Abstract:
BACKGROUND:Glomerulonephritis clusters in families. However, infections are common inducers of glomerulonephritis and may also cluster in families. Studies of adoptees and their biological and adoptive parents may disentangle genetic from environmental causes of familial clustering. This is the first adoption study aimed to estimate the genetic contribution to the familial transmission of glomerulonephritis. MATERIALS AND METHODS:We performed a family study for Swedish-born adoptees (born 1945-2000) and their biological and adoptive parents. The Swedish Multi-Generation Register was linked to the Hospital Inpatient Register for the period 1964-2012 and the Hospital Outpatient Register for 2001-2012. Odds ratio (OR) for glomerulonephritis was determined for adoptees with a biological parent with glomerulonephritis compared with adoptees without an affected biological parent. Similarly, the OR for glomerulonephritis was also determined in adoptees with an affected adoptive parent compared with adoptees without an affected adoptive parent. Heritability was estimated to be twice the observed tetrachoric correlation among adoptees and biological parents, under the assumption that only additive genetic factors contribute to the similarity between biological parents and adoptees. RESULTS:The OR for glomerulonephritis was 4.08 in adoptees (95% confidence interval [CI] 1.79-9.27, P-value = 0.001) of biological parents diagnosed with glomerulonephritis. The OR for glomerulonephritis was 1.67 in adoptees (95% CI 0.53-5.26, P-value = 0.380) of adoptive parents diagnosed with glomerulonephritis. The heritability was 48%. CONCLUSION:Family history of glomerulonephritis in a biological parent is a risk factor for glomerulonephritis. The present study indicates that genetic factors play an important role in the aetiology of glomerulonephritis.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Akrawi DS,Zöller B,Fjellstedt E,Sundquist J,Sundquist K,PirouziFard Mdoi
10.1111/eci.13148subject
Has Abstractpub_date
2019-08-01 00:00:00pages
e13148issue
8eissn
0014-2972issn
1365-2362journal_volume
49pub_type
杂志文章abstract:BACKGROUND:There is an ongoing debate on a potential protective role of habitual physical activity and passive heat therapy on the risk of COVID-19, a respiratory infectious disease that can manifest as severe pneumonia. To explore these putative roles, we evaluated the independent and joint associations of cardiorespi...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/eci.13490
更新日期:2021-01-10 00:00:00
abstract::The effect of indomethacin (75 mg/day for 3 days) on the response to i.v. angiotensin II was investigated in eight healthy, sodium-repleted, male subjects. Indomethacin reduced the release of aldosterone during the i.v. administration of angiotensin II (5, 10 and 20 ng kg-1 min-1), whereas the pressor response to angi...
journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1981-04-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.1995.tb01738.x
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abstract:BACKGROUND:Variation of percentageCD4+ T cells may accurately reflects the kinetics of a comprehensive immune recovery independently of the antiretroviral (ART) regimen. To test this we have investigated the relationship among peripheral blood T-cell subsets with the variation of percentageCD4+ T cells during follow up...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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pub_type: 杂志文章,meta分析,评审
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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pub_type: 杂志文章
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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doi:10.1111/eci.13078
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1984.tb01178.x
更新日期:1984-08-01 00:00:00
abstract::The esterolytic activity of mixed and parotid saliva in cystic fibrosis (CF) patients and normal subjects was determined using BAEE (alpha-Benzoyl-1-arginine-ethylester) as the substrate. Using soybean-trypsin-inhibitor the trypsin-like activity (TLA) was measured and plotted as a function of parotid flow rate. In add...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:1999-02-01 00:00:00
abstract::The effects of treating the anaemia of end-stage renal failure with erythropoietin were studied in nine dialysis patients. The increase in haemoglobin concentration (by 59% from 7.0 +/- 1.2 to 11.1 +/- 1.1 g dl-1) was associated with increases in exercise duration (by 41%) and maximum oxygen consumption (by 34%). Trea...
journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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