Abnormal processing of antral gastrin in active duodenal ulcer disease.

Abstract:

:The concentrations of gastrins containing the active C-terminal tetrapeptide amide (mainly gastrin-34 and gastrin-17) and the N-terminal tridecapeptide fragment of gastrin-17 were measured in antral and duodenal biopsy specimens. The antral concentration of the N-terminal gastrin fragment was much higher in patients with active duodenal ulcer (33.4 +/- 6.8 nmol g-1, mean +/- SEM, n = 15) than in controls (5.6 +/- 2.9 nmol g-1, n = 10), patients with gastric ulcer (5.6 +/- 1.8 nmol g-1, n = 10) or patients with pernicious anaemia (7.7 +/- 2.5 nmol g-1, n = 6). No differences were found between the groups regarding gastrin-34 and gastrin-17 concentrations. In duodenal extracts, the N- and C-terminal gastrin concentrations were similar in all groups of patients. These data suggest that the posttranslational processing of antral gastrin is abnormal in patients with active duodenal ulcer disease.

journal_name

Eur J Clin Invest

authors

Petersen B,Andersen BN

doi

10.1111/j.1365-2362.1984.tb01126.x

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

214-8

issue

3

eissn

0014-2972

issn

1365-2362

journal_volume

14

pub_type

杂志文章
  • Insulin time-dependent effects on the leg exchange of glucose and amino acids in man.

    abstract::Time-dependent effects of insulin on the leg exchange of glucose, lactate, glycerol, free fatty acids (FFA) and amino acids were measured in relation to oxygen uptake (leg and whole body) and whole body glucose assimilation including oxidation. Seven healthy males (58 +/- 3 years of age) were investigated before opera...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1991.tb01390.x

    authors: Lundgren F,Edén E,Arfvidsson B,Lundholm K

    更新日期:1991-08-01 00:00:00

  • Hereditary deficiency of triosephosphate isomerase in four unrelated families.

    abstract::Triosephosphate isomerase deficiencies in erythrocytes and leucocytes were discovered in three unrelated families by a heterozygote screening of 3000 blood samples. In addition, a family found by Schroter et al. [not published] was studied. In these four families, only heterozygote carriers were found. In the family d...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1979.tb00923.x

    authors: Eber SW,Dünnwald M,Belohradsky BH,Bidlingmaier F,Schievelbein H,Weinmann HM,Krietsch KG

    更新日期:1979-06-01 00:00:00

  • Chloride-depletion metabolic alkalosis induces ECF volume depletion via internal fluid shifts in nephrectomized dogs.

    abstract::We recently reported that chloride-depletion metabolic alkalosis (CDMA) results in renal losses of Na, K, and water. In these studies we investigated whether CDMA (induced using a new model that avoids external changes in Na and water balance) was also associated with internal Na and water shifts out of the ECF. CDMA ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1991.tb01370.x

    authors: Garella S,Cohen JJ,Northrup TE

    更新日期:1991-06-01 00:00:00

  • Radioimmunoassay of prostaglandins Falpha, E1 and E2 in human plasma.

    abstract::Antibodies against prostaglandins (PG)F2alpha, E1 and E2 were obtained inrabbits immunized with respectively PG F2alpha, PG E1 and PG E2 conjugated to bovine serum albumin by carbodiimide. A radioimmunoassay capable of measuring 7 pg of PG Falpha, 2 pg of PG E2 and 14 pg of PG E1 in human peripheral plasma is describe...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1975.tb00459.x

    authors: Dray F,Charbonnel B,Maclouf J

    更新日期:1975-07-29 00:00:00

  • Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease.

    abstract:BACKGROUND:The pleiotropic cytokine osteopontin (OPN) is thought to be involved in the pathogenesis of atherosclerosis. However, the relationship between OPN and renal function, a cardiovascular risk factor itself, is not known. Therefore, we assessed the relationship between OPN plasma levels and renal function in pat...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02271.x

    authors: Lorenzen J,Krämer R,Kliem V,Bode-Boeger SM,Veldink H,Haller H,Fliser D,Kielstein JT

    更新日期:2010-04-01 00:00:00

  • H2 S donor improves heart function and vascular relaxation in diabetes.

    abstract:BACKGROUND AND AIMS:Diabetes dramatically increases the risk of cardiovascular complications and mortality. Hydrogen sulphide plays an important role in reducing oxidative stress. Several studies demonstrated that hydrogen sulphide protects islet beta cells from oxidant stress damage and decreases apoptosis. The aim of...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13354

    authors: Dorofeyeva N,Drachuk K,Rajkumar R,Sabnis O,Sagach V

    更新日期:2021-01-01 00:00:00

  • Lipoprotein(a) levels in relation to diabetic complications in patients with non-insulin-dependent diabetes.

