Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187.

abstract：:The influence of insulin on lipolysis and glucose metabolism in abdominal adipose tissue was studied in situ with the microdialysis technique during a euglycaemic insulin clamp (1 mU kg-1 min-1) in nine cirrhotic patients and 10 controls. The cirrhotic patients displayed a 50% decrease in glucose utilization rate duri...

journal_title：European journal of clinical investigation

authors： Johansson U,Arner P,Bolinder J,Hagström-Toft E,Ungerstedt U,Eriksson LS

更新日期：1993-12-01 00:00:00

abstract：:Critical illness is an aetiologically and clinically heterogeneous syndrome that is characterised by organ failure and immune dysfunction. Mortality in critically ill patients is driven by inflammation-associated organ damage and a profound vulnerability to nosocomial infection. Both factors are influenced by the acti...

journal_title：European journal of clinical investigation

authors： Wood AJT,Vassallo A,Summers C,Chilvers ER,Conway-Morris A

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, which can relapse in many patients after antithyroid drug treatment withdrawal. Several studies have been performed to predict the clinical course of GD in patients treated with antithyroid drugs, without conclusive results. The...

journal_title：European journal of clinical investigation

authors： Orunesu E,Bagnasco M,Salmaso C,Altrinetti V,Bernasconi D,Del Monte P,Pesce G,Marugo M,Mela GS

更新日期：2004-03-01 00:00:00

abstract：:Tightly co-ordinated control of both insulin action and secretion is required in order to maintain glucose homeostasis. Gene knockout experiments have helped to define key signalling molecules that affect insulin action, including insulin and insulin-like growth factor-1 (IGF-1) receptors, insulin receptor substrate (...

journal_title：European journal of clinical investigation

authors： Rhodes CJ,White MF

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Advanced glycation end-products (AGEs) are increased in situations with hyperglycemia and oxidative stress such as diabetes mellitus. They are products of nonenzymatic glycation and oxidation of proteins and lipids. The kidney plays an important role in clearance and metabolism of AGEs. METHODS:Medline and ...

journal_title：European journal of clinical investigation

authors： Busch M,Franke S,Rüster C,Wolf G

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Passive smoking is a well-known risk factor for both recurrent respiratory infections and disturbed lipid profile. Whether passive smoking problems are related to altered lymphocyte survival and its relation to altered lipid profile are the points of concern in this work. MATERIALS AND METHODS:Urinary cotin...

journal_title：European journal of clinical investigation

authors： El-Hodhod MA,Hamdy AM,Ahmed MB,Youssef SR,Aly SM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Diacylglycerols (DAGs), which are well-known components of insect lipophorins, have been recently recognized as a major glyceride of human high-density lipoprotein (HDL). Moreover, DAGs are good substrates for hepatic lipase and for the phospholipid transfer protein (PLTP). The present work was undertaken to...

journal_title：European journal of clinical investigation

authors： Lalanne F,Pruneta V,Bernard S,Ponsin G

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Portal endotoxaemia has been speculated to be crucially involved in the pathogenesis of chronic hepatic inflammation, which is highly associated with the development of type 2 diabetes mellitus. This study tests whether portal endotoxaemia is a pathogenic link between chronic subacute hepatic inflammation an...

journal_title：European journal of clinical investigation

authors： Hsieh PS,Chan JY,Shyu JF,Chen YT,Loh CH

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Lipoprotein(a) [Lp(a)] is an important cardiovascular risk factor in the general population. However, prospective data on the vascular risk conferred by Lp(a) in patients with diabetes mellitus are scarce and controversial. It is not known whether the diabetic state affects the association of Lp(a) with vasc...

journal_title：European journal of clinical investigation

authors： Saely CH,Koch L,Schmid F,Marte T,Aczel S,Langer P,Hoefle G,Drexel H

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Coronary vasospasm (CVsp) has been reported to be an inflammatory disease, reflected by elevated high-sensitivity C-reactive protein (hs-CRP). We investigated the interactions among gender, age, hypertension and hs-CRP in patients with CVsp. MATERIALS AND METHODS:We retrospectively examined 722 Taiwanese pa...

journal_title：European journal of clinical investigation

authors： Hung MY,Hsu KH,Hung MJ,Cheng CW,Cherng WJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Disuse and/or local inflammation in the muscle cannot be excluded as potential influences for the decreased muscle force in patients hospitalised due to an acute chronic obstructive pulmonary disease (COPD) exacerbation. This study aims to compare expression levels of markers of disuse (insulin-like growth f...

