Liver enzymes are not directly involved in atrial fibrillation: a prospective cohort study.

Abstract:

BACKGROUND:Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation in men initially free of this heart condition. MATERIALS AND METHODS:We prospectively investigated change (delta) in liver enzymes and new-onset atrial fibrillation in a representative sample of 1428 men aged 60-79 years. RESULTS:Mean follow-up was 12·3 years, after which 108 new atrial fibrillation cases were identified. The liver enzymes did not differ at baseline or follow-up, except for gamma-glutamyl transferase which was higher at follow-up in men who developed atrial fibrillation compared to those who did not (P < 0·0001). Change in GGT was greater in men who developed AF than those who did not (+6·12 vs. -2·60 U/L, P = 0·036). N-terminal pro-brain natriuretic peptide (baseline and follow-up, P < 0·0001) and total bilirubin (follow-up only, P < 0·0001) were also higher in men who developed atrial fibrillation while serum haemoglobin was similar at baseline and follow-up (P ≥ 0·74). Atrial fibrillation was associated with change in gamma-glutamyl transferase (OR, 1·18; 95% CI, 1·01-1·37) after multiple adjustments and exclusions. However, after adjusting for baseline (P = 0·088) or change (P = 0·40) in N-terminal pro-brain natriuretic peptide, the association between atrial fibrillation and change in gamma-glutamyl transferase was lost. CONCLUSION:The direct relationship between atrial fibrillation and liver enzymes is absent and depends, at least in part, on the progression of heart failure as captured by N-terminal pro-brain natriuretic peptide.

journal_name

Eur J Clin Invest

authors

Schutte R,Whincup PH,Papacosta O,Lennon LT,Macfarlane PW,Wannamethee G

doi

10.1111/eci.12779

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

583-590

issue

8

eissn

0014-2972

issn

1365-2362

journal_volume

47

pub_type

杂志文章,多中心研究
  • Tetrahydroxylated bile acids in healthy human newborns.

    abstract::Urine was collected in four healthy infants, born after 35-39 weeks of gestation. The collections were made for 24 h starting immediately after birth. Bile acids were extracted, separated into conjugate groups, solvolysed, hydrolysed and quantified by gas-liquid chromatography as methyl ester trimethylsilyl ether deri...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1982.tb02236.x

    authors: Strandvik B,Wikström SA

    更新日期:1982-08-01 00:00:00

  • Glucagon-independent renal hyperaemia and hyperfiltration after an oral protein load in Child A liver cirrhosis.

    abstract::The work was designed to study the effects of a meat meal on glomerular filtration rate (GFR), renal plasma flow (RPF), and plasma concentrations of glucagon, insulin, growth hormone, renin, aldosterone, total amino acids, and NH3 in healthy humans (H) as well as in patients with Child A liver cirrhosis (LC). The meat...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1992.tb01932.x

    authors: De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R

    更新日期:1992-01-01 00:00:00

  • Bacteria and spontaneous experimental colitis: immunological changes.

    abstract:BACKGROUND:Intestinal commensal flora seems to be a requisite for both human and experimental intestinal inflammation. Our aim was to assess the immunological changes in the colon of IL-10(-/-) mice depending on the environmental conditions. MATERIALS AND METHODS:Twelve wild-type (WT) and 24 IL-10(-/-) 4-week-old mice...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2011.02499.x

    authors: Pedrosa E,Lorén V,Cabré E,Doménech E,Ojanguren I,Gassull MA,Mañé J

    更新日期:2011-10-01 00:00:00

  • Lipid and carbohydrate metabolism in uraemia.

    abstract::Lipid and carbohydrate metabolism variables were studied in twenty-eight patients with chronic renal failure (mean GFR 7.7 +/- 2.5 ml/min) and uraemic symptoms. 71% of the patients had hypertriglyceridaemia (greater than or equal to 2.2 mmol/l). Total serum cholesterol was normal while VLDL cholesterol was high and al...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1979.tb00886.x

    authors: Attman PO,Gustafson A

    更新日期:1979-08-01 00:00:00

  • Characteristics of thyroid carcinomas in aging patients.

    abstract:BACKGROUND:To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients. MATERIALS AND METHODS:In this study a retrospective analysis was performed wi...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2000.00598.x

    authors: Lin JD,Chao TC,Chen ST,Weng HF,Lin KD

    更新日期:2000-02-01 00:00:00

  • Strength and endurance training lead to different post exercise glucose profiles in diabetic participants using a continuous subcutaneous glucose monitoring system.

