The cytoplasmic Ca2+ response to glucose as an indicator of impairment of the pancreatic beta-cell function.

abstract：:A kindred in which several members have otherwise typical acute intermittent porphyria but normal erythrocyte uroporphyrinogen-I-synthase activity has been described from Finland. We studied two porphyric members of this kindred, two patients with typical acute intermittent porphyria, and two healthy controls using th...

journal_title：European journal of clinical investigation

authors： Mustajoki P,Tenhunen R

更新日期：1985-10-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of the monocyte-derived cytokines interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in idiopathic inflammatory bowel disease. Endoscopic biopsies of normal and inflamed intestinal mucosa were obtained from patients w...

journal_title：European journal of clinical investigation

authors： Grottrup-Wolfers E,Moeller J,Karbach U,Muller-Lissner S,Endres S

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Age is one the factors associated with poor prognosis in acute coronary syndromes (ACS) and elderly patients are a high-risk collective with few parameters for mid-term cardiovascular stratification. We aimed to assess the predictive value of ankle-brachial index (ABI) in patients (> 75 years) for 1-year mor...

journal_title：European journal of clinical investigation

authors： Cordero A,Morillas P,Bertomeu-González V,Quiles J,Soria F,Guindo J,Mazón P,Anguita M,Rodríguez-Padial L,González-Juanatey JR,Bertomeu-Martínez V,en nombre de los investigadores del estudio PAMISCA.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The investigation of the human follicle fluid proteome has gained much interest in the search of new markers as predictors for in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatment outcome. Follicular fluid folate, as substrate of one carbon (1-C) metabolism, affects follicular met...

journal_title：European journal of clinical investigation

authors： Twigt JM,Bezstarosti K,Demmers J,Lindemans J,Laven JS,Steegers-Theunissen RP

更新日期：2015-08-01 00:00:00

abstract：:As increased oxidative stress is probably a pathogenetic factor in the development of diabetic complications, we studied nerve function and endogenous antioxidants in plasma, erythrocytes and sciatic nerve of untreated and insulin-treated streptozotocin-diabetic rats. After 18 weeks, the diabetes-induced sciatic nerve...

journal_title：European journal of clinical investigation

authors： van Dam PS,Bravenboer B,van Asbeck BS,van Oirschot JF,Marx JJ,Gispen WH

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:EPB4.1 has been previously mapped to human chromosome 1p33-p34.2. In contradiction to this chromosomal location, we have mapped EPB4.1-1p36 by using fluorescence in situ hybridization and radiation hybrid mapping. In neuroblastomas, deletions of the telomeric end of chromosome 1 (1p36) are the most common ge...

journal_title：European journal of clinical investigation

authors： Huang S,Lichtenauer UD,Pack S,Wang C,Kim AC,Lutchman M,Koch CA,Torres-Cruz J,Huang SC,Benz EJ Jr,Christiansen H,Dockhorn-Dworniczak B,Poremba C,Vortmeyer AO,Chishti AH,Zhuang Z

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:In Western societies colonic cancer most frequently develops in the distal colon, largely as a result of the composition of the diet. Modulation of dietary factors is therefore an attractive modality to reduce colorectal cancer risk. This study aims to evaluate the potentially protective effects of calcium i...

journal_title：European journal of clinical investigation

authors： van Gorkom BA,van der Meer R,Karrenbeld A,van der Sluis T,Zwart N,Termont DS,Boersma-van Ek W,de Vries EG,Kleibeuker JH

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Diets and Omega-3 polyunsaturated fatty acids have been considered as important factors to reduce the risk of cardiovascular and inflammatory diseases, but there are few details on the effects on healthy subjects. The aim of the present study was to examine the variation of several physiological parameters i...

journal_title：European journal of clinical investigation

authors： Fontani G,Corradeschi F,Felici A,Alfatti F,Bugarini R,Fiaschi AI,Cerretani D,Montorfano G,Rizzo AM,Berra B

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:To reveal detailed histopathological changes, virus distributions, immunologic properties and multi-omic features caused by SARS-CoV-2 in the explanted lungs from the world's first successful lung transplantation of a COVID-19 patient. MATERIALS AND METHODS:A total of 36 samples were collected from the lung...

journal_title：European journal of clinical investigation

authors： Chen XJ,Li K,Xu L,Yu YJ,Wu B,He YL,Zhao WE,Li D,Luan CX,Hu L,Wang J,Ding JJ,Yu YF,Li JX,Tan ZM,Liu XF,Wei D,Zhang ZH,Guo XJ,Su C,Hu ZB,Guo YS,Chen JY,Chen F

