Peripheral and hepatic insulin sensitivity in healthy elderly human subjects.

abstract：BACKGROUND:Polymorphonuclear leucocytes (PMNLs) play a key role in the nonspecific immune defence. Cinacalcet reduces serum calcium levels in kidney transplant recipients with mineral bone disorder associated with chronic kidney disease. We investigated essential functions of PMNLs of kidney transplant recipients with ...

journal_title：European journal of clinical investigation

authors： Cohen G,Raupachova J,Borchhardt K,Hörl WH

更新日期：2013-05-01 00:00:00

abstract：:Basal cyclic AMP levels in blood mononuclear cells from healthy human donors has been studied. A great variation in cyclic AMP content ranging from below 2 to 20 pmol 10(-6) cells was seen. Incubation of the cells at 37 degrees C mostly showed a time-dependent decrease in basal cyclic AMP, levelling off after 16 h. Wh...

journal_title：European journal of clinical investigation

authors： Svenson M,Permin H,Wiik A

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Genetic factors may be important in modifying heart size due to long-term athletic training. The significance of polymorphisms of genes of the renin-angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known. METHODS:The angiotensin I-converting enz...

journal_title：European journal of clinical investigation

authors： Diet F,Graf C,Mahnke N,Wassmer G,Predel HG,Palma-Hohmann I,Rost R,Böhm M

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis ...

journal_title：European journal of clinical investigation

authors： Hong M,Park JW,Yang PS,Hwang I,Kim TH,Yu HT,Uhm JS,Joung B,Lee MH,Jee SH,Pak HN

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The Treating to New Targets (TNT) study has recently provided evidence that reduction in LDL-C levels below 2·6 mmol L⁻¹ lowers the risk of cerebrovascular events by an additional 20% to 25%, thereby confirming the value of statin therapy in preventing transient ischaemic attacks and stroke. Despite the prot...

journal_title：European journal of clinical investigation

authors： van den Bogaard B,van den Born BJ,Fayyad R,Waters DD,DeMicco DA,LaRosa JC,Kastelein JJ,Holme I,Treating to New Targets investigators.

更新日期：2011-02-01 00:00:00

abstract：:Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

journal_title：European journal of clinical investigation

authors： Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

更新日期：2004-02-01 00:00:00

abstract：:To examine the possible effects of hyperoxalaemia on anaerobic metabolism and erythrocyte pyruvate kinase activity, we induced a rise in plasma oxalate in 11 dialysis patients by the oral administration of ascorbic acid, 500 mg day-1 for 3 weeks. Blood samples were taken from the same antecubital vein before and after...

journal_title：European journal of clinical investigation

authors： Tomson CR,Channon SM,Ward MK,Laker MF

更新日期：1990-08-01 00:00:00

abstract：:We have examined the impact of race and positive family history of type 2 diabetes on glucose/insulin dynamics and the two components of glucose disposal in healthy, first-degree relatives of black and white American patients with type 2 diabetes mellitus who are at a greater risk from the disease and their healthy co...

journal_title：European journal of clinical investigation

authors： Osei K,Cottrell DA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The pathogenesis of tumour formation in the anterior pituitary including adrenocorticotropic hormone (ACTH)-secreting tumours has been intensively studied, but the causative mechanisms involved in pituitary cell transformation and tumourigenesis remain unclear. MATERIALS AND METHODS:We searched PubMed on an...

journal_title：European journal of clinical investigation

authors： Dworakowska D,Grossman AB

更新日期：2012-06-01 00:00:00

abstract：:Oral lichen planus (OLP) is a common oral disorder that manifests a mucosal reaction to a variety of aetiological factors, including liver disorder. This study investigated the relationship between OLP and hepatitis C virus (HCV) infection by studying the prevalence of hepatitis B and C virus infection or liver diseas...

journal_title：European journal of clinical investigation

authors： Nagao Y,Sata M,Tanikawa K,Itoh K,Kameyama T

更新日期：1995-12-01 00:00:00

abstract：:In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinol...

