ATP and arterial calcification.

Abstract:

BACKGROUND:Arterial calcification (AC) is a major health problem associated with extreme morbidity and a shortened survival. It is currently without any effective treatment. ATP and the purinergic system in general are now emerging as being important in the pathogenesis of AC and potentially provide a new focus for novel therapies. METHODS:This review systematically analyses and discusses the current literature examining the relevance of the purinergic system to AC. Particular emphasis is given to the enzymes associated with ATP metabolism and their role in maintaining a balance between promotion and inhibition of arterial mineralization. Points of controversy are highlighted, and areas for future research are suggested. CONCLUSION:The potential roles of ATP and the purinergic system in AC are beginning to be elucidated. While further work is necessary, current knowledge suggests that several components of the purinergic system could be targeted to develop new treatments for AC.

journal_name

Eur J Clin Invest

authors

Fish RS,Klootwijk E,Tam FW,Kleta R,Wheeler DC,Unwin RJ,Norman J

doi

10.1111/eci.12055

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

405-12

issue

4

eissn

0014-2972

issn

1365-2362

journal_volume

43

pub_type

杂志文章,评审
  • Effects of intravenous somatostatin and motilin on the blood glucose and hormonal response to oral glucose.

    abstract::Exogenous intravenous infusions of control saline, somatostatin, motilin and somatostatin and motilin together were compared in normal volunteers for their effects on the rise of blood glucose following 50 g oral glucose and for their effects on gastric emptying and plasma hormone concentrations. All regulatory peptid...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1982.tb02241.x

    authors: Long RG,Christofides ND,Fitzpatrick ML,O'Shaughnessy DJ,Bloom SR

    更新日期:1982-08-01 00:00:00

  • Physical laws of cholesterol gallstone fragmentation.

    abstract::Efficient fragmentation is the most important prerequisite for successful treatment of gallstones by extracorporeally induced shock waves. No data are available on the amount of energy necessary for stone disintegration and on the threshold energy below which no further fragmentation occurs. We therefore performed an ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1997.990648.x

    authors: Neubrand M,Greinwald I,Lobentanzer H,Paumgartner G,Hermeking H,Sauerbruch T

    更新日期:1997-03-01 00:00:00

  • Mechanisms of protein conservation during xylitol infusion after burn injury in rats: isotope kinetics and indirect calorimetry.

    abstract::In order to study the mechanisms by which nutrients influence post-trauma metabolism, Sprague-Dawley rats received a 25% full-thickness burn and were randomly assigned to receive 12.5 g kg-1 bodyweight (BW) per day amino acids (AA) only, AA and 14.7 g hydrous glucose kg-1 BW per day or AA and 14.7 g hydrous xylitol kg...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1991.tb01818.x

    authors: Georgieff M,Pscheidl E,Moldawer LL,Bistrian BR,Blackburn GL

    更新日期:1991-04-01 00:00:00

  • Effect of transdermal nitroglycerin on glucose-stimulated insulin release in healthy male volunteers.

    abstract:BACKGROUND:Morpholinosydnonimine, a nitric oxide (NO) donor, has been reported to inhibit insulin release in isolated pancreatic islets. We studied whether transdermal application of nitroglycerin, another NO donor widely used for angina prophylaxis, influenced glucose-stimulated insulin release in healthy, young, male...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2362.2000.00588.x

    authors: Kovacs P,Szilvassy Z,Hegyi P,Nemeth J,Ferdinandy P,Tosaki A

    更新日期:2000-01-01 00:00:00

  • Comprehensive geriatric assessment in older adults with cancer: Recommendations by the Italian Society of Geriatrics and Gerontology (SIGG).

    abstract:INTRODUCTION:Optimizing the approach to older adults with cancer is now a priority given the increasing frequency of new cancer diagnoses that are made in the older population. The comprehensive geriatric assessment (CGA) represents the gold-standard for (1) defining prognosis and ability to withstand cancer treatments...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13347

    authors: Fusco D,Ferrini A,Pasqualetti G,Giannotti C,Cesari M,Laudisio A,Ballestrero A,Scabini S,Odetti PR,Colloca GF,Monzani F,Nencioni A,Antonelli Incalzi R,Monacelli F,Oncogeriatrics Group of the Italian Society of Gerontology, Ger

    更新日期:2021-01-01 00:00:00

  • Effects of myocardial revascularization following acute coronary occlusion in pigs.

