Endothelial dysfunction in Buerger's disease and its relation to markers of inflammation.

abstract：BACKGROUND:The intestinal handling of dextran, an alpha-1,6-linked glucose polymer, is poor compared with starch, and some ingested dextran might therefore reach the lower small intestine. As luminal sugar up-regulates SGLT1 (sodium-dependent glucose transporter) locally, we report the effects of a dextran-enriched die...

journal_title：European journal of clinical investigation

authors： Debnam ES,Denholm EE,Grimble GK

更新日期：1998-08-01 00:00:00

abstract：:With advancing age both sexes have an increased incidence of osteoporotic fractures, although fractures are more common in women than in men. Whereas in women several potential risk factors have been identified, less is known about osteoporosis in men. A total of 27 Austrian men (mean age: 65 +/- 2 years) with atrauma...

journal_title：European journal of clinical investigation

authors： Resch H,Pietschmann P,Woloszczuk W,Krexner E,Bernecker P,Willvonseder R

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Differences in lipid parameters between patients with acute coronary syndromes (ACS) and patients with stable coronary artery disease (CAD) are unclear and are addressed in this study. METHODS:We enrolled 582 patients with angiographically proven stable CAD (of whom 26·9% had diabetes mellitus type 2 (T2DM)...

journal_title：European journal of clinical investigation

authors： Vonbank A,Saely CH,Rein P,Drexel H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Changes in bile acid (BA) pool, such as the reappearance of typically foetal-type molecular species with a 'flat' structure at the steroid ring, occur during hepatocarcinogenesis, both in humans and rodents. Moreover flat-BAs also appear during rat liver regeneration. These changes can be detected in urine. ...

journal_title：European journal of clinical investigation

authors： Stärkel P,Shindano T,Horsmans Y,Gigot JF,Fernandez-Tagarro M,Marin JJ,Monte MJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Increased intestinal permeability in cirrhosis exerts a pivotal role in the pathogenesis of spontaneous bacterial peritonitis and other complications of cirrhosis through promotion of systemic endotoxemia. This study was designed to investigate whether the expression of tight junction (TJ) proteins, which re...

journal_title：European journal of clinical investigation

authors： Assimakopoulos SF,Tsamandas AC,Tsiaoussis GI,Karatza E,Triantos C,Vagianos CE,Spiliopoulou I,Kaltezioti V,Charonis A,Nikolopoulou VN,Scopa CD,Thomopoulos KC

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The aim was to examine whether the inhibition of selective cyclooxygenase (COX) 2 activation could suppress the development of inflammatory reaction in visceral and subcutaneous abdominal fats of high-fat-induced obese rats. MATERIALS AND METHODS:The rats were fed separately regular diet (CONT), high-fat di...

journal_title：European journal of clinical investigation

authors： Hsieh PS,Lu KC,Chiang CF,Chen CH

更新日期：2010-02-01 00:00:00

abstract：:Pancreatic polypeptide was infused intravenously in healthy fasting subjects at 1 pmol kg-1 (n = 7) and 4 pmol kg-1 min-1 (n = 10) producing plasma PP concentrations of 223 +/- 37 pmol/l (mean +/- SEM) and 891 +/- 64 pmol/l respectively. These levels are similar to and four-fold higher than those seen after a normal m...

journal_title：European journal of clinical investigation

authors： Adrian TE,Greenberg GR,Barnes AJ,Christofides ND,Alberti KG,Bloom SR

更新日期：1980-06-01 00:00:00

abstract：:Deficient leucocyte sphingomyelinase activity has been demonstrated in a patient with the sea-blue histiocyte syndrome. Family studies revealed that two other cases previously diagnosed on clinical and histochemical criteria also had a pronounced diminution of sphingomyelinase activity. Both parents of the affected in...

journal_title：European journal of clinical investigation

authors： Fried K,Beer S,Krespin HI,Leiba H,Djaldetti M,Zitman D,Klibansky C

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Complement fragment C5a and neutrophils have been implicated in the pathogenesis of renal disease and C5a has also been shown to delay apoptosis of human neutrophils via a transcription-independent pathway. However, transcription-dependent pathways have not been well described. The present study examined whe...

journal_title：European journal of clinical investigation

authors： Perianayagam MC,Madias NE,Pereira BJ,Jaber BL

更新日期：2006-05-01 00:00:00

abstract：:The esterolytic activity of mixed and parotid saliva in cystic fibrosis (CF) patients and normal subjects was determined using BAEE (alpha-Benzoyl-1-arginine-ethylester) as the substrate. Using soybean-trypsin-inhibitor the trypsin-like activity (TLA) was measured and plotted as a function of parotid flow rate. In add...

