Polymorphonuclear leucocyte dysregulation in patients with gram-negative septicaemia assessed by flow cytometry.

abstract：:Investigations were carried out to analyse the interactions of alpha 2-antagonists (yohimbine, idazoxan, SK & F-86,466) with human fat cell alpha 2-adrenoceptors. All the alpha 2-antagonists enhanced the lipolytic potencies of epinephrine with an order of potency: yohimbine greater than idazoxan greater than SK & F-86...

journal_title：European journal of clinical investigation

authors： Galitzky J,Taouis M,Berlan M,Rivière D,Garrigues M,Lafontan M

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:The intestinal mucosa of patients with inflammatory bowel diseases (IBD) characteristically shows a high degree of inflammation when compared to healthy subjects. This appears to be attributable to an imbalance in local reactivity of inflammatory cells. In the present study, we tested the hypothesis that imm...

journal_title：European journal of clinical investigation

authors： Kovarik JJ,Tillinger W,Hofer J,Hölzl MA,Heinzl H,Saemann MD,Zlabinger GJ

更新日期：2011-03-01 00:00:00

abstract：:We present a sensitive time-resolved fluorometric immunofunctional assay (TR-FIA) for direct quantitation of functional growth hormone-binding protein (GHBP), using an immunoassay kit for growth hormone (GH-DELFIA). In addition to the immobilized GH antibody, one monoclonal antibody against GHBP was used. This anti-GH...

journal_title：European journal of clinical investigation

authors： Fisker S,Frystyk J,Skriver L,Vestbo E,Ho KK,Orskov H

更新日期：1996-09-01 00:00:00

abstract：:The purpose of this work was to examine in an open, randomized parallel-group study whether an intervention programme directed towards hypercholesterolaemia, smoking and diabetes mellitus in treated hypertensive men was associated with less complex formation between low-density lipoprotein (LDL) and human arterial pro...

journal_title：European journal of clinical investigation

authors： Fagerberg B,Wiklund O,Agewall S,Camejo G,Wikstrand RJ

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Age is one the factors associated with poor prognosis in acute coronary syndromes (ACS) and elderly patients are a high-risk collective with few parameters for mid-term cardiovascular stratification. We aimed to assess the predictive value of ankle-brachial index (ABI) in patients (> 75 years) for 1-year mor...

journal_title：European journal of clinical investigation

authors： Cordero A,Morillas P,Bertomeu-González V,Quiles J,Soria F,Guindo J,Mazón P,Anguita M,Rodríguez-Padial L,González-Juanatey JR,Bertomeu-Martínez V,en nombre de los investigadores del estudio PAMISCA.

更新日期：2011-12-01 00:00:00

abstract：:The influence of insulin on lipolysis and glucose metabolism in abdominal adipose tissue was studied in situ with the microdialysis technique during a euglycaemic insulin clamp (1 mU kg-1 min-1) in nine cirrhotic patients and 10 controls. The cirrhotic patients displayed a 50% decrease in glucose utilization rate duri...

journal_title：European journal of clinical investigation

authors： Johansson U,Arner P,Bolinder J,Hagström-Toft E,Ungerstedt U,Eriksson LS

更新日期：1993-12-01 00:00:00

abstract：:In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and ...

journal_title：European journal of clinical investigation

authors： Edvinsson L,Ekman R,Hedner P,Valdemarsson S

更新日期：1990-02-01 00:00:00

abstract：:Both ulcerative colitis and Crohn's disease, the two major forms of inflammatory bowel diseases, are recognized, at the moment, as perplexing and challenging clinical entities, in which several molecules and cell types are implicated. Recent molecular evidence proposes the intestinal microvascular remodelling or angio...

journal_title：European journal of clinical investigation

authors： Pousa ID,Maté J,Gisbert JP

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:To date it is not known whether gastric juice vitamin C levels are influenced by Helicobacter pylori CagA(+) strains. The aim of the present study, therefore, was to study the impact of H. pylori CagA status on gastric juice vitamin C levels. MATERIALS AND METHODS:We studied 30 H. pylori(+) patients, and th...

journal_title：European journal of clinical investigation

authors： Rokkas T,Liatsos C,Petridou E,Papatheodorou G,Karameris A,Ladas SD,Raptis SA

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The detection of important immunocompetence-like features on endocrine steroid cells raises questions about direct intercellular communication between the adrenal and immune systems. This article summarizes our recent work and new data on immune-adrenal interactions. MATERIALS AND METHODS:RT-PCR and immunoh...