    abstract::In a comparative study in pigs the extent of myocardial infarction has been estimated following a temporary three hour coronary occlusion and following a permanent coronary ligation. For evaluation of the cellular injury the infarct size has been determined by a histochemical staining procedure and correlated with ser...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1976.tb00487.x

    authors: Althaus U,Janett J,Scholl E,Riedwyl H

    更新日期:1976-01-30 00:00:00

  • Pulse wave velocity and augmentation index, but not intima-media thickness, are early indicators of vascular damage in hypercholesterolemic children.

    abstract:BACKGROUND:Arterial stiffness is an important determinant of cardiovascular risk. It is associated with several cardiovascular risk factors, including hypertension, diabetes and cigarette smoking. However, there are conflicting data about the relationship between arterial stiffness and hypercholesterolemia. Furthermore...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02260.x

    authors: Riggio S,Mandraffino G,Sardo MA,Iudicello R,Camarda N,Imbalzano E,Alibrandi A,Saitta C,Carerj S,Arrigo T,Saitta A

    更新日期:2010-03-01 00:00:00

  • Suppression of the nocturnal free fatty acid levels by bedtime cornstarch in NIDDM subjects.

    abstract::The aim of the present study was to examine the effects of a large dose of slow-release carbohydrates (CHOs) at bedtime on the nocturnal glucose, insulin and free fatty acid (FFA) levels, and to assess the putative effects on morning fasting and post-prandial glucose levels in patients with moderately controlled non-i...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2362.1997.880639.x

    authors: Axelsen M,Lönnroth P,Arvidsson Lenner R,Smith U

    更新日期:1997-02-01 00:00:00

  • Prognostic value of RV isovolumic acceleration and tissue strain in moderate HFrEF.

    abstract:BACKGROUND:Right ventricular (RV) dysfunction in heart failure (HF) with reduced left ventricular ejection fraction (LVEF) is associated with a poorer prognosis. No studies to date have investigated the prognostic utility of RV isovolumic acceleration (IVA) measured at tissue Doppler imaging (TDI) in HF. RV strain inst...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12505

    authors: Sciatti E,Vizzardi E,Bonadei I,Curnis A,D'Aloia A,Metra M

    更新日期:2015-10-01 00:00:00

  • Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity.

    abstract::Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being elucidated. This study was carried out to investigate the relationship between serum leptin, plasma insulin, insulin sensitivity and free testosterone in 46 men ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1997.2270773.x

    authors: Vettor R,De Pergola G,Pagano C,Englaro P,Laudadio E,Giorgino F,Blum WF,Giorgino R,Federspil G

    更新日期:1997-12-01 00:00:00

  • Altered intestinal tight junctions' expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability.

    abstract:BACKGROUND:Increased intestinal permeability in cirrhosis exerts a pivotal role in the pathogenesis of spontaneous bacterial peritonitis and other complications of cirrhosis through promotion of systemic endotoxemia. This study was designed to investigate whether the expression of tight junction (TJ) proteins, which re...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2011.02609.x

    authors: Assimakopoulos SF,Tsamandas AC,Tsiaoussis GI,Karatza E,Triantos C,Vagianos CE,Spiliopoulou I,Kaltezioti V,Charonis A,Nikolopoulou VN,Scopa CD,Thomopoulos KC

    更新日期:2012-04-01 00:00:00

  • High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction.

    abstract:BACKGROUND:Several clinical trials have suggested that a metabolic cocktail of glucose-insulin-potassium (GIK) decreases mortality rates in patients with acute myocardial infarction (AMI). It has also been reported that Fas-mediated apoptosis plays an important role in ischaemic/reperfusion injury in the rat model. Thi...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.2005.01468.x

    authors: Zhang L,Zhang L,Li YH,Zhang HY,Chen ML,Gao MM,Hu AH,Yang HS,Yang HS

    更新日期:2005-03-01 00:00:00

  • Effect of glucagon immunoneutralization on the increase in urea synthesis after hysterectomy in rats.

    abstract::To study the effect of glucagon immunoneutralization on postoperative changes of urea synthesis, hysterectomized rats were given one injection of a specific high titre antibody against pancreatic glucagon 24 h before operation raising the plasma glucagon binding capacity to values 10-20 times higher than the plasma gl...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1993.tb00756.x

    authors: Heindorff H,Holst JJ,Almdal T,Vilstrup H

    更新日期:1993-03-01 00:00:00

  • The diagnosis of pulmonary tuberculosis by gaschromatographic detection of tuberculostearic acid using flame ionisation detectors.

    abstract::It has been shown that the detection of tuberculostearic acid (TBSA) with gas chromatography-mass-spectrometry provides a highly specific, sensitive and rapid method for the diagnosis of various forms of tuberculosis. However, the need for complex and expensive equipment prevented the more widespread use of this metho...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1994.tb00975.x

    authors: Herz A,Leichsenring M,Felten M,Oosthuizen OJ,Mayatepek E,Haas W,Bremer HJ

