Hyperlipoprotein(a)aemia in nephrotic syndrome.

abstract：BACKGROUND:Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. MATERIALS AND METHODS:Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. RESULTS:TP metabolism is...

journal_title：European journal of clinical investigation

authors： Dewit O,Starkel P,Roblin X

更新日期：2010-11-01 00:00:00

abstract：:The saphenous vein is the most commonly used graft for revascularization procedures in patients with coronary artery disease and critical limb ischaemia. However, the patency rate of this vessel is poor, with a high proportion of patients requiring further surgery. Early graft occlusion is caused by vasoconstriction o...

journal_title：European journal of clinical investigation

authors： Dashwood MR

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Mutations in endoglin (ENG) and activin receptor-like kinase 1 (ALK-1 or ACVRL1) genes are the underlying basis of hereditary haemorrhagic telangiectasia (HHT) types 1 and 2, respectively. Both genes belong to the transforming growth factor-beta (TGF-beta) receptors superfamily and are expressed in endotheli...

journal_title：European journal of clinical investigation

authors： Thomas B,Eyries M,Montagne K,Martin S,Agrapart M,Simerman-François R,Letarte M,Soubrier F

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Inflammation is an established contributor in atherosclerosis and several other common diseases including diabetes. Therefore the study was to investigate how inflammatory factors affect lipid metabolism during recovery from hyperinsulinaemia in healthy individuals. MATERIALS AND METHODS:A total of 22 healt...

journal_title：European journal of clinical investigation

authors： Heliövaara MK,Teppo AM,Karonen SL,Ebeling P

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Angiotensin converting enzyme 2 (ACE2), a monocarboxylase that degrades angiotensin II to angiotensin 1-7, is also the functional receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and is highly expressed in the lungs and heart. Patients with SARS also suffered from cardiac disease ...

journal_title：European journal of clinical investigation

authors： Oudit GY,Kassiri Z,Jiang C,Liu PP,Poutanen SM,Penninger JM,Butany J

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To evaluate comprehensively the effects of 12 prophylaxis interventions for secondary prophylaxis of variceal bleeding using multiple-treatments meta-analysis. METHODS:PubMed, EMBASE and the Cochrane Library were searched prior to November 2011. Randomized controlled trials (RCTs) comparing the interventions...

journal_title：European journal of clinical investigation

authors： Shi KQ,Liu WY,Pan ZZ,Ling XF,Chen SL,Chen YP,Fan YC,Zheng MH

更新日期：2013-08-01 00:00:00

abstract：:Tumours in the adrenals originate from the adrenal cortex, the adrenal medulla or as metastases from extra-adrenal primaries. Differentiating between these three groups is the first task a pathologist has to tackle when dealing with specimens from the adrenal region. Whereas this is possible in every case with total r...

journal_title：European journal of clinical investigation

authors： Saeger W

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss of higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques (SPs) of aggregated amyloid-beta peptide (Abeta) and intracellular neurofibrillary tangles ...

journal_title：European journal of clinical investigation

authors： Yokota T,Mishra M,Akatsu H,Tani Y,Miyauchi T,Yamamoto T,Kosaka K,Nagai Y,Sawada T,Heese K

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Mitochondria are dynamic organelles that participate in energy conversion, metabolism, signaling and apoptosis. To fulfill their multiple tasks, mitochondria come in varied morphologies and ultrastructures resulting from the equilibrium between fusion and fission, Furthermore, they are in close contact with ...

journal_title：European journal of clinical investigation

authors： Scorrano L

更新日期：2013-08-01 00:00:00

abstract：:There is considerable information to indicate that when there is vessel injury, platelets can play a major role in the development of atherosclerosis and its thromboembolic complications in the non-diabetic population. Diabetes is a disease associated with an increased risk of vascular complications, but the nature of...

journal_title：European journal of clinical investigation

authors： Winocour PD

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Previous studies revealed that patients with Takotsubo syndrome (TTS) have a higher mortality rate than the general population and a comparable mortality to acute coronary syndrome (ACS). Repolarisation abnormalities, namely T-wave amplitude, may provide incremental prognostic information, in addition to tra...

journal_title：European journal of clinical investigation

authors： Gietzen T,El-Battrawy I,Lang S,Zhou XB,Ansari U,Behnes M,Borggrefe M,Akin I