    abstract::The relationship between serum levels of lipoprotein(a) Lp(a)) and the presence of chronic diabetic complications was studied in 194 patients with non-insulin-dependent diabetes mellitus (NIDDM; 75 males, 119 females; age 66 +/- 11 years; duration of diabetes, 11 (range 1-35) years). They were taking various treatment...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1993.tb00969.x

    authors: Heesen BJ,Wolffenbuttel BH,Leurs PB,Sels JP,Menheere PP,Jäckle-Beckers SE,Nieuwenhuijzen Kruseman AC

    更新日期:1993-09-01 00:00:00

  • Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy.

    abstract:BACKGROUND:Acute hyperglycaemia is known to increase gastrointestinal (GI) sensitivity in healthy subjects and may contribute to the increased prevalence of GI symptoms in diabetes patients. The aim of this study was to evaluate the effect of acute hyperglycaemia on perception and brain responses to painful visceral an...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02335.x

    authors: Frøkjaer JB,Søfteland E,Graversen C,Dimcevski G,Drewes AM

    更新日期:2010-10-01 00:00:00

  • Inflammation reduces HDL protection against primary cardiac risk.

    abstract:BACKGROUND:We recently reported high high-density lipoprotein (HDL) cholesterol as a predictor of recurrent risk in a subgroup of postinfarction patients defined by hypercholesterolemia and high C-reactive protein (CRP) levels. We investigated whether a similar high-risk subgroup might exist for incident cardiovascular...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02287.x

    authors: Corsetti JP,Gansevoort RT,Sparks CE,Dullaart RP

    更新日期:2010-06-01 00:00:00

  • Bile synthesis in rat models of inflammatory bowel diseases.

    abstract:BACKGROUND:A broad spectrum of hepatobiliary disorders are found in patients with inflammatory bowel diseases. The aim of the present work was to study interactions between gut and liver in experimental rat models of colitis and small bowel inflammation. MATERIALS AND METHODS:Colitis was induced either by trinitrobenz...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2007.01779.x

    authors: Dikopoulos N,Schmid RM,Bachem M,Buttenschoen K,Adler G,Chiang JY,Weidenbach H

    更新日期:2007-03-01 00:00:00

  • Identification of functional GRP-preferring bombesin receptors on human melanoma cells.

    abstract::Bombesin was originally isolated from amphibian skin, whereas its mammalian counterpart, gastrin-releasing peptide (GRP), was first identified in the nervous system of the gastrointestinal tract. Whether GRP is present in the human skin is not known. Bombesin-like peptides are also known to modulate growth. We therefo...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1997.900616.x

    authors: Pansky A,Peng F,Eberhard M,Baselgia L,Siegrist W,Baumann JB,Eberle AN,Beglinger C,Hildebrand P

    更新日期:1997-01-01 00:00:00

  • The relationship between renal volume and histology in obese and nonobese kidney donors.

    abstract:BACKGROUND:Obesity and related kidney diseases have become a global epidemic problem. However, the underlying pathogenesis of obesity-related renal diseases has not been clearly understood. In this study, we explored the link between renal volume (RV) determined by computed tomography (CT) and renal histology together ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12444

    authors: Tatar E,Sen S,Harman M,Kircelli F,Gungor O,Sarsik B,Asci G,Hoscoskun C,Basci A,Toz H

    更新日期:2015-06-01 00:00:00

  • Non-obese early onset diabetes mellitus in mutant cryptochrome1 transgenic mice.

    abstract:BACKGROUND:An earlier report described that transgenic mice ubiquitously expressing cryptochrome1 (CRY1) with a mutation in cystein414 (CRY1-AP Tg mice) display diabetes mellitus in addition to anomalous circadian behaviours. This study examined characteristic aspects of symptoms to clarify the diabetes type and pathog...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02359.x

    authors: Okano S,Hayasaka K,Igarashi M,Iwai H,Togashi Y,Nakajima O

    更新日期:2010-11-01 00:00:00

  • Plasma concentrations of endothelin in man: arterio-venous differences and release during venous stasis.