journal_title：European journal of clinical investigation

authors： Schöni M,Kaiser D,Drack E,Axmacher U

更新日期：1975-04-01 00:00:00

abstract：:The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...

journal_title：European journal of clinical investigation

authors： van't Hooft FM,van Tol A

更新日期：1985-12-01 00:00:00

abstract：:Oral lichen planus (OLP) is a common oral disorder that manifests a mucosal reaction to a variety of aetiological factors, including liver disorder. This study investigated the relationship between OLP and hepatitis C virus (HCV) infection by studying the prevalence of hepatitis B and C virus infection or liver diseas...

journal_title：European journal of clinical investigation

authors： Nagao Y,Sata M,Tanikawa K,Itoh K,Kameyama T

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Disuse and/or local inflammation in the muscle cannot be excluded as potential influences for the decreased muscle force in patients hospitalised due to an acute chronic obstructive pulmonary disease (COPD) exacerbation. This study aims to compare expression levels of markers of disuse (insulin-like growth f...

journal_title：European journal of clinical investigation

authors： Crul T,Spruit MA,Gayan-Ramirez G,Quarck R,Gosselink R,Troosters T,Pitta F,Decramer M

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Diabetes dramatically increases the risk of cardiovascular complications and mortality. Hydrogen sulphide plays an important role in reducing oxidative stress. Several studies demonstrated that hydrogen sulphide protects islet beta cells from oxidant stress damage and decreases apoptosis. The aim of...

journal_title：European journal of clinical investigation

authors： Dorofeyeva N,Drachuk K,Rajkumar R,Sabnis O,Sagach V

更新日期：2021-01-01 00:00:00

abstract：:In systemic lupus erythematosus (SLE) patients, most of the clinical manifestation share a vascular component triggered by endothelial dysfunction. Endothelial cells (ECs) activation occurs both on the arterial and venous side, and the high vascular density of kidneys accounts for the detrimental outcomes of SLE throu...

journal_title：European journal of clinical investigation

authors： Mancardi D,Arrigo E,Cozzi M,Cecchi I,Radin M,Fenoglio R,Roccatello D,Sciascia S

更新日期：2021-02-01 00:00:00

abstract：:In order to estimate their in-vivo reactivity two antacids of equal theoretical neutralizing capacity (approximately 3.9 mol/l at pH 3.5) but of different chemical composition were employed as intragastric titrant (pH 3.5) following a liquid protein meal (oxo) in two groups of five volunteers each. The two antacids ch...

journal_title：European journal of clinical investigation

authors： Halter F,Huber R,Häcki WH,Varga L,Bachmann C

更新日期：1982-06-01 00:00:00

abstract：:Diabetes Mellitus in its early stages, is associated with kidney enlargement and increased glomerular filtration rate in humans and in rats. The present study was designed to clarify the direct effect of diabetes on serum and tissue angiotensin converting enzyme (ACE) activity in streptozotocin-induced diabetic rats. ...

journal_title：European journal of clinical investigation

authors： Erman A,van Dyk DJ,Chen-Gal B,Giler ID,Rosenfeld JB,Boner G

更新日期：1993-10-01 00:00:00

abstract：:Whether leptin levels are related to insulin sensitivity or subject to acute regulation by insulin is not known. In 12 obese [body mass index (BMI) = 34.0 +/- 1.5 kg m-2] and 12 lean (BMI = 22.2 +/- 0.6 kg m-2) non-diabetic subjects, plasma leptin concentrations were measured in the fasting state and during 2 hours of...

journal_title：European journal of clinical investigation

authors： Muscelli E,Camastra S,Masoni A,Baldi S,Sironi AM,Natali A,Ferrannini E

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Both inflammation and oxidative stress may contribute to pathogenesis of metabolic syndrome (MetS). The C242T polymorphism (rs4673) in the CYBA gene, as the main components of NAD (P) H oxidase, causes inter-individual variability in the enzyme activity. We aimed to investigate the association between this p...

journal_title：European journal of clinical investigation

authors： Pourgholi L,Pourgholi F,Ziaee S,Goodarzynejad H,Hosseindokht M,Boroumand M,Mandegary A

更新日期：2020-09-01 00:00:00

abstract：:Approximately 20% of monocytes and peritoneal macrophages from renal failure patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were transferrin-receptor (TfR) positive by immunofluorescence, whereas cells from normal controls were generally TfR negative, as were monocytes from rheumatoid arthritis p...

journal_title：European journal of clinical investigation

authors： Moughal NA,McGregor SJ,Brock JH,Briggs JD,Junor BJ

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Bezafibrate reportedly lowers serum lipids and plasma fibrinogen in humans and rats, but the mechanism of this process has still to be clarified. We have addressed this problem by investigating the effects of bezafibrate on fibrinogen in the human hepatoma HepG2 cell line. METHODS:In cells cultured with and...