journal_title：European journal of clinical investigation

authors： Marx C,Bornstein SR,Wolkersdörfer GW

更新日期：2000-12-01 00:00:00

abstract：:The activity of delta-aminolaevulinate synthase was determined in the livers of fed female rats and was found to vary with the phase of their sexual cycle. The highest enzymic activity was obtained during preoestrus (38.0 +/- 3.2 nmol delta-aminolaevulinateg.g liver.-1 hour-1), the lowest during dioestrus (17.4 +/- 3....

journal_title：European journal of clinical investigation

authors： Held H,Przerwa M

更新日期：1976-09-10 00:00:00

abstract：BACKGROUND:Linear growth restriction is a unique feature of paediatric inflammatory bowel diseases (IBD), and reduced insulin-like growth factor (IGF-1) is a major determinant of short stature. We aimed to assess factors influencing somatic height in children suffering from IBD. MATERIALS AND METHODS:This was a retros...

journal_title：European journal of clinical investigation

authors： Chouliaras G,Mantzou A,Margoni D,Tsilifis N,Pervanidou P,Panayotou I,Kanaka-Gantenbein C,Chrousos GP,Roma-Giannikou E

更新日期：2018-08-01 00:00:00

abstract：:Serum prolactin levels were measured by radioimmunoassay in eighty patients (thirty-four males, forty-six females) with sarcoidosis before treatment. In twelve patients (15%) serum prolactin levels were more than two standard deviations above the mean of normal subjects. Hyperprolactinaemia was found most frequently (...

journal_title：European journal of clinical investigation

authors： Nakao K,Noma K,Sato B,Yano S,Yamamura Y,Tachibana T

更新日期：1978-02-01 00:00:00

abstract：:The stimulant action of branched-chain amino acids upon insulin release was examined in rat pancreatic islets incubated at physiological concentrations of D-glucose and L-glutamine. In the presence of the latter nutrients, L-leucine and L-isoleucine used together at a physiological concentration (0.25 mmol/l each) dou...

journal_title：European journal of clinical investigation

authors： Sener A,Malaisse WJ

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Plasma brain natriuretic peptide (BNP) is elevated in asymptomatic patients with various cardiac abnormalities. We tested the hypothesis that measuring BNP is useful for detecting asymptomatic patients with cardiac abnormalities who are not identified by conventional health check-up programmes. MATERIALS AN...

journal_title：European journal of clinical investigation

authors： Takase H,Toriyama T,Sugiura T,Takahashi A,Sugiyama M,Ohashi M,Ueda R,Dohi Y

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Minimal lipoprotein(a) [Lp(a)] target values are advocated for high-risk cardiovascular patients. We investigated the prognostic value of Lp(a) in the acute setting of patients with acute coronary syndromes (ACS). MATERIALS AND METHODS:Plasma levels of Lp(a) were collected at time of angiography from 1711 p...

journal_title：European journal of clinical investigation

authors： Gencer B,Rigamonti F,Nanchen D,Vuilleumier N,Kern I,Aghlmandi S,Klingenberg R,Räber L,Auer R,Carballo D,Carballo S,Heg D,Windecker S,Lüscher TF,Matter CM,Rodondi N,Mach F

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese...

journal_title：European journal of clinical investigation

authors： Fernández-Cao JC,Arija V,Aranda N,Basora J,Diez-Espino J,Estruch R,Fitó M,Corella D,Salas-Salvadó J

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The role of the pattern, quantity and site of insulin secretion in the tolerance to a glucose challenge is not fully evaluated in humans because it is difficult to obtain appropriate clinical models. DESIGN:To address this issue, we studied subjects with reduced pancreatic mass (hemipancreatectomized, HEMI)...

journal_title：European journal of clinical investigation

authors： Battezzati A,Zerbi A,Perseghin G,Caumo A,Terruzzi I,Di Carlo V,Luzi L

更新日期：2000-05-01 00:00:00

abstract：:Whether leptin levels are related to insulin sensitivity or subject to acute regulation by insulin is not known. In 12 obese [body mass index (BMI) = 34.0 +/- 1.5 kg m-2] and 12 lean (BMI = 22.2 +/- 0.6 kg m-2) non-diabetic subjects, plasma leptin concentrations were measured in the fasting state and during 2 hours of...

journal_title：European journal of clinical investigation

authors： Muscelli E,Camastra S,Masoni A,Baldi S,Sironi AM,Natali A,Ferrannini E

更新日期：1996-10-01 00:00:00

abstract：:Washed cells, from ascitic fluid, which contained predominantly polymorphonuclear leucocytes from casein treated donor mice, induced accelerated amyloid formation in untreated syngeneic recipient animals. A similar transfer model, with lymph node cell suspension, was ineffective. Amyloidogenesis was completely blocked...

journal_title：European journal of clinical investigation

authors： Kedar I,Ravid M

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:The tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), a physiological inhibitor of the proliferation of haematopoietic stem cells, is degraded by the angiotensin-I-converting enzyme (ACE). Whereas synthetic AcSDKP (Goralatide) protects normal mice from the haematological toxicity of chemotherapy, it has a lower ...

