Molecular insights into insulin action and secretion.


:Tightly co-ordinated control of both insulin action and secretion is required in order to maintain glucose homeostasis. Gene knockout experiments have helped to define key signalling molecules that affect insulin action, including insulin and insulin-like growth factor-1 (IGF-1) receptors, insulin receptor substrate (IRS) proteins and various downstream effector proteins. beta-cell function is also a tightly regulated process, with numerous factors (including certain signalling molecules) having an impact on insulin production, insulin secretion and beta-cell mass. While signalling molecules play important roles in insulin action and secretion under normal circumstances, abnormal insulin signalling in muscle, adipose tissue, liver and pancreas leads to insulin resistance and beta-cell dysfunction. In particular, the signalling protein IRS-2 may have a central role in linking these abnormalities, although other factors are likely to be involved.


Eur J Clin Invest


Rhodes CJ,White MF





Has Abstract


2002-06-01 00:00:00










32 Suppl 3


  • Relationship between impaired glucose tolerance, non-insulin-dependent diabetes mellitus and obesity.

    abstract::Plasma glucose concentration is the best predictor for the development of non-insulin-dependent diabetes mellitus (NIDDM). However, obesity is also a recognized risk factor for development of the disease, and is easier to track over time. Thus obesity could be of considerable clinical importance as a predictor of diab...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Ferrannini E,Camastra S

    更新日期:1998-09-01 00:00:00

  • Interactions of stress hormones on lipid and carbohydrate metabolism in man with partial insulin deficiency.

    abstract::The metabolic responses to 4-h infusions of adrenaline (3 micrograms kg-1 h-1) and cortisol (10 mg m-2 h-1 for 2 h followed by 5 mg m-2 h-1 for 2 h), separately and in combination, have been studied in six healthy subjects with concurrent somatostatin infusion (250 micrograms h-1). A combined infusion of adrenaline, c...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Pernet A,Johnston DG,Hammond V,Orskov H,Alberti KG

    更新日期:1986-08-01 00:00:00

  • Cardiovascular risk factors and collateral artery formation.

    abstract::Arterial lumen narrowing and vascular occlusion is the actual cause of morbidity and mortality in atherosclerotic disease. Collateral artery formation (arteriogenesis) refers to an active remodelling of non-functional vascular anastomoses to functional collateral arteries, capable to bypass the site of obstruction and...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: de Groot D,Pasterkamp G,Hoefer IE

    更新日期:2009-12-01 00:00:00

  • Changes in plasma renin activity and haemodynamics during vasodilator therapy in conscious dogs with myocardial infarction or chronic volume overload.

    abstract::The aim of the study was to compare the changes in plasma renin activity induced by a vasodilator in normal dogs and in dogs with an impaired cardiac reserve. In normal conscious dogs, a 60-min nitroprusside infusion increased plasma renin activity from 1.05 +/- 0.26 to 8.35 +/- 1.20 ng, angiotensin I ml-1 h-1 (P less...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Pouleur H,Engler RL,Link J,Printz MP,Covell JW

    更新日期:1983-08-01 00:00:00

  • Effects of myocardial revascularization following acute coronary occlusion in pigs.

    abstract::In a comparative study in pigs the extent of myocardial infarction has been estimated following a temporary three hour coronary occlusion and following a permanent coronary ligation. For evaluation of the cellular injury the infarct size has been determined by a histochemical staining procedure and correlated with ser...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Althaus U,Janett J,Scholl E,Riedwyl H

    更新日期:1976-01-30 00:00:00

  • Left ventricular and cardiac autonomic function in survivors of testicular cancer.

    abstract:BACKGROUND:Following cisplatin-based chemotherapy, survivors of testicular cancer have a high prevalence of cardiovascular risk factors and an increased risk of cardiovascular disease. Cardiac function has not been extensively studied and no comparisons have been made with men from the general population. DESIGN:Left ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Nuver J,Smit AJ,Sleijfer DT,van Gessel AI,van Roon AM,van der Meer J,van den Berg MP,Hoekstra HJ,Sluiter WJ,Gietema JA

    更新日期:2005-02-01 00:00:00

  • Altered endothelial gene expression associated with hereditary haemorrhagic telangiectasia.

