Ethanol-induced hypoglycaemia in man: its suppression by the alcohol dehydrogenase inhibitor 4-methylpyrazole.

Abstract:

:Infusion of ethanol (0.6 g/kg body wt) caused marked hypoglycaemia in subjects fasted for 36 h. Previous administration of the alcohol dehydrogenase (ADH) inhibitor 4-methylpyrazole (4-MP, 7 mg/kg body wt i.v.) strongly suppressed the ethanol-induced hypoglycaemia. The rate of ethanol elimination was 84.6 mg/kg per hour. 4-MP at the dose used caused a 21% reduction of ethanol elimination, but had no significant effect on blood acetaldehyde levels. 4-MP also significantly suppressed the ethanol-induced elevation of blood lactate and almost completely prevented the increase in the 3-hydroxybutyrate/acetoacetate ratio, but had only a slight effect on the lactate/pyruvate ratio of venous blood. The results demonstrate that the hypoglycaemia and lactacidaemia produced by the oxidation of alcohol can be prevented by a dose of 4-MP that diminishes or prevents the ethanol-induced shift in the NAD-coupled redox state of the liver.

journal_name

Eur J Clin Invest

authors

Salaspuro MP,Pikkarainen P,Lindros K

doi

10.1111/j.1365-2362.1977.tb01640.x

subject

Has Abstract

pub_date

1977-12-01 00:00:00

pages

487-90

issue

6

eissn

0014-2972

issn

1365-2362

journal_volume

7

pub_type

临床试验,杂志文章
  • Captopril and quinapril reduce reactive oxygen species.

    abstract:BACKGROUND:Angiotensin-converting enzyme inhibitors may affect reactive oxygen species in humans in vitro and in vivo. In the present study we evaluated whether angiotensin-converting enzyme inhibitors may affect NAD(P)H oxidase activity. MATERIALS AND METHODS:The production of reactive oxygen species was measured spe...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2002.01064.x

    authors: van der Giet M,Erinola M,Zidek W,Tepel M

    更新日期:2002-10-01 00:00:00

  • Impact of centralized evaluation of bone marrow histology in systemic mastocytosis.

    abstract:BACKGROUND:Bone marrow (BM) histology/immunohistochemistry, KIT D816V mutation analysis and serum tryptase measurements are mandatory tools for diagnosis of systemic mastocytosis (SM). MATERIALS AND METHODS:Within the 'German Registry of Disorders on Eosinophils and Mast Cells', we identified 65 patients with SM who h...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12607

    authors: Jawhar M,Schwaab J,Horny HP,Sotlar K,Naumann N,Fabarius A,Valent P,Cross NC,Hofmann WK,Metzgeroth G,Reiter A

    更新日期:2016-05-01 00:00:00

  • Effect of heparin and aspirin on platelet and clotting activation during leukapheresis.

    abstract::Beta-thromboglobulin (beta TG), serotonin (5HT) and fibrinopeptide A (FPA) were assessed in twenty-two normal donors before, during, and at the end of leukapheresis. Seven procedures were carried out adding heparin to the circuit, and seven adding acetyl salicylic acid (ASA). The remaining eight procedures were carrie...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1985.tb00166.x

    authors: Fabris F,Casonato A,Randi ML,Belloni M,Quaino V,Ongaro G,Girolami A

    更新日期:1985-08-01 00:00:00

  • Relation between insulin kinetics and insulin sensitivity in pregnancy.

    abstract:BACKGROUND:Different time-concentration profiles of plasma insulin following insulin modification of a frequently sampled intravenous glucose-tolerance-test (FSIVGTT) were observed in a study investigating maternal metabolism and fetal macrosomia. We aimed to investigate whether these differences were related to the vo...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2003.01193.x

    authors: Jolly MC,Hovorka R,Godsland I,Amin R,Lawrence N,Anyaoku V,Johnston D,Robinson S

    更新日期:2003-08-01 00:00:00

  • Determinants of the postpericardiotomy syndrome: a systematic review.

    abstract:BACKGROUND:Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the syndrome. The aim of this study was to provide an overview of existing literature around determinants of...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/eci.12764

    authors: van Osch D,Nathoe HM,Jacob KA,Doevendans PA,van Dijk D,Suyker WJ,Dieleman JM

    更新日期:2017-06-01 00:00:00

  • Bile synthesis in rat models of inflammatory bowel diseases.