    abstract:BACKGROUND:Although both strength training (ST) and endurance training (ET) seem to be beneficial in type 2 diabetes mellitus (T2D), little is known about post-exercise glucose profiles. The objective of the study was to report changes in blood glucose (BG) values after a 4-month ET and ST programme now that a device f...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.2005.01573.x

    authors: Cauza E,Hanusch-Enserer U,Strasser B,Kostner K,Dunky A,Haber P

    更新日期:2005-12-01 00:00:00

  • Body composition and serum lipids in female runners: influence of exercise level and menstrual bleeding pattern.

    abstract::The impact of running and menstrual disturbances on regional and total body fat distribution and serum lipids was investigated in 205 women. Body composition was measured by dual-energy X-ray absorptiometry. The total fat mass in the elite runners was approximately half of the normally active's (7.3 [0.48] kg vs. 14.3...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1995.tb01745.x

    authors: Hetland ML,Haarbo J,Christiansen C

    更新日期:1995-08-01 00:00:00

  • Anabolic effects of rhIGF-I/IGFBP-3 in vivo are influenced by thyroid status.

    abstract:BACKGROUND:There are close interrelationships between hormones that regulate bone formation and protein biosynthesis. For example, growth hormone and thyroid hormones can influence plasma levels of insulin-like growth factor-I (IGF-I). A patient's status regarding hormones other than IGF-I may thus indirectly modify th...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2362.2001.00793.x

    authors: Svanberg E,Healey J,Mascarenhas D

    更新日期:2001-04-01 00:00:00

  • Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency.

    abstract::We have reported that the disorder of lipoprotein metabolism in hyperalphalipoproteinaemic patients with a deficiency of cholesteryl ester transfer protein (CETP) is characterized by the polydisperse low density lipoprotein (LDL) particles and the accumulation of cholesteryl ester (CE) in high density lipoprotein (HDL...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1995.tb01710.x

    authors: Sakai N,Yamashita S,Hirano K,Ishigami M,Arai T,Kobayashi K,Funahashi T,Matsuzawa Y

    更新日期:1995-05-01 00:00:00

  • Urinary proteomics in obstructive sleep apnoea and obesity.

    abstract:BACKGROUND:Obstructive sleep apnoea (OSA) is a common complication of obesity and can have a substantial negative impact on a patient's quality of life and risk of cardiovascular disease. The aim of this case-control study was to undertake discovery profiling of urinary peptides using capillary electrophoresis-mass spe...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12346

    authors: Seetho IW,Siwy J,Albalat A,Mullen W,Mischak H,Parker RJ,Craig S,Duffy N,Hardy KJ,Burniston JG,Wilding JP

    更新日期:2014-11-01 00:00:00

  • Pregnancy-associated plasma protein A and mortality in haemodialysis.

    abstract:BACKGROUND:Elevated pregnancy-associated plasma protein A (PAPP-A) levels are associated with increased risk of death in ischaemic heart disease as well as in haemodialysis patients. Previous research indicates that the prognostic value of PAPP-A may be stronger in patients with concomitant diabetes mellitus or signs o...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/eci.12959

    authors: Nilsson E,Rudholm T,Stenvinkel P,Ärnlöv J

    更新日期:2018-08-01 00:00:00

  • Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease.

    abstract:BACKGROUND:The pleiotropic cytokine osteopontin (OPN) is thought to be involved in the pathogenesis of atherosclerosis. However, the relationship between OPN and renal function, a cardiovascular risk factor itself, is not known. Therefore, we assessed the relationship between OPN plasma levels and renal function in pat...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02271.x

    authors: Lorenzen J,Krämer R,Kliem V,Bode-Boeger SM,Veldink H,Haller H,Fliser D,Kielstein JT

    更新日期:2010-04-01 00:00:00

  • Decrease in circulating plasmacytoid dendritic cells during short-term systemic normobaric hypoxia.

    abstract:BACKGROUND:During exposure to high altitude, the immune system is altered. During hypoxia, an increase in interleukin (IL)-6 and high sensitivity C-reactive protein (hs-CRP), and an increase in natural killer cells and decrease in T cells in blood was shown. However, the impact of hypoxia on dendritic cells has not bee...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12416

    authors: Yilmaz A,Ratka J,Rohm I,Pistulli R,Goebel B,Asadi Y,Petri A,Kiehntopf M,Figulla HR,Jung C

    更新日期:2016-02-01 00:00:00

  • The effect of pegylated granulocyte colony-stimulating factor on collateral function and myocardial ischaemia in chronic coronary artery disease: A randomized controlled trial.