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Angiotensin converting enzyme 2 (ACE2), a monocarboxylase that degrades angiotensin II to angiotensin 1-7, is also the functional receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and is highly expressed in the lungs and heart. Patients with SARS also suffered from cardiac disease ...

journal_title：European journal of clinical investigation

authors： Oudit GY,Kassiri Z,Jiang C,Liu PP,Poutanen SM,Penninger JM,Butany J

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:In obese subjects, chronic low-grade inflammation contributes to an increased risk of metabolic abnormalities, which are reversed by weight loss. Sustained weight loss, however, is difficult to achieve and more insight into dietary approaches on anti-inflammatory responses in obese subjects is needed. In thi...

journal_title：European journal of clinical investigation

authors： Jellema A,Plat J,Mensink RP

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Hyperlipidemia is a common feature of the nephrotic syndrome (NS). From retrospective studies, it has been suggested that aggressive lipid-lowering with low-density lipoprotein apheresis (LDL-A) may not only improve dyslipidemia but also decrease urinary albumin excretion and increase serum levels of albumin...

journal_title：European journal of clinical investigation

authors： Stenvinkel P,Alvestrand A,Angelin B,Eriksson M

更新日期：2000-10-01 00:00:00

abstract：:Basal cyclic AMP levels in blood mononuclear cells from healthy human donors has been studied. A great variation in cyclic AMP content ranging from below 2 to 20 pmol 10(-6) cells was seen. Incubation of the cells at 37 degrees C mostly showed a time-dependent decrease in basal cyclic AMP, levelling off after 16 h. Wh...

journal_title：European journal of clinical investigation

authors： Svenson M,Permin H,Wiik A

更新日期：1984-08-01 00:00:00

abstract：:The secretion of insulin and glucagon was investigated in pancreatic islets from diabetic and nondiabetic sand rats of similar age and weight. The metabolic characterization was based on an intraperitoneal glucose tolerance test. Compared to nondiabetic animals diabetic sand rats had a diminished insulin content in th...

journal_title：European journal of clinical investigation

authors： Hahn HJ,Schäfer H,Gottschling HD,Fiedler H

更新日期：1976-01-30 00:00:00

abstract：:We have minimized methodological errors in the isotope dilution technique by using stable isotope, [6,6-2H2]glucose, thus avoiding the problem of contamination of tritiated glucose tracers and, by maintaining a constant plasma tracer enrichment have reduced error due to mixing transients. Using these modifications we ...

journal_title：European journal of clinical investigation

authors： Powrie JK,Smith GD,Hennessy TR,Shojaee-Moradie F,Kelly JM,Sönksen PH,Jones RH

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Soluble ST2 (sST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we...

journal_title：European journal of clinical investigation

authors： Willems S,Sels JW,Flier S,Versteeg D,Buhre WF,de Kleijn DP,Hoefer IE,Pasterkamp G

更新日期：2013-02-01 00:00:00

abstract：:The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...

journal_title：European journal of clinical investigation

authors： van't Hooft FM,van Tol A

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Studies in different animal models and plasma analyses in humans suggest that members of the interleukin-6 (IL-6) cytokine family may be involved in the pathogenesis of congestive heart failure (CHF). Accordingly, we have examined IL-6-related cytokines in chronic CHF in humans by analysing gene and protein ...

journal_title：European journal of clinical investigation

authors： Eiken HG,Øie E,Damås JK,Yndestad A,Bjerkeli V,Aass H,Simonsen S,Geiran OR,Tønnessen T,Christensen G,Frøland SS,Gullestad L,Attramadal H,Aukrust P

更新日期：2001-05-01 00:00:00

abstract：:The relationship between serum levels of lipoprotein(a) Lp(a)) and the presence of chronic diabetic complications was studied in 194 patients with non-insulin-dependent diabetes mellitus (NIDDM; 75 males, 119 females; age 66 +/- 11 years; duration of diabetes, 11 (range 1-35) years). They were taking various treatment...

journal_title：European journal of clinical investigation

authors： Heesen BJ,Wolffenbuttel BH,Leurs PB,Sels JP,Menheere PP,Jäckle-Beckers SE,Nieuwenhuijzen Kruseman AC

更新日期：1993-09-01 00:00:00

abstract：:We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia. Platelets from both normal and hypercholesterolaemic subjects showed irreversible aggregation with 0.3 units ml-1 thro...

