Abstract：
:Microparticles are small membrane vesicles that are released from cells upon activation or during apoptosis. Cellular microparticles in body fluids constitute a heterogeneous population, differing in cellular origin, numbers, size, antigenic composition and functional properties. Microparticles support coagulation by exposure of negatively charged phospholipids and sometimes tissue factor, the initiator of coagulation in vivo. Microparticles may transfer bioactive molecules to other cells or microparticles, thereby stimulating cells to produce cytokines, cell-adhesion molecules, growth factors and tissue factor, and modulate endothelial functions. Microparticles derived from various cells, most notably platelets but also leucocytes, lymphocytes, erythrocytes and endothelial cells, are present in the circulation of healthy subjects. Rare hereditary syndromes with disturbances in membrane vesiculation leading to a decreased numbers of microparticles clinically present with a bleeding tendency. In contrast, elevated numbers of microparticles are encountered in patients with a great variety of diseases with vascular involvement and hypercoagulability, including disseminated intravascular coagulation, acute coronary syndromes, peripheral arterial disease, diabetes mellitus and systemic inflammatory disease. Finally, microparticles are a major component of human atherosclerotic plaques. In view of their functional properties, cell-derived microparticles may be an important intermediate in the cascade of cellular and plasmatic dysfunctions underlying the process of atherogenesis.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Diamant M,Tushuizen ME,Sturk A,Nieuwland Rdoi
10.1111/j.1365-2362.2004.01355.xkeywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
392-401issue
6eissn
0014-2972issn
1365-2362pii
ECI1355journal_volume
34pub_type
杂志文章,评审abstract：:In contrast to bile salts, which undergo a highly efficient enterohepatic circulation with multiple regulatory and physiologic functions, glucuronic acid conjugates of bilirubin are biliary excretory molecules that in health do not have a continuing biologic life. Intestinal absorptive cells are devoid of recapture tr...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2362.2003.01214.x
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND: Cirrhotic patients are at considerable risk for bacterial infections, possibly through increased intestinal permeability and bacterial overgrowth. Proton pump inhibitors (PPIs) may increase infection risk. We aimed to explore the potential association between PPI use and bacterial infection risk in cirrhot...
journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.2011.02643.x
更新日期：2012-07-01 00:00:00
abstract：:Studies were designed to establish the acid inhibitory potency and plasma kinetics of somatostatin-28 (S-28) in humans and to determine whether the amount of S-28 released into the circulation after a meal is sufficient to regulate gastric acid secretion. A liquid meal induced a significant increase of S-28 (P < 0.01)...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2362.1994.tb02059.x
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Tumour necrosis factor alpha (TNF) mRNA expression has been reported to be up-regulated in adipose tissue from several rodent models of obesity and diabetes and from obese humans. This elevated expression has been assumed to be associated with the development of insulin resistance. However, the biological si...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1999.00520.x
更新日期：1999-08-01 00:00:00
abstract：:We have applied flow cytometry to the detection of activated platelets in patients with coronary heart disease. Paraformaldehyde-fixed platelets were incubated with one of the following monoclonal antibodies (MAbs): Bx-1 (anti-GP Ib), AP-2 (anti-GP IIb-IIIa complex), VH10 (anti-GMP-140, a glycoprotein of the alpha-gra...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1994.tb02426.x
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Adiponectin is an insulin-sensitizing, antiatherogenic and anti-inflammatory adipocytokine that circulates in three isoforms: a trimer [low-molecular weight (LMW)], a hexamer (trimer-dimer) of medium molecular weight (MMW) and a multimeric high molecular weight (HMW) isoform. Evidence is accumulating that HM...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2008.02028.x
更新日期：2008-11-01 00:00:00
abstract：:The effect of propranolol 160-640 mg/day for 3 months on the accelerated loss of bone matrix and mineral in hyperthyroidism was studied in seventeen patients. A rise in serum thyroxine (P less than 0.01) during the first 3 weeks was followed by a fall (P less than 0.02). Serum triiodothyronine declined during the stud...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1984.tb02095.x
更新日期：1984-04-01 00:00:00
abstract：:The electrical parameters and the unidirectional fluxes of 45Ca and 3H-mannitol were measured in preparations of rat colon descendens freed from the muscularis externa and mounted in a modified Ussing-chamber. Two criteria were used to differentiate between changes in the trans- and the paracellular calcium transport ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1986.tb01007.x
更新日期：1986-10-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1997.1550704.x
更新日期：1997-07-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1980.tb00040.x
更新日期：1980-08-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2362.32.s3.2.x
更新日期：2002-06-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1976.tb00544.x
更新日期：1976-11-30 00:00:00
abstract：BACKGROUND:Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis. It has been shown previously that this may result in a transient "oversaturation" of transferrin. METHODS:Ten stable haemodialysis patients on r-HuEPO treatment re...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章
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更新日期：2002-03-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2009.02153.x
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:The Treating to New Targets (TNT) study has recently provided evidence that reduction in LDL-C levels below 2·6 mmol L⁻¹ lowers the risk of cerebrovascular events by an additional 20% to 25%, thereby confirming the value of statin therapy in preventing transient ischaemic attacks and stroke. Despite the prot...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2362.2010.02387.x
更新日期：2011-02-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
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更新日期：2017-06-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1985.tb00166.x
更新日期：1985-08-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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更新日期：2003-11-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
abstract：:The aim of this research was to study exogenous prostacyclin effect on urinary kallikrein excretion (UKK) in man, to define whether prostacyclin-induced renin release and/or endogenously released cyclooxygenase products were responsible for prostacyclin-induced enhancement of UKK, to determine furosemide effect on UKK...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1986.tb01334.x
更新日期：1986-06-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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更新日期：1989-12-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-03-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1978.tb00868.x
更新日期：1978-12-01 00:00:00
abstract：BACKGROUND:Weight loss induced by bariatric surgery is an effective method to reverse obesity and comorbidities. The aim of this prospective weight loss study was to investigate changes of body fat distribution in relation to adiponectin and its isoforms and further to investigate the influence of both body fat distrib...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2008.01929.x
更新日期：2008-04-01 00:00:00
abstract：INTRODUCTION:Complement-mediated tubular injury may play an important role in the progression of renal diseases. C3d is a presumed marker of complement activation. Its precursor C3dg has been detected in the urine of patients with membranous nephropathy. However, little is known of the renal handling of C3d or its excr...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.2003.01153.x
更新日期：2003-06-01 00:00:00
