Abstract：
BACKGROUND:A high pulse pressure (PP) is associated with adverse cardiovascular (CV) outcomes; however, this relationship may be reversed in patients with heart failure with reduced ejection fraction (HFREF). METHODS:Patients from the WARCEF trial with left ventricular ejection fraction ≤35% were included. PP was divided into tertiles: ≤42, 42-54 and >54 mm Hg. Age and ejection fraction adjusted Kaplan-Meier curves were generated to evaluate the relationship between PP and outcomes [mortality, CV mortality, stroke and HF hospitalizations (HFH)]. Cox proportional hazards models were created incorporating PP as a continuous variable. The interaction of PP with New York Heart Association (NYHA) functional class was examined. Linear and restricted cubic splines were used to study nonlinear association between PP and outcomes. RESULTS:We included 2,299 patients with a mean(±SD) follow-up of 3.5 ± 1.8 years. The lowest tertile of PP (≤42 mm Hg) was associated with significantly higher CV mortality and HFH. Cox proportional hazards models showed a reduction in CV death and HFH with higher PP, with adjusted hazard ratios (HR) of 0.91 (P = 0.02) and 0.93 (P = 0.04) per 10 mm Hg increase in PP. This relationship was more pronounced in subjects with NYHA functional class III-IV. Spline analysis showed that the association between PP and CV mortality and HFH was only seen at PP values lower than 40 mm Hg. CONCLUSIONS:In patients with advanced HFREF, a low PP (<40 mm Hg) portends a worse prognosis, whereas a high PP (>50 mm Hg) predicts a relatively favourable prognosis.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Shah N,Qian M,Di Tullio MR,Graham S,Mann DL,Sacco RL,Lip GYH,Labovitz AJ,Ponikowski P,Lok DJ,Anker SD,Teerlink JR,Thompson JLP,Homma S,Freudenberger RS,WARCEF Investigators.doi
10.1111/eci.13092subject
Has Abstractpub_date
2019-02-23 00:00:00pages
e13092eissn
0014-2972issn
1365-2362pub_type
杂志文章abstract：BACKGROUND:The aim was to examine whether the inhibition of selective cyclooxygenase (COX) 2 activation could suppress the development of inflammatory reaction in visceral and subcutaneous abdominal fats of high-fat-induced obese rats. MATERIALS AND METHODS:The rats were fed separately regular diet (CONT), high-fat di...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2009.02239.x
更新日期：2010-02-01 00:00:00
abstract：:Pepsinogen A (PGA) and pepsinogen C (PGC) are negatively charged, low molecular weight (LMW) proteins with a striking difference in renal handling: PGA (molecular weight 43,500 daltons) shows a high fractional excretion while the fractional excretion of PGC (molecular weight 40,500 daltons) is low, presumably due to t...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1989.tb00234.x
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND:Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, which can relapse in many patients after antithyroid drug treatment withdrawal. Several studies have been performed to predict the clinical course of GD in patients treated with antithyroid drugs, without conclusive results. The...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2004.01318.x
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Acute hyperglycaemia is known to increase gastrointestinal (GI) sensitivity in healthy subjects and may contribute to the increased prevalence of GI symptoms in diabetes patients. The aim of this study was to evaluate the effect of acute hyperglycaemia on perception and brain responses to painful visceral an...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2010.02335.x
更新日期：2010-10-01 00:00:00
abstract：:Three different types of cardiovascular sequelae attributed to interferon therapy have been reported: arrhythmia, ischaemic heart disease and cardiomyopathy. We evaluated the left ventricular ejection fraction (LVEF) during alpha interferon therapy (3 MU administered subcutaneously three times a week for 6 months) in ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1995.tb01528.x
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Buerger's disease (BD) is a segmental occlusive vascular disease. The aim of this study was to detect functional changes in brachial artery and asymptomatic morphological changes in extra-cranial carotid arteries not affected by the disease process and to assess markers of inflammation and endothelial damage...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2006.01646.x
更新日期：2006-06-01 00:00:00
abstract：:The effects of percutaneous electrical stimulation (70 V, 300 microseconds pulses at 30 Hz) on muscle composition and rate of protein synthesis were studied in seven patients with quadriceps atrophy secondary to unilateral osteoarthritis of the knee (stimulated group). Quadriceps were stimulated on the affected side f...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1989.tb00219.x
