Abstract：
BACKGROUND:Fungal infections are still a relevant challenge for clinicians involved in the cure of patients with cancer. We retrospectively reviewed charts of hospitalized patients with haematological malignancies (HMs), in which a documented fungaemia was diagnosed between January 2011 and December 2015 at 28 adult and 6 paediatric Italian Hematology Departments. METHODS:During the study period, we recorded 215 fungal bloodstream infections (BSI). Microbiological analyses documented that BSI was due to moulds in 17 patients (8%) and yeasts in 198 patients (92%), being Candida spp identified in 174 patients (81%). RESULTS:Mortality rates were 70% and 39% for mould and yeast infections, respectively. Infection was the main cause of death in 53% of the mould and 18% of the yeast groups. At the multivariate analysis, ECOG ≥ 2 and septic shock were significantly associated with increased mortality, and removal of central venous catheter (CVC) survival was found to be protective. When considering patients with candidemia only, ECOG ≥ 2 and removal of CVC were statistically associated with overall mortality. CONCLUSIONS:Although candidemia represents a group of BSI with a good prognosis, its risk factors largely overlap with those identified for all fungaemias, even though the candidemia-related mortality is lower when compared to other fungal BSI. Management of fungal BSI is still a complex issue, in which both patients and disease characteristics should be focused to address a personalized approach.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Criscuolo M,Marchesi F,Candoni A,Cattaneo C,Nosari A,Veggia B,Verga L,Fracchiolla N,Vianelli N,Del Principe MI,Picardi M,Tumbarello M,Aversa F,Busca A,Pagano L,SEIFEM Group (Sorveglianza Epidemiologica Infezioni nelle Emopadoi
10.1111/eci.13083subject
Has Abstractpub_date
2019-05-01 00:00:00pages
e13083issue
5eissn
0014-2972issn
1365-2362journal_volume
49pub_type
杂志文章,多中心研究abstract：:To investigate the possible role of hepatitis C virus (HCV) in fulminant and subacute liver failure, we tested serum and liver of 13 patients undergoing orthotopic liver transplantation for the presence of HCV RNA. HCV RNA was detected in specimens from two out of eight patients negative for all viral markers with sus...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1992.tb01507.x
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:Stiff Person Syndrome (SPS) is a relatively rare but often overlooked autoimmune neurological disorder that targets antigens within the brain's inhibitory pathways resulting in incapacitating stiffness and spasms that impact on the patients' quality of life. Although a number of immunomodulating therapies si...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
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更新日期：2010-11-01 00:00:00
abstract：:Skeletal muscle glycogen deposition, and the activation of muscle glycogen synthase and pyruvate dehydrogenase during a hyerinsulinaemic euglycaemic clamp have been measured in six young and six elderly males matched for body mass index, physical activity and diet. Clamp glucose requirement (insulin, 0.1 U kg-1 h-1) w...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1988.tb01045.x
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abstract：:Pepsinogen A (PGA) and pepsinogen C (PGC) are negatively charged, low molecular weight (LMW) proteins with a striking difference in renal handling: PGA (molecular weight 43,500 daltons) shows a high fractional excretion while the fractional excretion of PGC (molecular weight 40,500 daltons) is low, presumably due to t...
journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
pub_type： 杂志文章,多中心研究
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1984.tb02095.x
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1978.tb00860.x
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1995.tb01541.x
更新日期：1995-03-01 00:00:00
abstract：:The ATP-binding cassette transporter P-glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P-glycoprotein-expressing cell lines, the generation of P-glycoprotein knockout mice as well as studies in animals and humans contributed to a better understanding on the role...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
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journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1990.tb01796.x
更新日期：1990-02-01 00:00:00
abstract：:Basal cyclic AMP levels in blood mononuclear cells from healthy human donors has been studied. A great variation in cyclic AMP content ranging from below 2 to 20 pmol 10(-6) cells was seen. Incubation of the cells at 37 degrees C mostly showed a time-dependent decrease in basal cyclic AMP, levelling off after 16 h. Wh...
journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1984.tb01179.x
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2362.1985.tb00160.x
更新日期：1985-06-01 00:00:00
abstract：:Deoxyribonucleic acid synthesis requires adequate cellular concentrations of the four deoxyribonucleoside triphosphates. Using a sensitive enzymic assay, we have measured the concentrations (pools) of these compounds in human bone marrow cells and in lymphocytes. The mean concentrations (pmol/10(6) cells) in normal hu...
journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1975.tb00446.x
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abstract：BACKGROUND:Blocking the renin-angiotensin system (RAS) with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors protects against renal injury in patients with chronic kidney disease (CKD). The aim of this study was to compare the chronic effects of telmisartan and enalapril on proteinuria, urinary...
journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1994.tb02062.x
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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doi：10.1046/j.1365-2362.2002.01005.x
更新日期：2002-06-01 00:00:00
abstract：:The effects of glucose on the cytoplasmic Ca2+ concentration (Ca2+i) regulating insulin release were investigated using pancreatic beta-cells representative for the normal and diabetic situations. Increase of the glucose concentration resulted in a slight lowering of Ca2+i followed by a rise, often manifested as high ...
journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1990.tb01771.x
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abstract：:Obesity is a multifactorial disease with a marked genetic component. The situation is further complicated by the heterogeneity of obesity demonstrated by the topographical distribution of body fat, e.g. upper body (central) and lower body (gluteal) obesity. Furthermore, the distribution of fat shows a stronger heritab...
journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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doi：10.1046/j.1365-2362.1997.900616.x
更新日期：1997-01-01 00:00:00
abstract：:To study further the role of hepatic cholesterol synthesis in patients with gallstones, the activity of the rate-limiting step in cholesterogenesis, hydroxymethyl glutaryl co-enzyme A reductase (HMGCoAR), was measured in operative wedge liver biopsies from ten patients with untreated cholesterol gallstones, six with p...
journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1980.tb00040.x
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abstract：:A kindred in which several members have otherwise typical acute intermittent porphyria but normal erythrocyte uroporphyrinogen-I-synthase activity has been described from Finland. We studied two porphyric members of this kindred, two patients with typical acute intermittent porphyria, and two healthy controls using th...
journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1985.tb00185.x
更新日期：1985-10-01 00:00:00
abstract：:As in women receiving oestrogens the administration of 17beta-oestradiol to ovariectomized female rats caused a rise in fasting plasma triglycerides and a fall in plasma glucose. Progesterone, on the other hand, had no significant effects. In the oestradiol treated rats, the portal vein basal insulin levels were sligh...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1977.tb01595.x
更新日期：1977-06-01 00:00:00