    abstract:BACKGROUND:A broad spectrum of hepatobiliary disorders are found in patients with inflammatory bowel diseases. The aim of the present work was to study interactions between gut and liver in experimental rat models of colitis and small bowel inflammation. MATERIALS AND METHODS:Colitis was induced either by trinitrobenz...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2007.01779.x

    authors: Dikopoulos N,Schmid RM,Bachem M,Buttenschoen K,Adler G,Chiang JY,Weidenbach H

    更新日期:2007-03-01 00:00:00

  • Inflammation reduces HDL protection against primary cardiac risk.

    abstract:BACKGROUND:We recently reported high high-density lipoprotein (HDL) cholesterol as a predictor of recurrent risk in a subgroup of postinfarction patients defined by hypercholesterolemia and high C-reactive protein (CRP) levels. We investigated whether a similar high-risk subgroup might exist for incident cardiovascular...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2010.02287.x

    authors: Corsetti JP,Gansevoort RT,Sparks CE,Dullaart RP

    更新日期:2010-06-01 00:00:00

  • Gallbladder motility and cholesterol crystallization in bile from patients with pigment and cholesterol gallstones.

    abstract:BACKGROUND:Little is known about gallbladder motility in patients with black pigment stones when compared to cholesterol gallstone patients, or about their relationship to biliary composition, crystallization and stone characteristics. DESIGN:Fasting and postprandial gallbladder volumes were studied by ultrasonography...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2000.00639.x

    authors: Portincasa P,Di Ciaula A,Vendemiale G,Palmieri V,Moschetta A,Vanberge-Henegouwen GP,Palasciano G

    更新日期:2000-04-01 00:00:00

  • Suppression of the nocturnal free fatty acid levels by bedtime cornstarch in NIDDM subjects.

    abstract::The aim of the present study was to examine the effects of a large dose of slow-release carbohydrates (CHOs) at bedtime on the nocturnal glucose, insulin and free fatty acid (FFA) levels, and to assess the putative effects on morning fasting and post-prandial glucose levels in patients with moderately controlled non-i...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2362.1997.880639.x

    authors: Axelsen M,Lönnroth P,Arvidsson Lenner R,Smith U

    更新日期:1997-02-01 00:00:00

  • Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cells.

    abstract::Patients with primary biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver. However, most of the patients with PBC do not show peripheral blood T cells response to PDC. In this study, we re-evaluated the ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2001.00847.x

    authors: Akbar SM,Yamamoto K,Miyakawa H,Ninomiya T,Abe M,Hiasa Y,Masumoto T,Horiike N,Onji M

    更新日期:2001-07-01 00:00:00

  • Body height in paediatric inflammatory bowel diseases: A structural equation model analysis.

    abstract:BACKGROUND:Linear growth restriction is a unique feature of paediatric inflammatory bowel diseases (IBD), and reduced insulin-like growth factor (IGF-1) is a major determinant of short stature. We aimed to assess factors influencing somatic height in children suffering from IBD. MATERIALS AND METHODS:This was a retros...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.12969

    authors: Chouliaras G,Mantzou A,Margoni D,Tsilifis N,Pervanidou P,Panayotou I,Kanaka-Gantenbein C,Chrousos GP,Roma-Giannikou E

    更新日期:2018-08-01 00:00:00

  • Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity.

    abstract::Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being elucidated. This study was carried out to investigate the relationship between serum leptin, plasma insulin, insulin sensitivity and free testosterone in 46 men ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1997.2270773.x

    authors: Vettor R,De Pergola G,Pagano C,Englaro P,Laudadio E,Giorgino F,Blum WF,Giorgino R,Federspil G

    更新日期:1997-12-01 00:00:00

  • Chronic Q fever associated with systemic sclerosis.

    abstract:BACKGROUND:After the Q fever outbreak in the Netherlands between 2007 and 2010, more than 300 patients with chronic Q fever have been identified. Some patients were also diagnosed with systemic sclerosis, a rare immune-mediated disease. We aimed to increase awareness of concomitant chronic Q fever infection and systemi...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13123

    authors: Jansen AFM,Raijmakers RPH,van Deuren M,Vonk MC,Bleeker-Rovers CP

    更新日期:2019-07-01 00:00:00

  • Effect of glucagon immunoneutralization on the increase in urea synthesis after hysterectomy in rats.

