Serum cardiovascular risk biomarkers in pre-pubertal obese children.

abstract：:Fibromuscular dysplasia (FMD) is an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small and medium-sized arteries, mostly involving renal and cervical arteries. As a result of better and more systematic screening, it appears that in...

journal_title：European journal of clinical investigation

authors： Van der Niepen P,van Tussenbroek F,Devos H,Debing E,Di Monaco S,Goffette P,Astarci P,Persu A

更新日期：2018-11-01 00:00:00

abstract：:In a comparative study in pigs the extent of myocardial infarction has been estimated following a temporary three hour coronary occlusion and following a permanent coronary ligation. For evaluation of the cellular injury the infarct size has been determined by a histochemical staining procedure and correlated with ser...

journal_title：European journal of clinical investigation

authors： Althaus U,Janett J,Scholl E,Riedwyl H

更新日期：1976-01-30 00:00:00

abstract：:The effects of dazoxiben on finger-blood flow in response to cold challenge were studied in normal subjects and patients with Raynaud's phenomenon. In normal subjects concentrations of TXB2 and 6-oxo-PGF1 alpha were measured in blood taken from dorsal hand veins following cold challenge. In a parallel multicentre stud...

journal_title：European journal of clinical investigation

authors： Tindall H,Tooke JE,Menys VC,Martin MF,Davies JA

更新日期：1985-02-01 00:00:00

abstract：:Ten men with Klinefelter's syndrome were studied to assess the effect of testosterone replacement on plasma lipids and apolipoproteins. Measurements taken before the insertion of a testosterone ester implant were compared with those obtained 1 week and 4 weeks later. Mean plasma testosterone, androstenedione, total ch...

journal_title：European journal of clinical investigation

authors： Jones DB,Higgins B,Billet JS,Price WH,Edwards CR,Beastall GH,Shepherd J,Sweeting VM,Horn DB,Wenham PR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Adiponectin is an insulin-sensitizing, antiatherogenic and anti-inflammatory adipocytokine that circulates in three isoforms: a trimer [low-molecular weight (LMW)], a hexamer (trimer-dimer) of medium molecular weight (MMW) and a multimeric high molecular weight (HMW) isoform. Evidence is accumulating that HM...

journal_title：European journal of clinical investigation

authors： Kaser S,Tatarczyk T,Stadlmayr A,Ciardi C,Ress C,Tschoner A,Sandhofer A,Paulweber B,Ebenbichler CF,Patsch JR

更新日期：2008-11-01 00:00:00

abstract：:A kindred in which several members have otherwise typical acute intermittent porphyria but normal erythrocyte uroporphyrinogen-I-synthase activity has been described from Finland. We studied two porphyric members of this kindred, two patients with typical acute intermittent porphyria, and two healthy controls using th...

journal_title：European journal of clinical investigation

authors： Mustajoki P,Tenhunen R

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Microcirculatory changes contribute to clinical symptoms and disease progression in chronic heart failure (CHF). A depression of coronary flow reserve is associated with a lower myocardial capillary density in biopsies. We hypothesized that changes in cardiac microcirculation might also be refl...

journal_title：European journal of clinical investigation

authors： Wadowski PP,Hülsmann M,Schörgenhofer C,Lang IM,Wurm R,Gremmel T,Koppensteiner R,Steinlechner B,Schwameis M,Jilma B

更新日期：2018-02-01 00:00:00

abstract：:Lymphocytes were used as a cellular model for the in vitro measurements of maximal ouabain binding sites in order to assess any changes in young men at increased risk of developing essential hypertension, and to analyse whether any such changes were associated to borderline hypertension and/or heredity. Four groups we...

journal_title：European journal of clinical investigation

authors： Nielsen JR,Pedersen KE,Klitgaard NA,Johansen T

更新日期：1989-02-01 00:00:00

abstract：AIMS:Obesity, diabetes and cardiovascular disease are associated with COVID-19 risk and severity. Because epicardial adipose tissue (EAT) expresses ACE2, we wanted to identify the main factors associated with ACE2 levels and its cleavage enzyme, ADAM17, in epicardial fat. MATERIALS AND METHODS:Epicardial and subcutane...

journal_title：European journal of clinical investigation

authors： Couselo-Seijas M,Almengló C,M Agra-Bermejo R,Luis Fernandez Á,Alvarez E,R González-Juanatey J,Eiras S

更新日期：2020-11-29 00:00:00

abstract：:Bile acid kinetics and biliary lipid composition were determined in ten hypothyroid patients before and after treatment with L-thyroxine. Hypothyroid patients had normal synthesis rates of cholic acid and chenodeoxycholic acid. Hormone treatment, which lowered plasma cholesterol by about 35%, stimulated the formation ...