journal_title：European journal of clinical investigation

authors： D'Angelo A,Kluft C,Verheijen JH,Rijken DC,Mozzi E,Mannucci PM

更新日期：1985-12-01 00:00:00

abstract：:Antibodies against prostaglandins (PG)F2alpha, E1 and E2 were obtained inrabbits immunized with respectively PG F2alpha, PG E1 and PG E2 conjugated to bovine serum albumin by carbodiimide. A radioimmunoassay capable of measuring 7 pg of PG Falpha, 2 pg of PG E2 and 14 pg of PG E1 in human peripheral plasma is describe...

journal_title：European journal of clinical investigation

authors： Dray F,Charbonnel B,Maclouf J

更新日期：1975-07-29 00:00:00

abstract：:The retardation of gastric emptying induced by infusion of triglyceride into the small intestine is associated with suppression of antral pressure waves and stimulation of basal pyloric tone in combination with phasic pressure waves localized to the pylorus. The role of nitric oxide (NO) mechanisms in the control of p...

journal_title：European journal of clinical investigation

authors： Sun WM,Doran S,Lingenfelser T,Hebbard GS,Morley JE,Dent J,Horowitz M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The sympathetic nervous exerts a key role in cardiovascular homeostasis control by regulating cardiac output, systemic vascular resistance, heart rate and blood pressure. MATERIALS AND METHODS:Data collected during the past 30 years have unequivocally shown that in a considerable number of cardiovascular as...

journal_title：European journal of clinical investigation

authors： Grassi G,Seravalle G,Mancia G

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) exacerbates the risk of death due to cardiovascular disease (CVD). Modifications to blood lipid metabolism which manifest as increases in circulating triglycerides and reductions in high-density lipoprotein (HDL) cholesterol are thought to contribute to increased risk. In CKD pat...

journal_title：European journal of clinical investigation

authors： Brinck JW,Thomas A,Brulhart-Meynet MC,Lauer E,Frej C,Dahlbäck B,Stenvinkel P,James RW,Frias MA

更新日期：2018-02-01 00:00:00

abstract：:Propranolol is used clinically as a prophylactic drug to prevent oesophageal variceal bleeding in cirrhotic patients with portal hypertension. Vascular hyporesponsiveness is a common characteristic of the portal hypertensive state. The present study aimed to investigate whether chronic administration of propranolol co...

journal_title：European journal of clinical investigation

authors： Huang YT,Lin HC,Tsai JF,Hou MC,Hong CY

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Improvement of renal concentration capacity was long ago shown to occur after surgery for primary hyperparathyroidism (pHPT). Study of concentration capacity is of interest, as it was also shown to be a predictive factor for the risk of death in patients with pHPT, and it affected the risk of death independe...

journal_title：European journal of clinical investigation

authors： Hedbäck G,Abrahamsson K,Odén A

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:N(ε)-(carboxymethyl)lysine (CML) is one of the major advanced glycation end products in both diabetics and nondiabetics. CML depositions in the microvasculature have recently been linked to the aetiology of acute myocardial infarction and cognitive impairment in Alzheimer's disease, possibly related to local ...

journal_title：European journal of clinical investigation

authors： Fuijkschot WW,de Graaff HJ,Berishvili E,Kakabadze Z,Kupreishvili K,Meinster E,Houtman M,van Broekhoven A,Schalkwijk CG,Vonk AB,Krijnen PA,Smulders YM,Niessen HW

更新日期：2016-04-01 00:00:00

abstract：:The effect of indomethacin (75 mg/day for 3 days) on the response to i.v. angiotensin II was investigated in eight healthy, sodium-repleted, male subjects. Indomethacin reduced the release of aldosterone during the i.v. administration of angiotensin II (5, 10 and 20 ng kg-1 min-1), whereas the pressor response to angi...

journal_title：European journal of clinical investigation

authors： Vierhapper H,Waldhäusl W,Nowotny P

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese...

journal_title：European journal of clinical investigation

authors： Fernández-Cao JC,Arija V,Aranda N,Basora J,Diez-Espino J,Estruch R,Fitó M,Corella D,Salas-Salvadó J

