当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL INVESTIGATION期刊下所有文献 > Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis.

Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis.

Abstract：

BACKGROUND:HFE knockout mice (C57BL/6 x 129/Ola strain) mimic the functional aberrations of human hereditary haemochromatosis (HH) in short-term experiments. The present study investigates functional and morphological long-term changes. METHODS:HFE(o/o), HFE(+/o) and HFE(+/+) mice were maintained on iron-rich and control diets for 2 weeks, 3, 12 and 18 months. Light microscopic tissue iron distribution, pathomorphological alterations, tissue iron content and oxidative stress were analysed in liver, pancreas, spleen, gastrointestinal tract, kidneys and myocardium. Additionally, duodenal 59Fe absorption and 59Fe whole body loss were measured. RESULTS:Iron distribution between organs and microscopic iron deposition in the tissues resembled the patterns described in HH. After 3 months of iron-rich feeding duodenal 59Fe absorption decreased to approximately 15% of iron-adequate controls but remained about twice as high in HFE(o/o) as in HFE(+/+) mice. Hepatic iron concentrations reached only half the values known to induce hepatic fibrosis in rats and humans, while whole body 59Fe loss was about twice as high. Consequently no hepatic fibrosis developed, although massive hepatocellular iron deposition and indication for oxidative stress were observed. CONCLUSION:C57BL/6 x 129/O1a HFE(o/o) mice mimic HH iron distribution and the regulation of intestinal iron absorption after long-term feeding. However, characteristic morphological late changes in untreated HH are not modelled.

journal_name

Eur J Clin Invest

journal_title

European journal of clinical investigation

authors

Lebeau A,Frank J,Biesalski HK,Weiss G,Srai SK,Simpson RJ,McKie AT,Bahram S,Gilfillan S,Schümann K

doi

10.1046/j.1365-2362.2002.01026.x

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

603-12

issue

8

eissn

0014-2972

issn

1365-2362

pii

1026

journal_volume

32

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION文献大全
  • The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts.

    abstract：:Hyperthyroidism is associated with an increase in both osteoblast and osteoclast activity. We have previously shown that, in vitro, osteoclasts do not respond directly to tri-iodothyronine to increase bone resorption but that the effect is mediated by another bone cell, probably the osteoblast. To investigate this iss...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1996.160289.x

    authors： Allain TJ,Yen PM,Flanagan AM,McGregor AM

    更新日期：1996-05-01 00:00:00

  • Determination of heparin-induced IgG antibody in heparin-induced thrombocytopenia type II.

    abstract：BACKGROUND:Heparin-induced thrombocytopenia is a relatively uncommon but severe side-effect of heparin therapy. Heparin-induced IgG antibody has been elucidated to be the main isotype and the most pathogenic antibody in the pathophysiology. As affected patients are at high risk of developing thrombotic events, confirma...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1999.00433.x

    authors： Wang LC,Huhle G,Malsch R,Hoffmann V,Song XL,Harenberg J

    更新日期：1999-03-01 00:00:00

  • Non-obese early onset diabetes mellitus in mutant cryptochrome1 transgenic mice.

    abstract：BACKGROUND:An earlier report described that transgenic mice ubiquitously expressing cryptochrome1 (CRY1) with a mutation in cystein414 (CRY1-AP Tg mice) display diabetes mellitus in addition to anomalous circadian behaviours. This study examined characteristic aspects of symptoms to clarify the diabetes type and pathog...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02359.x

    authors： Okano S,Hayasaka K,Igarashi M,Iwai H,Togashi Y,Nakajima O

    更新日期：2010-11-01 00:00:00

  • TGF-beta1 overexpression in the transversalis fascia of patients with direct inguinal hernia.

    abstract：BACKGROUND:The aetiology of inguinal hernia includes changes in collagen turnover and metalloproteinase (MMP) expression, and direct hernia has been linked to increased MMP-2 expression. Since transforming growth factor beta1 (TGFbeta1) plays a role in tissue remodelling, this growth factor could directly affect metall...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2007.01816.x

    authors： Pascual G,Corrales C,Gómez-Gil V,Buján J,Bellón JM

    更新日期：2007-06-01 00:00:00

  • Increased rate of lumbar spondylolisthesis in rheumatoid arthritis: A case-control study.

    abstract：OBJECTIVE:The aim of this study was to compare the prevalence of lumbar spondylolisthesis (SPL) in patients suffering from low back pain (LBP) with or without rheumatoid arthritis (RA) and to identify potential factors associated with SPL in patients with RA. METHODS:We performed a case-control study. Cases and contro...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12991

    authors： Hagege B,Tubach F,Alfaiate T,Forien M,Dieudé P,Ottaviani S

    更新日期：2018-09-01 00:00:00

  • Chronic administration of propranolol improves vascular contractile responsiveness in portal hypertensive rats.

