Increase in type I and type IV collagenolytic activity in primary cultures of keratoconus cornea.

abstract：:The work was designed to study the effects of a meat meal on glomerular filtration rate (GFR), renal plasma flow (RPF), and plasma concentrations of glucagon, insulin, growth hormone, renin, aldosterone, total amino acids, and NH3 in healthy humans (H) as well as in patients with Child A liver cirrhosis (LC). The meat...

journal_title：European journal of clinical investigation

authors： De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R

更新日期：1992-01-01 00:00:00

abstract：AIM:Observationally, low serum testosterone among men is associated with cardiovascular diseases and its risk factors, but it is unclear whether raising endogenous androgens would be protective. To clarify the role of androgens, the association of two different androgen biomarkers (serum testosterone and androstanediol...

journal_title：European journal of clinical investigation

authors： Schooling CM

更新日期：2013-12-01 00:00:00

abstract：:Two methods of measurement of fractional calcium absorption have been compared in the same individuals. There is a significant correlation between fractional 47Ca absorption as measured with a blood counting method and with an external counting method after intravenous and oral administration of 47Ca (P less than 0.00...

journal_title：European journal of clinical investigation

authors： Juttmann JR,Ruis AM,Hagenouw-Taal JC,Lockefeer JH,Birkenhäger JC

更新日期：1978-06-01 00:00:00

abstract：:Approximately 20% of monocytes and peritoneal macrophages from renal failure patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were transferrin-receptor (TfR) positive by immunofluorescence, whereas cells from normal controls were generally TfR negative, as were monocytes from rheumatoid arthritis p...

journal_title：European journal of clinical investigation

authors： Moughal NA,McGregor SJ,Brock JH,Briggs JD,Junor BJ

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have...

journal_title：European journal of clinical investigation

authors： MacLeod MJ,De Lange RP,Breen G,Meiklejohn D,Lemmon H,Clair DS

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The aetiology of inguinal hernia includes changes in collagen turnover and metalloproteinase (MMP) expression, and direct hernia has been linked to increased MMP-2 expression. Since transforming growth factor beta1 (TGFbeta1) plays a role in tissue remodelling, this growth factor could directly affect metall...

journal_title：European journal of clinical investigation

authors： Pascual G,Corrales C,Gómez-Gil V,Buján J,Bellón JM

更新日期：2007-06-01 00:00:00

abstract：:The serum concentrations of collagen type IV,7S, collagen type IV,nc1, and aminoterminal type III procollagen peptide immunoreactive components were measured by means of specific radioimmunoassays during development of granulation tissue in rats. The results were compared with tissue deposition of basement membranes a...

journal_title：European journal of clinical investigation

authors： Hørslev-Petersen K,Pedersen LR,Bentsen KD,Brocks D,Garbarsch C,Kim KY,Hahn EG,Schuppan D,Lorenzen I

更新日期：1988-08-01 00:00:00

abstract：:Deficiency of apolipoprotein C-II (apo C-II), the cofactor for lipoprotein lipase, results in the familial chylomicronaemia syndrome characterized by severe hypertriglyceridaemia and fasting chylomicronaemia. To investigate the biochemical features of the heterozygous state for apo C-II deficiency, we characterized th...

journal_title：European journal of clinical investigation

authors： Gabelli C,Bilato C,Santamarina-Fojo S,Martini S,Brewer HB Jr,Crepaldi G,Baggio G

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:The Treating to New Targets (TNT) study has recently provided evidence that reduction in LDL-C levels below 2·6 mmol L⁻¹ lowers the risk of cerebrovascular events by an additional 20% to 25%, thereby confirming the value of statin therapy in preventing transient ischaemic attacks and stroke. Despite the prot...

journal_title：European journal of clinical investigation

authors： van den Bogaard B,van den Born BJ,Fayyad R,Waters DD,DeMicco DA,LaRosa JC,Kastelein JJ,Holme I,Treating to New Targets investigators.