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:In vitro fertilisation (IVF) has been widely used during the last decades. Recent studies demonstrated some alterations in IVF children's metabolic profile compared with controls. The recently reported lipocalins retinol-binding protein 4 (RBP-4) and neutrophil gelatinase-associated lipocalin (NGAL), as well...

journal_title：European journal of clinical investigation

authors： Sakka SD,Margeli A,Loutradis D,Chrousos GP,Papassotiriou I,Kanaka-Gantenbein C

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the syndrome. The aim of this study was to provide an overview of existing literature around determinants of...

journal_title：European journal of clinical investigation

authors： van Osch D,Nathoe HM,Jacob KA,Doevendans PA,van Dijk D,Suyker WJ,Dieleman JM

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The intestinal mucosa of patients with inflammatory bowel diseases (IBD) characteristically shows a high degree of inflammation when compared to healthy subjects. This appears to be attributable to an imbalance in local reactivity of inflammatory cells. In the present study, we tested the hypothesis that imm...

journal_title：European journal of clinical investigation

authors： Kovarik JJ,Tillinger W,Hofer J,Hölzl MA,Heinzl H,Saemann MD,Zlabinger GJ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:A hyaluronan-loading test has been developed for assessment of hyaluronan kinetics and applied in patients with liver and joint diseases. This test describes the metabolic process of hyaluronan but cannot define the specific contribution of different organs. A method for labelling of hyaluronan with the shor...

journal_title：European journal of clinical investigation

authors： Lindqvist U,Westerberg G,Bergström M,Torsteindottir I,Gustafson S,Sundin A,Lööf L,Långström B

更新日期：2000-07-01 00:00:00

abstract：:We have applied flow cytometry to the detection of activated platelets in patients with coronary heart disease. Paraformaldehyde-fixed platelets were incubated with one of the following monoclonal antibodies (MAbs): Bx-1 (anti-GP Ib), AP-2 (anti-GP IIb-IIIa complex), VH10 (anti-GMP-140, a glycoprotein of the alpha-gra...

journal_title：European journal of clinical investigation

authors： Nurden AT,Macchi L,Bihour C,Durrieu C,Besse P,Nurden P

更新日期：1994-02-01 00:00:00

abstract：:The effects of glucose on the cytoplasmic Ca2+ concentration (Ca2+i) regulating insulin release were investigated using pancreatic beta-cells representative for the normal and diabetic situations. Increase of the glucose concentration resulted in a slight lowering of Ca2+i followed by a rise, often manifested as high ...

journal_title：European journal of clinical investigation

authors： Hellman B,Berne C,Grapengiesser E,Grill V,Gylfe E,Lund PE

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Childhood obesity is associated with premature cardiovascular complications. However, little is known about the effect of a family-based behavioural intervention on the relationship between arterial function, blood pressure and biomarkers in pre-pubertal children with obesity. DESIGN:This was a single centr...

journal_title：European journal of clinical investigation

authors： Maggio ABR,Farpour-Lambert NJ,Aggoun Y,Galan K,Montecucco F,Mach F,Beghetti M

更新日期：2018-09-01 00:00:00

abstract：:While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implement...

journal_title：European journal of clinical investigation

authors： Mischak H,Ioannidis JP,Argiles A,Attwood TK,Bongcam-Rudloff E,Broenstrup M,Charonis A,Chrousos GP,Delles C,Dominiczak A,Dylag T,Ehrich J,Egido J,Findeisen P,Jankowski J,Johnson RW,Julien BA,Lankisch T,Leung HY,Maahs

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the progressive failure of hypoglycaemia counterregulation in long-standing type 1 diabetes are poorly understood. Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypo...

journal_title：European journal of clinical investigation

authors： Bischof MG,Brehm A,Bernroider E,Krssák M,Mlynárik V,Krebs M,Roden M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Several studies have reported a significant gender difference in low-density lipoprotein (LDL) size, with men being characterized by smaller, denser LDL particles than women, and it has been suggested that the contribution of the greater accumulation of visceral adipose tissue in men compared with women may ...

journal_title：European journal of clinical investigation

authors： Lemieux I,Pascot A,Lamarche B,Prud'homme D,Nadeau A,Bergeron J,Després JP

更新日期：2002-12-01 00:00:00