Influence of insulin on glucose metabolism and lipolysis in adipose tissue in situ in patients with liver cirrhosis.

abstract：:Propranolol is used clinically as a prophylactic drug to prevent oesophageal variceal bleeding in cirrhotic patients with portal hypertension. Vascular hyporesponsiveness is a common characteristic of the portal hypertensive state. The present study aimed to investigate whether chronic administration of propranolol co...

journal_title：European journal of clinical investigation

authors： Huang YT,Lin HC,Tsai JF,Hou MC,Hong CY

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Diacylglycerols (DAGs), which are well-known components of insect lipophorins, have been recently recognized as a major glyceride of human high-density lipoprotein (HDL). Moreover, DAGs are good substrates for hepatic lipase and for the phospholipid transfer protein (PLTP). The present work was undertaken to...

journal_title：European journal of clinical investigation

authors： Lalanne F,Pruneta V,Bernard S,Ponsin G

更新日期：1999-02-01 00:00:00

abstract：:Increased activity of the Na+/H+ antiport may be a major abnormality in essential hypertension. The activity of this transport system was investigated in lymphocytes from 13 patients with untreated essential hypertension (Ht) and 13 normotensive control subjects (Nt) on an ad libitum (130-170 mmol d-1) NaCl intake. Fu...

journal_title：European journal of clinical investigation

authors： Göbel BO,Hoffmann G,Ruppert M,Stumpe KO,Vetter H,Siffert W,Düsing R

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) of marine origin are well recognized. Because of the shortness of marine resources vegetable oils are increasingly used in fish farming. The effects on human health of fish fed on vegetable oils are largely unknown. METHODS:In a dou...

journal_title：European journal of clinical investigation

authors： Seierstad SL,Seljeflot I,Johansen O,Hansen R,Haugen M,Rosenlund G,Frøyland L,Arnesen H

更新日期：2005-01-01 00:00:00

abstract：:The effects of dazoxiben on finger-blood flow in response to cold challenge were studied in normal subjects and patients with Raynaud's phenomenon. In normal subjects concentrations of TXB2 and 6-oxo-PGF1 alpha were measured in blood taken from dorsal hand veins following cold challenge. In a parallel multicentre stud...

journal_title：European journal of clinical investigation

authors： Tindall H,Tooke JE,Menys VC,Martin MF,Davies JA

更新日期：1985-02-01 00:00:00

abstract：:Activities of urea cycle enzymes were measured in the liver of starved rats 12 and 48 h after bilateral nephrectomy. Control experiments (sham-operated, starved rats) revealed that the activities of only two enzymes of the cycle are altered in the uraemic state: argininosuccinic acid synthetase (EC 6.3.4.5.), which is...

journal_title：European journal of clinical investigation

authors： Hoppe-Seyler G

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis ...

journal_title：European journal of clinical investigation

authors： Hong M,Park JW,Yang PS,Hwang I,Kim TH,Yu HT,Uhm JS,Joung B,Lee MH,Jee SH,Pak HN

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Reduced aortic distensibility predicts cardiovascular mortality in patients with type 2 diabetes and impaired glucose tolerance. Cardiac autonomic neuropathy is common in subjects with diabetes. However, the relationship between the elastic properties of the aorta and autonomic neuropathy has not been studie...

journal_title：European journal of clinical investigation

authors： Tentolouris N,Liatis S,Moyssakis I,Tsapogas P,Psallas M,Diakoumopoulou E,Voteas V,Katsilambros N

更新日期：2003-12-01 00:00:00

abstract：:The ATP-binding cassette transporter P-glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P-glycoprotein-expressing cell lines, the generation of P-glycoprotein knockout mice as well as studies in animals and humans contributed to a better understanding on the role...

journal_title：European journal of clinical investigation

authors： Fromm MF

更新日期：2003-11-01 00:00:00

abstract：:We evaluated the influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects (H): 40 lean [body mass index (BMI) < or = 25 kg m-2] H with normotensive parents (F-), 50 lean H with one or two parents hypertensive (F+), 30 obese HF- (BMI > or = 30 kg m-2) and 35 obese HF+. ...

journal_title：European journal of clinical investigation

authors： Grandi AM,Gaudio G,Fachinetti A,Zanzi P,Bianchi L,Ceriani L,Guasti L,Venco A

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To investigate alterations in endothelial nitric oxide synthase and inducible nitric oxide synthase mRNA expressions and nitric oxide release in the myocardium during ischaemia/reperfusion and determine whether these changes are ischaemic and/or reperfusion dependent. MATERIALS AND METHODS:Isolated rat heart...