更新日期：2011-02-01 00:00:00

abstract：:To understand better impairment of glucose utilization in diabetics during a hyperosmolal state, in vitro models were established to evaluate the effects of hyperosmolality on basal glucose uptake as well as glucagon dependent glucose release by isolated hepatocytes. In these studies simulating a hyperglycaemic (40 mm...

journal_title：European journal of clinical investigation

authors： Komjati M,Kastner G,Waldhäusl W,Bratusch-Marrain P

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. MATERIALS AND...

journal_title：European journal of clinical investigation

authors： Leitão J,Carvalhana S,Cochicho J,Silva AP,Velasco F,Medeiros I,Alves AC,Bourbon M,Oliveiros B,Rodrigues V,Sousa R,Sampaio F,Carvalho A,Cortez-Pinto H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Arterial calcification (AC) is a major health problem associated with extreme morbidity and a shortened survival. It is currently without any effective treatment. ATP and the purinergic system in general are now emerging as being important in the pathogenesis of AC and potentially provide a new focus for nov...

journal_title：European journal of clinical investigation

authors： Fish RS,Klootwijk E,Tam FW,Kleta R,Wheeler DC,Unwin RJ,Norman J

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:In dialysis patients, cardiac troponin T (cTNT) is often elevated despite the absence of acute myocardial ischaemia, and amino-terminal pro-B-natriuretic peptide (NT-proBNP) is markedly higher compared to non-haemodialysis patients. In a longitudinal observation, we evaluated the association of cTNT and NT-p...

journal_title：European journal of clinical investigation

authors： Sommerer C,Beimler J,Schwenger V,Heckele N,Katus HA,Giannitsis E,Zeier M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Thymosin β4 (Tβ4) was recently found at high concentration in the bronchoalveolar lavage fluid (BALF) of scleroderma patients with lung involvement. It has been hypothesized that Tβ4 may exert a cyto-protective effect during lung injury because lower Tβ4 levels were associated with interstitial lung disease ...

journal_title：European journal of clinical investigation

authors： Conte E,Genovese T,Gili E,Esposito E,Iemmolo M,Fruciano M,Fagone E,Pistorio MP,Crimi N,Cuzzocrea S,Vancheri C

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...

journal_title：European journal of clinical investigation

authors： Turan RG,Brehm M,Koestering M,Tobias Z,Bartsch T,Steiner S,Picard F,Ebner P,Schannwell CM,Strauer BE

更新日期：2007-11-01 00:00:00

abstract：:Arterial lumen narrowing and vascular occlusion is the actual cause of morbidity and mortality in atherosclerotic disease. Collateral artery formation (arteriogenesis) refers to an active remodelling of non-functional vascular anastomoses to functional collateral arteries, capable to bypass the site of obstruction and...

journal_title：European journal of clinical investigation

authors： de Groot D,Pasterkamp G,Hoefer IE

更新日期：2009-12-01 00:00:00

abstract：:Fibronectin is a glycoprotein found in body fluids, loose connective tissue matrix and in basement membranes. Fibronectin in rheumatoid arthritis synovial fluid was immunologically indistinguishable from the plasma form, as shown by double-diffusion analysis. Fibronectin isolated from rheumatoid synovial fluid by affi...

journal_title：European journal of clinical investigation

authors： Vartio T,Vaheri A,Von Essen R,Isomäki H,Stenman S

更新日期：1981-06-01 00:00:00

abstract：:Serum testosterone, LH, and FSH before and after i.v. injection of LHRH were studied in ten acromegalic men and in twenty-one males after hypophysectomy. Controls were normal men matched according to age. Compared to the controls, basal FSH was slightly higher and basal LGH slightly lower in the untreated acromegalics...

journal_title：European journal of clinical investigation

authors： Lindholm J,Rasmussen P,Korsgaard O

更新日期：1977-04-01 00:00:00

abstract：:Nitrogen load can be reduced by substituting dietary protein intake with keto or hydroxy analogues of amino acids. To investigate their intestinal absorption, human jejunal brush border membrane vesicles were used to measure uptake of L-leucine hydroxy analogue (L-LHA) and L-lactate. Uptake assays were performed under...

journal_title：European journal of clinical investigation

authors： Friedrich M,Murer H,Sterchi E,Berger EG

更新日期：1992-02-01 00:00:00

abstract：:A continuous intravenous infusion of L-leucine (300 mumols min-1) was given to 12 healthy females over a 2 1/2 h period. Arterial plasma concentrations of amino acids and the keto acids of the branched-chain amino acids (BCAA) were measured. In six subjects muscle biopsies were taken before and at the end of the infus...

journal_title：European journal of clinical investigation

authors： Alvestrand A,Hagenfeldt L,Merli M,Oureshi A,Eriksson LS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Profilin-1 is a ubiquitous, actin-binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin-1 levels with fatal and nonfatal CVE in a coh...

