The role of polymorphonuclear leucocytes and T lymphocytes in experimental murine amyloidosis.

Abstract:

:Washed cells, from ascitic fluid, which contained predominantly polymorphonuclear leucocytes from casein treated donor mice, induced accelerated amyloid formation in untreated syngeneic recipient animals. A similar transfer model, with lymph node cell suspension, was ineffective. Amyloidogenesis was completely blocked by colchicine treatment of the donors while treatment of the recipients had no effect. A casein induced amyloidogenic stimulus was transferred from nude C3H mice to their normal littermates. When the order was reversed, no amyloidosis occurred in the nude recipients. These experiments indicate the possible involvement of two cells in the biphasic process of casein induced murine amyloid formation: the polymorphonuclear leucocyte in the first phase and the T lymphocyte in the second.

journal_name

Eur J Clin Invest

authors

Kedar I,Ravid M

doi

10.1111/j.1365-2362.1980.tb00011.x

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

63-5

issue

1

eissn

0014-2972

issn

1365-2362

journal_volume

10

pub_type

杂志文章
  • PPARgamma2 protects against obesity by means of a mechanism that mediates insulin resistance.

    abstract:BACKGROUND:Many studies have focused on the physiological parameters and genetic predisposition of subjects presenting both obesity and insulin resistance (IR) and it has been suggested that the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) Pro12Ala variant may contribute to the observed variability i...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2009.02198.x

    authors: Macias-Gonzalez M,Moreno-Santos I,García-Almeida JM,Tinahones FJ,Garcia-Fuentes E

    更新日期:2009-11-01 00:00:00

  • Bile acid metabolism in hypothyroid subjects: response to substitution therapy.

    abstract::Bile acid kinetics and biliary lipid composition were determined in ten hypothyroid patients before and after treatment with L-thyroxine. Hypothyroid patients had normal synthesis rates of cholic acid and chenodeoxycholic acid. Hormone treatment, which lowered plasma cholesterol by about 35%, stimulated the formation ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1983.tb00071.x

    authors: Angelin B,Einarsson K,Leijd B

    更新日期:1983-02-01 00:00:00

  • High levels of desmosines in urine and plasma of patients with pseudoxanthoma elasticum.

    abstract:BACKGROUND:Pseudoxanthoma elasticum (PXE), a rare heritable disorder caused by mutations of the ABCC6 gene, is characterized by fragmentation and mineralization of elastic fibres. We determined the extent of degradation of elastin by measuring and comparing the amount of desmosines in plasma and urine of PXE patients, ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2004.01306.x

    authors: Annovazzi L,Viglio S,Gheduzzi D,Pasquali-Ronchetti I,Zanone C,Cetta G,Iadarola P

    更新日期:2004-02-01 00:00:00

  • Heterozygous apolipoprotein C-II deficiency: lipoprotein and apoprotein phenotype and RsaI restriction enzyme polymorphism in the Apo C-IIPadova kindred.

    abstract::Deficiency of apolipoprotein C-II (apo C-II), the cofactor for lipoprotein lipase, results in the familial chylomicronaemia syndrome characterized by severe hypertriglyceridaemia and fasting chylomicronaemia. To investigate the biochemical features of the heterozygous state for apo C-II deficiency, we characterized th...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1993.tb00960.x

    authors: Gabelli C,Bilato C,Santamarina-Fojo S,Martini S,Brewer HB Jr,Crepaldi G,Baggio G

    更新日期:1993-09-01 00:00:00

  • Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.

    abstract::In contrast to bile salts, which undergo a highly efficient enterohepatic circulation with multiple regulatory and physiologic functions, glucuronic acid conjugates of bilirubin are biliary excretory molecules that in health do not have a continuing biologic life. Intestinal absorptive cells are devoid of recapture tr...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2362.2003.01214.x

    authors: Vítek L,Carey MC

    更新日期:2003-09-01 00:00:00

  • Amadori-albumin correlates with microvascular complications and precedes nephropathy in type 1 diabetic patients.

    abstract:BACKGROUND:Amadori-albumin, a major glycated protein, is involved in experimental hyperglycaemia-induced microvascular complications, and is associated with advanced nephropathy in Type I diabetic patients in humans. Our aim was to assess the association of Amadori-albumin with early nephropathy and with retinopathy in...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2362.2002.01011.x

    authors: Schalkwijk CG,Chaturvedi N,Twaafhoven H,van Hinsbergh VW,Stehouwer CD,EUCLID Study Group.