journal_title：European journal of clinical investigation

authors： Angelin B,Einarsson K,Leijd B

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the significance of the development of a restrictive response to an acute saline load, defined as an increase in the ratio of peak early to peak late diastolic transmitral flow velocity (E/A ratio) associated with a decrease in the deceleration time, in patients with mild...

journal_title：European journal of clinical investigation

authors： Triposkiadis F,Moyssakis I,Makris T,Hatzizaharias A,Hadjinikolaou L,Kyriakidis M

更新日期：2001-08-01 00:00:00

abstract：:We present a sensitive time-resolved fluorometric immunofunctional assay (TR-FIA) for direct quantitation of functional growth hormone-binding protein (GHBP), using an immunoassay kit for growth hormone (GH-DELFIA). In addition to the immobilized GH antibody, one monoclonal antibody against GHBP was used. This anti-GH...

journal_title：European journal of clinical investigation

authors： Fisker S,Frystyk J,Skriver L,Vestbo E,Ho KK,Orskov H

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:A hyaluronan-loading test has been developed for assessment of hyaluronan kinetics and applied in patients with liver and joint diseases. This test describes the metabolic process of hyaluronan but cannot define the specific contribution of different organs. A method for labelling of hyaluronan with the shor...

journal_title：European journal of clinical investigation

authors： Lindqvist U,Westerberg G,Bergström M,Torsteindottir I,Gustafson S,Sundin A,Lööf L,Långström B

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Early detection of fungal infection is essential for beginning of prompt and specific therapy. In this study we describe a rapid and sensitive procedure to detect, by polymerase chain reaction (PCR) assays, a wide range of medically important opportunistic and pathogenic fungi in dermal specimens from dermat...

journal_title：European journal of clinical investigation

authors： Turin L,Riva F,Galbiati G,Cainelli T

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnoea (OSA) is a common complication of obesity and can have a substantial negative impact on a patient's quality of life and risk of cardiovascular disease. The aim of this case-control study was to undertake discovery profiling of urinary peptides using capillary electrophoresis-mass spe...

journal_title：European journal of clinical investigation

authors： Seetho IW,Siwy J,Albalat A,Mullen W,Mischak H,Parker RJ,Craig S,Duffy N,Hardy KJ,Burniston JG,Wilding JP

更新日期：2014-11-01 00:00:00

abstract：:In a prospective study we investigated the possible changes in fasting serum total homocysteine concentrations during continuous micronized 17 beta-oestradiol, 2 mg daily, in combination with cyclic dydrogesterone, 10 mg daily during the first 14 days of each 28 day cycle, in 21 healthy non-hysterectomized postmenopau...

journal_title：European journal of clinical investigation

authors： van der Mooren MJ,Wouters MG,Blom HJ,Schellekens LA,Eskes TK,Rolland R

更新日期：1994-11-01 00:00:00

abstract：:To assess the degree of immune system activation associated with addiction or hepatotropic viruses infection, we examined 60 HIV-negative heroin addicts for the presence of hepatitis B virus (HBV) infection markers, hepatitis C virus antibodies (anti-HCV), various auto-antibodies, and serum levels of soluble interleuk...

journal_title：European journal of clinical investigation

authors： Dalekos GN,Manoussakis MN,Zervou E,Tsianos EV,Moutsopoulos HM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Alcohol may have a cardioprotective effect. One possible mechanism is by modifying insulin resistance/secretion. The aims of this study were: (i) to examine the effect of short-term alcohol consumption on the metabolic control of glucose tolerance; (ii) to study the influence of short-term alcohol consumptio...

journal_title：European journal of clinical investigation

authors： Flanagan DE,Pratt E,Murphy J,Vaile JC,Petley GW,Godsland IF,Kerr D

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Diabetes dramatically increases the risk of cardiovascular complications and mortality. Hydrogen sulphide plays an important role in reducing oxidative stress. Several studies demonstrated that hydrogen sulphide protects islet beta cells from oxidant stress damage and decreases apoptosis. The aim of...

journal_title：European journal of clinical investigation

authors： Dorofeyeva N,Drachuk K,Rajkumar R,Sabnis O,Sagach V

更新日期：2021-01-01 00:00:00

abstract：:Serum lactic dehydrogenase (S-LDH) was analysed at diagnosis in ninety-three patients with multiple myeloma. The patients were then followed up after a mean observation period of 39 months (SD 29). Serum lactic dehydrogenase was elevated in twenty-seven out of ninety-three patients and found to correlate with the seru...