journal_title：European journal of clinical investigation

authors： Eroglu E,Unal HU,Guclu A,Kocyigit I,Karaman M,Saglam M,Gezer M,Tas A,Zararsiz G,Eyileten T,Aydin İ,Oguz Y,Gungor O,Yilmaz MI

更新日期：2017-12-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by progressive, irreversible loss of cardiac and skeletal muscular function. Muscular enlargement in DMD is attributed to oedema, due to the increased cytoplasmic Na+ concentration. The aim of this review was to present the current experien...

journal_title：European journal of clinical investigation

authors： Mavrogeni S,Papavasiliou A,Giannakopoulou K,Markousis-Mavrogenis G,Pons MR,Karanasios E,Nikas I,Papadopoulos G,Kolovou G,Chrousos GP

更新日期：2017-12-01 00:00:00

abstract：:Tightly co-ordinated control of both insulin action and secretion is required in order to maintain glucose homeostasis. Gene knockout experiments have helped to define key signalling molecules that affect insulin action, including insulin and insulin-like growth factor-1 (IGF-1) receptors, insulin receptor substrate (...

journal_title：European journal of clinical investigation

authors： Rhodes CJ,White MF

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:The DALI low-density lipoprotein (LDL) apheresis system is the first whole-blood apheresis system in regular clinical use. DALI stands for direct adsorption of lipoproteins, which describes the basic principle of operation of this newly developed LDL apheresis procedure. METHODS:The selective removal of LDL...

journal_title：European journal of clinical investigation

authors： Dräger LJ,Julius U,Kraenzle K,Schaper J,Toepfer M,Zygan K,Otto V,Steinhagen-Thiessen E

更新日期：1998-12-01 00:00:00

abstract：:The metabolic responses to 4-h infusions of adrenaline (3 micrograms kg-1 h-1) and cortisol (10 mg m-2 h-1 for 2 h followed by 5 mg m-2 h-1 for 2 h), separately and in combination, have been studied in six healthy subjects with concurrent somatostatin infusion (250 micrograms h-1). A combined infusion of adrenaline, c...

journal_title：European journal of clinical investigation

authors： Pernet A,Johnston DG,Hammond V,Orskov H,Alberti KG

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Na+,K(+)-ATPase activity was evaluated in relation to membrane composition and molecular organization in erythrocyte membranes from obese patients by the amphyphylic molecule 6-dodecanoyl-2-dimethylamino-naphthalene (Laurdan). Its possible relationship with fat distribution and hyperinsulinaemia was also inv...

journal_title：European journal of clinical investigation

authors： Faloia E,Garrapa GG,Martarelli D,Camilloni MA,Lucarelli G,Staffolani R,Mantero F,Curatola G,Mazzanti L

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:In Western societies colonic cancer most frequently develops in the distal colon, largely as a result of the composition of the diet. Modulation of dietary factors is therefore an attractive modality to reduce colorectal cancer risk. This study aims to evaluate the potentially protective effects of calcium i...

journal_title：European journal of clinical investigation

authors： van Gorkom BA,van der Meer R,Karrenbeld A,van der Sluis T,Zwart N,Termont DS,Boersma-van Ek W,de Vries EG,Kleibeuker JH

更新日期：2002-09-01 00:00:00

abstract：:We have reported that the disorder of lipoprotein metabolism in hyperalphalipoproteinaemic patients with a deficiency of cholesteryl ester transfer protein (CETP) is characterized by the polydisperse low density lipoprotein (LDL) particles and the accumulation of cholesteryl ester (CE) in high density lipoprotein (HDL...

journal_title：European journal of clinical investigation

authors： Sakai N,Yamashita S,Hirano K,Ishigami M,Arai T,Kobayashi K,Funahashi T,Matsuzawa Y

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Previous studies revealed that patients with Takotsubo syndrome (TTS) have a higher mortality rate than the general population and a comparable mortality to acute coronary syndrome (ACS). Repolarisation abnormalities, namely T-wave amplitude, may provide incremental prognostic information, in addition to tra...

journal_title：European journal of clinical investigation

authors： Gietzen T,El-Battrawy I,Lang S,Zhou XB,Ansari U,Behnes M,Borggrefe M,Akin I

更新日期：2019-04-01 00:00:00

abstract：:We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia. Platelets from both normal and hypercholesterolaemic subjects showed irreversible aggregation with 0.3 units ml-1 thro...

journal_title：European journal of clinical investigation

authors： Smith CC,Wilson AP,Prichard BN,Betteridge DJ

更新日期：1989-06-01 00:00:00