当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL INVESTIGATION期刊下所有文献 > Relationship of Helicobacter pylori CagA(+) status to gastric juice vitamin C levels.

Relationship of Helicobacter pylori CagA(+) status to gastric juice vitamin C levels.

Abstract：

BACKGROUND:To date it is not known whether gastric juice vitamin C levels are influenced by Helicobacter pylori CagA(+) strains. The aim of the present study, therefore, was to study the impact of H. pylori CagA status on gastric juice vitamin C levels. MATERIALS AND METHODS:We studied 30 H. pylori(+) patients, and the results were compared with 10 endoscopically and histologically normal H. pylori(-) subjects (control group) who were similar to the H. pylori(+) group in terms of age and sex. In all patients, gastric juice vitamin C levels were determined and the severity of gastritis was graded on a scale of 0 (absent) to 3 (severe). CagA was determined by immunoblotting the sera from patients against H. pylori antigens. RESULTS:Among 30 H. pylori(+) patients, 20 were CagA(+) and 10 CagA(-). In the entire group of H. pylori(+) patients, the median gastric juice vitamin C levels (mg L-1) were 16.35 (range 3.5-33.6) and were significantly lower (P < 0.001) than in the control group of H. pylori(-) patients [35.5 (23.1-50.2)]. In addition, in the entire group of H. pylori(+) patients there was a highly significant (P < 0.0001) inverse correlation between the gastritis activity score and the gastric juice vitamin C levels. In the group of H. pylori CagA(+) patients, the median levels of gastric juice vitamin C were 13.8 (3.5-31.2) and were significantly lower than the corresponding levels in both the H. pylori CagA(-) group [24.8 (22-33.6), P < 0.01] and the H. pylori(-) control group [35.5 (23.1-50.2), P < 0.001], the last groups being similar. Furthermore, the gastritis activity median score in the H. pylori CagA(+) group [2 (1-3)] was significantly higher (P < 0.05) than in the H. pylori CagA(-) group [1 (1-2)]. CONCLUSION:These data indicate that infection with CagA(+) H. pylori strains significantly lowers the gastric juice vitamin C levels in comparison with CagA(-) H. pylori strains, which might have a significant impact on gastric carcinogenesis.

journal_name

Eur J Clin Invest

journal_title

European journal of clinical investigation

authors

Rokkas T,Liatsos C,Petridou E,Papatheodorou G,Karameris A,Ladas SD,Raptis SA

doi

10.1046/j.1365-2362.1999.00432.x

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

56-62

issue

eissn

0014-2972

issn

1365-2362

journal_volume

pub_type

杂志文章

在线工具

Relationship of Helicobacter pylori CagA(+) status to gastric juice vitamin C levels.