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:Given that role of magnesium in insulin secretion is uncertain, our objective was to determine whether oral supplementation with magnesium chloride (MgCl(2)) improves the ability of beta-cells to compensate for variations in insulin sensitivity in non-diabetic individuals with significant hypomagnesaemia. M...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2362.2010.02422.x
更新日期：2011-04-01 00:00:00
abstract：:The impact of running and menstrual disturbances on regional and total body fat distribution and serum lipids was investigated in 205 women. Body composition was measured by dual-energy X-ray absorptiometry. The total fat mass in the elite runners was approximately half of the normally active's (7.3 [0.48] kg vs. 14.3...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1995.tb01745.x
更新日期：1995-08-01 00:00:00
abstract：:We present a sensitive time-resolved fluorometric immunofunctional assay (TR-FIA) for direct quantitation of functional growth hormone-binding protein (GHBP), using an immunoassay kit for growth hormone (GH-DELFIA). In addition to the immobilized GH antibody, one monoclonal antibody against GHBP was used. This anti-GH...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1996.2010558.x
更新日期：1996-09-01 00:00:00
abstract：:Deficient leucocyte sphingomyelinase activity has been demonstrated in a patient with the sea-blue histiocyte syndrome. Family studies revealed that two other cases previously diagnosed on clinical and histochemical criteria also had a pronounced diminution of sphingomyelinase activity. Both parents of the affected in...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1978.tb00860.x
更新日期：1978-08-01 00:00:00
abstract：:Whether leptin levels are related to insulin sensitivity or subject to acute regulation by insulin is not known. In 12 obese [body mass index (BMI) = 34.0 +/- 1.5 kg m-2] and 12 lean (BMI = 22.2 +/- 0.6 kg m-2) non-diabetic subjects, plasma leptin concentrations were measured in the fasting state and during 2 hours of...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1996.tb02142.x
更新日期：1996-10-01 00:00:00
abstract：AIMS:Obesity, diabetes and cardiovascular disease are associated with COVID-19 risk and severity. Because epicardial adipose tissue (EAT) expresses ACE2, we wanted to identify the main factors associated with ACE2 levels and its cleavage enzyme, ADAM17, in epicardial fat. MATERIALS AND METHODS:Epicardial and subcutane...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.13463
更新日期：2020-11-29 00:00:00
abstract：BACKGROUND:C-reactive protein (CRP) is a well-documented predictor of cardiovascular diseases and mortality. We aimed to better understand the distribution and determinants of CRP in the population. MATERIALS AND METHODS:Study participants were men and women aged 40-79 in the UK-based EPIC-Norfolk population-based coh...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.12116
更新日期：2013-09-01 00:00:00
abstract：:We evaluated the influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects (H): 40 lean [body mass index (BMI) < or = 25 kg m-2] H with normotensive parents (F-), 50 lean H with one or two parents hypertensive (F+), 30 obese HF- (BMI > or = 30 kg m-2) and 35 obese HF+. ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1997.1700725.x
更新日期：1997-09-01 00:00:00
abstract：:As in women receiving oestrogens the administration of 17beta-oestradiol to ovariectomized female rats caused a rise in fasting plasma triglycerides and a fall in plasma glucose. Progesterone, on the other hand, had no significant effects. In the oestradiol treated rats, the portal vein basal insulin levels were sligh...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1977.tb01595.x
更新日期：1977-06-01 00:00:00
abstract：:The effect of the potent specific cholecystokinin (CCK) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of CCK, gastrin, pancreatic polypeptide (PP), neurotensin, glucose-dependent insulinotropic polypeptide (GIP), insulin and C peptide was investigated in a placebo-controlled study in 10 heal...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2362.1991.tb01402.x
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:Variation of percentageCD4+ T cells may accurately reflects the kinetics of a comprehensive immune recovery independently of the antiretroviral (ART) regimen. To test this we have investigated the relationship among peripheral blood T-cell subsets with the variation of percentageCD4+ T cells during follow up...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.2003.01168.x
更新日期：2003-07-01 00:00:00
abstract：:The study aimed to assess vascular reactivity to noradrenaline with and without neuropeptide Y in diabetic rats, and to determine whether any abnormality could be attributed to insulin deficiency or to hyperglycaemia per se. The authors compared non-diabetic rats (n = 9) and rats with streptozotocin-induced diabetes t...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1995.tb01976.x
