Fibronectin in synovial fluid and tissue in rheumatoid arthritis.

Abstract:

:Fibronectin is a glycoprotein found in body fluids, loose connective tissue matrix and in basement membranes. Fibronectin in rheumatoid arthritis synovial fluid was immunologically indistinguishable from the plasma form, as shown by double-diffusion analysis. Fibronectin isolated from rheumatoid synovial fluid by affinity chromatography on gelatin--Sepharose had a polypeptide pattern similar to that of plasma fibronectin in SDS--polyacrylamide gel electrophoresis. In fifty-one patients with rheumatoid arthritis and related diseases fibronectin concentrations is synovial fluid were 445 +/- 103 micrograms/ml (mean +/- SD) and within normal range, 335 +/- 52 micrograms/ml, in plasma. Immunofluorescence staining showed a prominent increase of fibronectin in the proliferating synovial connective tissue in rheumatoid arthritis as compared to normal synovial membrane. The results suggest an increased local production of fibronectin in rheumatoid synovial tissue.

journal_name

Eur J Clin Invest

authors

Vartio T,Vaheri A,Von Essen R,Isomäki H,Stenman S

doi

10.1111/j.1365-2362.1981.tb01842.x

subject

Has Abstract

pub_date

1981-06-01 00:00:00

pages

207-12

issue

3

eissn

0014-2972

issn

1365-2362

journal_volume

11

pub_type

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