The relationship between renal volume and histology in obese and nonobese kidney donors.

abstract：BACKGROUND:Angiotensin converting enzyme 2 (ACE2), a monocarboxylase that degrades angiotensin II to angiotensin 1-7, is also the functional receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and is highly expressed in the lungs and heart. Patients with SARS also suffered from cardiac disease ...

journal_title：European journal of clinical investigation

authors： Oudit GY,Kassiri Z,Jiang C,Liu PP,Poutanen SM,Penninger JM,Butany J

更新日期：2009-07-01 00:00:00

abstract：:beta-Adrenoceptor binding on peripheral blood mononuclear cells (PBMC) of healthy adult volunteers was investigated using the radioligand 125iodo-cyanopindolol (ICYP). Saturation binding studies were performed with nine different concentrations of ICYP. Receptor density and affinity were calculated by Scatchard plots....

journal_title：European journal of clinical investigation

authors： Griese M,Körholz U,Körholz D,Seeger K,Wahn V,Reinhardt D

更新日期：1988-04-01 00:00:00

abstract：:Thyroid hormones occasionally appear less effective when administered alone to patients with panhypopituitarism, and manifestations suggestive of hypothyroidism have been reported in patients suffering from untreated Addison's disease. In the latter condition, thyrotropin secretion is increased: this occurs already af...

journal_title：European journal of clinical investigation

authors： De Nayer P,Dozin B,Vandeput Y,Bottazzo FC,Crabbe J

更新日期：1987-04-01 00:00:00

abstract：:During chronic high-altitude (HA) exposure, basal and exercise-induced noradrenaline (NA) increases do not parallel blood pressure (BP) changes observed; unlike beta-adrenergic receptors, to our knowledge no data are available on alpha-receptors. We studied platelet alpha 2- and leucocyte beta-receptors and basal cate...

journal_title：European journal of clinical investigation

authors： Zaccaria M,Borea PA,Opocher G,Ponchia A,Varani K,Fraccarollo D,Scandellari C

更新日期：1997-04-01 00:00:00

abstract：:Inheritance is a major determinant of increased sodium-lithium countertransport (SLC) activity in hypertension. However, hyperlipidaemia can also cause increased SLC activity in some individuals and it is difficult to distinguish this effect from the effect of hypertension. Erythrocyte SLC activity and its kinetic det...

journal_title：European journal of clinical investigation

authors： Rutherford PA,Thomas TH,Laker MF,Wilkinson R

更新日期：1992-11-01 00:00:00

abstract：:Patients with primary biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver. However, most of the patients with PBC do not show peripheral blood T cells response to PDC. In this study, we re-evaluated the ...

journal_title：European journal of clinical investigation

authors： Akbar SM,Yamamoto K,Miyakawa H,Ninomiya T,Abe M,Hiasa Y,Masumoto T,Horiike N,Onji M

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:We have investigated the potential for using antisense technology as a means of delivering treatment for acute myeloblastic leukaemia (FAB-M2) by gene therapy. MATERIALS AND METHODS:A test recombinant adenovirus vector was constructed containing human c-myc antisense fragments to study the effects of alteri...

journal_title：European journal of clinical investigation

authors： Chen JP,Chen L,Leek J,Lin C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Amadori-albumin, a major glycated protein, is involved in experimental hyperglycaemia-induced microvascular complications, and is associated with advanced nephropathy in Type I diabetic patients in humans. Our aim was to assess the association of Amadori-albumin with early nephropathy and with retinopathy in...

journal_title：European journal of clinical investigation

authors： Schalkwijk CG,Chaturvedi N,Twaafhoven H,van Hinsbergh VW,Stehouwer CD,EUCLID Study Group.

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...

journal_title：European journal of clinical investigation

authors： Turan RG,Brehm M,Koestering M,Tobias Z,Bartsch T,Steiner S,Picard F,Ebner P,Schannwell CM,Strauer BE

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:There is ongoing controversy whether angiotensin-converting enzyme inhibitors (ACE-I) contribute to anaemia by causing hyporesponsiveness to erythropoiesis-stimulating agents (ESA). However, it is unknown whether or not plasma levels or area under the curve (AUC) of ACE-I are associated with responsiveness t...

journal_title：European journal of clinical investigation

authors： Winnicki W,Prehslauer A,Kletzmayr J,Herkner H,Sunder-Plassmann G,Brunner M,Hörl WH,Sengoelge G

