Bile acid metabolism in hypothyroid subjects: response to substitution therapy.

abstract：BACKGROUND:Studies in different animal models and plasma analyses in humans suggest that members of the interleukin-6 (IL-6) cytokine family may be involved in the pathogenesis of congestive heart failure (CHF). Accordingly, we have examined IL-6-related cytokines in chronic CHF in humans by analysing gene and protein ...

journal_title：European journal of clinical investigation

authors： Eiken HG,Øie E,Damås JK,Yndestad A,Bjerkeli V,Aass H,Simonsen S,Geiran OR,Tønnessen T,Christensen G,Frøland SS,Gullestad L,Attramadal H,Aukrust P

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Diverticular disease (DD) and irritable bowel syndrome (IBS) share a similar symptom pattern. However, comparative studies are flawed by different age at onset of symptoms. We aimed to verify whether clinical features distinguish DD from IBS. MATERIALS AND METHODS:Patients with DD or IBS, matched for age an...

journal_title：European journal of clinical investigation

authors： Cuomo R,Barbara G,Andreozzi P,Bassotti G,Casetti T,Grassini M,Ierardi E,Maconi G,Marchi S,Sarnelli G,Savarino V,Usai P,Vozzella L,Annibale B

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Obesity and related kidney diseases have become a global epidemic problem. However, the underlying pathogenesis of obesity-related renal diseases has not been clearly understood. In this study, we explored the link between renal volume (RV) determined by computed tomography (CT) and renal histology together ...

journal_title：European journal of clinical investigation

authors： Tatar E,Sen S,Harman M,Kircelli F,Gungor O,Sarsik B,Asci G,Hoscoskun C,Basci A,Toz H

更新日期：2015-06-01 00:00:00

abstract：:The work was designed to study the effects of a meat meal on glomerular filtration rate (GFR), renal plasma flow (RPF), and plasma concentrations of glucagon, insulin, growth hormone, renin, aldosterone, total amino acids, and NH3 in healthy humans (H) as well as in patients with Child A liver cirrhosis (LC). The meat...

journal_title：European journal of clinical investigation

authors： De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The acute-phase response and anaemia of chronic disease are characterized by hypoferraemia associated with an increased ferritin synthesis, which might be mediated by the activated cytokine cascade. METHODS:We examined the prolonged effects of isolated limb perfusion (ILP) with recombinant human tumour necr...

journal_title：European journal of clinical investigation

authors： Feelders RA,Vreugdenhil G,Eggermont AM,Kuiper-Kramer PA,van Eijk HG,Swaak AJ

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Expression of acinar cell-specific genes requires the pancreas transcription factor 1alpha (Ptf1alpha). p48 is the only component of Ptf1alpha that is involved in both acinar gene regulation and pancreatic ontogenesis. MATERIALS AND METHODS:To determine whether Ptf1alpha/p48 expression is regulated during p...

journal_title：European journal of clinical investigation

authors： Molero X,Adell T,Skoudy A,Padilla MA,Gómez JA,Chalaux E,Malagelada JR,Real FX

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The pathogenesis of tumour formation in the anterior pituitary including adrenocorticotropic hormone (ACTH)-secreting tumours has been intensively studied, but the causative mechanisms involved in pituitary cell transformation and tumourigenesis remain unclear. MATERIALS AND METHODS:We searched PubMed on an...

journal_title：European journal of clinical investigation

authors： Dworakowska D,Grossman AB

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Different studies, mostly cross-sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim of this study was to determine the association between thyroid function and the risk for obesity. MATERIALS AND METHODS:In this po...

journal_title：European journal of clinical investigation

authors： Soriguer F,Valdes S,Morcillo S,Esteva I,Almaraz MC,de Adana MS,Tapia MJ,Dominguez M,Gutierrez-Repiso C,Rubio-Martin E,Garrido-Sanchez L,Perez V,Garriga MJ,Rojo-Martinez G,Garcia-Fuentes E

更新日期：2011-11-01 00:00:00

abstract：:Lymphocytes were used as a cellular model for the in vitro measurements of maximal ouabain binding sites in order to assess any changes in young men at increased risk of developing essential hypertension, and to analyse whether any such changes were associated to borderline hypertension and/or heredity. Four groups we...