    abstract::To study the effect of glucagon immunoneutralization on postoperative changes of urea synthesis, hysterectomized rats were given one injection of a specific high titre antibody against pancreatic glucagon 24 h before operation raising the plasma glucagon binding capacity to values 10-20 times higher than the plasma gl...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1993.tb00756.x

    authors: Heindorff H,Holst JJ,Almdal T,Vilstrup H

    更新日期:1993-03-01 00:00:00

  • Platelet and vessel associated prostacyclin and thromboxane A2/prostaglandin endoperoxide receptors.

    abstract::Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, n...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2362.1988.tb01157.x

    authors: Jaschonek K,Muller CP

    更新日期:1988-02-01 00:00:00

  • Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10.

    abstract:BACKGROUND:The pathogenesis of atherosclerosis and acute coronary syndromes involves inflammation and immunological mechanisms. We hypothesized that patients with unstable angina may have an imbalance between inflammatory and anti-inflammatory cytokines. DESIGN:Plasma levels of tumour necrosis factor (TNF)alpha and in...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2002.01069.x

    authors: Waehre T,Halvorsen B,Damås JK,Yndestad A,Brosstad F,Gullestad L,Kjekshus J,Frøland SS,Aukrust P

    更新日期:2002-11-01 00:00:00

  • Metastatic pheochromocytoma and paraganglioma.

    abstract:BACKGROUND:Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumours with a strong genetic background. DESIGN:We searched the PubMed database through February 2015 to identify studies characterizing metastatic PCs/PGLs as well as currently established and evolving therapies. RESULTS...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/eci.12495

    authors: Angelousi A,Kassi E,Zografos G,Kaltsas G

    更新日期:2015-09-01 00:00:00

  • Effect of hyperosmolality on basal and hormone-stimulated hepatic glucose metabolism in vitro.

    abstract::To understand better impairment of glucose utilization in diabetics during a hyperosmolal state, in vitro models were established to evaluate the effects of hyperosmolality on basal glucose uptake as well as glucagon dependent glucose release by isolated hepatocytes. In these studies simulating a hyperglycaemic (40 mm...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1989.tb00206.x

    authors: Komjati M,Kastner G,Waldhäusl W,Bratusch-Marrain P

    更新日期:1989-04-01 00:00:00

  • Effects of myocardial revascularization following acute coronary occlusion in pigs.

    abstract::In a comparative study in pigs the extent of myocardial infarction has been estimated following a temporary three hour coronary occlusion and following a permanent coronary ligation. For evaluation of the cellular injury the infarct size has been determined by a histochemical staining procedure and correlated with ser...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1976.tb00487.x

    authors: Althaus U,Janett J,Scholl E,Riedwyl H

    更新日期:1976-01-30 00:00:00

  • New p53 mutations in hilar cholangiocarcinoma.

    abstract:BACKGROUND:Inactivation of the tumour suppressor gene, p53, is the commonest genetic abnormality in human cancer. The study of the type of p53 mutation in a given tumour may provide prognostic information, clues to aetiology and become useful for therapeutics. MATERIALS AND METHODS:The molecular characterisation of p5...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2000.00717.x

    authors: Tullo A,D'Erchia AM,Honda K,Kelly MD,Habib NA,Saccone C,Sbisà E

    更新日期:2000-09-01 00:00:00

  • Changes in potassium content of erythrocytes during exercise in man.

    abstract::Factors affecting erythrocyte K+ content and plasma electrolytes during light exercise were examined in 8 normal subjects and 27 patients with chronic obstructive lung disease. The patients were classified into bronchitis, emphysema and intermediate groups. Arterial blood was obtained during rest, after 2, 5, and 7 mi...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1975.tb00469.x

    authors: Kawakami Y,Kishi F,Uchiyama K,Irie T,Murao M

    更新日期:1975-09-12 00:00:00

  • Pathways of renal injury in systemic gram-negative sepsis.

    abstract::Acute renal failure is a grave complication of systemic gram-negative sepsis. The pathophysiological mechanisms of sepsis leading to kidney injury result in part from systemic inflammatory and haemodynamic alterations. These are triggered by the interaction of endotoxin with Toll-like receptor 4 (TLR4) on cells of the...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2362.2008.02007.x

    authors: El-Achkar TM,Hosein M,Dagher PC

    更新日期:2008-10-01 00:00:00

  • Different pre-analytical techniques and the results of 50 g oral glucose challenge tests.

