Abstract:
OBJECTIVE:The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:A total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double-blinded, parallel group study. FBF responses to intra-arterial acetylcholine (ACh) and glycerol trinitrate (GTN) were measured before and after 21 days of intravenous treatment with 600 mg alpha-lipoic acid or placebo. RESULTS:FBF responses were comparable at baseline. After treatment, FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo. By contrast, ALA treatment increased endothelium-dependent vasodilatation to ACh (P < 0.05) but not to GTN compared with baseline. CONCLUSIONS:Intravenous ALA treatment improves endothelium-dependent vasodilatation in patients with type 2 diabetes, in the absence of effects on forearm vasomotor function. If this salutary action translates into vascular risk reduction remains to be established.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Heinisch BB,Francesconi M,Mittermayer F,Schaller G,Gouya G,Wolzt M,Pleiner Jdoi
10.1111/j.1365-2362.2009.02236.xsubject
Has Abstractpub_date
2010-02-01 00:00:00pages
148-54issue
2eissn
0014-2972issn
1365-2362pii
ECI2236journal_volume
40pub_type
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