journal_title：European journal of clinical investigation

authors： Simonsson B,Brenning G,Källander C,Ahre A

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Acute hyperglycaemia is known to inhibit jejunal interdigestive motility. This study was undertaken to establish the effects of hyperglycaemia on fed jejunal motility and small intestinal transit time, and to establish if the effects of hyperglycaemia are mediated in part by hyperinsulinaemia. METHODS:Nine ...

journal_title：European journal of clinical investigation

authors： Byrne MM,Pluntke K,Wank U,Schirra J,Arnold R,Göke B,Katschinski M

更新日期：1998-01-01 00:00:00

abstract：:The aim of this research was to study exogenous prostacyclin effect on urinary kallikrein excretion (UKK) in man, to define whether prostacyclin-induced renin release and/or endogenously released cyclooxygenase products were responsible for prostacyclin-induced enhancement of UKK, to determine furosemide effect on UKK...

journal_title：European journal of clinical investigation

authors： Pierucci A,Simonetti BM,Ciabattoni G,Taggi F,Morabito S,Vastano S,Pugliese F

更新日期：1986-06-01 00:00:00

abstract：:While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implement...

journal_title：European journal of clinical investigation

authors： Mischak H,Ioannidis JP,Argiles A,Attwood TK,Bongcam-Rudloff E,Broenstrup M,Charonis A,Chrousos GP,Delles C,Dominiczak A,Dylag T,Ehrich J,Egido J,Findeisen P,Jankowski J,Johnson RW,Julien BA,Lankisch T,Leung HY,Maahs

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Heparin-induced thrombocytopenia is a relatively uncommon but severe side-effect of heparin therapy. Heparin-induced IgG antibody has been elucidated to be the main isotype and the most pathogenic antibody in the pathophysiology. As affected patients are at high risk of developing thrombotic events, confirma...

journal_title：European journal of clinical investigation

authors： Wang LC,Huhle G,Malsch R,Hoffmann V,Song XL,Harenberg J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Kinetic abnormalities of apolipoprotein B (apoB)-containing lipoproteins in noninsulin-dependent diabetes mellitus (NIDDM) remain poorly understood. To get further insight into these abnormalities we performed a stable isotope kinetic experiment comparing the metabolism of apoB-containing lipoproteins in mod...

journal_title：European journal of clinical investigation

authors： Duvillard L,Pont F,Florentin E,Galland-Jos C,Gambert P,Vergès B

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Intestinal commensal flora seems to be a requisite for both human and experimental intestinal inflammation. Our aim was to assess the immunological changes in the colon of IL-10(-/-) mice depending on the environmental conditions. MATERIALS AND METHODS:Twelve wild-type (WT) and 24 IL-10(-/-) 4-week-old mice...

journal_title：European journal of clinical investigation

authors： Pedrosa E,Lorén V,Cabré E,Doménech E,Ojanguren I,Gassull MA,Mañé J

更新日期：2011-10-01 00:00:00

abstract：:As in women receiving oestrogens the administration of 17beta-oestradiol to ovariectomized female rats caused a rise in fasting plasma triglycerides and a fall in plasma glucose. Progesterone, on the other hand, had no significant effects. In the oestradiol treated rats, the portal vein basal insulin levels were sligh...

journal_title：European journal of clinical investigation

authors： Mandour T,Kissebah AH,Wynn V

更新日期：1977-06-01 00:00:00

abstract：:After feeding intact conscious dogs 1000 g mashed meat, peripheral venous immunoreactive insulin activity (IRI) increases before any enhancement of amino nitrogen concentration. This course of IRI is paralleled by a decrease of free fatty acids. Meal feeding in dogs, whose pancreatic juice is completely diverted from ...

journal_title：European journal of clinical investigation

authors： Fischer U,Hommel H,Gottschling HD,Nowak W

更新日期：1976-11-30 00:00:00

abstract：:The effects of glucose on the cytoplasmic Ca2+ concentration (Ca2+i) regulating insulin release were investigated using pancreatic beta-cells representative for the normal and diabetic situations. Increase of the glucose concentration resulted in a slight lowering of Ca2+i followed by a rise, often manifested as high ...

journal_title：European journal of clinical investigation

authors： Hellman B,Berne C,Grapengiesser E,Grill V,Gylfe E,Lund PE

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated the presence of receptors for somatostatin, a neuropeptide with immunoregulatory properties, in the inflammatory lesions of patients suffering from sarcoidosis and other granulomatous diseases by in vivo somatostatin receptor scintigraphy and in vitro autoradiography. How...

journal_title：European journal of clinical investigation

authors： ten Bokum AM,Hofland LJ,de Jong G,Bouma J,Melief MJ,Kwekkeboom DJ,Schonbrunn A,Mooy CM,Laman JD,Lamberts SW,van Hagen PM

更新日期：1999-07-01 00:00:00