更新日期：2019-04-01 00:00:00

abstract：:Reduced glutathione (GSH) and activity of GSH related enzymes play a key role in defence against oxygen free radicals, whose production is, as known, raised in patients affected by diabetes mellitus, and at the same time they may contribute to the process of platelet aggregation. The purpose of this study was to evalu...

journal_title：European journal of clinical investigation

authors： Di Simplicio P,de Giorgio LA,Cardaioli E,Lecis R,Miceli M,Rossi R,Anichini R,Mian M,Seghieri G,Franconi F

更新日期：1995-09-01 00:00:00

abstract：:The siblings presented here are the third family found in Japan with familial LCAT deficiency. Their post-heparin plasma lipoprotein lipase and hepatic triglyceride lipase activities were measured selectively by an immunochemical method. Plasma triglyceride levels were elevated, and post-heparin plasma lipoprotein lip...

journal_title：European journal of clinical investigation

authors： Murayama N,Asano Y,Kato K,Sakamoto Y,Hosoda S,Yamada N,Kodama T,Murase T,Akanuma Y

更新日期：1984-04-01 00:00:00

abstract：:Urodilatin (ANF(95-126)) is an analogue of the atrial natriuretic factor (ANF(99-126)), which has been isolated from human urine. Recently we have shown in healthy volunteers, that intravenous bolus injections of synthetic urodilatin produce more pronounced reductions of pulmonary arterial pressure than ANF(99-126). T...

journal_title：European journal of clinical investigation

authors： Kentsch M,Ludwig D,Drummer C,Gerzer R,Müller-Esch G

更新日期：1992-10-01 00:00:00

abstract：:Microdialysis was used to selectively assess the effect of the paracrine renin-angiotensin system (RAS) on interstitial glucose and lactate concentration profiles in skeletal muscle of healthy volunteers (n = 8) during basal and insulin-stimulated conditions. Paracrine RAS was selectively inhibited by local retrodialy...

journal_title：European journal of clinical investigation

authors： Müller M,Fasching P,Schmid R,Burgdorff T,Waldhäusl W,Eichler HG

更新日期：1997-10-01 00:00:00

abstract：:Efficient fragmentation is the most important prerequisite for successful treatment of gallstones by extracorporeally induced shock waves. No data are available on the amount of energy necessary for stone disintegration and on the threshold energy below which no further fragmentation occurs. We therefore performed an ...

journal_title：European journal of clinical investigation

authors： Neubrand M,Greinwald I,Lobentanzer H,Paumgartner G,Hermeking H,Sauerbruch T

更新日期：1997-03-01 00:00:00

abstract：:Nitrogen load can be reduced by substituting dietary protein intake with keto or hydroxy analogues of amino acids. To investigate their intestinal absorption, human jejunal brush border membrane vesicles were used to measure uptake of L-leucine hydroxy analogue (L-LHA) and L-lactate. Uptake assays were performed under...

journal_title：European journal of clinical investigation

authors： Friedrich M,Murer H,Sterchi E,Berger EG

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Several studies have suggested that chronic obstructive pulmonary disease (COPD) could be predictive of the prognosis in patients with heart failure (HF), but yield conflicting findings. Therefore, we conducted a meta-analysis to examine the impact of COPD on adverse outcomes in patients with HF. METHODS:We...

journal_title：European journal of clinical investigation

authors： Xu S,Ye Z,Ma J,Yuan T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Stiff Person Syndrome (SPS) is a relatively rare but often overlooked autoimmune neurological disorder that targets antigens within the brain's inhibitory pathways resulting in incapacitating stiffness and spasms that impact on the patients' quality of life. Although a number of immunomodulating therapies si...

journal_title：European journal of clinical investigation

authors： Alexopoulos H,Dalakas MC

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Genetic factors may be important in modifying heart size due to long-term athletic training. The significance of polymorphisms of genes of the renin-angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known. METHODS:The angiotensin I-converting enz...

journal_title：European journal of clinical investigation

authors： Diet F,Graf C,Mahnke N,Wassmer G,Predel HG,Palma-Hohmann I,Rost R,Böhm M