    abstract:BACKGROUND:Mutations in endoglin (ENG) and activin receptor-like kinase 1 (ALK-1 or ACVRL1) genes are the underlying basis of hereditary haemorrhagic telangiectasia (HHT) types 1 and 2, respectively. Both genes belong to the transforming growth factor-beta (TGF-beta) receptors superfamily and are expressed in endotheli...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Thomas B,Eyries M,Montagne K,Martin S,Agrapart M,Simerman-François R,Letarte M,Soubrier F

    更新日期:2007-07-01 00:00:00

  • Calcium affects biomarkers of colon carcinogenesis after right hemicolectomy.

    abstract:BACKGROUND:In Western societies colonic cancer most frequently develops in the distal colon, largely as a result of the composition of the diet. Modulation of dietary factors is therefore an attractive modality to reduce colorectal cancer risk. This study aims to evaluate the potentially protective effects of calcium i...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: van Gorkom BA,van der Meer R,Karrenbeld A,van der Sluis T,Zwart N,Termont DS,Boersma-van Ek W,de Vries EG,Kleibeuker JH

    更新日期:2002-09-01 00:00:00

  • Serum cardiovascular risk biomarkers in pre-pubertal obese children.

    abstract:BACKGROUND:Childhood obesity is associated with premature cardiovascular complications. However, little is known about the effect of a family-based behavioural intervention on the relationship between arterial function, blood pressure and biomarkers in pre-pubertal children with obesity. DESIGN:This was a single centr...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Maggio ABR,Farpour-Lambert NJ,Aggoun Y,Galan K,Montecucco F,Mach F,Beghetti M

    更新日期:2018-09-01 00:00:00

  • Lipoprotein Lp(a) as predictor of myocardial infarction in comparison to fibrinogen, LDL cholesterol and other risk factors: results from the prospective Göttingen Risk Incidence and Prevalence Study (GRIPS).

    abstract::Based on pathophysiological findings Lp(a) is considered to be a cardiovascular risk factor. The Göttingen Risk Incidence and Prevalence Study (GRIPS) provides the possibility to evaluate this impact of Lp(a) on the basis of a large prospective cohort study. GRIPS included 6002 men, aged 40-59.9 years at baseline. Dat...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Cremer P,Nagel D,Labrot B,Mann H,Muche R,Elster H,Seidel D

    更新日期:1994-07-01 00:00:00

  • Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state.

    abstract:BACKGROUND:In obese subjects, chronic low-grade inflammation contributes to an increased risk of metabolic abnormalities, which are reversed by weight loss. Sustained weight loss, however, is difficult to achieve and more insight into dietary approaches on anti-inflammatory responses in obese subjects is needed. In thi...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jellema A,Plat J,Mensink RP

    更新日期:2004-11-01 00:00:00

  • Effect of pronounced weight loss on visceral fat, liver steatosis and adiponectin isoforms.

    abstract:BACKGROUND:Weight loss induced by bariatric surgery is an effective method to reverse obesity and comorbidities. The aim of this prospective weight loss study was to investigate changes of body fat distribution in relation to adiponectin and its isoforms and further to investigate the influence of both body fat distrib...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Engl J,Sturm W,Sandhofer A,Kaser S,Tschoner A,Tatarczyk T,Weiss H,Tilg H,Patsch JR,Ebenbichler CF

    更新日期:2008-04-01 00:00:00

  • The role of melatonin in pathogenesis of aspirin-sensitive asthma.

    abstract:BACKGROUND:Platelets are involved in the pathogenesis of bronchial asthma, including aspirin-sensitive asthma (ASA). The pineal hormone melatonin (MT) has been described as inhibiting several physiological processes in platelets. The MT metabolite - N-acetyl-5-methoxy-kynurenamine - has a chemical structure similar to ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Evsyukova HV

    更新日期:1999-06-01 00:00:00

  • Inhaled nitric oxide does not influence bleeding time or platelet function in healthy volunteers.

    abstract:BACKGROUND:Bleeding time has been reported to increase during gaseous nitric oxide (NO) inhalation in healthy volunteers and patients, and it has been speculated that inhaled NO inhibits platelet function. However, results have not been unanimous, and we have been unable to document any effects of inhaled NO on circula...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章


    authors: Albert J,Norman M,Wallén NH,Frostell C,Hjemdahl P

    更新日期:1999-11-01 00:00:00

  • Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency.