    更新日期:2002-07-01 00:00:00

  • The glomerular sieving of pepsinogen A and C in man.

    abstract::Pepsinogen A (PGA) and pepsinogen C (PGC) are negatively charged, low molecular weight (LMW) proteins with a striking difference in renal handling: PGA (molecular weight 43,500 daltons) shows a high fractional excretion while the fractional excretion of PGC (molecular weight 40,500 daltons) is low, presumably due to t...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1989.tb00234.x

    authors: ten Kate RW,Pals G,Res JC,van Kamp GJ,Verheugt FW,Pronk JC,Donker AJ,Eriksson AW,Meuwissen SG

    更新日期:1989-06-01 00:00:00

  • Circulating anti-(xanthine oxidoreductase) antibodies in healthy human adults.

    abstract::Levels of free anti-(xanthine oxidoreductase) (XOR) antibodies in the serum of normal healthy human subjects were determined, using both human and bovine enzyme as antigen, in an enzyme-linked immunosorbent assay (ELISA). Levels of IgM class anti-(human XOR) antibodies were found to be particularly high (mean values r...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1997.1550704.x

    authors: Benboubetra M,Gleeson A,Harris CP,Khan J,Arrar L,Brennand D,Reid J,Reckless JD,Harrison R

    更新日期:1997-07-01 00:00:00

  • Hepatic and extrahepatic triglyceride lipase activity in uraemic patients on chronic haemodialysis.

    abstract::In eleven patients with chronic renal insufficiency treated by intermittent haemodialysis and in ten normal subjects, hepatic and extrahepatic triglyceride lipase activity of post heparin plasma was selectively measured, utilizing the different sensitivity of both enzymes to inhibition by protamine sulphate. In uraemi...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1978.tb00844.x

    authors: Bolzano K,Krempler F,Sandhofer F

    更新日期:1978-10-01 00:00:00

  • Relation between insulin kinetics and insulin sensitivity in pregnancy.

    abstract:BACKGROUND:Different time-concentration profiles of plasma insulin following insulin modification of a frequently sampled intravenous glucose-tolerance-test (FSIVGTT) were observed in a study investigating maternal metabolism and fetal macrosomia. We aimed to investigate whether these differences were related to the vo...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2003.01193.x

    authors: Jolly MC,Hovorka R,Godsland I,Amin R,Lawrence N,Anyaoku V,Johnston D,Robinson S

    更新日期:2003-08-01 00:00:00

  • Influence of apolipoprotein E polymorphism on plasma vitamin A and vitamin E levels.

    abstract:BACKGROUND:Plasma concentrations of vitamins A and E are positively correlated with those of concurrent lipids and, on the other hand, lipid levels are influenced by apolipoprotein E polymorphism. Therefore, the effect of this polymorphism on both vitamins was analysed in an adult population. MATERIALS AND METHODS:Sub...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2002.00983.x

    authors: Gómez-Coronado D,Entrala A,Alvarez JJ,Ortega H,Olmos JM,Castro M,Sastre A,Herrera E,Lasunción MA

    更新日期:2002-04-01 00:00:00

  • National curves of foetal growth in singleton foetuses of Greek origin.

    abstract:BACKGROUND:Foetal growth monitoring is an essential component of prenatal care with postnatal impact. The aim of the study was to construct reference ranges for foetal biometric parameters in Greek foetuses and to compare them with previously published models. MATERIALS AND METHODS:Measurements from 1200 Greek foetuse...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12611

    authors: Sotiriadis A,Eleftheriades M,Chatzinikolaou F,Hassiakos D,Chrousos GP,Pervanidou P

    更新日期:2016-05-01 00:00:00

  • TGF-beta1 overexpression in the transversalis fascia of patients with direct inguinal hernia.

    abstract:BACKGROUND:The aetiology of inguinal hernia includes changes in collagen turnover and metalloproteinase (MMP) expression, and direct hernia has been linked to increased MMP-2 expression. Since transforming growth factor beta1 (TGFbeta1) plays a role in tissue remodelling, this growth factor could directly affect metall...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2007.01816.x

    authors: Pascual G,Corrales C,Gómez-Gil V,Buján J,Bellón JM

    更新日期:2007-06-01 00:00:00

  • Temporal changes of soluble ST2 after cardiovascular interventions.

    abstract:BACKGROUND:Soluble ST2 (sST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12022

    authors: Willems S,Sels JW,Flier S,Versteeg D,Buhre WF,de Kleijn DP,Hoefer IE,Pasterkamp G