更新日期：2012-10-01 00:00:00

abstract：:The clinical and physiological relevance of the relationship between gastrin and calcitonin has been investigated in normal subjects and in patients suffering from gastritis or duodenal ulcer. Basal plasma levels of calcitonin are increased in these patients but there is no significant relationship between calcitonin ...

journal_title：European journal of clinical investigation

authors： Heynen G,Brassine A,Daubresse JC,Ligny G,Kanis JA,Gaspar S,Franchimont P

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Childhood obesity is associated with premature cardiovascular complications. However, little is known about the effect of a family-based behavioural intervention on the relationship between arterial function, blood pressure and biomarkers in pre-pubertal children with obesity. DESIGN:This was a single centr...

journal_title：European journal of clinical investigation

authors： Maggio ABR,Farpour-Lambert NJ,Aggoun Y,Galan K,Montecucco F,Mach F,Beghetti M

更新日期：2018-09-01 00:00:00

abstract：:The ATP-binding cassette transporter P-glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P-glycoprotein-expressing cell lines, the generation of P-glycoprotein knockout mice as well as studies in animals and humans contributed to a better understanding on the role...

journal_title：European journal of clinical investigation

authors： Fromm MF

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Diacylglycerols (DAGs), which are well-known components of insect lipophorins, have been recently recognized as a major glyceride of human high-density lipoprotein (HDL). Moreover, DAGs are good substrates for hepatic lipase and for the phospholipid transfer protein (PLTP). The present work was undertaken to...

journal_title：European journal of clinical investigation

authors： Lalanne F,Pruneta V,Bernard S,Ponsin G

更新日期：1999-02-01 00:00:00

abstract：:We measured the renal haemodynamic and proteinuric response to a meat meal (MM) in ten persistently proteinuric insulin-dependent diabetic patients in a randomized cross-over study of 3 weeks on low protein diet (LPD) or normal protein intake (NPD). On LPD, protein intake (0.64 +/- 0.05 vs 1.15 +/- 0.09 g kg-1 body we...

journal_title：European journal of clinical investigation

authors： Pinto JR,Bending JJ,Dodds RA,Viberti GC

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Over the past decades, the prevalence of obesity has markedly increased worldwide. Stress is recognized as a substantial contributor to increased body weight; therefore, stress management interventions, especially cognitive behavioural, are becoming increasingly popular. The impact of stress management on st...

journal_title：European journal of clinical investigation

authors： Simos DS,Kokkinos A,Tentolouris N,Dimosthenopoulos C,Mantzou E,Artemiadis A,Bacopoulou F,Nicolaides NC,Kosta O,Chrousos GP,Darviri C

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Smoking is associated with dyslipidaemia, particularly raised plasma triglycerides and reduced high-density lipoprotein (HDL)-cholesterol and a delayed clearance of triglyceride in fat tolerance tests. The aim of this study was to investigate whether these phenomena could be explained by a reduced lipoprot...

journal_title：European journal of clinical investigation

authors： Freeman DJ,Caslake MJ,Griffin BA,Hinnie J,Tan CE,Watson TD,Packard CJ,Shepherd J

更新日期：1998-07-01 00:00:00

abstract：:The contribution of the kinetics of exogeneous and endogenous lipoproteins in determining the level of triglyceride in fasting plasma was assessed in a group of 19 normolipidaemic and hypertriglyceridaemic subjects. From data derived during a 9-h infusion of [15N]-glycine, we have assessed very low density lipoprotein...

journal_title：European journal of clinical investigation

authors： Cortner JA,Le NA,Coates PM,Bennett MJ,Cryer DR

更新日期：1992-03-01 00:00:00

abstract：:The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...

journal_title：European journal of clinical investigation

authors： van't Hooft FM,van Tol A

更新日期：1985-12-01 00:00:00

abstract：:The effect of the potent specific cholecystokinin (CCK) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of CCK, gastrin, pancreatic polypeptide (PP), neurotensin, glucose-dependent insulinotropic polypeptide (GIP), insulin and C peptide was investigated in a placebo-controlled study in 10 heal...

journal_title：European journal of clinical investigation

authors： Schmidt WE,Creutzfeldt W,Höcker M,Nustede R,Choudhury AR,Schleser A,Rovati LC,Fölsch UR

更新日期：1991-10-01 00:00:00

abstract：:The venous system plays a pivotal role in volume and blood pressure homeostasis. We tested the hypothesis that the visco-elastic properties of the peripheral venous system are reduced in patients with (incipient) diabetic nephropathy. Twenty-two normotensive patients with long-term insulin-dependent diabetes mellitus ...