journal_title：European journal of clinical investigation

authors： Pevni D,Frolkis I,Shapira I,Schwartz D,Schwartz IF,Chernichovski T,Lev-Ran O,Sharony R,Uretzky G

更新日期：2005-09-01 00:00:00

abstract：:The stimulant action of branched-chain amino acids upon insulin release was examined in rat pancreatic islets incubated at physiological concentrations of D-glucose and L-glutamine. In the presence of the latter nutrients, L-leucine and L-isoleucine used together at a physiological concentration (0.25 mmol/l each) dou...

journal_title：European journal of clinical investigation

authors： Sener A,Malaisse WJ

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Renal size and function reflect the health of the kidney. These parameters are associated with age, gender and body weight. The kidneys are also influenced by micro- and macrovascular diseases. Atherosclerotic markers and risk factors may influence the age-related changes of renal size and function. METHODS...

journal_title：European journal of clinical investigation

authors： Bax L,van der Graaf Y,Rabelink AJ,Algra A,Beutler JJ,Mali WP,SMART Study Group.

更新日期：2003-01-01 00:00:00

abstract：:The activity of delta-aminolaevulinate synthase was determined in the livers of fed female rats and was found to vary with the phase of their sexual cycle. The highest enzymic activity was obtained during preoestrus (38.0 +/- 3.2 nmol delta-aminolaevulinateg.g liver.-1 hour-1), the lowest during dioestrus (17.4 +/- 3....

journal_title：European journal of clinical investigation

authors： Held H,Przerwa M

更新日期：1976-09-10 00:00:00

abstract：BACKGROUND:Fat tissue is a common material for autologous transplantation in plastic and reconstructive surgery. Basic fibroblast growth factor (bFGF) ameliorates the fat graft survival. A transplantation model has shown the gene expression of matrix metalloproteinases (MMPs) to increase in adipocytes. The aim of this ...

journal_title：European journal of clinical investigation

authors： Kuramochi D,Unoki H,Bujo H,Kubota Y,Jiang M,Rikihisa N,Udagawa A,Yoshimoto S,Ichinose M,Saito Y

更新日期：2008-10-01 00:00:00

abstract：:Assuming that lithium is exclusively reabsorbed in the proximal tubules pari passu with sodium (Na), the lithium clearance (CLi) has been advanced as an index of filtrate delivery from the proximal tubules. In order to determine whether water loads in a range commonly given during clearance studies affect CLi, we stud...

journal_title：European journal of clinical investigation

authors： Boer WH,Koomans HA,Dorhout Mees EJ

更新日期：1988-06-01 00:00:00

abstract：:Pulmonary plasma kinetics of endogenous noradrenaline (NA) and tritium labelled L-noradrenaline (3H-NA) was studied in fifteen subjects during pulmonary arterial catheterization. Plasma NA concentration in femoral artery ranged from 0.5 to 8.2 nmol l-1, mean 2.3 nmol l-1, which was not significantly different from tha...

journal_title：European journal of clinical investigation

authors： Henriksen JH,Christensen NJ,Ring-Larsen H

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Many chronic diseases are adversely affected by elevated iron levels. It has been speculated that this relationship is mediated by increased oxidative stress, due to the ability of iron to generate reactive oxygen species. The aim of this study was to assess the relationship between elevated iron levels and ...

journal_title：European journal of clinical investigation

authors： Aranda N,Fernandez-Cao JC,Tous M,Arija V

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Inactivation of the tumour suppressor gene, p53, is the commonest genetic abnormality in human cancer. The study of the type of p53 mutation in a given tumour may provide prognostic information, clues to aetiology and become useful for therapeutics. MATERIALS AND METHODS:The molecular characterisation of p5...

journal_title：European journal of clinical investigation

authors： Tullo A,D'Erchia AM,Honda K,Kelly MD,Habib NA,Saccone C,Sbisà E

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Passive smoking is a well-known risk factor for both recurrent respiratory infections and disturbed lipid profile. Whether passive smoking problems are related to altered lymphocyte survival and its relation to altered lipid profile are the points of concern in this work. MATERIALS AND METHODS:Urinary cotin...

journal_title：European journal of clinical investigation

authors： El-Hodhod MA,Hamdy AM,Ahmed MB,Youssef SR,Aly SM

更新日期：2011-04-01 00:00:00

abstract：:A significant rise in serum concentrations of aluminum was demonstrated in 23 patients prophylactically treated with the antacid magaldrate, whereas no increase in serum aluminium was observed in another 26 critically ill patients, in whom the use of antacids was avoided. In parallel, urinary excretion rates of alumin...