journal_title：European journal of clinical investigation

authors： Binsack R,Stegmeier K,Dörge L,Völkl A

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The mammalian target of rapamycin (mTOR) has recently been implicated in leukaemic cell growth, tumour-associated angiogenesis and expression of vascular endothelial growth factor (VEGF). We examined whether mTOR plays a role as regulator of growth and VEGF-expression in acute myeloid leukaemia (AML). Three ...

journal_title：European journal of clinical investigation

authors： Böhm A,Aichberger KJ,Mayerhofer M,Herrmann H,Florian S,Krauth MT,Derdak S,Samorapoompichit P,Sonneck K,Vales A,Gleixner KV,Pickl WF,Sperr WR,Valent P

更新日期：2009-05-01 00:00:00

abstract：:1. The activity of lipoprotein lipase (E.C.3.1.1.3) extracted and released from adipose tissue has been measured in obese subjects with mild or severe hypertriglyceridaemia. The Intralipid tolerance test has been studied as a measure of in vivo clearance of exogenous triglyceride from plasma. 2. Plasma triglyceride cl...

journal_title：European journal of clinical investigation

authors： Taylor KG,Holdsworth G,Galton DJ

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:During COVID-19 outbreak, oncological care has been reorganized. Patients with cancer have been reported to experience a more severe COVID-19 syndrome; moreover, there are concerns of a potential interference between immune checkpoint inhibitors (ICIs) and SARS-CoV-2 pathogenesis. MATERIALS AND METHODS:Betw...

journal_title：European journal of clinical investigation

authors： Tagliamento M,Spagnolo F,Poggio F,Soldato D,Conte B,Ruelle T,Barisione E,De Maria A,Del Mastro L,Di Maio M,Lambertini M

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The ratio of serum C-reactive protein (CRP) to albumin has been proven to be a more accurate indicator than albumin and CRP levels alone in determining the prognosis of patients with cancer and critical illness. The aim of this study was to determine whether the CRP/albumin ratio (CAR) can be linked to imper...

journal_title：European journal of clinical investigation

authors： Karabağ Y,Çağdaş M,Rencuzogullari I,Karakoyun S,Artaç İ,İliş D,Yesin M,Çağdaş ÖS,Altıntaş B,Burak C,Tanboğa HI

更新日期：2018-06-01 00:00:00

abstract：AIMS:This study estimated the resource implications and budget impact of managing adults with Fabry disease in Italy, from the perspective of the Servizio Sanitario Nazionale (SSN). METHODS:A decision model was constructed using published clinical outcomes and clinician-derived resource utilisation estimates depicting...

journal_title：European journal of clinical investigation

authors： Guest JF,Concolino D,Di Vito R,Feliciani C,Parini R,Zampetti A

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Foetal growth monitoring is an essential component of prenatal care with postnatal impact. The aim of the study was to construct reference ranges for foetal biometric parameters in Greek foetuses and to compare them with previously published models. MATERIALS AND METHODS:Measurements from 1200 Greek foetuse...

journal_title：European journal of clinical investigation

authors： Sotiriadis A,Eleftheriades M,Chatzinikolaou F,Hassiakos D,Chrousos GP,Pervanidou P

更新日期：2016-05-01 00:00:00

abstract：:Studies were designed to establish the acid inhibitory potency and plasma kinetics of somatostatin-28 (S-28) in humans and to determine whether the amount of S-28 released into the circulation after a meal is sufficient to regulate gastric acid secretion. A liquid meal induced a significant increase of S-28 (P < 0.01)...

journal_title：European journal of clinical investigation

authors： Hildebrand P,Ensinck JW,Buettiker J,Drewe J,Burckhardt B,Gyr K,Beglinger C

更新日期：1994-01-01 00:00:00

abstract：:Anaemia is a common condition among pre-end-stage renal disease (pre-ESRD) patients with chronic kidney disease (CKD). Indeed, data from clinical studies indicate that anaemia may be present in as many as two-thirds of such patients. Use of recombinant human erythropoietin (EPO) provides an effective means of correcti...

journal_title：European journal of clinical investigation

authors： McClellan WM,Jurkovitz C,Abramson J

更新日期：2005-12-01 00:00:00

abstract：:Fibromuscular dysplasia (FMD) is an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small and medium-sized arteries, mostly involving renal and cervical arteries. As a result of better and more systematic screening, it appears that in...

journal_title：European journal of clinical investigation

authors： Van der Niepen P,van Tussenbroek F,Devos H,Debing E,Di Monaco S,Goffette P,Astarci P,Persu A

更新日期：2018-11-01 00:00:00