    更新日期:2013-02-01 00:00:00

  • Agalsidase alpha and hearing in Fabry disease: data from the Fabry Outcome Survey.

    abstract::Fabry disease is an X-linked lysosomal storage disorder characterized by multi-organ dysfunction, including hearing loss - mainly sensorineural. The recent introduction of enzyme replacement therapy (ERT) has resulted in improvements in renal and cardiac function, pain and quality of life. One study has also suggested...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2362.2006.01701.x

    authors: Hajioff D,Hegemann S,Conti G,Beck M,Sunder-Plassmann G,Widmer U,Mehta A,Keilmann A

    更新日期:2006-09-01 00:00:00

  • Variation in serum type III procollagen peptide with age in healthy subjects and its comparative value in the assessment of disease activity in children and adults with chronic active hepatitis.

    abstract::To determine the comparative value of serum Type III procollagen peptide (PIIIP) in paediatric and adult liver disease we have measured PIIIP in 201 healthy subjects (aged 1 day-77 years) and twenty-one children and five adults with chronic active hepatitis (CAH). Healthy children had significantly higher PIIIP levels...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1985.tb00147.x

    authors: Trivedi P,Cheeseman P,Portmann B,Hegarty J,Mowat AP

    更新日期:1985-04-01 00:00:00

  • Hepatocyte growth factor and interferon-γ inducible protein-10 are related to visceral adiposity.

    abstract:BACKGROUND:Increased production of chemokines by adipose tissue and defective adipose tissue oxygenation as a result of obesity may induce leucocyte infiltration and subsequent systemic inflammation. OBJECTIVES:1-To determine the relation between the amount of visceral and subcutaneous adipose tissue and the chemokine...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12054

    authors: Faber DR,van der Graaf Y,Westerink J,Kanhai DA,Monajemi H,Visseren FL,SMART study Group.

    更新日期:2013-04-01 00:00:00

  • A revised systematic review and meta-analysis on the effect of statins on D-dimer levels.

    abstract:BACKGROUND:D-dimers are generated during endogenous fibrinolysis of a blood clot and have a central role in diagnostic algorithms to rule out venous thromboembolism. HMG-CoA reductase inhibitors, more commonly called statins, are known to have effects independent of LDL-cholesterol lowering, including antithrombotic pr...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,meta分析

    doi:10.1111/eci.13130

    authors: Schol-Gelok S,Morelli F,Arends LR,Boersma E,Kruip MJHA,Versmissen J,van Gelder T

    更新日期:2019-08-01 00:00:00

  • Circulating somatostatin-28 is not a physiologic regulator of gastric acid production in man.

    abstract::Studies were designed to establish the acid inhibitory potency and plasma kinetics of somatostatin-28 (S-28) in humans and to determine whether the amount of S-28 released into the circulation after a meal is sufficient to regulate gastric acid secretion. A liquid meal induced a significant increase of S-28 (P < 0.01)...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1994.tb02059.x

    authors: Hildebrand P,Ensinck JW,Buettiker J,Drewe J,Burckhardt B,Gyr K,Beglinger C

    更新日期:1994-01-01 00:00:00

  • Uptake of triglyceride fatty acids in adipose tissue in vivo in man.

    abstract::Currently available information on adipose tissue metabolism in man is mainly based on studies in vitro. In the present work adipose tissue lipid uptake was studied in vivo in man. 100 g glucose and 120 g milk fat with 10 microCi U-14C oleic acid were given in the overnight fasting state to eight women and 2 h after a...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1990.tb02263.x

    authors: Mårin P,Rebuffé-Scrive M,Björntorp P

    更新日期:1990-04-01 00:00:00

  • Bile synthesis in rat models of inflammatory bowel diseases.

    abstract:BACKGROUND:A broad spectrum of hepatobiliary disorders are found in patients with inflammatory bowel diseases. The aim of the present work was to study interactions between gut and liver in experimental rat models of colitis and small bowel inflammation. MATERIALS AND METHODS:Colitis was induced either by trinitrobenz...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2007.01779.x

    authors: Dikopoulos N,Schmid RM,Bachem M,Buttenschoen K,Adler G,Chiang JY,Weidenbach H

    更新日期:2007-03-01 00:00:00

  • The effect of meal feeding and of sham-feeding on insulin secretion in dogs.

