Abstract:
METHODS:Ten samples of decidua basalis from pre-eclamptic women and 10 from healthy primigravid women subjected to caesarean section (control tissues) were investigated immunohistochemically for changes in angiogenesis and expression of tenascin, an extracellular matrix protein thought to modulate angiogenesis. In addition, pre-eclamptic and control samples were grafted onto the chick embryo chorioallantoic membrane (CAM) to study their possible angiogenic activity in vivo. RESULTS:Although the microvessel area was low in control samples, it increased significantly in the pre-eclamptic decidua. In parallel, the area covered by tenascin staining underwent a significant expansion that was highly correlated with the microvessel area. Angiogenic activity was assessed both macroscopically and microscopically on histological sections 4 days after grafting. In contrast to control samples, pre-eclamptic decidua induced an intense capillary growth, and numerous capillaries converging towards the implant and forming a spoke-wheel pattern were evident. Histological examination using a planimetric point-count method showed that microvessel counts in the CAM area under and around the pre-eclamptic implants were significantly higher than those of control samples. Again, the extracellular matrix of nearby microvessels was strongly immunoreactive with tenascin. CONCLUSION:It is suggested that, unlike normal decidua, pre-eclamptic decidua displays an intense, autonomous angiogenic activity, probably mediated by tenascin in addition to its own angiogenic factors.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Ribatti D,Loverro G,Vacca A,Greco P,Roncali L,Selvaggi Ldoi
10.1046/j.1365-2362.1998.00294.xsubject
Has Abstractpub_date
1998-05-01 00:00:00pages
373-8issue
5eissn
0014-2972issn
1365-2362journal_volume
28pub_type
杂志文章abstract::Primary biliary cirrhosis and primary sclerosing cholangitis are well recognized chronic cholestatic liver diseases that are considered to have an autoimmune basis. Recent progress in the study of autoimmune liver diseases has improved the recognition and characterization of these conditions. An important component of...
journal_title:European journal of clinical investigation
pub_type: 杂志文章,评审
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journal_title:European journal of clinical investigation
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更新日期:1994-08-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2018-07-01 00:00:00
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更新日期:1985-10-01 00:00:00
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更新日期:2001-10-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-11-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2362.2010.02420.x
更新日期:2011-04-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-02-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1987.tb01224.x
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Acute ischaemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing poststroke recovery. In smokers with AIS, inflammation might be further upregulated, increasing ischaemia/reperfusion injury. Here, the predictive value of leucocyte and adhesion molecules levels on poststroke out...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
abstract::Serum prolactin levels were measured by radioimmunoassay in eighty patients (thirty-four males, forty-six females) with sarcoidosis before treatment. In twelve patients (15%) serum prolactin levels were more than two standard deviations above the mean of normal subjects. Hyperprolactinaemia was found most frequently (...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1978.tb00806.x
更新日期:1978-02-01 00:00:00
abstract::The effect of the potent specific cholecystokinin (CCK) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of CCK, gastrin, pancreatic polypeptide (PP), neurotensin, glucose-dependent insulinotropic polypeptide (GIP), insulin and C peptide was investigated in a placebo-controlled study in 10 heal...
journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章
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更新日期:1991-10-01 00:00:00