Advanced glycation end-products and the kidney.

abstract：:In systemic lupus erythematosus (SLE) patients, most of the clinical manifestation share a vascular component triggered by endothelial dysfunction. Endothelial cells (ECs) activation occurs both on the arterial and venous side, and the high vascular density of kidneys accounts for the detrimental outcomes of SLE throu...

journal_title：European journal of clinical investigation

authors： Mancardi D,Arrigo E,Cozzi M,Cecchi I,Radin M,Fenoglio R,Roccatello D,Sciascia S

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Augmentation index (AIx) is a measure of arterial wave reflection, providing information on the workload of the heart. and is a possible marker for cardiovascular disease risk. The relation of alcohol consumption with cardiovascular disease (CVD) risk is U-shaped with a protective effect of moderate alcohol ...

journal_title：European journal of clinical investigation

authors： van Trijp MJ,Bos WJ,van der Schouw YT,Muller M,Grobbee DE,Bots ML

更新日期：2005-10-01 00:00:00

abstract：:Inflammation is a well-coordinated process in response to tissue injury or infection aimed at restoration of tissue homoeostasis. Platelets and neutrophils are typically viewed important in the context of haemostasis and bacterial killing, respectively. However, as these cells are equipped with readily available armou...

journal_title：European journal of clinical investigation

authors： Soehnlein O

更新日期：2018-02-01 00:00:00

abstract：:The serum concentrations of collagen type IV,7S, collagen type IV,nc1, and aminoterminal type III procollagen peptide immunoreactive components were measured by means of specific radioimmunoassays during development of granulation tissue in rats. The results were compared with tissue deposition of basement membranes a...

journal_title：European journal of clinical investigation

authors： Hørslev-Petersen K,Pedersen LR,Bentsen KD,Brocks D,Garbarsch C,Kim KY,Hahn EG,Schuppan D,Lorenzen I

更新日期：1988-08-01 00:00:00

abstract：:The effect of marine n-3 polyunsaturated fatty acids on proliferation of human T-cells in vitro was compared to other polyunsaturated, monounsaturated and saturated fatty acids. Monoenes and saturated fatty acids had little effect on T-cell proliferation. Eicosapentaenoic acid and docosahexaenoic acid exerted a strong...

journal_title：European journal of clinical investigation

authors： Søyland E,Nenseter MS,Braathen L,Drevon CA

更新日期：1993-02-01 00:00:00

abstract：:In contrast to bile salts, which undergo a highly efficient enterohepatic circulation with multiple regulatory and physiologic functions, glucuronic acid conjugates of bilirubin are biliary excretory molecules that in health do not have a continuing biologic life. Intestinal absorptive cells are devoid of recapture tr...

journal_title：European journal of clinical investigation

authors： Vítek L,Carey MC

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Lipoprotein(a) [Lp(a)] is an atherothrombotic plasma lipoprotein with unknown function. Little is known about the catabolism of this lipoprotein, in particular the steps related to apolipoprotein(a) [apo(a)] fragmentation and excretion by the kidney. MATERIAL AND METHODS:High plasma levels (up to 9 mg dL(-1...

journal_title：European journal of clinical investigation

authors： Frank S,Hrzenjak A,Blaschitz A,Dohr G,Kostner GM

更新日期：2001-06-01 00:00:00

abstract：:Fibromuscular dysplasia (FMD) is an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small and medium-sized arteries, mostly involving renal and cervical arteries. As a result of better and more systematic screening, it appears that in...

journal_title：European journal of clinical investigation

authors： Van der Niepen P,van Tussenbroek F,Devos H,Debing E,Di Monaco S,Goffette P,Astarci P,Persu A

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Gastrointestinal symptoms are common on acute exposure to high-altitude (HA). Underlying mechanisms are not understood, but vascular shunting away from the gut could be responsible. Therefore, blood flow in the superior mesenteric artery (SMA) and hepatic portal vein (HPV) was examined at sea level (SL) and ...

journal_title：European journal of clinical investigation

authors： Kalson NS,Hext F,Davies AJ,Chan CW,Wright AD,Imray CH,Birmingham Medical Research Expeditionary Society.