    更新日期:1994-02-01 00:00:00

  • Use of an artificial neural network to predict Graves' disease outcome within 2 years of drug withdrawal.

    abstract:BACKGROUND:Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, which can relapse in many patients after antithyroid drug treatment withdrawal. Several studies have been performed to predict the clinical course of GD in patients treated with antithyroid drugs, without conclusive results. The...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2004.01318.x

    authors: Orunesu E,Bagnasco M,Salmaso C,Altrinetti V,Bernasconi D,Del Monte P,Pesce G,Marugo M,Mela GS

    更新日期:2004-03-01 00:00:00

  • Gallbladder motility and cholesterol crystallization in bile from patients with pigment and cholesterol gallstones.

    abstract:BACKGROUND:Little is known about gallbladder motility in patients with black pigment stones when compared to cholesterol gallstone patients, or about their relationship to biliary composition, crystallization and stone characteristics. DESIGN:Fasting and postprandial gallbladder volumes were studied by ultrasonography...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2000.00639.x

    authors: Portincasa P,Di Ciaula A,Vendemiale G,Palmieri V,Moschetta A,Vanberge-Henegouwen GP,Palasciano G

    更新日期:2000-04-01 00:00:00

  • The type and time of menopause as decisive factors for bone mass changes.

    abstract:BACKGROUND:Early menopause, whether it be natural or surgical, is one of the established risk factors for osteoporosis. Surgical menopause, however, differs from natural menopause owing to the abrupt cessation of estrogen secretion. This study attempts to investigate the influence of menopause type on bone mineral dens...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1999.00541.x

    authors: Hadjidakis D,Kokkinakis E,Sfakianakis M,Raptis SA

    更新日期:1999-10-01 00:00:00

  • Polymorphonuclear leucocyte dysregulation in patients with gram-negative septicaemia assessed by flow cytometry.

    abstract::Flow cytometry was used to study phagocytic function and release of reactive oxygen intermediates (ROI) following phagocytosis by granulocytes in 14 patients (six female, eight male) with gram-negative septicaemia prior to, during, and after therapy compared with a group of healthy controls. Phagocytic capacity was as...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1995.tb01723.x

    authors: Wenisch C,Parschalk P,Hasenhündl M,Griesmacher A,Graninger W

    更新日期:1995-06-01 00:00:00

  • Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure.

    abstract::This study focuses on the role of platelet membrane glycoproteins and platelet-leucocyte adhesion in patients with sepsis and multiple organ failure (MOF). Specifically, the study raises the following issues: (1) the influence of sepsis and MOF on platelet activation as assessed by surface expression of platelet membr...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1995.tb01694.x

    authors: Gawaz M,Fateh-Moghadam S,Pilz G,Gurland HJ,Werdan K

    更新日期:1995-11-01 00:00:00

  • Discrepancies in the catabolic pathways of human and rat high-density lipoprotein apolipoprotein A-I in the rat.

    abstract::The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1985.tb00291.x

    authors: van't Hooft FM,van Tol A

    更新日期:1985-12-01 00:00:00

  • Mild portal endotoxaemia induces subacute hepatic inflammation and pancreatic beta-cell dysfunction in rats.

    abstract:BACKGROUND:Portal endotoxaemia has been speculated to be crucially involved in the pathogenesis of chronic hepatic inflammation, which is highly associated with the development of type 2 diabetes mellitus. This study tests whether portal endotoxaemia is a pathogenic link between chronic subacute hepatic inflammation an...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2008.01991.x

    authors: Hsieh PS,Chan JY,Shyu JF,Chen YT,Loh CH

    更新日期:2008-09-01 00:00:00

  • Association of high plasma antioxidant capacity with new lesion formation in carotid atherosclerosis: a prospective study.

    abstract:BACKGROUND:In atherosclerosis, both reductions and elevations in plasma levels of antioxidants have been reported. This study investigated total antioxidant capacity of plasma from subjects with atherosclerotic disease. MATERIALS AND METHODS:The study population consisted of 48 men with or without carotid atherosclero...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1998.00357.x

    authors: Reinisch N,Kiechl S,Mayr C,Schratzberger P,Dunzendorfer S,Kähler CM,Buratti T,Willeit J,Wiedermann CJ

    更新日期:1998-10-01 00:00:00

  • High-density lipoprotein from end-stage renal disease patients exhibits superior cardioprotection and increase in sphingosine-1-phosphate.

