Abstract：
:The electrical parameters and the unidirectional fluxes of 45Ca and 3H-mannitol were measured in preparations of rat colon descendens freed from the muscularis externa and mounted in a modified Ussing-chamber. Two criteria were used to differentiate between changes in the trans- and the paracellular calcium transport after treatment with 1,25(OH)2D3: the fluxes of the simultaneously measured 3H-mannitol as a paracellular marker; the 45Ca fluxes in preparations with clamped potentials. After a short-time (6 h) pretreatment by s.c. administration of 1,25(OH)2D3 (250 ng kg-1) in normal rats the mucosa (m) to serosa (s) 45Ca flux under short circuit conditions increased about 65%, whereas the electrical parameters and the 3H-mannitol fluxes remained unchanged. In clamped epithelia the PD-independent m to s 45Ca flux was increased, whereas the PD-dependent flux remained unchanged. In contrast, after long-time (4 days) induction by 1,25(OH)2D3 the m to s 45Ca flux increased under short circuit conditions by about 100% and the m to s 3H-mannitol flux increased by 50%, PD and Isc decreased by more than 60%, whereas tissue resistance was the same, in clamped epithelia the calculated PD-independent, transcellular m to s 45Ca flux was 2.4 times and the PD-dependent, paracellular 45Ca-flux was 1.9 times higher than in controls, whereas the s to m 45Ca flux remained unchanged. On the basis of the relevant references the following conclusions were drawn: after short-time exposure to 1,25(OH)2D3 only the PD-dependent, transcellular m to s calcium transport is increased; this is probably due to a liponomic effect of 1,25(OH)2D3 at the brush border membrane.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Karbach U,Rummel Wdoi
10.1111/j.1365-2362.1986.tb01007.xsubject
Has Abstractpub_date
1986-10-01 00:00:00pages
347-51issue
5eissn
0014-2972issn
1365-2362journal_volume
16pub_type
杂志文章abstract：:1. The oral absorption of magnesium, its myocardial uptake and exchangeable magnesium have been studied in patients with coronary heart disease and controls using the radioactive isotope magnesium-28. 2. No significant difference in oral absorption or myocardial uptake was found between patients and controls. 3. The e...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1978.tb00817.x
更新日期：1978-04-01 00:00:00
abstract：:ATPase activities were determined in haemolysed and dialysed erythrocytes and in haemoglobin-free membranes of twenty patients with essential hypertension and twenty normotensive controls. Ouabain-sensitive ATPase (Na-K-ATPase) activity of haemolysate but not that of membranes was decreased in hypertensives whereas ou...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1985.tb00170.x
更新日期：1985-08-01 00:00:00
abstract：:Eur J Clin Invest 2012; 42 (6): 579-588 ABSTRACT: Glucose-based methods are currently gold standards for identifying individuals at risk of type 2 diabetes. Obviously, these methods only consider one of many pathologies of impaired glucose metabolism and they all suffer from a poor specificity as type 2 diabetes risk ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2362.2012.02678.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. MATERIALS AND METHODS:Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. RESULTS:TP metabolism is...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2362.2010.02346.x
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation i...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,多中心研究
doi：10.1111/eci.12779
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Several studies have reported a significant gender difference in low-density lipoprotein (LDL) size, with men being characterized by smaller, denser LDL particles than women, and it has been suggested that the contribution of the greater accumulation of visceral adipose tissue in men compared with women may ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.2002.01092.x
更新日期：2002-12-01 00:00:00
abstract：:The concentration in serum of cathodal trypsinogen has been studied in certain clinical and experimental situations. The concentration correlated with pancreatic amylase activity. Low levels were found in patients with malabsorption due to exocrine pancreatic insufficiency. The concentration rose after endoscopic retr...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1978.tb00868.x
更新日期：1978-12-01 00:00:00
abstract：:Disseminated intravascular coagulation (DIC) is a frequently occurring complication of sepsis and may contribute to multiple organ failure. More insight into the pathogenesis of this derangement of the coagulation system is necessary to develop more effective therapeutic strategies for this condition. Recently, more d...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2362.1997.570614.x
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumours with a strong genetic background. DESIGN:We searched the PubMed database through February 2015 to identify studies characterizing metastatic PCs/PGLs as well as currently established and evolving therapies. RESULTS...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/eci.12495
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:We aimed to analyse the pre-analytical process and its effect of 50 g of oral glucose challenge test results for screening gestational diabetes mellitus. RESEARCH DESIGN AND METHODS:The 50 g oral glucose challenge test was performed to 30 pregnant women, and the blood was collected as two samples for three t...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.13481
更新日期：2020-12-22 00:00:00
abstract：:The stimulant action of branched-chain amino acids upon insulin release was examined in rat pancreatic islets incubated at physiological concentrations of D-glucose and L-glutamine. In the presence of the latter nutrients, L-leucine and L-isoleucine used together at a physiological concentration (0.25 mmol/l each) dou...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1981.tb02013.x
更新日期：1981-12-01 00:00:00
abstract：BACKGROUND:Na+,K(+)-ATPase activity was evaluated in relation to membrane composition and molecular organization in erythrocyte membranes from obese patients by the amphyphylic molecule 6-dodecanoyl-2-dimethylamino-naphthalene (Laurdan). Its possible relationship with fat distribution and hyperinsulinaemia was also inv...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1999.00458.x
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Following cisplatin-based chemotherapy, survivors of testicular cancer have a high prevalence of cardiovascular risk factors and an increased risk of cardiovascular disease. Cardiac function has not been extensively studied and no comparisons have been made with men from the general population. DESIGN:Left ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2005.01460.x
更新日期：2005-02-01 00:00:00