journal_title：European journal of clinical investigation

authors： Nielsen JR,Pedersen KE,Klitgaard NA,Johansen T

更新日期：1989-02-01 00:00:00

abstract：:Insulin resistance has been reported in normal ageing but discrepancies between such studies may be related to compounding factors such as body composition and exercise patterns. We employed a two-step hyperinsulinaemic euglycaemic clamp to assess peripheral and hepatic tissue insulin sensitivity and glucose recycling...

journal_title：European journal of clinical investigation

authors： Broughton DL,James OW,Alberti KG,Taylor R

更新日期：1991-02-01 00:00:00

abstract：:Novel, powerful and long-acting inhibitors of gastric acid secretion include second generation H2-blockers and so-called proton pump inhibitors, such as omeprazole. Gastric carcinoids were found to develop in experimental animals as a consequence of continuous long-term administration of several of these highly effect...

journal_title：European journal of clinical investigation

authors： Håkanson R,Sundler F

更新日期：1990-10-01 00:00:00

abstract：:Acute hypoglycaemia enhances intestinal sugar uptake but the mechanisms involved are unknown. Results from the present study show increased galactose movement across the brush border and basolateral membranes of isolated upper, but not mid-villus, jejunal enterocytes 45 min after intravenous administration of insulin ...

journal_title：European journal of clinical investigation

authors： Debnam ES,Chowrimootoo G

更新日期：1993-08-01 00:00:00

abstract：:With advancing age both sexes have an increased incidence of osteoporotic fractures, although fractures are more common in women than in men. Whereas in women several potential risk factors have been identified, less is known about osteoporosis in men. A total of 27 Austrian men (mean age: 65 +/- 2 years) with atrauma...

journal_title：European journal of clinical investigation

authors： Resch H,Pietschmann P,Woloszczuk W,Krexner E,Bernecker P,Willvonseder R

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the progressive failure of hypoglycaemia counterregulation in long-standing type 1 diabetes are poorly understood. Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypo...

journal_title：European journal of clinical investigation

authors： Bischof MG,Brehm A,Bernroider E,Krssák M,Mlynárik V,Krebs M,Roden M

更新日期：2006-03-01 00:00:00

abstract：:Serum prolactin levels were measured by radioimmunoassay in eighty patients (thirty-four males, forty-six females) with sarcoidosis before treatment. In twelve patients (15%) serum prolactin levels were more than two standard deviations above the mean of normal subjects. Hyperprolactinaemia was found most frequently (...

journal_title：European journal of clinical investigation

authors： Nakao K,Noma K,Sato B,Yano S,Yamamura Y,Tachibana T

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Little is known about gallbladder motility in patients with black pigment stones when compared to cholesterol gallstone patients, or about their relationship to biliary composition, crystallization and stone characteristics. DESIGN:Fasting and postprandial gallbladder volumes were studied by ultrasonography...

journal_title：European journal of clinical investigation

authors： Portincasa P,Di Ciaula A,Vendemiale G,Palmieri V,Moschetta A,Vanberge-Henegouwen GP,Palasciano G

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Insulin resistance significantly correlated with a non-dipper type of essential hypertension. Thiazolidinediones (TZD), oral hypoglycaemic agents that act as insulin sensitizers, have been demonstrated in multiple in vivo and in vitro studies to possess antihypertensive properties. This study examined the ef...

journal_title：European journal of clinical investigation

authors： Anan F,Masaki T,Fukunaga N,Teshima Y,Iwao T,Kaneda K,Umeno Y,Okada K,Wakasugi K,Yonemochi H,Eshima N,Saikawa T,Yoshimatsu H

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:The pleiotropic cytokine osteopontin (OPN) is thought to be involved in the pathogenesis of atherosclerosis. However, the relationship between OPN and renal function, a cardiovascular risk factor itself, is not known. Therefore, we assessed the relationship between OPN plasma levels and renal function in pat...

journal_title：European journal of clinical investigation

authors： Lorenzen J,Krämer R,Kliem V,Bode-Boeger SM,Veldink H,Haller H,Fliser D,Kielstein JT

更新日期：2010-04-01 00:00:00

abstract：:The aim of this study was to assess the effect of intravenous dextran on bacterial translocation and intestinal vascular endothelial and epithelial barrier function after experimental partial hepatectomy. We determined systemic arterial pressure, enteric bacterial growth (proximal and distal small intestine and colon)...