    abstract::Endothelin-1 is a recently described endothelium-derived vasoconstricting peptide. Plasma concentrations of immunoreactive (IR-) endothelin were investigated in six healthy young men applying a radioimmunoassay after extraction of endothelin from plasma. In venous plasma a mean concentration of 1.3 +/- 0.4 pmol l-1 wa...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1990.tb01892.x

    authors: Wagner OF,Nowotny P,Vierhapper H,Waldhäusl W

    更新日期:1990-10-01 00:00:00

  • Effects of insulin-like growth factor-I (IGF-I), insulin and combined IGF-I-insulin infusions on protein metabolism in dogs.

    abstract::The effect of infusions of recombinant insulin-like growth factor-I (IGF-I) (34, 103 or 688 pmol min-1 kg-1), insulin (3.4, 10.3 or 68.8 pmol min-1 kg-1) or combined infusions (34 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin or 103 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin) on protein metabolism, using an infusion of [1-14...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1994.tb01094.x

    authors: Umpleby AM,Shojaee-Moradie F,Thomason MJ,Kelly JM,Skottner A,Sonksen PH,Jones RH

    更新日期:1994-05-01 00:00:00

  • Do changes in gastro-intestinal blood flow explain high-altitude anorexia?

    abstract:BACKGROUND:Gastrointestinal symptoms are common on acute exposure to high-altitude (HA). Underlying mechanisms are not understood, but vascular shunting away from the gut could be responsible. Therefore, blood flow in the superior mesenteric artery (SMA) and hepatic portal vein (HPV) was examined at sea level (SL) and ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02324.x

    authors: Kalson NS,Hext F,Davies AJ,Chan CW,Wright AD,Imray CH,Birmingham Medical Research Expeditionary Society.

    更新日期:2010-08-01 00:00:00

  • Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population.

    abstract:BACKGROUND:Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2001.00851.x

    authors: MacLeod MJ,De Lange RP,Breen G,Meiklejohn D,Lemmon H,Clair DS

    更新日期:2001-07-01 00:00:00

  • Bone mass and biochemical parameters of bone metabolism in men with spinal osteoporosis.

    abstract::With advancing age both sexes have an increased incidence of osteoporotic fractures, although fractures are more common in women than in men. Whereas in women several potential risk factors have been identified, less is known about osteoporosis in men. A total of 27 Austrian men (mean age: 65 +/- 2 years) with atrauma...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1992.tb01503.x

    authors: Resch H,Pietschmann P,Woloszczuk W,Krexner E,Bernecker P,Willvonseder R

    更新日期:1992-08-01 00:00:00

  • Increased thromboxane formation in patients with antiphospholipid syndrome.

    abstract::Thirty-one patients with IgG antibodies to cardiolipin (ACLA) were studied to determine their in vivo formation of the platelet aggregating and vasoconstricting substance thromboxane A2 (TxA2) and the platelet inhibiting and vasodilating substance prostacyclin (PGI2). This was done by measurements in urine of their en...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1990.tb01908.x

    authors: Arfors L,Vesterqvist O,Johnsson H,Gréen K

    更新日期:1990-12-01 00:00:00

  • Fungaemia in haematological malignancies: SEIFEM-2015 survey.

    abstract:BACKGROUND:Fungal infections are still a relevant challenge for clinicians involved in the cure of patients with cancer. We retrospectively reviewed charts of hospitalized patients with haematological malignancies (HMs), in which a documented fungaemia was diagnosed between January 2011 and December 2015 at 28 adult an...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/eci.13083

    authors: Criscuolo M,Marchesi F,Candoni A,Cattaneo C,Nosari A,Veggia B,Verga L,Fracchiolla N,Vianelli N,Del Principe MI,Picardi M,Tumbarello M,Aversa F,Busca A,Pagano L,SEIFEM Group (Sorveglianza Epidemiologica Infezioni nelle Emopa

    更新日期:2019-05-01 00:00:00

  • Carotid intima-media thickness predicts carotid plaque development: Meta-analysis of seven studies involving 9341 participants.

    abstract:BACKGROUND:Carotid intima-media thickness and carotid plaque are well-established imaging markers used to capture different stages of the atherosclerotic disease process. We aimed to quantify to which extent carotid intima-media thickness predicts incidence of first-ever carotid plaque. MATERIALS AND METHODS:Two indep...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13217

    authors: Tschiderer L,Klingenschmid G,Seekircher L,Willeit P

    更新日期:2020-04-01 00:00:00

  • SOX6 rs7117858 polymorphism is associated with osteoporosis and obesity-related phenotypes.