    abstract::After feeding intact conscious dogs 1000 g mashed meat, peripheral venous immunoreactive insulin activity (IRI) increases before any enhancement of amino nitrogen concentration. This course of IRI is paralleled by a decrease of free fatty acids. Meal feeding in dogs, whose pancreatic juice is completely diverted from ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1976.tb00544.x

    authors: Fischer U,Hommel H,Gottschling HD,Nowak W

    更新日期:1976-11-30 00:00:00

  • Effects of long-term PPI treatment on producing bowel symptoms and SIBO.

    abstract:BACKGROUND:Gastroesophageal reflux disease (GERD), including erosive reflux disease and non-erosive reflux disease (NERD), is a chronic disease with a significant negative effect on quality of life. State-of-the-art treatment involves proton pump inhibitors (PPIs). However, relapse of symptoms occurs in the majority of...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02419.x

    authors: Compare D,Pica L,Rocco A,De Giorgi F,Cuomo R,Sarnelli G,Romano M,Nardone G

    更新日期:2011-04-01 00:00:00

  • Risk score to predict mortality in continuous ambulatory peritoneal dialysis patients.

    abstract:BACKGROUND:Patients with continuous ambulatory peritoneal dialysis (CAPD) have high all-cause mortality risk that varies extensively among different conditions. The objective of this study was to develop and validate risk models to predict the 2-year all-cause mortality risks of CAPD patients. MATERIAL AND METHODS:A t...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12344

    authors: Zhao C,Luo Q,Xia X,He F,Peng F,Yu X,Huang F

    更新日期:2014-11-01 00:00:00

  • Liver enzymes are not directly involved in atrial fibrillation: a prospective cohort study.

    abstract:BACKGROUND:Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation i...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/eci.12779

    authors: Schutte R,Whincup PH,Papacosta O,Lennon LT,Macfarlane PW,Wannamethee G

    更新日期:2017-08-01 00:00:00

  • Proposed mechanism of induction of gastric carcinoids: the gastrin hypothesis.

    abstract::Novel, powerful and long-acting inhibitors of gastric acid secretion include second generation H2-blockers and so-called proton pump inhibitors, such as omeprazole. Gastric carcinoids were found to develop in experimental animals as a consequence of continuous long-term administration of several of these highly effect...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2362.1990.tb01780.x

    authors: Håkanson R,Sundler F

    更新日期:1990-10-01 00:00:00

  • Relationships between plasma isotope enrichments of leucine and alpha-ketoisocaproic acid during continuous infusion of labelled leucine.

    abstract::The ratio at steady-state of alpha-ketoisocaproic acid (KIC) to leucine 13C enrichments in plasma during continuous infusion of [13C]leucine was examined in 58 studies under a variety of conditions. The ratio was lower (P less than 0.001) in 'arterialized' venous plasma (mean +/- SD 0.85 +/- 0.09) than in deep venous ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1988.tb01280.x

    authors: Thompson GN,Pacy PJ,Ford GC,Merritt H,Halliday D

    更新日期:1988-12-01 00:00:00

  • Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency.

    abstract::We have reported that the disorder of lipoprotein metabolism in hyperalphalipoproteinaemic patients with a deficiency of cholesteryl ester transfer protein (CETP) is characterized by the polydisperse low density lipoprotein (LDL) particles and the accumulation of cholesteryl ester (CE) in high density lipoprotein (HDL...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1995.tb01710.x

    authors: Sakai N,Yamashita S,Hirano K,Ishigami M,Arai T,Kobayashi K,Funahashi T,Matsuzawa Y

    更新日期:1995-05-01 00:00:00

  • The effects of fish oil on gene expression in patients with polycystic ovary syndrome.

    abstract:BACKGROUND:This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS:This randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/eci.12893

    authors: Rahmani E,Jamilian M,Dadpour B,Nezami Z,Vahedpoor Z,Mahmoodi S,Aghadavod E,Taghizadeh M,Beiki Hassan A,Asemi Z

    更新日期:2018-03-01 00:00:00

  • Effects of telmisartan and enalapril on renoprotection in patients with mild to moderate chronic kidney disease.

    abstract:BACKGROUND:Blocking the renin-angiotensin system (RAS) with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors protects against renal injury in patients with chronic kidney disease (CKD). The aim of this study was to compare the chronic effects of telmisartan and enalapril on proteinuria, urinary...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.2010.02319.x

    authors: Nakamura T,Fujiwara N,Kawagoe Y,Sugaya T,Ueda Y,Koide H

    更新日期:2010-09-01 00:00:00