journal_title：European journal of clinical investigation

authors： Comte L,Lorgeot V,Bignon J,Volkov L,Dupuis F,Wdzieczak-Bakala J,Praloran V

更新日期：1998-10-01 00:00:00

abstract：:Type III hyperlipoproteinaemia (HLP) is usually associated with homozygosity for apolipoprotein (apo) E2 (arg-158-->Cys). We identified a 46-year-old white female with severe hyperlipidaemia and the heterozygous apo E3/2* phenotype. Typical clinical characteristics of type III HLP, i.e. palmar xanthomas (orange-yellow...

journal_title：European journal of clinical investigation

authors： Feussner G,Albanese M,Mann WA,Valencia A,Schuster H

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss of higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques (SPs) of aggregated amyloid-beta peptide (Abeta) and intracellular neurofibrillary tangles ...

journal_title：European journal of clinical investigation

authors： Yokota T,Mishra M,Akatsu H,Tani Y,Miyauchi T,Yamamoto T,Kosaka K,Nagai Y,Sawada T,Heese K

更新日期：2006-11-01 00:00:00

abstract：:The retardation of gastric emptying induced by infusion of triglyceride into the small intestine is associated with suppression of antral pressure waves and stimulation of basal pyloric tone in combination with phasic pressure waves localized to the pylorus. The role of nitric oxide (NO) mechanisms in the control of p...

journal_title：European journal of clinical investigation

authors： Sun WM,Doran S,Lingenfelser T,Hebbard GS,Morley JE,Dent J,Horowitz M

更新日期：1996-08-01 00:00:00

abstract：:Inheritance is a major determinant of increased sodium-lithium countertransport (SLC) activity in hypertension. However, hyperlipidaemia can also cause increased SLC activity in some individuals and it is difficult to distinguish this effect from the effect of hypertension. Erythrocyte SLC activity and its kinetic det...

journal_title：European journal of clinical investigation

authors： Rutherford PA,Thomas TH,Laker MF,Wilkinson R

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVES:EPB4.1 has been previously mapped to human chromosome 1p33-p34.2. In contradiction to this chromosomal location, we have mapped EPB4.1-1p36 by using fluorescence in situ hybridization and radiation hybrid mapping. In neuroblastomas, deletions of the telomeric end of chromosome 1 (1p36) are the most common ge...

journal_title：European journal of clinical investigation

authors： Huang S,Lichtenauer UD,Pack S,Wang C,Kim AC,Lutchman M,Koch CA,Torres-Cruz J,Huang SC,Benz EJ Jr,Christiansen H,Dockhorn-Dworniczak B,Poremba C,Vortmeyer AO,Chishti AH,Zhuang Z

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:To reveal detailed histopathological changes, virus distributions, immunologic properties and multi-omic features caused by SARS-CoV-2 in the explanted lungs from the world's first successful lung transplantation of a COVID-19 patient. MATERIALS AND METHODS:A total of 36 samples were collected from the lung...

journal_title：European journal of clinical investigation

authors： Chen XJ,Li K,Xu L,Yu YJ,Wu B,He YL,Zhao WE,Li D,Luan CX,Hu L,Wang J,Ding JJ,Yu YF,Li JX,Tan ZM,Liu XF,Wei D,Zhang ZH,Guo XJ,Su C,Hu ZB,Guo YS,Chen JY,Chen F

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of tumour formation in the anterior pituitary including adrenocorticotropic hormone (ACTH)-secreting tumours has been intensively studied, but the causative mechanisms involved in pituitary cell transformation and tumourigenesis remain unclear. MATERIALS AND METHODS:We searched PubMed on an...

journal_title：European journal of clinical investigation

authors： Dworakowska D,Grossman AB

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Expression of acinar cell-specific genes requires the pancreas transcription factor 1alpha (Ptf1alpha). p48 is the only component of Ptf1alpha that is involved in both acinar gene regulation and pancreatic ontogenesis. MATERIALS AND METHODS:To determine whether Ptf1alpha/p48 expression is regulated during p...

journal_title：European journal of clinical investigation

authors： Molero X,Adell T,Skoudy A,Padilla MA,Gómez JA,Chalaux E,Malagelada JR,Real FX

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Memory and cognitive functions are known to decline with advancing age. Studies have suggested that this may be due to a decrease in cholinergic function in the brains of elderly people. This review aims to assess studies documented in the literature dealing with the 'scopolamine model' of dementia. METHODS...

journal_title：European journal of clinical investigation

authors： Ebert U,Kirch W

更新日期：1998-11-01 00:00:00