    abstract:OBJECTIVE:To test the effect of long-term pegfilgrastim on collateral function and myocardial ischaemia in patients with chronic stable coronary artery disease (CAD). METHODS:This was a prospective clinical trial with randomized 2:1 allocation to pegfilgrastim or placebo for 6 months. The primary study endpoint was co...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/eci.13035

    authors: Traupe T,Stoller M,Gloekler S,Meier P,Seiler C

    更新日期:2019-01-01 00:00:00

  • Interactions among gender, age, hypertension and C-reactive protein in coronary vasospasm.

    abstract:BACKGROUND:Coronary vasospasm (CVsp) has been reported to be an inflammatory disease, reflected by elevated high-sensitivity C-reactive protein (hs-CRP). We investigated the interactions among gender, age, hypertension and hs-CRP in patients with CVsp. MATERIALS AND METHODS:We retrospectively examined 722 Taiwanese pa...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02360.x

    authors: Hung MY,Hsu KH,Hung MJ,Cheng CW,Cherng WJ

    更新日期:2010-12-01 00:00:00

  • Trans- and paracellular calcium transport across the colonic mucosa after short- and long-term treatment with 1,25-dihydroxyvitamin D3.

    abstract::The electrical parameters and the unidirectional fluxes of 45Ca and 3H-mannitol were measured in preparations of rat colon descendens freed from the muscularis externa and mounted in a modified Ussing-chamber. Two criteria were used to differentiate between changes in the trans- and the paracellular calcium transport ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1986.tb01007.x

    authors: Karbach U,Rummel W

    更新日期:1986-10-01 00:00:00

  • Strategies used by individuals to prevent burnout.

    abstract:BACKGROUND:Burnout represents a syndrome that is related to demanding job characteristics combined with the absence of resources or motivational job characteristics. The aim of this position study was to present strategies that individuals use to minimize burnout and its unfavourable effects. MATERIALS AND METHODS:The...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/eci.12494

    authors: Demerouti E

    更新日期:2015-10-01 00:00:00

  • Determinants of fasting plasma triglyceride levels: metabolism of hepatic and intestinal lipoproteins.

    abstract::The contribution of the kinetics of exogeneous and endogenous lipoproteins in determining the level of triglyceride in fasting plasma was assessed in a group of 19 normolipidaemic and hypertriglyceridaemic subjects. From data derived during a 9-h infusion of [15N]-glycine, we have assessed very low density lipoprotein...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1992.tb01821.x

    authors: Cortner JA,Le NA,Coates PM,Bennett MJ,Cryer DR

    更新日期:1992-03-01 00:00:00

  • Acute insulin administration does not affect plasma leptin levels in lean or obese subjects.

    abstract::Whether leptin levels are related to insulin sensitivity or subject to acute regulation by insulin is not known. In 12 obese [body mass index (BMI) = 34.0 +/- 1.5 kg m-2] and 12 lean (BMI = 22.2 +/- 0.6 kg m-2) non-diabetic subjects, plasma leptin concentrations were measured in the fasting state and during 2 hours of...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1996.tb02142.x

    authors: Muscelli E,Camastra S,Masoni A,Baldi S,Sironi AM,Natali A,Ferrannini E

    更新日期:1996-10-01 00:00:00

  • Hyperlipoprotein(a)aemia in nephrotic syndrome.

    abstract::The nephrotic syndrome is frequently associated with hyperlipidaemia and hyperfibrinogenaemia, leading to an increased coronary and thrombotic risk, which may be enhanced by high lipoprotein (a) [Lp(a)] concentrations. We followed the quantitative and qualitative pattern of plasma lipoproteins over 18 months in a pati...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1996.132283.x

    authors: Thiery J,Ivandic B,Bahlmann G,Walli AK,Seidel D

    更新日期:1996-04-01 00:00:00

  • Altered intestinal tight junctions' expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability.

    abstract:BACKGROUND:Increased intestinal permeability in cirrhosis exerts a pivotal role in the pathogenesis of spontaneous bacterial peritonitis and other complications of cirrhosis through promotion of systemic endotoxemia. This study was designed to investigate whether the expression of tight junction (TJ) proteins, which re...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2011.02609.x

    authors: Assimakopoulos SF,Tsamandas AC,Tsiaoussis GI,Karatza E,Triantos C,Vagianos CE,Spiliopoulou I,Kaltezioti V,Charonis A,Nikolopoulou VN,Scopa CD,Thomopoulos KC

    更新日期:2012-04-01 00:00:00

  • Patterns of co-occurrence of three single nucleotide polymorphisms of the 5,10-methylenetetrahydrofolate reductase gene in kidney transplant recipients.