更新日期：2010-08-01 00:00:00

abstract：:With advancing age both sexes have an increased incidence of osteoporotic fractures, although fractures are more common in women than in men. Whereas in women several potential risk factors have been identified, less is known about osteoporosis in men. A total of 27 Austrian men (mean age: 65 +/- 2 years) with atrauma...

journal_title：European journal of clinical investigation

authors： Resch H,Pietschmann P,Woloszczuk W,Krexner E,Bernecker P,Willvonseder R

更新日期：1992-08-01 00:00:00

abstract：:This study focuses on the role of platelet membrane glycoproteins and platelet-leucocyte adhesion in patients with sepsis and multiple organ failure (MOF). Specifically, the study raises the following issues: (1) the influence of sepsis and MOF on platelet activation as assessed by surface expression of platelet membr...

journal_title：European journal of clinical investigation

authors： Gawaz M,Fateh-Moghadam S,Pilz G,Gurland HJ,Werdan K

更新日期：1995-11-01 00:00:00

abstract：:Both ulcerative colitis and Crohn's disease, the two major forms of inflammatory bowel diseases, are recognized, at the moment, as perplexing and challenging clinical entities, in which several molecules and cell types are implicated. Recent molecular evidence proposes the intestinal microvascular remodelling or angio...

journal_title：European journal of clinical investigation

authors： Pousa ID,Maté J,Gisbert JP

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Early menopause, whether it be natural or surgical, is one of the established risk factors for osteoporosis. Surgical menopause, however, differs from natural menopause owing to the abrupt cessation of estrogen secretion. This study attempts to investigate the influence of menopause type on bone mineral dens...

journal_title：European journal of clinical investigation

authors： Hadjidakis D,Kokkinakis E,Sfakianakis M,Raptis SA

更新日期：1999-10-01 00:00:00

abstract：:The venous system plays a pivotal role in volume and blood pressure homeostasis. We tested the hypothesis that the visco-elastic properties of the peripheral venous system are reduced in patients with (incipient) diabetic nephropathy. Twenty-two normotensive patients with long-term insulin-dependent diabetes mellitus ...

journal_title：European journal of clinical investigation

authors： Schaper NC,Houben AJ,Schoon Y,Kooman JP,Huvers FC,Nieuwenhuijzen Kruseman AC

更新日期：1994-06-01 00:00:00

abstract：:Efficient fragmentation is the most important prerequisite for successful treatment of gallstones by extracorporeally induced shock waves. No data are available on the amount of energy necessary for stone disintegration and on the threshold energy below which no further fragmentation occurs. We therefore performed an ...

journal_title：European journal of clinical investigation

authors： Neubrand M,Greinwald I,Lobentanzer H,Paumgartner G,Hermeking H,Sauerbruch T

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To test the effect of long-term pegfilgrastim on collateral function and myocardial ischaemia in patients with chronic stable coronary artery disease (CAD). METHODS:This was a prospective clinical trial with randomized 2:1 allocation to pegfilgrastim or placebo for 6 months. The primary study endpoint was co...

journal_title：European journal of clinical investigation

authors： Traupe T,Stoller M,Gloekler S,Meier P,Seiler C

更新日期：2019-01-01 00:00:00

abstract：:The ratio at steady-state of alpha-ketoisocaproic acid (KIC) to leucine 13C enrichments in plasma during continuous infusion of [13C]leucine was examined in 58 studies under a variety of conditions. The ratio was lower (P less than 0.001) in 'arterialized' venous plasma (mean +/- SD 0.85 +/- 0.09) than in deep venous ...

journal_title：European journal of clinical investigation

authors： Thompson GN,Pacy PJ,Ford GC,Merritt H,Halliday D

更新日期：1988-12-01 00:00:00

abstract：:Patients with primary biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver. However, most of the patients with PBC do not show peripheral blood T cells response to PDC. In this study, we re-evaluated the ...

journal_title：European journal of clinical investigation

authors： Akbar SM,Yamamoto K,Miyakawa H,Ninomiya T,Abe M,Hiasa Y,Masumoto T,Horiike N,Onji M

更新日期：2001-07-01 00:00:00

abstract：:Transfers or exchanges of cholesterol esters and triglycerides between lipoproteins are mediated by a specialized protein referred to as cholesteryl ester transfer protein (CETP), whereas those of phospholipids (PLs) are facilitated by both CETP and a specific phospholipid transfer protein (PLTP). In the present study...

journal_title：European journal of clinical investigation

authors： Elchebly M,Pulcini T,Porokhov B,Berthezene F,Ponsin G

更新日期：1996-03-01 00:00:00

abstract：:In search of new practical diagnostic methods for the early diagnosis of hereditary medullary carcinoma of the thyroid (MCT) calcitonin release has been studied following induction by pentagastrin, cholecystokinin-pancreozymin (the C-terminal octapeptide, C8-CCK, and the native swine extract), and ethanol in eighteen ...

