Effect of nitroglycerin on pulmonary perfusion distribution and gas exchange of normal subjects.

Abstract:

:In eight healthy subjects we assessed the effects of 3 mg sublingual nitroglycerin on lung distribution of ventilation and perfusion using 133Xe (sitting, supine and lateral decubitus) and on alveolo-arterial O2 and CO2 partial pressure differences [(PAO2-PaO2), (PaCO2-PACO2)] and physiological dead space to tidal volume ratio (VD/VT) (sitting). In all studied positions, nitroglycerin induced a significant decrease in uppermost perfusion indices, and a significant increase in dependent perfusion indices, without changing the distribution of ventilation. Significant increases in (PaCO2-PACO2) and VD/VT were observed up to 60 min after nitroglycerin. No changes in (PAO2-PaO2) occurred, except for a transient decrease due to transient hyperventilation following nitroglycerin. The redistribution of pulmonary perfusion after nitroglycerin may be attributed to the passive effects of lowered pulmonary vascular pressures, and to possible action on extra-alveolar vessels. The evolution of the indices of pulmonary gas exchange is compatible with the observed redistribution of ventilation/perfusion relationships.

journal_name

Eur J Clin Invest

authors

Nemery B,Vanderlinden-Mahieu S,Piret L,Brasseur L,Frans A

doi

10.1111/j.1365-2362.1982.tb00956.x

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

177-84

issue

2

eissn

0014-2972

issn

1365-2362

journal_volume

12

pub_type

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