Abstract：
BACKGROUND:Based on a report of a marked increase in the erythropoietin concentration ([EPO]) a few hours after the cessation of a single 2-h session of O(2) breathing, short periods of O(2) administration have been advocated as a therapy for anaemia. Accordingly, the purpose of the present study was to evaluate this theory by investigating the effect of 10 daily short-term exposures to normobaric O(2) over a 2-week period on the plasma [EPO] in healthy individuals. MATERIAL AND METHODS:Twenty men were assigned to either an experimental (NBO(2)) or to a control (AIR) group. The NBO(2) group breathed 100% normobaric O(2) for 2 h every weekday over a 2-week period. The AIR group breathed air within the same time protocol. Blood samples were collected at the pre-, mid- and post-intervention periods to determine [EPO]. RESULTS:[EPO] of the NBO(2) group was significantly lower than that of the AIR group during the mid- and post-periods (P < 0·001). [EPO] of the NBO(2) group showed a slight, albeit statistically nonsignificant, decrease during the mid (∼11%)- and post (∼16%)-periods. CONCLUSIONS:Daily short-term exposures to normobaric hyperoxia do not increase the [EPO] in healthy individuals. The increased O(2) tension suppresses [EPO]. Hence, administration of pure O(2) to enhance erythropoiesis is not warranted.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Keramidas ME,Norman B,Gustafsson T,Eiken O,Mekjavic IBdoi
10.1111/j.1365-2362.2011.02578.xsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
260-5issue
3eissn
0014-2972issn
1365-2362journal_volume
42pub_type
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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