    abstract::We have reported that the disorder of lipoprotein metabolism in hyperalphalipoproteinaemic patients with a deficiency of cholesteryl ester transfer protein (CETP) is characterized by the polydisperse low density lipoprotein (LDL) particles and the accumulation of cholesteryl ester (CE) in high density lipoprotein (HDL...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Sakai N,Yamashita S,Hirano K,Ishigami M,Arai T,Kobayashi K,Funahashi T,Matsuzawa Y

    更新日期:1995-05-01 00:00:00

  • Impact of T-inversion on the outcome of Takotsubo syndrome as compared to acute coronary syndrome.

    abstract:BACKGROUND:Previous studies revealed that patients with Takotsubo syndrome (TTS) have a higher mortality rate than the general population and a comparable mortality to acute coronary syndrome (ACS). Repolarisation abnormalities, namely T-wave amplitude, may provide incremental prognostic information, in addition to tra...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Gietzen T,El-Battrawy I,Lang S,Zhou XB,Ansari U,Behnes M,Borggrefe M,Akin I

    更新日期:2019-04-01 00:00:00

  • Pathways of renal injury in systemic gram-negative sepsis.

    abstract::Acute renal failure is a grave complication of systemic gram-negative sepsis. The pathophysiological mechanisms of sepsis leading to kidney injury result in part from systemic inflammatory and haemodynamic alterations. These are triggered by the interaction of endotoxin with Toll-like receptor 4 (TLR4) on cells of the...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: El-Achkar TM,Hosein M,Dagher PC

    更新日期:2008-10-01 00:00:00

  • Hepatic and extrahepatic triglyceride lipase activity in uraemic patients on chronic haemodialysis.

    abstract::In eleven patients with chronic renal insufficiency treated by intermittent haemodialysis and in ten normal subjects, hepatic and extrahepatic triglyceride lipase activity of post heparin plasma was selectively measured, utilizing the different sensitivity of both enzymes to inhibition by protamine sulphate. In uraemi...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Bolzano K,Krempler F,Sandhofer F

    更新日期:1978-10-01 00:00:00

  • Sympathetic activation in cardiovascular disease: evidence, clinical impact and therapeutic implications.

    abstract:BACKGROUND:The sympathetic nervous exerts a key role in cardiovascular homeostasis control by regulating cardiac output, systemic vascular resistance, heart rate and blood pressure. MATERIALS AND METHODS:Data collected during the past 30 years have unequivocally shown that in a considerable number of cardiovascular as...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: Grassi G,Seravalle G,Mancia G

    更新日期:2015-12-01 00:00:00

  • Ethanol-induced hypoglycaemia in man: its suppression by the alcohol dehydrogenase inhibitor 4-methylpyrazole.

    abstract::Infusion of ethanol (0.6 g/kg body wt) caused marked hypoglycaemia in subjects fasted for 36 h. Previous administration of the alcohol dehydrogenase (ADH) inhibitor 4-methylpyrazole (4-MP, 7 mg/kg body wt i.v.) strongly suppressed the ethanol-induced hypoglycaemia. The rate of ethanol elimination was 84.6 mg/kg per ho...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章


    authors: Salaspuro MP,Pikkarainen P,Lindros K

    更新日期:1977-12-01 00:00:00

  • Prevalence and risk factors of fatty liver in Portuguese adults.

    abstract:BACKGROUND:Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. MATERIALS AND...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Leitão J,Carvalhana S,Cochicho J,Silva AP,Velasco F,Medeiros I,Alves AC,Bourbon M,Oliveiros B,Rodrigues V,Sousa R,Sampaio F,Carvalho A,Cortez-Pinto H

    更新日期:2020-06-01 00:00:00

  • Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity.

    abstract::Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being elucidated. This study was carried out to investigate the relationship between serum leptin, plasma insulin, insulin sensitivity and free testosterone in 46 men ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Vettor R,De Pergola G,Pagano C,Englaro P,Laudadio E,Giorgino F,Blum WF,Giorgino R,Federspil G

    更新日期:1997-12-01 00:00:00

  • Altered intestinal tight junctions' expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability.

