Abstract:
BACKGROUND:Our aim in the present study was to determine whether endothelial NO synthase gene (ecNOS) polymorphisms are associated with myocardial infarction (MI). METHODS:Forty chromosomes from patients with MI were screened for polymorphisms of the ecNOS gene using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis and sequencing. Ten polymorphisms were detected: three in the 5' flanking sequence at positions -1474, -924 and -788, two in coding sequences 774C --> T (silent) and G894 --> T (Glu-298 --> Asp) and five in introns 2, 11, 12, 22 and 23. Five hundred and thirty-one patients with MI and 610 control subjects recruited in France and Northern Ireland in the ECTIM study were genotyped for these polymorphisms. RESULTS:Glu-298 homozygotes were more frequent among patients with MI than in control subjects in the French population [OR = 1.47 (1.03-1.97), P < 0.009], but no such difference was observed in Northern Ireland. No significant difference between cases and control subjects was detected for the other polymorphisms. Our search for a possible association of the combination of ecNOS polymorphisms with MI by logistic regression analysis was also negative. CONCLUSIONS:We have explored a set of polymorphisms of the ecNOS gene in a large case-control study of MI and found that the polymorphisms were not consistently associated with MI.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Poirier O,Mao C,Mallet C,Nicaud V,Herrmann SM,Evans A,Ruidavets JB,Arveiler D,Luc G,Tiret L,Soubrier F,Cambien Fdoi
10.1046/j.1365-2362.1999.00451.xkeywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
284-90issue
4eissn
0014-2972issn
1365-2362journal_volume
29pub_type
杂志文章abstract::To understand better impairment of glucose utilization in diabetics during a hyperosmolal state, in vitro models were established to evaluate the effects of hyperosmolality on basal glucose uptake as well as glucagon dependent glucose release by isolated hepatocytes. In these studies simulating a hyperglycaemic (40 mm...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1989.tb00206.x
更新日期:1989-04-01 00:00:00
abstract::The capillary permeability in human skeletal muscle, expressed as capillary diffusion capacity (CDC) for 51Cr-EDTA, was determined during exercise with a local clearance method in two groups of healthy male subjects: a younger group with a mean age of 30 years and an older one with a mean age of 58 years. The main fin...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1979.tb00897.x
更新日期:1979-10-01 00:00:00
abstract:OBJECTIVE:To test the effect of long-term pegfilgrastim on collateral function and myocardial ischaemia in patients with chronic stable coronary artery disease (CAD). METHODS:This was a prospective clinical trial with randomized 2:1 allocation to pegfilgrastim or placebo for 6 months. The primary study endpoint was co...
journal_title:European journal of clinical investigation
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2362.2009.02124.x
更新日期:2009-06-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1977.tb01587.x
更新日期:1977-04-01 00:00:00
abstract::In man, HCl acidosis reduces blood and urinary urea with a concomitant rise in ammonium (NH4+) excretion. Significantly less urea is excreted following NH4Cl administration than following equimolar ingestion of NH4 HCO3. The results of these alterations in nitrogen excretion are interpreted in terms of bicarbonate uti...
journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1988.tb01023.x
更新日期:1988-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1979.tb00888.x
更新日期:1979-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1993.tb00794.x
更新日期:1993-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1976.tb00487.x
更新日期:1976-01-30 00:00:00
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doi:10.1111/eci.13123
更新日期:2019-07-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1046/j.1365-2362.2003.01153.x
更新日期:2003-06-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2362.2010.02443.x
更新日期:2011-06-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.2003.01139.x
更新日期:2003-03-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1985.tb00170.x
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章
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更新日期:1994-06-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.1999.00432.x
更新日期:1999-01-01 00:00:00
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更新日期:2012-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2362.1981.tb02125.x
更新日期:1981-08-01 00:00:00
abstract::Levels of free anti-(xanthine oxidoreductase) (XOR) antibodies in the serum of normal healthy human subjects were determined, using both human and bovine enzyme as antigen, in an enzyme-linked immunosorbent assay (ELISA). Levels of IgM class anti-(human XOR) antibodies were found to be particularly high (mean values r...
journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.1997.1550704.x
更新日期:1997-07-01 00:00:00
abstract::Urodilatin (ANF(95-126)) is an analogue of the atrial natriuretic factor (ANF(99-126)), which has been isolated from human urine. Recently we have shown in healthy volunteers, that intravenous bolus injections of synthetic urodilatin produce more pronounced reductions of pulmonary arterial pressure than ANF(99-126). T...
journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-10-01 00:00:00
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更新日期:2013-12-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00