    abstract：:Propranolol is used clinically as a prophylactic drug to prevent oesophageal variceal bleeding in cirrhotic patients with portal hypertension. Vascular hyporesponsiveness is a common characteristic of the portal hypertensive state. The present study aimed to investigate whether chronic administration of propranolol co...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1997.1590708.x

    authors： Huang YT,Lin HC,Tsai JF,Hou MC,Hong CY

    更新日期：1997-07-01 00:00:00

  • Prevalence and risk factors of fatty liver in Portuguese adults.

    abstract：BACKGROUND:Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. MATERIALS AND...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13235

    authors： Leitão J,Carvalhana S,Cochicho J,Silva AP,Velasco F,Medeiros I,Alves AC,Bourbon M,Oliveiros B,Rodrigues V,Sousa R,Sampaio F,Carvalho A,Cortez-Pinto H

    更新日期：2020-06-01 00:00:00

  • Relative down-regulation of apoptosis and autophagy genes in colorectal cancer.

    abstract：BACKGROUND:Cancer is often caused by disturbance in the regulation and/or execution of programmed cell death (PCD, including apoptosis and autophagy). Our aim was to investigate these two pathways simultaneously in the same samples to understand further the pathological roles of PCDs in colorectal cancer. MATERIALS AN...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02383.x

    authors： Chang YT,Tseng HC,Huang CC,Chen YP,Chiang HC,Chou FP

    更新日期：2011-01-01 00:00:00

  • Bile synthesis in rat models of inflammatory bowel diseases.

    abstract：BACKGROUND:A broad spectrum of hepatobiliary disorders are found in patients with inflammatory bowel diseases. The aim of the present work was to study interactions between gut and liver in experimental rat models of colitis and small bowel inflammation. MATERIALS AND METHODS:Colitis was induced either by trinitrobenz...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2007.01779.x

    authors： Dikopoulos N,Schmid RM,Bachem M,Buttenschoen K,Adler G,Chiang JY,Weidenbach H

    更新日期：2007-03-01 00:00:00

  • Implementation of proteomic biomarkers: making it work.

    abstract：:While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implement...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2012.02674.x

    authors： Mischak H,Ioannidis JP,Argiles A,Attwood TK,Bongcam-Rudloff E,Broenstrup M,Charonis A,Chrousos GP,Delles C,Dominiczak A,Dylag T,Ehrich J,Egido J,Findeisen P,Jankowski J,Johnson RW,Julien BA,Lankisch T,Leung HY,Maahs

    更新日期：2012-09-01 00:00:00

  • Left ventricular and cardiac autonomic function in survivors of testicular cancer.

    abstract：BACKGROUND:Following cisplatin-based chemotherapy, survivors of testicular cancer have a high prevalence of cardiovascular risk factors and an increased risk of cardiovascular disease. Cardiac function has not been extensively studied and no comparisons have been made with men from the general population. DESIGN:Left ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2005.01460.x

    authors： Nuver J,Smit AJ,Sleijfer DT,van Gessel AI,van Roon AM,van der Meer J,van den Berg MP,Hoekstra HJ,Sluiter WJ,Gietema JA

    更新日期：2005-02-01 00:00:00

  • Lipid and carbohydrate metabolism in uraemia.

    abstract：:Lipid and carbohydrate metabolism variables were studied in twenty-eight patients with chronic renal failure (mean GFR 7.7 +/- 2.5 ml/min) and uraemic symptoms. 71% of the patients had hypertriglyceridaemia (greater than or equal to 2.2 mmol/l). Total serum cholesterol was normal while VLDL cholesterol was high and al...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1979.tb00886.x

    authors： Attman PO,Gustafson A

    更新日期：1979-08-01 00:00:00

  • Cellular immune-endocrine interaction in adrenocortical tissues.

    abstract：BACKGROUND:The detection of important immunocompetence-like features on endocrine steroid cells raises questions about direct intercellular communication between the adrenal and immune systems. This article summarizes our recent work and new data on immune-adrenal interactions. MATERIALS AND METHODS:RT-PCR and immunoh...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2000.0300s3001.x

    authors： Marx C,Bornstein SR,Wolkersdörfer GW

    更新日期：2000-12-01 00:00:00

  • Bacterial infections in cirrhosis: role of proton pump inhibitors and intestinal permeability.

