Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.

abstract：BACKGROUND:In inflammatory bowel diseases, changes in autonomic enteric regulation may also affect neural cardiovascular control. However, while cardiac autonomic modulation has been shown to be impaired in active ulcerative colitis, the occurrence of cardiovascular autonomic alterations, also in the quiescent phase of...

journal_title：European journal of clinical investigation

authors： Coruzzi P,Castiglioni P,Parati G,Brambilla V,Brambilla L,Gualerzi M,Cademartiri F,Franzè A,De Angelis G,Di Rienzo M,Di Mario F

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Changes in bile acid (BA) pool, such as the reappearance of typically foetal-type molecular species with a 'flat' structure at the steroid ring, occur during hepatocarcinogenesis, both in humans and rodents. Moreover flat-BAs also appear during rat liver regeneration. These changes can be detected in urine. ...

journal_title：European journal of clinical investigation

authors： Stärkel P,Shindano T,Horsmans Y,Gigot JF,Fernandez-Tagarro M,Marin JJ,Monte MJ

更新日期：2009-01-01 00:00:00

abstract：:Microvascular research is seriously hampered by the great temporal and spatial variability of the measured skin blood flow and variation in sympathetic vasomotor reflexes within and between persons. Therefore skin vasomotor reflexes were studied before and after ulnar nerve blockade within the same person, resulting i...

journal_title：European journal of clinical investigation

authors： Netten PM,Wollersheim H,Gielen MJ,Den Arend JA,Lutterman JA,Thien T

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated the presence of receptors for somatostatin, a neuropeptide with immunoregulatory properties, in the inflammatory lesions of patients suffering from sarcoidosis and other granulomatous diseases by in vivo somatostatin receptor scintigraphy and in vitro autoradiography. How...

journal_title：European journal of clinical investigation

authors： ten Bokum AM,Hofland LJ,de Jong G,Bouma J,Melief MJ,Kwekkeboom DJ,Schonbrunn A,Mooy CM,Laman JD,Lamberts SW,van Hagen PM

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation i...

journal_title：European journal of clinical investigation

authors： Schutte R,Whincup PH,Papacosta O,Lennon LT,Macfarlane PW,Wannamethee G

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The acute-phase response and anaemia of chronic disease are characterized by hypoferraemia associated with an increased ferritin synthesis, which might be mediated by the activated cytokine cascade. METHODS:We examined the prolonged effects of isolated limb perfusion (ILP) with recombinant human tumour necr...

journal_title：European journal of clinical investigation

authors： Feelders RA,Vreugdenhil G,Eggermont AM,Kuiper-Kramer PA,van Eijk HG,Swaak AJ

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:It is well known that space travel cause post-flight orthostatic hypotension and it was assumed that autonomic cardiovascular control deteriorates in space. Lower body negative pressure (LBNP) was used to assess autonomic function of the cardiovascular system. METHODS:LBNP tests were performed on six crew-m...

journal_title：European journal of clinical investigation

authors： Baisch F,Beck L,Blomqvist G,Wolfram G,Drescher J,Rome JL,Drummer C

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Excess of cardiovascular risk among patients with chronic inflammatory diseases has been attributed to increased arterial stiffness. Hypercholesterolaemia has been demonstrated to promote a low-grade inflammatory status. The objective of the present study was to define, in hypercholesterolaemia, the influenc...

journal_title：European journal of clinical investigation

authors： Pirro M,Schillaci G,Savarese G,Gemelli F,Vaudo G,Siepi D,Bagaglia F,Mannarino E

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Glomerulonephritis clusters in families. However, infections are common inducers of glomerulonephritis and may also cluster in families. Studies of adoptees and their biological and adoptive parents may disentangle genetic from environmental causes of familial clustering. This is the first adoption study aim...

journal_title：European journal of clinical investigation

authors： Akrawi DS,Zöller B,Fjellstedt E,Sundquist J,Sundquist K,PirouziFard M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Increased production of chemokines by adipose tissue and defective adipose tissue oxygenation as a result of obesity may induce leucocyte infiltration and subsequent systemic inflammation. OBJECTIVES:1-To determine the relation between the amount of visceral and subcutaneous adipose tissue and the chemokine...

journal_title：European journal of clinical investigation

authors： Faber DR,van der Graaf Y,Westerink J,Kanhai DA,Monajemi H,Visseren FL,SMART study Group.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:In the 13C-octanoate breath test, the shape of the 13CO2 excretion curve in the ascending portion reflects a pattern of gastric emptying (GE). Recent scintigraphic studies have revealed an overall delay in solid GE in fertile women compared with men. However, it remains unknown whether women have a different...

