and disturbed lipid profile. Whether passive smoking problems are related to altered lymphocyte survival and its relation to altered lipid profile are the points of concern in this work. MATERIALS AND METHODS:Urinary cotin...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02420.x

    authors: El-Hodhod MA,Hamdy AM,Ahmed MB,Youssef SR,Aly SM

    更新日期:2011-04-01 00:00:00

  • On-treatment lipoprotein components and risk of cerebrovascular events in the Treating to New Targets study.

    abstract:BACKGROUND:The Treating to New Targets (TNT) study has recently provided evidence that reduction in LDL-C levels below 2·6 mmol L⁻¹ lowers the risk of cerebrovascular events by an additional 20% to 25%, thereby confirming the value of statin therapy in preventing transient ischaemic attacks and stroke. Despite the prot...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1365-2362.2010.02387.x

    authors: van den Bogaard B,van den Born BJ,Fayyad R,Waters DD,DeMicco DA,LaRosa JC,Kastelein JJ,Holme I,Treating to New Targets investigators.

    更新日期:2011-02-01 00:00:00

  • Alterations in the peritoneal transport of water and solutes during peritonitis in continuous ambulatory peritoneal dialysis patients.

    abstract::The in situ intraperitoneal volume and the mass transfer area coefficients (MTC) of urea, lactate, creatinine, glucose, kanamycin, inulin, beta 2-microglobulin, albumin and IgG were studied in eight continuous ambulatory peritoneal dialysis (CAPD) patients. All patients were studied during a 4-h dialysis dwell, first ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1987.tb01224.x

    authors: Krediet RT,Zuyderhoudt FM,Boeschoten EW,Arisz L

    更新日期:1987-02-01 00:00:00

  • Monocyte count at onset predicts poststroke outcomes during a 90-day follow-up.

    abstract:BACKGROUND:Acute ischaemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing poststroke recovery. In smokers with AIS, inflammation might be further upregulated, increasing ischaemia/reperfusion injury. Here, the predictive value of leucocyte and adhesion molecules levels on poststroke out...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12795

    authors: Liberale L,Montecucco F,Bonaventura A,Casetta I,Seraceni S,Trentini A,Padroni M,Dallegri F,Fainardi E,Carbone F

    更新日期:2017-10-01 00:00:00

  • Serum prolactin levels in eighty patients with sarcoidosis.

    abstract::Serum prolactin levels were measured by radioimmunoassay in eighty patients (thirty-four males, forty-six females) with sarcoidosis before treatment. In twelve patients (15%) serum prolactin levels were more than two standard deviations above the mean of normal subjects. Hyperprolactinaemia was found most frequently (...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1978.tb00806.x

    authors: Nakao K,Noma K,Sato B,Yano S,Yamamura Y,Tachibana T

    更新日期:1978-02-01 00:00:00

  • Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man. Feedback control of cholecystokinin and gastrin secretion.

    abstract::The effect of the potent specific cholecystokinin (CCK) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of CCK, gastrin, pancreatic polypeptide (PP), neurotensin, glucose-dependent insulinotropic polypeptide (GIP), insulin and C peptide was investigated in a placebo-controlled study in 10 heal...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2362.1991.tb01402.x

    authors: Schmidt WE,Creutzfeldt W,Höcker M,Nustede R,Choudhury AR,Schleser A,Rovati LC,Fölsch UR

    更新日期:1991-10-01 00:00:00