journal_title：European journal of clinical investigation

authors： Wang XO,Sun ZW,Soltesz V,Deng XM,Andersson R

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Platelets are involved in the pathogenesis of bronchial asthma, including aspirin-sensitive asthma (ASA). The pineal hormone melatonin (MT) has been described as inhibiting several physiological processes in platelets. The MT metabolite - N-acetyl-5-methoxy-kynurenamine - has a chemical structure similar to ...

journal_title：European journal of clinical investigation

authors： Evsyukova HV

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Differences in lipid parameters between patients with acute coronary syndromes (ACS) and patients with stable coronary artery disease (CAD) are unclear and are addressed in this study. METHODS:We enrolled 582 patients with angiographically proven stable CAD (of whom 26·9% had diabetes mellitus type 2 (T2DM)...

journal_title：European journal of clinical investigation

authors： Vonbank A,Saely CH,Rein P,Drexel H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Four peptide hormones of a family of six hormones, i.e. atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-natriuretic peptide (CNP), long acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide, significantly decrease the number of adenocarcinoma cells in culture. The pres...

journal_title：European journal of clinical investigation

authors： Vesely BA,Song S,Sanchez-Ramos J,Fitz SR,Alli AA,Solivan SM,Gower WR Jr,Vesely DL

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:In vitro fertilisation (IVF) has been widely used during the last decades. Recent studies demonstrated some alterations in IVF children's metabolic profile compared with controls. The recently reported lipocalins retinol-binding protein 4 (RBP-4) and neutrophil gelatinase-associated lipocalin (NGAL), as well...

journal_title：European journal of clinical investigation

authors： Sakka SD,Margeli A,Loutradis D,Chrousos GP,Papassotiriou I,Kanaka-Gantenbein C

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Renal size and function reflect the health of the kidney. These parameters are associated with age, gender and body weight. The kidneys are also influenced by micro- and macrovascular diseases. Atherosclerotic markers and risk factors may influence the age-related changes of renal size and function. METHODS...

journal_title：European journal of clinical investigation

authors： Bax L,van der Graaf Y,Rabelink AJ,Algra A,Beutler JJ,Mali WP,SMART Study Group.

更新日期：2003-01-01 00:00:00

abstract：:To determine if the sex differences in clearance of long chain fatty acids by the liver observed in the rat are relevant to humans, the authors isolated hepatocytes from human adult males and females (five per group) and measured the initial (unidirectional) clearance of [3H]-palmitate from buffer containing albumin. ...

journal_title：European journal of clinical investigation

authors： Pond SM,Gordon RA,Bass L

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Renal impairment and type 2 diabetes mellitus (DM) are well-known independent risk factors for mortality. The evidence of their combined effects on mortality is unclear, but of importance because it may determine aggressiveness of treatment. This study sought to assess and quantify the effect modification of...

journal_title：European journal of clinical investigation

authors： Selvarajah S,Uiterwaal CS,Haniff J,van der Graaf Y,Visseren FL,Bots ML,SMART study group.

更新日期：2013-02-01 00:00:00

abstract：:The contribution of the kinetics of exogeneous and endogenous lipoproteins in determining the level of triglyceride in fasting plasma was assessed in a group of 19 normolipidaemic and hypertriglyceridaemic subjects. From data derived during a 9-h infusion of [15N]-glycine, we have assessed very low density lipoprotein...

journal_title：European journal of clinical investigation

authors： Cortner JA,Le NA,Coates PM,Bennett MJ,Cryer DR

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS:This randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, ...

journal_title：European journal of clinical investigation

authors： Rahmani E,Jamilian M,Dadpour B,Nezami Z,Vahedpoor Z,Mahmoodi S,Aghadavod E,Taghizadeh M,Beiki Hassan A,Asemi Z

更新日期：2018-03-01 00:00:00

abstract：:In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and ...

journal_title：European journal of clinical investigation

authors： Edvinsson L,Ekman R,Hedner P,Valdemarsson S

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Abnormal erythrocyte Na/Li countertransport is associated with diseases such as essential hypertension and diabetic renal disease. Although it seems unlikely that Na/Li countertransport contributes to any disease process, it may be abnormal because of a change in the cell membrane that is part of the disease...

journal_title：European journal of clinical investigation

authors： Thomas TH,Rutherford PA,Vareesangthip K,Wilkinson R,West IC

更新日期：1998-04-01 00:00:00