journal_title：European journal of clinical investigation

authors： Schaper NC,Houben AJ,Schoon Y,Kooman JP,Huvers FC,Nieuwenhuijzen Kruseman AC

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis. It has been shown previously that this may result in a transient "oversaturation" of transferrin. METHODS:Ten stable haemodialysis patients on r-HuEPO treatment re...

journal_title：European journal of clinical investigation

authors： Kooistra MP,Kersting S,Gosriwatana I,Lu S,Nijhoff-Schutte J,Hider RC,Marx JJ

更新日期：2002-03-01 00:00:00

abstract：:A continuous intravenous infusion of L-leucine (300 mumols min-1) was given to 12 healthy females over a 2 1/2 h period. Arterial plasma concentrations of amino acids and the keto acids of the branched-chain amino acids (BCAA) were measured. In six subjects muscle biopsies were taken before and at the end of the infus...

journal_title：European journal of clinical investigation

authors： Alvestrand A,Hagenfeldt L,Merli M,Oureshi A,Eriksson LS

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:N(ε)-(carboxymethyl)lysine (CML) is one of the major advanced glycation end products in both diabetics and nondiabetics. CML depositions in the microvasculature have recently been linked to the aetiology of acute myocardial infarction and cognitive impairment in Alzheimer's disease, possibly related to local ...

journal_title：European journal of clinical investigation

authors： Fuijkschot WW,de Graaff HJ,Berishvili E,Kakabadze Z,Kupreishvili K,Meinster E,Houtman M,van Broekhoven A,Schalkwijk CG,Vonk AB,Krijnen PA,Smulders YM,Niessen HW

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Platelets are involved in the pathogenesis of bronchial asthma, including aspirin-sensitive asthma (ASA). The pineal hormone melatonin (MT) has been described as inhibiting several physiological processes in platelets. The MT metabolite - N-acetyl-5-methoxy-kynurenamine - has a chemical structure similar to ...

journal_title：European journal of clinical investigation

authors： Evsyukova HV

更新日期：1999-06-01 00:00:00

abstract：:Fabry disease is an X-linked lysosomal storage disorder characterized by multi-organ dysfunction, including hearing loss - mainly sensorineural. The recent introduction of enzyme replacement therapy (ERT) has resulted in improvements in renal and cardiac function, pain and quality of life. One study has also suggested...

journal_title：European journal of clinical investigation

authors： Hajioff D,Hegemann S,Conti G,Beck M,Sunder-Plassmann G,Widmer U,Mehta A,Keilmann A

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Lipoprotein(a) [Lp(a)] is an important cardiovascular risk factor in the general population. However, prospective data on the vascular risk conferred by Lp(a) in patients with diabetes mellitus are scarce and controversial. It is not known whether the diabetic state affects the association of Lp(a) with vasc...

journal_title：European journal of clinical investigation

authors： Saely CH,Koch L,Schmid F,Marte T,Aczel S,Langer P,Hoefle G,Drexel H

更新日期：2006-02-01 00:00:00

abstract：:Urine was collected in four healthy infants, born after 35-39 weeks of gestation. The collections were made for 24 h starting immediately after birth. Bile acids were extracted, separated into conjugate groups, solvolysed, hydrolysed and quantified by gas-liquid chromatography as methyl ester trimethylsilyl ether deri...

journal_title：European journal of clinical investigation

authors： Strandvik B,Wikström SA

更新日期：1982-08-01 00:00:00

abstract：:The human placenta secretes large amounts of corticotropin-releasing hormone (CRH) which was thought to exert a paracrine action in the placenta. We have recently characterized high-affinity binding sites for CRH in the human placenta. However, our studies utilized whole placental membranes, which did not identify the...

journal_title：European journal of clinical investigation

authors： Saeed B,Fawcett M,Self C

更新日期：2001-02-01 00:00:00

abstract：:An increase in plasma renin activity (PRA) following experimental coronary occlusion has previously been demonstrated in anaesthetized and conscious dogs. The purpose of the present study was to analyse the mechanism of this renin release. In two distinct models of myocardial ischaemia in anaesthetized dogs--i.e. occl...

journal_title：European journal of clinical investigation

authors： Ertl G,Meesmann M,Kochsiek K

更新日期：1985-12-01 00:00:00