Abstract：
:Moderate and progressive hypertension was produced experimentally in rats by progressive aortic constriction. The progression of the stenosis was assessed by the differences of pressure across the stenosis. Haemodynamic studies were performed 15, 30 and 60 days after the ligature was placed or after sham operation. Fifteen days after surgery, when the ligated rats did not show any increase in carotic pressure, they showed augmented cardiac output (50.3 +/- 5.4 v. 29.7 +/- 2.0 ml min-1 100 g-1; mean +/- -SEM) and a decreased total peripheral resistance (2.23 +/- 0.21 v. 3.67 +/- 0.20 mmHg ml-1 min 100 g). They also had decreased vascular resistance in both kidneys and in skeletal muscle samples above and below the ligature as well as increased plasma renin content and normal values of plasma volume and extracellular volume. Later in the evolution of hypertension, carotic pressure and the pressure gradient across the stenosis increased (51.8 +/- 4.5 v. 0.9 +/- 1.6 mmHg in controls), cardiac output decreased to control values, total peripheral resistance as well as renal and muscular vascular resistances increased. Plasma and extracellular volume remained unchanged in ligated rats in contrast to controls where they decreased. Perfusion pressure of the kidney below the ligature did never fall below control values (97.2 +/- 3.4 v. 100.4 +/- 2.4 mmHg). A small but constant degree of elastosis and a double layer of myocytes in the renal arterioles above the ligature was the only histological finding.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Martín-Paredero V,Casado S,López-Novoa JMdoi
10.1111/j.1365-2362.1984.tb01178.xsubject
Has Abstractpub_date
1984-08-01 00:00:00pages
262-7issue
4eissn
0014-2972issn
1365-2362journal_volume
14pub_type
杂志文章abstract：BACKGROUND:Portal endotoxaemia has been speculated to be crucially involved in the pathogenesis of chronic hepatic inflammation, which is highly associated with the development of type 2 diabetes mellitus. This study tests whether portal endotoxaemia is a pathogenic link between chronic subacute hepatic inflammation an...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2008.01991.x
更新日期：2008-09-01 00:00:00
abstract：:The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1985.tb00291.x
更新日期：1985-12-01 00:00:00
abstract：BACKGROUND:Renal size and function reflect the health of the kidney. These parameters are associated with age, gender and body weight. The kidneys are also influenced by micro- and macrovascular diseases. Atherosclerotic markers and risk factors may influence the age-related changes of renal size and function. METHODS...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.2003.01091.x
更新日期：2003-01-01 00:00:00
abstract：:Changes in blood glucose homeostasis induced by the new somatostatin analogue BIM 23014 (BIM) were studied. Eight normal men (study 1) received either vehicle or 1000, 2000 and 3000 micrograms BIM as a 24 h s.c. infusion. Blood glucose, plasma insulin, C-peptide, glucagon and growth hormone (GH) were measured before t...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2362.1992.tb01448.x
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:Interleukin 18(IL-18) is a pro-atherosclerotic cytokine. Elevated IL-18 levels and the genetic variation of the IL-18 have been previously linked with acute coronary events and cardiovascular mortality among patients with coronary artery disease (CAD). We studied the possible association between the IL-18 ge...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2010.02356.x
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Antihyperglycemic drugs have been linked to new-onset atrial fibrillation (NAF). However, the effect of the different classes of antihyperglycemic drugs on the development of NAF in elderly patients has not been well studied. In this study, we investigated the association between different classes of antihyp...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.12754
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:The intestinal handling of dextran, an alpha-1,6-linked glucose polymer, is poor compared with starch, and some ingested dextran might therefore reach the lower small intestine. As luminal sugar up-regulates SGLT1 (sodium-dependent glucose transporter) locally, we report the effects of a dextran-enriched die...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1998.00352.x
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:There is an ongoing debate on a potential protective role of habitual physical activity and passive heat therapy on the risk of COVID-19, a respiratory infectious disease that can manifest as severe pneumonia. To explore these putative roles, we evaluated the independent and joint associations of cardiorespi...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.13490
更新日期：2021-01-10 00:00:00
abstract：BACKGROUND:Chronic lung diseases contribute significantly to the morbidity and mortality of the population. There are few effective treatments for many chronic lung diseases, and even fewer therapies that can arrest or reverse the progress of the disease. DESIGN:In this review, we present the current state of regenera...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2362.2012.02667.x
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Several studies have suggested that chronic obstructive pulmonary disease (COPD) could be predictive of the prognosis in patients with heart failure (HF), but yield conflicting findings. Therefore, we conducted a meta-analysis to examine the impact of COPD on adverse outcomes in patients with HF. METHODS:We...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
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更新日期：2021-01-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2006.01722.x
更新日期：2006-11-01 00:00:00
abstract：:Activities of urea cycle enzymes were measured in the liver of starved rats 12 and 48 h after bilateral nephrectomy. Control experiments (sham-operated, starved rats) revealed that the activities of only two enzymes of the cycle are altered in the uraemic state: argininosuccinic acid synthetase (EC 6.3.4.5.), which is...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1975.tb00423.x
更新日期：1975-02-01 00:00:00
abstract：BACKGROUND:Thyroid hormone has important effects on the cardiovascular system. The consequences of episodes of acute hypothyroidism on cardiac function have been investigated in only a few studies, and their results are inconclusive. Our objective was to investigate the effects of acute hypothyroidism on cardiac functi...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2009.02088.x