    abstract:OBJECTIVE:We aimed to analyse the pre-analytical process and its effect of 50 g of oral glucose challenge test results for screening gestational diabetes mellitus. RESEARCH DESIGN AND METHODS:The 50 g oral glucose challenge test was performed to 30 pregnant women, and the blood was collected as two samples for three t...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/eci.13481

    authors: Eldem S,Oskovi-Kaplan ZA,Engin-Ustun Y,Yilmaz C,Caglar AT,Ozgu-Erdinc AS

    更新日期:2020-12-22 00:00:00

  • Liraglutide relieves cardiac dilated function than DPP-4 inhibitors.

    abstract:INTRODUCTION:Diabetes mellitus is a progressive disease with cardiovascular complications. This study evaluated the effects of liraglutide, a glucagon-like peptide-1 analogue and the dipeptidyl peptidase 4 inhibitors sitagliptin and linagliptin on cardiac function in type 2 diabetes patients with renal impairment. MAT...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/eci.13007

    authors: Hiramatsu T,Asano Y,Mabuchi M,Imai K,Iguchi D,Furuta S

    更新日期:2018-10-01 00:00:00

  • Biocompatibility of coated and uncoated charcoal during haemoperfusion in healthy dogs.

    abstract::The biocompatibility of two commercially available charcoal columns, one containing coated and the other uncoated but immobilized charcoal, was compared during four haemoperfusions with each in eight healthy greyhounds. Reductions in arterial levels of platelets (49% and 42% respectively) and leucocytes (both 21%) wer...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1977.tb01626.x

    authors: Weston MJ,Hanid A,Rubin MH,Langley PG,Mellon PJ,Williams R

    更新日期:1977-10-01 00:00:00

  • Incomplete suppression of hepatic glucose production in non-insulin dependent diabetes mellitus measured with [6,6-2H2]glucose enriched glucose infusion during hyperinsulinaemic euglycaemic clamps.

    abstract::We have minimized methodological errors in the isotope dilution technique by using stable isotope, [6,6-2H2]glucose, thus avoiding the problem of contamination of tritiated glucose tracers and, by maintaining a constant plasma tracer enrichment have reduced error due to mixing transients. Using these modifications we ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1992.tb01458.x

    authors: Powrie JK,Smith GD,Hennessy TR,Shojaee-Moradie F,Kelly JM,Sönksen PH,Jones RH

    更新日期:1992-04-01 00:00:00

  • Sex differences in initial clearance of palmitate by human hepatocytes.

    abstract::To determine if the sex differences in clearance of long chain fatty acids by the liver observed in the rat are relevant to humans, the authors isolated hepatocytes from human adult males and females (five per group) and measured the initial (unidirectional) clearance of [3H]-palmitate from buffer containing albumin. ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.1996.101246.x

    authors: Pond SM,Gordon RA,Bass L

    更新日期:1996-01-01 00:00:00

  • The 13C/2H-glucose test for determination of small intestinal lactase activity.

    abstract::To diagnose hypolactasia, determination of lactase enzyme activity in small intestinal biopsy material is considered to be the golden standard. Because of its strongly invasive character and the sampling problems, alternative methods have been looked for. We analysed the 13C-glucose response in serum after consumption...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1046/j.1365-2362.2001.00791.x

    authors: Vonk RJ,Stellaard F,Priebe MG,Koetse HA,Hagedoorn RE,De Bruijn S,Elzinga H,Lenoir-Wijnkoop I,Antoine JM

    更新日期:2001-03-01 00:00:00

  • Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury.

    abstract::Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.2004.01304.x

    authors: Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

    更新日期:2004-02-01 00:00:00

  • Effects of plasma infusion on plasma lipids, apoproteins and plasma enzyme activities in familial lecithin: cholesterol acyltransferase deficiency.

    abstract::The siblings presented here are the third family found in Japan with familial LCAT deficiency. Their post-heparin plasma lipoprotein lipase and hepatic triglyceride lipase activities were measured selectively by an immunochemical method. Plasma triglyceride levels were elevated, and post-heparin plasma lipoprotein lip...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章

    doi:10.1111/j.1365-2362.1984.tb02100.x

    authors: Murayama N,Asano Y,Kato K,Sakamoto Y,Hosoda S,Yamada N,Kodama T,Murase T,Akanuma Y

    更新日期:1984-04-01 00:00:00