journal_title：European journal of clinical investigation

authors： Crul T,Spruit MA,Gayan-Ramirez G,Quarck R,Gosselink R,Troosters T,Pitta F,Decramer M

更新日期：2007-11-01 00:00:00

abstract：:In order to study the mechanisms by which nutrients influence post-trauma metabolism, Sprague-Dawley rats received a 25% full-thickness burn and were randomly assigned to receive 12.5 g kg-1 bodyweight (BW) per day amino acids (AA) only, AA and 14.7 g hydrous glucose kg-1 BW per day or AA and 14.7 g hydrous xylitol kg...

journal_title：European journal of clinical investigation

authors： Georgieff M,Pscheidl E,Moldawer LL,Bistrian BR,Blackburn GL

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Morpholinosydnonimine, a nitric oxide (NO) donor, has been reported to inhibit insulin release in isolated pancreatic islets. We studied whether transdermal application of nitroglycerin, another NO donor widely used for angina prophylaxis, influenced glucose-stimulated insulin release in healthy, young, male...

journal_title：European journal of clinical investigation

authors： Kovacs P,Szilvassy Z,Hegyi P,Nemeth J,Ferdinandy P,Tosaki A

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:Nitric oxide synthase (NOS) 3-deficient (NOS-3 KO) mice have an increased systemic arterial pressure but develop portal hypertension to the same extent as wildtype (WT) mice. We hypothesized that other vasodilators in the portal circulation compensate for the lack in NOS-3 activity. We used quantitative...

journal_title：European journal of clinical investigation

authors： Biecker E,Sägesser H,Reichen J

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients. MATERIALS AND METHODS:In this study a retrospective analysis was performed wi...

journal_title：European journal of clinical investigation

authors： Lin JD,Chao TC,Chen ST,Weng HF,Lin KD

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease (GERD), including erosive reflux disease and non-erosive reflux disease (NERD), is a chronic disease with a significant negative effect on quality of life. State-of-the-art treatment involves proton pump inhibitors (PPIs). However, relapse of symptoms occurs in the majority of...

journal_title：European journal of clinical investigation

authors： Compare D,Pica L,Rocco A,De Giorgi F,Cuomo R,Sarnelli G,Romano M,Nardone G

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Different time-concentration profiles of plasma insulin following insulin modification of a frequently sampled intravenous glucose-tolerance-test (FSIVGTT) were observed in a study investigating maternal metabolism and fetal macrosomia. We aimed to investigate whether these differences were related to the vo...

journal_title：European journal of clinical investigation

authors： Jolly MC,Hovorka R,Godsland I,Amin R,Lawrence N,Anyaoku V,Johnston D,Robinson S

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated the presence of receptors for somatostatin, a neuropeptide with immunoregulatory properties, in the inflammatory lesions of patients suffering from sarcoidosis and other granulomatous diseases by in vivo somatostatin receptor scintigraphy and in vitro autoradiography. How...

journal_title：European journal of clinical investigation

authors： ten Bokum AM,Hofland LJ,de Jong G,Bouma J,Melief MJ,Kwekkeboom DJ,Schonbrunn A,Mooy CM,Laman JD,Lamberts SW,van Hagen PM

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is followed by post AMI cardiac remodelling, often leading to congestive heart failure. Homing of c-kit+ endothelial progenitor cells (EPC) has been thought to be the optimal source for regenerating infarcted myocardium. METHODS:Immune function of viable peripheral blood mo...

journal_title：European journal of clinical investigation

authors： Ankersmit HJ,Hoetzenecker K,Dietl W,Soleiman A,Horvat R,Wolfsberger M,Gerner C,Hacker S,Mildner M,Moser B,Lichtenauer M,Podesser BK

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:D-dimers are generated during endogenous fibrinolysis of a blood clot and have a central role in diagnostic algorithms to rule out venous thromboembolism. HMG-CoA reductase inhibitors, more commonly called statins, are known to have effects independent of LDL-cholesterol lowering, including antithrombotic pr...

journal_title：European journal of clinical investigation

authors： Schol-Gelok S,Morelli F,Arends LR,Boersma E,Kruip MJHA,Versmissen J,van Gelder T