    abstract:BACKGROUND:Increased intestinal permeability in cirrhosis exerts a pivotal role in the pathogenesis of spontaneous bacterial peritonitis and other complications of cirrhosis through promotion of systemic endotoxemia. This study was designed to investigate whether the expression of tight junction (TJ) proteins, which re...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Assimakopoulos SF,Tsamandas AC,Tsiaoussis GI,Karatza E,Triantos C,Vagianos CE,Spiliopoulou I,Kaltezioti V,Charonis A,Nikolopoulou VN,Scopa CD,Thomopoulos KC

    更新日期:2012-04-01 00:00:00

  • Advanced glycation end-products and the kidney.

    abstract:BACKGROUND:Advanced glycation end-products (AGEs) are increased in situations with hyperglycemia and oxidative stress such as diabetes mellitus. They are products of nonenzymatic glycation and oxidation of proteins and lipids. The kidney plays an important role in clearance and metabolism of AGEs. METHODS:Medline and ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: Busch M,Franke S,Rüster C,Wolf G

    更新日期:2010-08-01 00:00:00

  • The effect of pegylated granulocyte colony-stimulating factor on collateral function and myocardial ischaemia in chronic coronary artery disease: A randomized controlled trial.

    abstract:OBJECTIVE:To test the effect of long-term pegfilgrastim on collateral function and myocardial ischaemia in patients with chronic stable coronary artery disease (CAD). METHODS:This was a prospective clinical trial with randomized 2:1 allocation to pegfilgrastim or placebo for 6 months. The primary study endpoint was co...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验


    authors: Traupe T,Stoller M,Gloekler S,Meier P,Seiler C

    更新日期:2019-01-01 00:00:00

  • The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia.

    abstract::Disseminated intravascular coagulation (DIC) is a frequently occurring complication of sepsis and may contribute to multiple organ failure. More insight into the pathogenesis of this derangement of the coagulation system is necessary to develop more effective therapeutic strategies for this condition. Recently, more d...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: Levi M,van der Poll T,ten Cate H,van Deventer SJ

    更新日期:1997-01-01 00:00:00

  • Preconception folic acid use influences the follicle fluid proteome.

    abstract:BACKGROUND:The investigation of the human follicle fluid proteome has gained much interest in the search of new markers as predictors for in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatment outcome. Follicular fluid folate, as substrate of one carbon (1-C) metabolism, affects follicular met...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Twigt JM,Bezstarosti K,Demmers J,Lindemans J,Laven JS,Steegers-Theunissen RP

    更新日期:2015-08-01 00:00:00

  • Diabetes mellitus, glucose tolerance and insulin response to glucose in patients with primary hyperparathyroidism before and after parathyroidectomy.

    abstract::In a retrospectively analyzed series of 441 patients operated for primary hyperparathyroidism (HPT), the prevalence of diabetes mellitus was 8.2%, which was three times higher than in the unselected age-matched population. Following parathyroid surgery, the need for antidiabetic treatment was unchanged. The insulin re...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Ljunghall S,Palmér M,Akerström G,Wide L

    更新日期:1983-10-01 00:00:00

  • Monocyte count at onset predicts poststroke outcomes during a 90-day follow-up.

    abstract:BACKGROUND:Acute ischaemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing poststroke recovery. In smokers with AIS, inflammation might be further upregulated, increasing ischaemia/reperfusion injury. Here, the predictive value of leucocyte and adhesion molecules levels on poststroke out...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Liberale L,Montecucco F,Bonaventura A,Casetta I,Seraceni S,Trentini A,Padroni M,Dallegri F,Fainardi E,Carbone F

    更新日期:2017-10-01 00:00:00

  • Recovery of T-cell subsets after antiretroviral therapy in HIV-infected children.

    abstract:BACKGROUND:Variation of percentageCD4+ T cells may accurately reflects the kinetics of a comprehensive immune recovery independently of the antiretroviral (ART) regimen. To test this we have investigated the relationship among peripheral blood T-cell subsets with the variation of percentageCD4+ T cells during follow up...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Resino S,Bellón JM,Gurbindo D,León JA,Muñoz-Fernández MA

    更新日期:2003-07-01 00:00:00