journal_title：European journal of clinical investigation

authors： Ittel TH,Gladziwa U,Mück W,Sieberth HG

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) inhibition aggravates hepatic damage and encephalopathy and increases mortality in rats with thioacetamide (TAA)-induced acute liver failure. Statins enhance NO production but whether they influence the above parameters are unknown. MATERIAL AND METHODS:Male Sprague-Dawley rats were used. ...

journal_title：European journal of clinical investigation

authors： Huang HC,Chang CC,Wang SS,Chan CY,Lee FY,Chuang CL,Hsin IF,Teng TH,Lin HC,Lee SD

更新日期：2012-02-01 00:00:00

abstract：:We have applied flow cytometry to the detection of activated platelets in patients with coronary heart disease. Paraformaldehyde-fixed platelets were incubated with one of the following monoclonal antibodies (MAbs): Bx-1 (anti-GP Ib), AP-2 (anti-GP IIb-IIIa complex), VH10 (anti-GMP-140, a glycoprotein of the alpha-gra...

journal_title：European journal of clinical investigation

authors： Nurden AT,Macchi L,Bihour C,Durrieu C,Besse P,Nurden P

更新日期：1994-02-01 00:00:00

abstract：:Reduced glutathione (GSH) and activity of GSH related enzymes play a key role in defence against oxygen free radicals, whose production is, as known, raised in patients affected by diabetes mellitus, and at the same time they may contribute to the process of platelet aggregation. The purpose of this study was to evalu...

journal_title：European journal of clinical investigation

authors： Di Simplicio P,de Giorgio LA,Cardaioli E,Lecis R,Miceli M,Rossi R,Anichini R,Mian M,Seghieri G,Franconi F

更新日期：1995-09-01 00:00:00

abstract：:Serum testosterone, LH, and FSH before and after i.v. injection of LHRH were studied in ten acromegalic men and in twenty-one males after hypophysectomy. Controls were normal men matched according to age. Compared to the controls, basal FSH was slightly higher and basal LGH slightly lower in the untreated acromegalics...

journal_title：European journal of clinical investigation

authors： Lindholm J,Rasmussen P,Korsgaard O

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Recently, a new mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) encoding gene was first described (1793G > A). Only few reports have studied the prevalence of this polymorphism, especially in combination with other MTHFR mutations (677C > T, 1298A > C). METHODS:We cross-sectionally identifi...

journal_title：European journal of clinical investigation

authors： Winkelmayer WC,Sunder-Plassmann G,Huber A,Födinger M

更新日期：2004-09-01 00:00:00

abstract：:In eight healthy subjects we assessed the effects of 3 mg sublingual nitroglycerin on lung distribution of ventilation and perfusion using 133Xe (sitting, supine and lateral decubitus) and on alveolo-arterial O2 and CO2 partial pressure differences [(PAO2-PaO2), (PaCO2-PACO2)] and physiological dead space to tidal vol...

journal_title：European journal of clinical investigation

authors： Nemery B,Vanderlinden-Mahieu S,Piret L,Brasseur L,Frans A

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:During COVID-19 outbreak, oncological care has been reorganized. Patients with cancer have been reported to experience a more severe COVID-19 syndrome; moreover, there are concerns of a potential interference between immune checkpoint inhibitors (ICIs) and SARS-CoV-2 pathogenesis. MATERIALS AND METHODS:Betw...

journal_title：European journal of clinical investigation

authors： Tagliamento M,Spagnolo F,Poggio F,Soldato D,Conte B,Ruelle T,Barisione E,De Maria A,Del Mastro L,Di Maio M,Lambertini M

更新日期：2020-09-01 00:00:00

abstract：:Patients with primary biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver. However, most of the patients with PBC do not show peripheral blood T cells response to PDC. In this study, we re-evaluated the ...

journal_title：European journal of clinical investigation

authors： Akbar SM,Yamamoto K,Miyakawa H,Ninomiya T,Abe M,Hiasa Y,Masumoto T,Horiike N,Onji M

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Portal endotoxaemia has been speculated to be crucially involved in the pathogenesis of chronic hepatic inflammation, which is highly associated with the development of type 2 diabetes mellitus. This study tests whether portal endotoxaemia is a pathogenic link between chronic subacute hepatic inflammation an...

journal_title：European journal of clinical investigation

authors： Hsieh PS,Chan JY,Shyu JF,Chen YT,Loh CH

更新日期：2008-09-01 00:00:00