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:The platelet-to-lymphocyte ratio (PLR) has been found to predict clinical outcomes in borderline ovarian tumours and the other genital neoplasms. However, its prognostic value in patients with ovarian cancer remains controversial. The aim of this study was to assess its prognostic value in ovarian cancer. M...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,meta分析,评审
doi：10.1111/eci.12917
更新日期：2018-05-01 00:00:00
abstract：:Thyroid hormones occasionally appear less effective when administered alone to patients with panhypopituitarism, and manifestations suggestive of hypothyroidism have been reported in patients suffering from untreated Addison's disease. In the latter condition, thyrotropin secretion is increased: this occurs already af...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1987.tb02388.x
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:The intestinal handling of dextran, an alpha-1,6-linked glucose polymer, is poor compared with starch, and some ingested dextran might therefore reach the lower small intestine. As luminal sugar up-regulates SGLT1 (sodium-dependent glucose transporter) locally, we report the effects of a dextran-enriched die...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1998.00352.x
更新日期：1998-08-01 00:00:00
abstract：:Activities of urea cycle enzymes were measured in the liver of starved rats 12 and 48 h after bilateral nephrectomy. Control experiments (sham-operated, starved rats) revealed that the activities of only two enzymes of the cycle are altered in the uraemic state: argininosuccinic acid synthetase (EC 6.3.4.5.), which is...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1975.tb00423.x
更新日期：1975-02-01 00:00:00
abstract：:The nephrotic syndrome is frequently associated with hyperlipidaemia and hyperfibrinogenaemia, leading to an increased coronary and thrombotic risk, which may be enhanced by high lipoprotein (a) [Lp(a)] concentrations. We followed the quantitative and qualitative pattern of plasma lipoproteins over 18 months in a pati...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1996.132283.x
更新日期：1996-04-01 00:00:00
abstract：:Oral lichen planus (OLP) is a common oral disorder that manifests a mucosal reaction to a variety of aetiological factors, including liver disorder. This study investigated the relationship between OLP and hepatitis C virus (HCV) infection by studying the prevalence of hepatitis B and C virus infection or liver diseas...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1995.tb01966.x
更新日期：1995-12-01 00:00:00
abstract：:A haemolytically inactive alpha-mobile complement C8 component was identified by crossed immunoelectrophoresis in a 27-year-old male with recurrent meningococcal infections and absence of complement mediated serum haemolytic activity. The patient's serum/plasma contained no demonstrable normal C8. C8 inhibitor activit...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1983.tb00084.x
更新日期：1983-04-01 00:00:00
abstract：BACKGROUND:Based on a report of a marked increase in the erythropoietin concentration ([EPO]) a few hours after the cessation of a single 2-h session of O(2) breathing, short periods of O(2) administration have been advocated as a therapy for anaemia. Accordingly, the purpose of the present study was to evaluate this t...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2011.02578.x
更新日期：2012-03-01 00:00:00
abstract：:The effect of sequential combined hormone replacement therapy on the susceptibility of low-density lipoprotein to oxidative modification was investigated in a double-blind, randomized placebo-controlled study. Hypercholesterolaemic, postmenopausal women were supplemented with 17 beta-oestradiol and norethisterone acet...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2362.1996.390593.x
更新日期：1996-12-01 00:00:00
abstract：INTRODUCTION:Diabetes mellitus is a progressive disease with cardiovascular complications. This study evaluated the effects of liraglutide, a glucagon-like peptide-1 analogue and the dipeptidyl peptidase 4 inhibitors sitagliptin and linagliptin on cardiac function in type 2 diabetes patients with renal impairment. MAT...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,随机对照试验
doi：10.1111/eci.13007
更新日期：2018-10-01 00:00:00
abstract：:Anaemia is a common condition among pre-end-stage renal disease (pre-ESRD) patients with chronic kidney disease (CKD). Indeed, data from clinical studies indicate that anaemia may be present in as many as two-thirds of such patients. Use of recombinant human erythropoietin (EPO) provides an effective means of correcti...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2362.2005.01532.x
更新日期：2005-12-01 00:00:00