abstract：:The developmental aspects of characteristic intestinal lipoprotein synthesis, chlomicrons (CM), very low density lipoproteins (VLDL) and high density lipoproteins (HDL), are unknown. Our objective was to determine the ontogeny of intestinal lipid and lipoprotein synthesis in both the jejunum and the ileum. Explants of...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1992.tb01945.x
更新日期：1992-02-01 00:00:00
abstract：:To understand better impairment of glucose utilization in diabetics during a hyperosmolal state, in vitro models were established to evaluate the effects of hyperosmolality on basal glucose uptake as well as glucagon dependent glucose release by isolated hepatocytes. In these studies simulating a hyperglycaemic (40 mm...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1989.tb00206.x
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:Buerger's disease (BD) is a segmental occlusive vascular disease. The aim of this study was to detect functional changes in brachial artery and asymptomatic morphological changes in extra-cranial carotid arteries not affected by the disease process and to assess markers of inflammation and endothelial damage...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2006.01646.x
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Chronic lung diseases contribute significantly to the morbidity and mortality of the population. There are few effective treatments for many chronic lung diseases, and even fewer therapies that can arrest or reverse the progress of the disease. DESIGN:In this review, we present the current state of regenera...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2362.2012.02667.x
更新日期：2012-08-01 00:00:00
abstract：:beta-Adrenoceptor binding on peripheral blood mononuclear cells (PBMC) of healthy adult volunteers was investigated using the radioligand 125iodo-cyanopindolol (ICYP). Saturation binding studies were performed with nine different concentrations of ICYP. Receptor density and affinity were calculated by Scatchard plots....
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1988.tb02416.x
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND:Cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) of marine origin are well recognized. Because of the shortness of marine resources vegetable oils are increasingly used in fish farming. The effects on human health of fish fed on vegetable oils are largely unknown. METHODS:In a dou...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2362.2005.01443.x
更新日期：2005-01-01 00:00:00
abstract：:The study aimed to assess vascular reactivity to noradrenaline with and without neuropeptide Y in diabetic rats, and to determine whether any abnormality could be attributed to insulin deficiency or to hyperglycaemia per se. The authors compared non-diabetic rats (n = 9) and rats with streptozotocin-induced diabetes t...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1995.tb01976.x
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Vitamin E supplementation is associated with a reduced risk of developing atherosclerotic events; probably because it inhibits low-density lipoprotein (LDL) oxidation, an initial step in atherosclerosis. Metal ion-dependent LDL oxidation is a commonly used method to estimate oxidizability of LDL, but the eff...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2362.1999.00579.x
更新日期：1999-12-01 00:00:00
abstract：INTRODUCTION:Complement-mediated tubular injury may play an important role in the progression of renal diseases. C3d is a presumed marker of complement activation. Its precursor C3dg has been detected in the urine of patients with membranous nephropathy. However, little is known of the renal handling of C3d or its excr...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.2003.01153.x
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Mitochondria are dynamic organelles that participate in energy conversion, metabolism, signaling and apoptosis. To fulfill their multiple tasks, mitochondria come in varied morphologies and ultrastructures resulting from the equilibrium between fusion and fission, Furthermore, they are in close contact with ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/eci.12135
更新日期：2013-08-01 00:00:00
abstract：:The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1985.tb00291.x
更新日期：1985-12-01 00:00:00
abstract：BACKGROUND:Polymorphonuclear leucocytes (PMNLs) play a key role in the nonspecific immune defence. Cinacalcet reduces serum calcium levels in kidney transplant recipients with mineral bone disorder associated with chronic kidney disease. We investigated essential functions of PMNLs of kidney transplant recipients with ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.12075
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Increased production of chemokines by adipose tissue and defective adipose tissue oxygenation as a result of obesity may induce leucocyte infiltration and subsequent systemic inflammation. OBJECTIVES:1-To determine the relation between the amount of visceral and subcutaneous adipose tissue and the chemokine...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.12054
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Bone marrow (BM) histology/immunohistochemistry, KIT D816V mutation analysis and serum tryptase measurements are mandatory tools for diagnosis of systemic mastocytosis (SM). MATERIALS AND METHODS:Within the 'German Registry of Disorders on Eosinophils and Mast Cells', we identified 65 patients with SM who h...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.12607
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:It has been speculated that oral hypoglycaemic agents that block K-ATP channels could potentially increase blood pressure by blocking such channels in vascular myocytes. No information about this issue exists regarding nateglinide. DESIGN:A multicentre, double-blind, placebo-controlled, randomized trial was...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2362.2007.01918.x
更新日期：2008-03-01 00:00:00
abstract：:To examine the possible effects of hyperoxalaemia on anaerobic metabolism and erythrocyte pyruvate kinase activity, we induced a rise in plasma oxalate in 11 dialysis patients by the oral administration of ascorbic acid, 500 mg day-1 for 3 weeks. Blood samples were taken from the same antecubital vein before and after...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1990.tb01878.x
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:After the Q fever outbreak in the Netherlands between 2007 and 2010, more than 300 patients with chronic Q fever have been identified. Some patients were also diagnosed with systemic sclerosis, a rare immune-mediated disease. We aimed to increase awareness of concomitant chronic Q fever infection and systemi...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.13123
更新日期：2019-07-01 00:00:00