更新日期：2019-08-01 00:00:00

abstract：:The work was designed to study the effects of a meat meal on glomerular filtration rate (GFR), renal plasma flow (RPF), and plasma concentrations of glucagon, insulin, growth hormone, renin, aldosterone, total amino acids, and NH3 in healthy humans (H) as well as in patients with Child A liver cirrhosis (LC). The meat...

journal_title：European journal of clinical investigation

authors： De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumours with a strong genetic background. DESIGN:We searched the PubMed database through February 2015 to identify studies characterizing metastatic PCs/PGLs as well as currently established and evolving therapies. RESULTS...

journal_title：European journal of clinical investigation

authors： Angelousi A,Kassi E,Zografos G,Kaltsas G

更新日期：2015-09-01 00:00:00

abstract：:Administration of the murine IgG2a CD3 monoclonal antibody OKT3 exerts a transient nephrotoxic effect. Increased levels of group II secretory phospholipase A2 (sPLA2-II) might account for this nephrotoxicity as sPLA2-II induces the biosynthesis of prostaglandins, vasoactive lipid mediators that influence glomerular ha...

journal_title：European journal of clinical investigation

authors： Wever PC,Roest RW,Wolbink-Kamp AM,Wolbink GJ,Weening JJ,Hack CE,ten Berge JM

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Immunosuppression associated with surgery may predispose to increased tumour growth or recurrence. Lymphocytes are central components of the immune network, signalling specific and non-specific responses in tumour immunosurveillance. This study was therefore designed to compare the effects of minimally invas...

journal_title：European journal of clinical investigation

authors： Leaver HA,Craig SR,Yap PL,Walker WS

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:A high pulse pressure (PP) is associated with adverse cardiovascular (CV) outcomes; however, this relationship may be reversed in patients with heart failure with reduced ejection fraction (HFREF). METHODS:Patients from the WARCEF trial with left ventricular ejection fraction ≤35% were included. PP was divi...

journal_title：European journal of clinical investigation

authors： Shah N,Qian M,Di Tullio MR,Graham S,Mann DL,Sacco RL,Lip GYH,Labovitz AJ,Ponikowski P,Lok DJ,Anker SD,Teerlink JR,Thompson JLP,Homma S,Freudenberger RS,WARCEF Investigators.

更新日期：2019-02-23 00:00:00

abstract：:We have examined the impact of race and positive family history of type 2 diabetes on glucose/insulin dynamics and the two components of glucose disposal in healthy, first-degree relatives of black and white American patients with type 2 diabetes mellitus who are at a greater risk from the disease and their healthy co...

journal_title：European journal of clinical investigation

authors： Osei K,Cottrell DA

更新日期：1994-12-01 00:00:00

abstract：:Whether leptin levels are related to insulin sensitivity or subject to acute regulation by insulin is not known. In 12 obese [body mass index (BMI) = 34.0 +/- 1.5 kg m-2] and 12 lean (BMI = 22.2 +/- 0.6 kg m-2) non-diabetic subjects, plasma leptin concentrations were measured in the fasting state and during 2 hours of...

journal_title：European journal of clinical investigation

authors： Muscelli E,Camastra S,Masoni A,Baldi S,Sironi AM,Natali A,Ferrannini E

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the progressive failure of hypoglycaemia counterregulation in long-standing type 1 diabetes are poorly understood. Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypo...

journal_title：European journal of clinical investigation

authors： Bischof MG,Brehm A,Bernroider E,Krssák M,Mlynárik V,Krebs M,Roden M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The acute-phase response and anaemia of chronic disease are characterized by hypoferraemia associated with an increased ferritin synthesis, which might be mediated by the activated cytokine cascade. METHODS:We examined the prolonged effects of isolated limb perfusion (ILP) with recombinant human tumour necr...

journal_title：European journal of clinical investigation

authors： Feelders RA,Vreugdenhil G,Eggermont AM,Kuiper-Kramer PA,van Eijk HG,Swaak AJ

更新日期：1998-07-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of the monocyte-derived cytokines interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in idiopathic inflammatory bowel disease. Endoscopic biopsies of normal and inflamed intestinal mucosa were obtained from patients w...

journal_title：European journal of clinical investigation

authors： Grottrup-Wolfers E,Moeller J,Karbach U,Muller-Lissner S,Endres S

更新日期：1996-02-01 00:00:00