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Adiponectin is an insulin-sensitizing, antiatherogenic and anti-inflammatory adipocytokine that circulates in three isoforms: a trimer [low-molecular weight (LMW)], a hexamer (trimer-dimer) of medium molecular weight (MMW) and a multimeric high molecular weight (HMW) isoform. Evidence is accumulating that HM...

journal_title：European journal of clinical investigation

authors： Kaser S,Tatarczyk T,Stadlmayr A,Ciardi C,Ress C,Tschoner A,Sandhofer A,Paulweber B,Ebenbichler CF,Patsch JR

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) need regular monitoring, usually by blood urea and creatinine measurements, needing venepuncture, frequent attendances and a healthcare professional, with significant inconvenience. Noninvasive monitoring will potentially simplify and improve monitoring. We tested t...

journal_title：European journal of clinical investigation

authors： Ebah LM,Read I,Sayce A,Morgan J,Chaloner C,Brenchley P,Mitra S

更新日期：2012-08-01 00:00:00

abstract：:Increased plasma levels of soluble adhesion molecules are associated with an increased risk of atherothrombosis. The pathophysiological mechanisms responsible for these associations are not known. The aim of the present study was to investigate the association of soluble intercellular adhesion molecule-1 (sICAM-1) con...

journal_title：European journal of clinical investigation

authors： Becker A,van Hinsbergh VW,Jager A,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Bouter LM,Stehouwer CD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...

journal_title：European journal of clinical investigation

authors： Turan RG,Brehm M,Koestering M,Tobias Z,Bartsch T,Steiner S,Picard F,Ebner P,Schannwell CM,Strauer BE

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Soluble ST2 (sST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we...

journal_title：European journal of clinical investigation

authors： Willems S,Sels JW,Flier S,Versteeg D,Buhre WF,de Kleijn DP,Hoefer IE,Pasterkamp G

更新日期：2013-02-01 00:00:00

abstract：:Urine was collected in four healthy infants, born after 35-39 weeks of gestation. The collections were made for 24 h starting immediately after birth. Bile acids were extracted, separated into conjugate groups, solvolysed, hydrolysed and quantified by gas-liquid chromatography as methyl ester trimethylsilyl ether deri...

journal_title：European journal of clinical investigation

authors： Strandvik B,Wikström SA

更新日期：1982-08-01 00:00:00

abstract：:We present a sensitive time-resolved fluorometric immunofunctional assay (TR-FIA) for direct quantitation of functional growth hormone-binding protein (GHBP), using an immunoassay kit for growth hormone (GH-DELFIA). In addition to the immobilized GH antibody, one monoclonal antibody against GHBP was used. This anti-GH...

journal_title：European journal of clinical investigation

authors： Fisker S,Frystyk J,Skriver L,Vestbo E,Ho KK,Orskov H

更新日期：1996-09-01 00:00:00

abstract：:The developmental aspects of characteristic intestinal lipoprotein synthesis, chlomicrons (CM), very low density lipoproteins (VLDL) and high density lipoproteins (HDL), are unknown. Our objective was to determine the ontogeny of intestinal lipid and lipoprotein synthesis in both the jejunum and the ileum. Explants of...

journal_title：European journal of clinical investigation

authors： Mehran M,Thibault L,Russo P,Garofalo C,Levy E

更新日期：1992-02-01 00:00:00

abstract：:To assess the degree of immune system activation associated with addiction or hepatotropic viruses infection, we examined 60 HIV-negative heroin addicts for the presence of hepatitis B virus (HBV) infection markers, hepatitis C virus antibodies (anti-HCV), various auto-antibodies, and serum levels of soluble interleuk...

journal_title：European journal of clinical investigation

authors： Dalekos GN,Manoussakis MN,Zervou E,Tsianos EV,Moutsopoulos HM

更新日期：1993-04-01 00:00:00

abstract：:ATPase activities were determined in haemolysed and dialysed erythrocytes and in haemoglobin-free membranes of twenty patients with essential hypertension and twenty normotensive controls. Ouabain-sensitive ATPase (Na-K-ATPase) activity of haemolysate but not that of membranes was decreased in hypertensives whereas ou...

journal_title：European journal of clinical investigation

authors： Walter U,Müller S

更新日期：1985-08-01 00:00:00