journal_title：European journal of clinical investigation

authors： Smith CC,Wilson AP,Prichard BN,Betteridge DJ

更新日期：1989-06-01 00:00:00

abstract：:A haemolytically inactive alpha-mobile complement C8 component was identified by crossed immunoelectrophoresis in a 27-year-old male with recurrent meningococcal infections and absence of complement mediated serum haemolytic activity. The patient's serum/plasma contained no demonstrable normal C8. C8 inhibitor activit...

journal_title：European journal of clinical investigation

authors： Brandslund I,Teisner B,Strate M,Grunnet N,Svehag SE,Isager H,Wang P

更新日期：1983-04-01 00:00:00

abstract：:Diabetes Mellitus in its early stages, is associated with kidney enlargement and increased glomerular filtration rate in humans and in rats. The present study was designed to clarify the direct effect of diabetes on serum and tissue angiotensin converting enzyme (ACE) activity in streptozotocin-induced diabetic rats. ...

journal_title：European journal of clinical investigation

authors： Erman A,van Dyk DJ,Chen-Gal B,Giler ID,Rosenfeld JB,Boner G

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Expression of acinar cell-specific genes requires the pancreas transcription factor 1alpha (Ptf1alpha). p48 is the only component of Ptf1alpha that is involved in both acinar gene regulation and pancreatic ontogenesis. MATERIALS AND METHODS:To determine whether Ptf1alpha/p48 expression is regulated during p...

journal_title：European journal of clinical investigation

authors： Molero X,Adell T,Skoudy A,Padilla MA,Gómez JA,Chalaux E,Malagelada JR,Real FX

更新日期：2007-10-01 00:00:00

abstract：:Based on pathophysiological findings Lp(a) is considered to be a cardiovascular risk factor. The Göttingen Risk Incidence and Prevalence Study (GRIPS) provides the possibility to evaluate this impact of Lp(a) on the basis of a large prospective cohort study. GRIPS included 6002 men, aged 40-59.9 years at baseline. Dat...

journal_title：European journal of clinical investigation

authors： Cremer P,Nagel D,Labrot B,Mann H,Muche R,Elster H,Seidel D

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:SOX6 has been recently proposed as a pleiotropic gene for obesity and osteoporosis. The aim of this study was to investigate whether the rs7117858 genetic variant in SOX6 was associated with bone mass assessed by quantitative ultrasound (QUS) and obesity-related measures in a population of young adults. MET...

journal_title：European journal of clinical investigation

authors： Correa-Rodríguez M,Schmidt-RioValle J,Rueda-Medina B

更新日期：2018-10-01 00:00:00

abstract：:The effect of infusions of recombinant insulin-like growth factor-I (IGF-I) (34, 103 or 688 pmol min-1 kg-1), insulin (3.4, 10.3 or 68.8 pmol min-1 kg-1) or combined infusions (34 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin or 103 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin) on protein metabolism, using an infusion of [1-14...

journal_title：European journal of clinical investigation

authors： Umpleby AM,Shojaee-Moradie F,Thomason MJ,Kelly JM,Skottner A,Sonksen PH,Jones RH

更新日期：1994-05-01 00:00:00

abstract：:Two methods of measurement of fractional calcium absorption have been compared in the same individuals. There is a significant correlation between fractional 47Ca absorption as measured with a blood counting method and with an external counting method after intravenous and oral administration of 47Ca (P less than 0.00...

journal_title：European journal of clinical investigation

authors： Juttmann JR,Ruis AM,Hagenouw-Taal JC,Lockefeer JH,Birkenhäger JC

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. MATERIALS AND...

journal_title：European journal of clinical investigation

authors： Leitão J,Carvalhana S,Cochicho J,Silva AP,Velasco F,Medeiros I,Alves AC,Bourbon M,Oliveiros B,Rodrigues V,Sousa R,Sampaio F,Carvalho A,Cortez-Pinto H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) represents the most relevant cause of death and morbidity in the adult population of developed and developing countries. During the last decades, a strong research effort has been performed to identify more selective markers and better assess the cardiovascular risk in both prim...

journal_title：European journal of clinical investigation

authors： Quercioli A,Montecucco F,Bertolotto M,Ottonello L,Pende A,Mach F,Dallegri F

更新日期：2010-07-01 00:00:00

abstract：:We measured the renal haemodynamic and proteinuric response to a meat meal (MM) in ten persistently proteinuric insulin-dependent diabetic patients in a randomized cross-over study of 3 weeks on low protein diet (LPD) or normal protein intake (NPD). On LPD, protein intake (0.64 +/- 0.05 vs 1.15 +/- 0.09 g kg-1 body we...

journal_title：European journal of clinical investigation

authors： Pinto JR,Bending JJ,Dodds RA,Viberti GC

更新日期：1991-04-01 00:00:00