journal_title：European journal of clinical investigation

authors： Sanaka M,Yamamoto T,Anjiki H,Osaki Y,Kuyama Y

更新日期：2006-08-01 00:00:00

abstract：:The permeability of the gastrointestinal tract was investigated by means of polyethylene glycol (PEG), given orally. The PEG solutions contained oligomers with molecular weights from 414 to 1206. The urinary recovery of ingested PEG was determined by high performance liquid chromatography (HPLC). Considerable inter- a...

journal_title：European journal of clinical investigation

authors： Philipsen EK,Batsberg W,Christensen AB

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Our aim in the present study was to determine whether endothelial NO synthase gene (ecNOS) polymorphisms are associated with myocardial infarction (MI). METHODS:Forty chromosomes from patients with MI were screened for polymorphisms of the ecNOS gene using polymerase chain reaction-single-strand conformatio...

journal_title：European journal of clinical investigation

authors： Poirier O,Mao C,Mallet C,Nicaud V,Herrmann SM,Evans A,Ruidavets JB,Arveiler D,Luc G,Tiret L,Soubrier F,Cambien F

更新日期：1999-04-01 00:00:00

abstract：:The secretion of insulin and glucagon was investigated in pancreatic islets from diabetic and nondiabetic sand rats of similar age and weight. The metabolic characterization was based on an intraperitoneal glucose tolerance test. Compared to nondiabetic animals diabetic sand rats had a diminished insulin content in th...

journal_title：European journal of clinical investigation

authors： Hahn HJ,Schäfer H,Gottschling HD,Fiedler H

更新日期：1976-01-30 00:00:00

abstract：BACKGROUND:Increased intestinal permeability in cirrhosis exerts a pivotal role in the pathogenesis of spontaneous bacterial peritonitis and other complications of cirrhosis through promotion of systemic endotoxemia. This study was designed to investigate whether the expression of tight junction (TJ) proteins, which re...

journal_title：European journal of clinical investigation

authors： Assimakopoulos SF,Tsamandas AC,Tsiaoussis GI,Karatza E,Triantos C,Vagianos CE,Spiliopoulou I,Kaltezioti V,Charonis A,Nikolopoulou VN,Scopa CD,Thomopoulos KC

更新日期：2012-04-01 00:00:00

abstract：:Based on pathophysiological findings Lp(a) is considered to be a cardiovascular risk factor. The Göttingen Risk Incidence and Prevalence Study (GRIPS) provides the possibility to evaluate this impact of Lp(a) on the basis of a large prospective cohort study. GRIPS included 6002 men, aged 40-59.9 years at baseline. Dat...

journal_title：European journal of clinical investigation

authors： Cremer P,Nagel D,Labrot B,Mann H,Muche R,Elster H,Seidel D

更新日期：1994-07-01 00:00:00

abstract：:The siblings presented here are the third family found in Japan with familial LCAT deficiency. Their post-heparin plasma lipoprotein lipase and hepatic triglyceride lipase activities were measured selectively by an immunochemical method. Plasma triglyceride levels were elevated, and post-heparin plasma lipoprotein lip...

journal_title：European journal of clinical investigation

authors： Murayama N,Asano Y,Kato K,Sakamoto Y,Hosoda S,Yamada N,Kodama T,Murase T,Akanuma Y

更新日期：1984-04-01 00:00:00

abstract：:Increased activity of the Na+/H+ antiport may be a major abnormality in essential hypertension. The activity of this transport system was investigated in lymphocytes from 13 patients with untreated essential hypertension (Ht) and 13 normotensive control subjects (Nt) on an ad libitum (130-170 mmol d-1) NaCl intake. Fu...

journal_title：European journal of clinical investigation

authors： Göbel BO,Hoffmann G,Ruppert M,Stumpe KO,Vetter H,Siffert W,Düsing R

更新日期：1994-08-01 00:00:00

abstract：:A haemolytically inactive alpha-mobile complement C8 component was identified by crossed immunoelectrophoresis in a 27-year-old male with recurrent meningococcal infections and absence of complement mediated serum haemolytic activity. The patient's serum/plasma contained no demonstrable normal C8. C8 inhibitor activit...

journal_title：European journal of clinical investigation

authors： Brandslund I,Teisner B,Strate M,Grunnet N,Svehag SE,Isager H,Wang P

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the significance of the development of a restrictive response to an acute saline load, defined as an increase in the ratio of peak early to peak late diastolic transmitral flow velocity (E/A ratio) associated with a decrease in the deceleration time, in patients with mild...