更新日期：2009-03-01 00:00:00
abstract：:Portal-systemic spill-over of unconjugated ursodeoxycholic acid (UDCA) was assessed in ten healthy subjects, six patients with mild chronic liver disease and eight patients with cirrhosis. Following oral administration of UDCA (1.5 mg/kg body weight), serum concentrations of unconjugated UDCA were measured during 2 h ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1983.tb00126.x
更新日期：1983-12-01 00:00:00
abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2007.01876.x
更新日期：2007-11-01 00:00:00
abstract：:The relationship between changes in ketone concentrations and leucine metabolism (seven obese subjects), glucose and alanine metabolism (seven obese subjects) was investigated using radioisotopic techniques after 12 h, 60 h and 2 weeks starvation. Leucine metabolism was also measured in five lean subjects after 12 h a...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1995.tb01755.x
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD). Low magnesium levels are associated with VC, and recent in vitro studies confirm a protective role of magnesium, which is mediated by its entry into the VSMCs through the Transient Receptor Potential Melastatin 7 (...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/eci.12517
更新日期：2015-11-01 00:00:00
abstract：:Exogenous intravenous infusions of control saline, somatostatin, motilin and somatostatin and motilin together were compared in normal volunteers for their effects on the rise of blood glucose following 50 g oral glucose and for their effects on gastric emptying and plasma hormone concentrations. All regulatory peptid...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2362.1982.tb02241.x
更新日期：1982-08-01 00:00:00
abstract：BACKGROUND:There is ongoing controversy whether angiotensin-converting enzyme inhibitors (ACE-I) contribute to anaemia by causing hyporesponsiveness to erythropoiesis-stimulating agents (ESA). However, it is unknown whether or not plasma levels or area under the curve (AUC) of ACE-I are associated with responsiveness t...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2012.02699.x
更新日期：2012-10-01 00:00:00
abstract：:Acute renal failure is a grave complication of systemic gram-negative sepsis. The pathophysiological mechanisms of sepsis leading to kidney injury result in part from systemic inflammatory and haemodynamic alterations. These are triggered by the interaction of endotoxin with Toll-like receptor 4 (TLR4) on cells of the...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2362.2008.02007.x
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:We hypothesized the existence of different hormonal response patterns to repeated lower body negative pressure (LBNP) and head-up tilt (HUT) in healthy males. We compared hormonal, cardiovascular and plasma volume changes from rest to stress within- and between-LBNP and HUT applications. Hormones investigate...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2011.02476.x
更新日期：2011-08-01 00:00:00
abstract：:The collagenolytic activities were assayed in fibroblast cultures established from ten keratoconus and six control corneal explants. The assays included those for both type I and type IV collagenase. The amount of free, directly assayable type I collagenase was highly increased in the media of keratoconus primary cell...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1986.tb01311.x
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:The tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), a physiological inhibitor of the proliferation of haematopoietic stem cells, is degraded by the angiotensin-I-converting enzyme (ACE). Whereas synthetic AcSDKP (Goralatide) protects normal mice from the haematological toxicity of chemotherapy, it has a lower ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1998.00356.x
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:Immunosuppression associated with surgery may predispose to increased tumour growth or recurrence. Lymphocytes are central components of the immune network, signalling specific and non-specific responses in tumour immunosurveillance. This study was therefore designed to compare the effects of minimally invas...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2362.2000.00622.x
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:A total of 30 subjects with type 2 diabetes were incl...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2362.2009.02236.x
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) remodel circulating lipoproteins and play a role in the antiatherogenic reverse cholesterol transport pathway. The present study determined whether abnormalities in the LDL subfraction pattern in type 2 diabetic patients were ...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.2003.01132.x
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Expression of acinar cell-specific genes requires the pancreas transcription factor 1alpha (Ptf1alpha). p48 is the only component of Ptf1alpha that is involved in both acinar gene regulation and pancreatic ontogenesis. MATERIALS AND METHODS:To determine whether Ptf1alpha/p48 expression is regulated during p...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2007.01856.x
更新日期：2007-10-01 00:00:00
abstract：:Alpha-naphthyl-isothiocyanate (ANIT)-induced intrahepatic cholangitis was associated with significant polyuria in rats. The urine output in the experimental rats was about two and a half to four fold higher than that in the controls. The polyuria was accompanied by polydypsia and disappeared when water intake was limi...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1983.tb00059.x
更新日期：1983-02-01 00:00:00
abstract：BACKGROUND:Bezafibrate reportedly lowers serum lipids and plasma fibrinogen in humans and rats, but the mechanism of this process has still to be clarified. We have addressed this problem by investigating the effects of bezafibrate on fibrinogen in the human hepatoma HepG2 cell line. METHODS:In cells cultured with and...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.1998.00251.x
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the significance of the development of a restrictive response to an acute saline load, defined as an increase in the ratio of peak early to peak late diastolic transmitral flow velocity (E/A ratio) associated with a decrease in the deceleration time, in patients with mild...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1046/j.1365-2362.2001.00873.x
更新日期：2001-08-01 00:00:00