    abstract：BACKGROUND:  Cirrhotic patients are at considerable risk for bacterial infections, possibly through increased intestinal permeability and bacterial overgrowth. Proton pump inhibitors (PPIs) may increase infection risk. We aimed to explore the potential association between PPI use and bacterial infection risk in cirrhot...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2011.02643.x

    authors： van Vlerken LG,Huisman EJ,van Hoek B,Renooij W,de Rooij FW,Siersema PD,van Erpecum KJ

    更新日期：2012-07-01 00:00:00

  • Scopolamine model of dementia: electroencephalogram findings and cognitive performance.

    abstract：BACKGROUND:Memory and cognitive functions are known to decline with advancing age. Studies have suggested that this may be due to a decrease in cholinergic function in the brains of elderly people. This review aims to assess studies documented in the literature dealing with the 'scopolamine model' of dementia. METHODS...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2362.1998.00393.x

    authors： Ebert U,Kirch W

    更新日期：1998-11-01 00:00:00

  • Is the renal kallikrein system relevant to sodium sensitivity in patients with essential hypertension.

    abstract：:In twenty-five outpatients with essential hypertension, the relevance of renal kallikrein excretion for inter-individual differences in the blood pressure response to changes in dietary sodium intake was investigated. The patients were studied during 2 weeks of high (300 mmol) and 2 weeks of low (50-100 mmol) sodium i...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1985.tb00160.x

    authors： Koolen MI,Daha MR,van Brummelen P

    更新日期：1985-06-01 00:00:00

  • Assessment of the left ventricular diastolic reserve in essential hypertension: the acute saline load test.

    abstract：OBJECTIVE:The aim of this study was to evaluate the significance of the development of a restrictive response to an acute saline load, defined as an increase in the ratio of peak early to peak late diastolic transmitral flow velocity (E/A ratio) associated with a decrease in the deceleration time, in patients with mild...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2001.00873.x

    authors： Triposkiadis F,Moyssakis I,Makris T,Hatzizaharias A,Hadjinikolaou L,Kyriakidis M

    更新日期：2001-08-01 00:00:00

  • Soluble TWEAK plasma levels increase after renal transplantation and associate with the improvement of endothelial function.

    abstract：BACKGROUND:Soluble TWEAK (sTWEAK) and asymmetric dimethyl arginine (ADMA) concentrations have been associated with endothelial function in patients with chronic kidney disease (CKD). We tested the hypothesis that the improvement in endothelial function observed after renal transplantation is directly linked to the norm...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12166

    authors： Yilmaz MI,Sonmez A,Saglam M,Yaman H,Unal HU,Gok M,Cetinkaya H,Eyileten T,Oguz Y,Sari S,Yildirim AO,Vural A,Carrero JJ,Blanco-Colio LM

    更新日期：2013-12-01 00:00:00

  • Fast, simple and highly sensitive double-rounded polymerase chain reaction assay to detect medically relevant fungi in dermatological specimens.

    abstract：BACKGROUND:Early detection of fungal infection is essential for beginning of prompt and specific therapy. In this study we describe a rapid and sensitive procedure to detect, by polymerase chain reaction (PCR) assays, a wide range of medically important opportunistic and pathogenic fungi in dermal specimens from dermat...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2000.00659.x

    authors： Turin L,Riva F,Galbiati G,Cainelli T

    更新日期：2000-06-01 00:00:00

  • Progressive renovascular hypertension by increasing aortic constriction in rats.

    abstract：:Moderate and progressive hypertension was produced experimentally in rats by progressive aortic constriction. The progression of the stenosis was assessed by the differences of pressure across the stenosis. Haemodynamic studies were performed 15, 30 and 60 days after the ligature was placed or after sham operation. Fi...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1984.tb01178.x

    authors： Martín-Paredero V,Casado S,López-Novoa JM

    更新日期：1984-08-01 00:00:00

  • Four peptide hormones' specific decrease (up to 97%) of human prostate carcinoma cells.

    abstract：BACKGROUND:Mortality from prostate cancer remains a significant problem with current treatment(s), with an expected 30 350 deaths from prostate cancer in 2005. Long-acting natriuretic peptide, vessel dilator, kaliuretic peptide and atrial natriuretic peptide have significant anticancer effects in breast and pancreatic ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2005.01569.x

    authors： Vesely BA,Alli AA,Song SJ,Gower WR Jr,Sanchez-Ramos J,Vesely DL

    更新日期：2005-11-01 00:00:00

  • Multifactorial treatment of hypertensive men at high cardiovascular risk and low-density lipoprotein cholesterol affinity to human arterial proteoglycans.