    abstract:BACKGROUND:Chronic kidney disease (CKD) exacerbates the risk of death due to cardiovascular disease (CVD). Modifications to blood lipid metabolism which manifest as increases in circulating triglycerides and reductions in high-density lipoprotein (HDL) cholesterol are thought to contribute to increased risk. In CKD pat...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12866

    authors: Brinck JW,Thomas A,Brulhart-Meynet MC,Lauer E,Frej C,Dahlbäck B,Stenvinkel P,James RW,Frias MA

    更新日期:2018-02-01 00:00:00

  • The glomerular sieving of pepsinogen A and C in man.

    abstract::Pepsinogen A (PGA) and pepsinogen C (PGC) are negatively charged, low molecular weight (LMW) proteins with a striking difference in renal handling: PGA (molecular weight 43,500 daltons) shows a high fractional excretion while the fractional excretion of PGC (molecular weight 40,500 daltons) is low, presumably due to t...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1989.tb00234.x

    authors: ten Kate RW,Pals G,Res JC,van Kamp GJ,Verheugt FW,Pronk JC,Donker AJ,Eriksson AW,Meuwissen SG

    更新日期:1989-06-01 00:00:00

  • Interactions of stress hormones on lipid and carbohydrate metabolism in man with partial insulin deficiency.

    abstract::The metabolic responses to 4-h infusions of adrenaline (3 micrograms kg-1 h-1) and cortisol (10 mg m-2 h-1 for 2 h followed by 5 mg m-2 h-1 for 2 h), separately and in combination, have been studied in six healthy subjects with concurrent somatostatin infusion (250 micrograms h-1). A combined infusion of adrenaline, c...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1986.tb01347.x

    authors: Pernet A,Johnston DG,Hammond V,Orskov H,Alberti KG

    更新日期:1986-08-01 00:00:00

  • Plasma vitamin D metabolites in a patient with sporadic hypophosphataemic osteomalacia (adult-onset type).

    abstract::Sporadic hypophosphataemic osteomalacia (adult-onset type) was demonstrated in a 40-year-old man on the basis of severe osteomalacia, hypophosphataemia, hyperphosphaturia and glycinuria. Plasma immunoreactive parathyroid hormone (iPTH) concentration was 9.3 ng prot./ml (normal range: 4-8 ng prot./ml). Plasma 25-hydrox...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1980.tb00047.x

    authors: Ulmann A,Bouchard P,Garabédian M,Bourdeau A,Witmer-Cournot G,Lacour B,Balsan S,Funck-Brentano JL

    更新日期:1980-10-01 00:00:00

  • On the mechanism of renin release during experimental myocardial ischaemia.

    abstract::An increase in plasma renin activity (PRA) following experimental coronary occlusion has previously been demonstrated in anaesthetized and conscious dogs. The purpose of the present study was to analyse the mechanism of this renin release. In two distinct models of myocardial ischaemia in anaesthetized dogs--i.e. occl...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1985.tb00288.x

    authors: Ertl G,Meesmann M,Kochsiek K

    更新日期:1985-12-01 00:00:00

  • Effect of nitroglycerin on pulmonary perfusion distribution and gas exchange of normal subjects.

    abstract::In eight healthy subjects we assessed the effects of 3 mg sublingual nitroglycerin on lung distribution of ventilation and perfusion using 133Xe (sitting, supine and lateral decubitus) and on alveolo-arterial O2 and CO2 partial pressure differences [(PAO2-PaO2), (PaCO2-PACO2)] and physiological dead space to tidal vol...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1982.tb00956.x

    authors: Nemery B,Vanderlinden-Mahieu S,Piret L,Brasseur L,Frans A

    更新日期:1982-04-01 00:00:00

  • The impact of chronic obstructive pulmonary disease on hospitalization and mortality in patients with heart failure.

    abstract:BACKGROUND:Several studies have suggested that chronic obstructive pulmonary disease (COPD) could be predictive of the prognosis in patients with heart failure (HF), but yield conflicting findings. Therefore, we conducted a meta-analysis to examine the impact of COPD on adverse outcomes in patients with HF. METHODS:We...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/eci.13402

    authors: Xu S,Ye Z,Ma J,Yuan T

    更新日期:2021-01-01 00:00:00

  • Increased iron levels and lipid peroxidation in a Mediterranean population of Spain.

    abstract:BACKGROUND:Many chronic diseases are adversely affected by elevated iron levels. It has been speculated that this relationship is mediated by increased oxidative stress, due to the ability of iron to generate reactive oxygen species. The aim of this study was to assess the relationship between elevated iron levels and ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12625

    authors: Aranda N,Fernandez-Cao JC,Tous M,Arija V

    更新日期:2016-06-01 00:00:00