Abstract:
:We evaluated the influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects (H): 40 lean [body mass index (BMI) < or = 25 kg m-2] H with normotensive parents (F-), 50 lean H with one or two parents hypertensive (F+), 30 obese HF- (BMI > or = 30 kg m-2) and 35 obese HF+. The four groups were comparable in terms of age, sex and ambulatory blood pressure values. We evaluated glucose, insulin and C-peptide before and 30, 60, 90 and 120 min after an oral glucose load, insulin sensitivity index (ISI, fasting glucose/insulin ratio), fasting insulin/C-peptide ratio (I/Cp). Glucose, fasting and during test, and I/Cp were similar among the four groups; insulin and C-peptide, fasting and stimulated, were significantly higher and ISI lower in obese H than in lean H; at similar BMI, insulin and C-peptide were significantly higher in F+ than in F-. Insulin directly correlated with night-time blood pressure only in lean HF-. The correlation between insulin and BMI was significantly closer in F-than in F+. In conclusion, family history of hypertension appears to play a relevant role in insulin sensitivity in hypertensive subjects also in the presence of obesity.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Grandi AM,Gaudio G,Fachinetti A,Zanzi P,Bianchi L,Ceriani L,Guasti L,Venco Adoi
10.1046/j.1365-2362.1997.1700725.xsubject
Has Abstractpub_date
1997-09-01 00:00:00pages
774-9issue
9eissn
0014-2972issn
1365-2362journal_volume
27pub_type
杂志文章abstract::Activities of urea cycle enzymes were measured in the liver of starved rats 12 and 48 h after bilateral nephrectomy. Control experiments (sham-operated, starved rats) revealed that the activities of only two enzymes of the cycle are altered in the uraemic state: argininosuccinic acid synthetase (EC 6.3.4.5.), which is...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1975.tb00423.x
更新日期:1975-02-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-03-01 00:00:00
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更新日期:2008-03-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1977.tb01595.x
更新日期:1977-06-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.1996.510601.x
更新日期:1996-12-01 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1046/j.1365-2362.1997.900616.x
更新日期:1997-01-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1046/j.1365-2362.1998.00294.x
更新日期:1998-05-01 00:00:00
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更新日期:2003-11-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2018-06-01 00:00:00
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更新日期:2014-11-01 00:00:00
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更新日期:2021-01-01 00:00:00