journal_title：European journal of clinical investigation

authors： Triposkiadis F,Moyssakis I,Makris T,Hatzizaharias A,Hadjinikolaou L,Kyriakidis M

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Recent data suggest that, among other factors, comorbidity may be an important prognostic variable in patients with myelodysplastic syndromes (MDS) who are eligible for haematopoietic stem cell transplantation (SCT). PATIENTS AND METHODS:We examined the overall survival (OS) and underlying risk factors in 4...

journal_title：European journal of clinical investigation

authors： Boehm A,Sperr WR,Leitner G,Worel N,Oehler L,Jaeger E,Mitterbauer M,Haas OA,Valent P,Kalhs P,Rabitsch W

更新日期：2008-12-01 00:00:00

abstract：:The effects of dazoxiben on finger-blood flow in response to cold challenge were studied in normal subjects and patients with Raynaud's phenomenon. In normal subjects concentrations of TXB2 and 6-oxo-PGF1 alpha were measured in blood taken from dorsal hand veins following cold challenge. In a parallel multicentre stud...

journal_title：European journal of clinical investigation

authors： Tindall H,Tooke JE,Menys VC,Martin MF,Davies JA

更新日期：1985-02-01 00:00:00

abstract：:The capillary permeability in human skeletal muscle, expressed as capillary diffusion capacity (CDC) for 51Cr-EDTA, was determined during exercise with a local clearance method in two groups of healthy male subjects: a younger group with a mean age of 30 years and an older one with a mean age of 58 years. The main fin...

journal_title：European journal of clinical investigation

authors： Berglund B,Efendić S,Strandell T,Luft R

更新日期：1979-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the prevalence of lumbar spondylolisthesis (SPL) in patients suffering from low back pain (LBP) with or without rheumatoid arthritis (RA) and to identify potential factors associated with SPL in patients with RA. METHODS:We performed a case-control study. Cases and contro...

journal_title：European journal of clinical investigation

authors： Hagege B,Tubach F,Alfaiate T,Forien M,Dieudé P,Ottaviani S

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Most of the previous reports found cirrhosis patients with a high risk of subsequent tuberculosis (TB). However, data about the risk of developing liver cirrhosis in TB patients are limited. As a hepatitis endemic area, the risk of liver cirrhosis in patients with TB should be elucidated in Taiwan. METHODS:...

journal_title：European journal of clinical investigation

authors： Peng YC,Lin CL,Hsu WY,Chang CS,Yeh HZ,Kao CH

更新日期：2015-07-01 00:00:00

abstract：:Estimations of the prevalence of central nervous system involvement in patients with systemic lupus erythematosus (SLE) vary from 25 to 75%. In order to assess possible deficits in memory, attention, and/or reaction time, a battery of neuropsychological tests was administered to 15 patients with SLE and to two matched...

journal_title：European journal of clinical investigation

authors： Ferstl R,Niemann T,Biehl G,Hinrichsen H,Kirch W

更新日期：1992-10-01 00:00:00

abstract：:Many diseases with a major public health impact are the result of complex interactions between environmental factors and multiple genes. In the past decade, methods for genome analysis, in particular quantitative trait locus (QTL) analysis in animal models, were developed to identify and localize the genes responsible...

journal_title：European journal of clinical investigation

authors： Hillebrandt S,Matern S,Lammert F

更新日期：2003-02-01 00:00:00

abstract：:The effect of infusions of recombinant insulin-like growth factor-I (IGF-I) (34, 103 or 688 pmol min-1 kg-1), insulin (3.4, 10.3 or 68.8 pmol min-1 kg-1) or combined infusions (34 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin or 103 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin) on protein metabolism, using an infusion of [1-14...

journal_title：European journal of clinical investigation

authors： Umpleby AM,Shojaee-Moradie F,Thomason MJ,Kelly JM,Skottner A,Sonksen PH,Jones RH

更新日期：1994-05-01 00:00:00

abstract：:Plasma glucose concentration is the best predictor for the development of non-insulin-dependent diabetes mellitus (NIDDM). However, obesity is also a recognized risk factor for development of the disease, and is easier to track over time. Thus obesity could be of considerable clinical importance as a predictor of diab...

journal_title：European journal of clinical investigation

authors： Ferrannini E,Camastra S

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Given that role of magnesium in insulin secretion is uncertain, our objective was to determine whether oral supplementation with magnesium chloride (MgCl(2)) improves the ability of beta-cells to compensate for variations in insulin sensitivity in non-diabetic individuals with significant hypomagnesaemia. M...

journal_title：European journal of clinical investigation

authors： Guerrero-Romero F,Rodríguez-Morán M

更新日期：2011-04-01 00:00:00