    abstract:BACKGROUND:Recently, a new mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) encoding gene was first described (1793G > A). Only few reports have studied the prevalence of this polymorphism, especially in combination with other MTHFR mutations (677C > T, 1298A > C). METHODS:We cross-sectionally identifi...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2004.01394.x

    authors: Winkelmayer WC,Sunder-Plassmann G,Huber A,Födinger M

    更新日期:2004-09-01 00:00:00

  • Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.

    abstract::Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2004.01304.x

    authors: Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

    更新日期:2004-02-01 00:00:00

  • A novel protein glycan biomarker and LCAT activity in metabolic syndrome.

    abstract:BACKGROUND:The cholesterol-esterifying enzyme, lecithin:cholesterol acyltransferase (LCAT), is instrumental in high-density lipoprotein (HDL) remodelling. LCAT may also modify oxidative and inflammatory processes, as supported by an inverse relationship with HDL antioxidative functionality and a positive relationship w...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12481

    authors: Gruppen EG,Connelly MA,Otvos JD,Bakker SJ,Dullaart RP

    更新日期:2015-08-01 00:00:00

  • Sex differences in initial clearance of palmitate by human hepatocytes.

    abstract::To determine if the sex differences in clearance of long chain fatty acids by the liver observed in the rat are relevant to humans, the authors isolated hepatocytes from human adult males and females (five per group) and measured the initial (unidirectional) clearance of [3H]-palmitate from buffer containing albumin. ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1996.101246.x

    authors: Pond SM,Gordon RA,Bass L

    更新日期:1996-01-01 00:00:00

  • The influence of sorafenib on hepatic encephalopathy and the mechanistic survey in cirrhotic rats.

    abstract:BACKGROUND:Sorafenib, a multikinase inhibitor that inhibits angiogenesis and carcinogenesis, has been used for patients with advanced hepatocellular carcinoma. However, sporadic cases have been reported with the development of hepatic encephalopathy (HE) after sorafenib treatment, mostly in those with cirrhosis. Liver ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12006

    authors: Hsu SJ,Hsin IF,Lin YL,Chen YC,Huang HC,Lee FY,Lin HC,Chang CC,Lee SD

    更新日期:2012-12-01 00:00:00

  • Changes in potassium content of erythrocytes during exercise in man.

    abstract::Factors affecting erythrocyte K+ content and plasma electrolytes during light exercise were examined in 8 normal subjects and 27 patients with chronic obstructive lung disease. The patients were classified into bronchitis, emphysema and intermediate groups. Arterial blood was obtained during rest, after 2, 5, and 7 mi...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1975.tb00469.x

    authors: Kawakami Y,Kishi F,Uchiyama K,Irie T,Murao M

    更新日期:1975-09-12 00:00:00

  • Ascorbate-induced hyperoxalaemia has no significant effect on lactate generation or erythrocyte 2,3,diphosphoglycerate in dialysis patients.

    abstract::To examine the possible effects of hyperoxalaemia on anaerobic metabolism and erythrocyte pyruvate kinase activity, we induced a rise in plasma oxalate in 11 dialysis patients by the oral administration of ascorbic acid, 500 mg day-1 for 3 weeks. Blood samples were taken from the same antecubital vein before and after...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1990.tb01878.x

    authors: Tomson CR,Channon SM,Ward MK,Laker MF

    更新日期:1990-08-01 00:00:00

  • Very long chain n-3 and n-6 polyunsaturated fatty acids inhibit proliferation of human T-lymphocytes in vitro.

    abstract::The effect of marine n-3 polyunsaturated fatty acids on proliferation of human T-cells in vitro was compared to other polyunsaturated, monounsaturated and saturated fatty acids. Monoenes and saturated fatty acids had little effect on T-cell proliferation. Eicosapentaenoic acid and docosahexaenoic acid exerted a strong...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1993.tb00750.x

    authors: Søyland E,Nenseter MS,Braathen L,Drevon CA

    更新日期:1993-02-01 00:00:00

  • Zotarolimus-eluting vs. sirolimus-eluting coronary stents in patients with and without acute coronary syndromes: a SORT OUT III substudy.

    abstract:OBJECTIVES:To compare clinical outcomes among patients with acute coronary syndrome treated with zotarolimus-eluting and sirolimus-eluting stents in the SORT OUT III trial. BACKGROUND:Currently, only limited data allow direct comparison of clinical outcomes among patients with acute coronary syndrome treated with a se...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1365-2362.2012.02692.x

    authors: Thim T,Maeng M,Kaltoft A,Jensen LO,Tilsted HH,Hansen PR,Kelbaek H,Thayssen P,Ravkilde J,Madsen M,Sørensen HT,Thuesen L,Lassen JF

    更新日期:2012-10-01 00:00:00