journal_title：European journal of clinical investigation

authors： Telenius-Berg M,Almqvist S,Berg B,Hedner P,Ingemansson S,Tibblin S,Wasthed B

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:We hypothesized the existence of different hormonal response patterns to repeated lower body negative pressure (LBNP) and head-up tilt (HUT) in healthy males. We compared hormonal, cardiovascular and plasma volume changes from rest to stress within- and between-LBNP and HUT applications. Hormones investigate...

journal_title：European journal of clinical investigation

authors： Roessler A,Goswami N,Haditsch B,Loeppky JA,Luft FC,Hinghofer-Szalkay H

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called 'vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Altera...

journal_title：European journal of clinical investigation

authors： de Boer MP,Wijnstok NJ,Serné EH,Eringa EC,Stehouwer CD,Flyvbjerg A,Hoekstra T,Heymans MW,Meijer RI,Twisk JW,Smulders YM

更新日期：2014-07-01 00:00:00

abstract：:Most physicians and other healthcare professionals are unaware of the pervasiveness of poor quality clinical evidence that contributes considerably to overuse, underuse, avoidable adverse events, missed opportunities for right care and wasted healthcare resources. The Medical Misinformation Mess comprises four key pro...

journal_title：European journal of clinical investigation

authors： Ioannidis JPA,Stuart ME,Brownlee S,Strite SA

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE), a rare heritable disorder caused by mutations of the ABCC6 gene, is characterized by fragmentation and mineralization of elastic fibres. We determined the extent of degradation of elastin by measuring and comparing the amount of desmosines in plasma and urine of PXE patients, ...

journal_title：European journal of clinical investigation

authors： Annovazzi L,Viglio S,Gheduzzi D,Pasquali-Ronchetti I,Zanone C,Cetta G,Iadarola P

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The pleiotropic cytokine osteopontin (OPN) is thought to be involved in the pathogenesis of atherosclerosis. However, the relationship between OPN and renal function, a cardiovascular risk factor itself, is not known. Therefore, we assessed the relationship between OPN plasma levels and renal function in pat...

journal_title：European journal of clinical investigation

authors： Lorenzen J,Krämer R,Kliem V,Bode-Boeger SM,Veldink H,Haller H,Fliser D,Kielstein JT

更新日期：2010-04-01 00:00:00

abstract：:Prostacyclin, an unstable metabolite of arachidonic acid metabolism, has been shown to have potent platelet antiaggregatory and vasodilator activity. Available evidence suggests that arterial prostacyclin production is diminished in the diabetic state. In this study we have examined the sensitivity of platelets from d...

journal_title：European journal of clinical investigation

authors： Betteridge DJ,El Tahir KE,Reckless JP,Williams KI

更新日期：1982-10-01 00:00:00

abstract：:The urinary excretion of free light immunoglobulin chains IgG, IgA, and Fcγ fragment material has been estimated in 12 healthy individuals and 7 subjects with tubular or glomerular proteinuria. Measurements were carried out by immunochemical methods after separation of concentrated urinary immunoglobulin components by...

journal_title：European journal of clinical investigation

authors： Peterson PA,Berggård I

更新日期：1971-08-01 00:00:00

abstract：BACKGROUND:Angiotensin converting enzyme 2 (ACE2), a monocarboxylase that degrades angiotensin II to angiotensin 1-7, is also the functional receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and is highly expressed in the lungs and heart. Patients with SARS also suffered from cardiac disease ...

journal_title：European journal of clinical investigation

authors： Oudit GY,Kassiri Z,Jiang C,Liu PP,Poutanen SM,Penninger JM,Butany J

更新日期：2009-07-01 00:00:00

abstract：:Urine was collected in four healthy infants, born after 35-39 weeks of gestation. The collections were made for 24 h starting immediately after birth. Bile acids were extracted, separated into conjugate groups, solvolysed, hydrolysed and quantified by gas-liquid chromatography as methyl ester trimethylsilyl ether deri...

journal_title：European journal of clinical investigation

authors： Strandvik B,Wikström SA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. MATERIALS AND...

journal_title：European journal of clinical investigation

authors： Leitão J,Carvalhana S,Cochicho J,Silva AP,Velasco F,Medeiros I,Alves AC,Bourbon M,Oliveiros B,Rodrigues V,Sousa R,Sampaio F,Carvalho A,Cortez-Pinto H

更新日期：2020-06-01 00:00:00