    abstract：:The purpose of this work was to examine in an open, randomized parallel-group study whether an intervention programme directed towards hypercholesterolaemia, smoking and diabetes mellitus in treated hypertensive men was associated with less complex formation between low-density lipoprotein (LDL) and human arterial pro...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2362.1996.2030543.x

    authors： Fagerberg B,Wiklund O,Agewall S,Camejo G,Wikstrand RJ

    更新日期：1996-11-01 00:00:00

  • Strategies used by individuals to prevent burnout.

    abstract：BACKGROUND:Burnout represents a syndrome that is related to demanding job characteristics combined with the absence of resources or motivational job characteristics. The aim of this position study was to present strategies that individuals use to minimize burnout and its unfavourable effects. MATERIALS AND METHODS:The...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/eci.12494

    authors： Demerouti E

    更新日期：2015-10-01 00:00:00

  • Uptake of triglyceride fatty acids in adipose tissue in vivo in man.

    abstract：:Currently available information on adipose tissue metabolism in man is mainly based on studies in vitro. In the present work adipose tissue lipid uptake was studied in vivo in man. 100 g glucose and 120 g milk fat with 10 microCi U-14C oleic acid were given in the overnight fasting state to eight women and 2 h after a...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1990.tb02263.x

    authors： Mårin P,Rebuffé-Scrive M,Björntorp P

    更新日期：1990-04-01 00:00:00

  • The effect of captopril on catecholamines, renin activity, angiotensin II and aldosterone in plasma during physical exercise in hypertensive patients.

    abstract：:The studies were designed to explore the effect of the converting enzyme inhibitor captopril on the activity of the sympathetic nervous system during basal conditions and following graded physical exercise in patients with essential hypertension. Seven males and two females, aged 36-59 years, were hospitalized under m...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1981.tb02001.x

    authors： Manhem P,Bramnert M,Hulthén UL,Hökfelt B

    更新日期：1981-10-01 00:00:00

  • Capillary permeability in healthy males with different insulin response to glucose.

    abstract：:The capillary permeability in human skeletal muscle, expressed as capillary diffusion capacity (CDC) for 51Cr-EDTA, was determined during exercise with a local clearance method in two groups of healthy male subjects: a younger group with a mean age of 30 years and an older one with a mean age of 58 years. The main fin...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1979.tb00897.x

    authors： Berglund B,Efendić S,Strandell T,Luft R

    更新日期：1979-10-01 00:00:00

  • Potential clinical applications of siRNA technique: benefits and limitations.

    abstract：BACKGROUND:RNA interference (RNAi) has become the method of choice for researchers wishing to target specific genes for silencing and has provided immense potential as therapeutic tools. This narrative review article aimed to understand potential benefits and limitations of RNAi technique for clinical application and i...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.2010.02400.x

    authors： Chen SH,Zhaori G

    更新日期：2011-02-01 00:00:00

  • Pulse pressure and prognosis in patients with heart failure with reduced ejection fraction.

    abstract：BACKGROUND:A high pulse pressure (PP) is associated with adverse cardiovascular (CV) outcomes; however, this relationship may be reversed in patients with heart failure with reduced ejection fraction (HFREF). METHODS:Patients from the WARCEF trial with left ventricular ejection fraction ≤35% were included. PP was divi...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13092

    authors： Shah N,Qian M,Di Tullio MR,Graham S,Mann DL,Sacco RL,Lip GYH,Labovitz AJ,Ponikowski P,Lok DJ,Anker SD,Teerlink JR,Thompson JLP,Homma S,Freudenberger RS,WARCEF Investigators.

    更新日期：2019-02-23 00:00:00

  • Polymorphisms of the endothelial nitric oxide synthase gene - no consistent association with myocardial infarction in the ECTIM study.

    abstract：BACKGROUND:Our aim in the present study was to determine whether endothelial NO synthase gene (ecNOS) polymorphisms are associated with myocardial infarction (MI). METHODS:Forty chromosomes from patients with MI were screened for polymorphisms of the ecNOS gene using polymerase chain reaction-single-strand conformatio...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1999.00451.x

    authors： Poirier O,Mao C,Mallet C,Nicaud V,Herrmann SM,Evans A,Ruidavets JB,Arveiler D,Luc G,Tiret L,Soubrier F,Cambien F

    更新日期：1999-04-01 00:00:00

  • Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.

    abstract：:Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2004.01304.x

    authors： Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

    更新日期：2004-02-01 00:00:00