    abstract:BACKGROUND:SOX6 has been recently proposed as a pleiotropic gene for obesity and osteoporosis. The aim of this study was to investigate whether the rs7117858 genetic variant in SOX6 was associated with bone mass assessed by quantitative ultrasound (QUS) and obesity-related measures in a population of young adults. MET...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13011

    authors: Correa-Rodríguez M,Schmidt-RioValle J,Rueda-Medina B

    更新日期:2018-10-01 00:00:00

  • Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.

    abstract::Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2004.01304.x

    authors: Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

    更新日期:2004-02-01 00:00:00

  • Prevalence and risk of gingival enlargement in patients treated with anticonvulsant drugs.

    abstract:BACKGROUND:Predictors of gingival enlargement in patients treated with anti-epileptics have not been previously assessed. This study was conducted to determine, with the aid of two indices that score vertical and horizontal overgrowth, the prevalence and risk factors for gingival enlargement in patients treated with ph...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2001.00869.x

    authors: Brunet L,Miranda J,Roset P,Berini L,Farré M,Mendieta C

    更新日期:2001-09-01 00:00:00

  • Hyperlipoprotein(a)aemia in nephrotic syndrome.

    abstract::The nephrotic syndrome is frequently associated with hyperlipidaemia and hyperfibrinogenaemia, leading to an increased coronary and thrombotic risk, which may be enhanced by high lipoprotein (a) [Lp(a)] concentrations. We followed the quantitative and qualitative pattern of plasma lipoproteins over 18 months in a pati...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1996.132283.x

    authors: Thiery J,Ivandic B,Bahlmann G,Walli AK,Seidel D

    更新日期:1996-04-01 00:00:00

  • Prevention of age-induced N(ε)-(carboxymethyl)lysine accumulation in the microvasculature.

    abstract:OBJECTIVE:N(ε)-(carboxymethyl)lysine (CML) is one of the major advanced glycation end products in both diabetics and nondiabetics. CML depositions in the microvasculature have recently been linked to the aetiology of acute myocardial infarction and cognitive impairment in Alzheimer's disease, possibly related to local ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12599

    authors: Fuijkschot WW,de Graaff HJ,Berishvili E,Kakabadze Z,Kupreishvili K,Meinster E,Houtman M,van Broekhoven A,Schalkwijk CG,Vonk AB,Krijnen PA,Smulders YM,Niessen HW

    更新日期:2016-04-01 00:00:00

  • Impact of centralized evaluation of bone marrow histology in systemic mastocytosis.

    abstract:BACKGROUND:Bone marrow (BM) histology/immunohistochemistry, KIT D816V mutation analysis and serum tryptase measurements are mandatory tools for diagnosis of systemic mastocytosis (SM). MATERIALS AND METHODS:Within the 'German Registry of Disorders on Eosinophils and Mast Cells', we identified 65 patients with SM who h...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12607

    authors: Jawhar M,Schwaab J,Horny HP,Sotlar K,Naumann N,Fabarius A,Valent P,Cross NC,Hofmann WK,Metzgeroth G,Reiter A

    更新日期:2016-05-01 00:00:00

  • The effects of administrations of HCl, NH4Cl and NH4HCO3 on the excretion of urea and ammonium in man.

    abstract::In man, HCl acidosis reduces blood and urinary urea with a concomitant rise in ammonium (NH4+) excretion. Significantly less urea is excreted following NH4Cl administration than following equimolar ingestion of NH4 HCO3. The results of these alterations in nitrogen excretion are interpreted in terms of bicarbonate uti...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2362.1977.tb01655.x

    authors: Fine A,Carlyle JE,Bourke E

    更新日期:1977-12-01 00:00:00

  • The effects of fish oil on gene expression in patients with polycystic ovary syndrome.

    abstract:BACKGROUND:This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS:This randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/eci.12893

    authors: Rahmani E,Jamilian M,Dadpour B,Nezami Z,Vahedpoor Z,Mahmoodi S,Aghadavod E,Taghizadeh M,Beiki Hassan A,Asemi Z

    更新日期:2018-03-01 00:00:00

  • Is the pattern of solid-phase gastric emptying different between genders?

    abstract:BACKGROUND:In the 13C-octanoate breath test, the shape of the 13CO2 excretion curve in the ascending portion reflects a pattern of gastric emptying (GE). Recent scintigraphic studies have revealed an overall delay in solid GE in fertile women compared with men. However, it remains unknown whether women have a different...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2006.01674.x

    authors: Sanaka M,Yamamoto T,Anjiki H,Osaki Y,Kuyama Y

    更新日期:2006-08-01 00:00:00