Nonalcoholic fatty liver disease increases the risk of gastroesophageal reflux disease: A systematic review and meta-analysis.

abstract：:To determine the comparative value of serum Type III procollagen peptide (PIIIP) in paediatric and adult liver disease we have measured PIIIP in 201 healthy subjects (aged 1 day-77 years) and twenty-one children and five adults with chronic active hepatitis (CAH). Healthy children had significantly higher PIIIP levels...

journal_title：European journal of clinical investigation

authors： Trivedi P,Cheeseman P,Portmann B,Hegarty J,Mowat AP

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Early menopause, whether it be natural or surgical, is one of the established risk factors for osteoporosis. Surgical menopause, however, differs from natural menopause owing to the abrupt cessation of estrogen secretion. This study attempts to investigate the influence of menopause type on bone mineral dens...

journal_title：European journal of clinical investigation

authors： Hadjidakis D,Kokkinakis E,Sfakianakis M,Raptis SA

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Early detection of fungal infection is essential for beginning of prompt and specific therapy. In this study we describe a rapid and sensitive procedure to detect, by polymerase chain reaction (PCR) assays, a wide range of medically important opportunistic and pathogenic fungi in dermal specimens from dermat...

journal_title：European journal of clinical investigation

authors： Turin L,Riva F,Galbiati G,Cainelli T

更新日期：2000-06-01 00:00:00

abstract：:During chronic high-altitude (HA) exposure, basal and exercise-induced noradrenaline (NA) increases do not parallel blood pressure (BP) changes observed; unlike beta-adrenergic receptors, to our knowledge no data are available on alpha-receptors. We studied platelet alpha 2- and leucocyte beta-receptors and basal cate...

journal_title：European journal of clinical investigation

authors： Zaccaria M,Borea PA,Opocher G,Ponchia A,Varani K,Fraccarollo D,Scandellari C

更新日期：1997-04-01 00:00:00

abstract：:The activity of delta-aminolaevulinate synthase was determined in the livers of fed female rats and was found to vary with the phase of their sexual cycle. The highest enzymic activity was obtained during preoestrus (38.0 +/- 3.2 nmol delta-aminolaevulinateg.g liver.-1 hour-1), the lowest during dioestrus (17.4 +/- 3....

journal_title：European journal of clinical investigation

authors： Held H,Przerwa M

更新日期：1976-09-10 00:00:00

abstract：BACKGROUND:Cancer is often caused by disturbance in the regulation and/or execution of programmed cell death (PCD, including apoptosis and autophagy). Our aim was to investigate these two pathways simultaneously in the same samples to understand further the pathological roles of PCDs in colorectal cancer. MATERIALS AN...

journal_title：European journal of clinical investigation

authors： Chang YT,Tseng HC,Huang CC,Chen YP,Chiang HC,Chou FP

更新日期：2011-01-01 00:00:00

abstract：:Currently available information on adipose tissue metabolism in man is mainly based on studies in vitro. In the present work adipose tissue lipid uptake was studied in vivo in man. 100 g glucose and 120 g milk fat with 10 microCi U-14C oleic acid were given in the overnight fasting state to eight women and 2 h after a...

journal_title：European journal of clinical investigation

authors： Mårin P,Rebuffé-Scrive M,Björntorp P

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:The platelet-to-lymphocyte ratio (PLR) has been found to predict clinical outcomes in borderline ovarian tumours and the other genital neoplasms. However, its prognostic value in patients with ovarian cancer remains controversial. The aim of this study was to assess its prognostic value in ovarian cancer. M...

journal_title：European journal of clinical investigation

authors： Tian C,Song W,Tian X,Sun Y

更新日期：2018-05-01 00:00:00

abstract：:Taurodeoxycholic acid increases the incidence of aspirin induced gastric bleeding in rats and in vitro is well bound by Aludrox (aluminium hydroxide) and poorly bound by Maalox (aluminium hydroxide and magnesium hydroxide). We studied the relevance of this binding, as demonstrated in vitro, by observing the effect of ...

journal_title：European journal of clinical investigation

authors： Morgan RJ,Nelson LM,Russell RI,Plevin T

更新日期：1980-12-01 00:00:00

abstract：OBJECTIVE:To test the effect of long-term pegfilgrastim on collateral function and myocardial ischaemia in patients with chronic stable coronary artery disease (CAD). METHODS:This was a prospective clinical trial with randomized 2:1 allocation to pegfilgrastim or placebo for 6 months. The primary study endpoint was co...

journal_title：European journal of clinical investigation

authors： Traupe T,Stoller M,Gloekler S,Meier P,Seiler C

更新日期：2019-01-01 00:00:00

abstract：:The studies were designed to explore the effect of the converting enzyme inhibitor captopril on the activity of the sympathetic nervous system during basal conditions and following graded physical exercise in patients with essential hypertension. Seven males and two females, aged 36-59 years, were hospitalized under m...

journal_title：European journal of clinical investigation

authors： Manhem P,Bramnert M,Hulthén UL,Hökfelt B

更新日期：1981-10-01 00:00:00

abstract：:Arterial lumen narrowing and vascular occlusion is the actual cause of morbidity and mortality in atherosclerotic disease. Collateral artery formation (arteriogenesis) refers to an active remodelling of non-functional vascular anastomoses to functional collateral arteries, capable to bypass the site of obstruction and...

journal_title：European journal of clinical investigation

authors： de Groot D,Pasterkamp G,Hoefer IE

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis ...

journal_title：European journal of clinical investigation

authors： Hong M,Park JW,Yang PS,Hwang I,Kim TH,Yu HT,Uhm JS,Joung B,Lee MH,Jee SH,Pak HN

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated the presence of receptors for somatostatin, a neuropeptide with immunoregulatory properties, in the inflammatory lesions of patients suffering from sarcoidosis and other granulomatous diseases by in vivo somatostatin receptor scintigraphy and in vitro autoradiography. How...

journal_title：European journal of clinical investigation

authors： ten Bokum AM,Hofland LJ,de Jong G,Bouma J,Melief MJ,Kwekkeboom DJ,Schonbrunn A,Mooy CM,Laman JD,Lamberts SW,van Hagen PM

更新日期：1999-07-01 00:00:00

abstract：:Patients with primary biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver. However, most of the patients with PBC do not show peripheral blood T cells response to PDC. In this study, we re-evaluated the ...

journal_title：European journal of clinical investigation

authors： Akbar SM,Yamamoto K,Miyakawa H,Ninomiya T,Abe M,Hiasa Y,Masumoto T,Horiike N,Onji M

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Diabetes dramatically increases the risk of cardiovascular complications and mortality. Hydrogen sulphide plays an important role in reducing oxidative stress. Several studies demonstrated that hydrogen sulphide protects islet beta cells from oxidant stress damage and decreases apoptosis. The aim of...

journal_title：European journal of clinical investigation

authors： Dorofeyeva N,Drachuk K,Rajkumar R,Sabnis O,Sagach V

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Analytical statistics revealed a variety of risk factors for hypertension, but the complex interplay between different factors remains to be determined by more powerful statistical techniques. METHODS:Analytical as well as new, explorative statistical methods such as natural segmentation (k-means) and predi...

journal_title：European journal of clinical investigation

authors： Lukas A,Kumbein F,Temml C,Mayer B,Oberbauer R

更新日期：2003-03-01 00:00:00

abstract：:Increased cardiovascular mortality is an unresolved problem in patients with chronic renal failure. Cardiac hypertrophy is observed in the majority of patients with chronic renal failure undergoing haemodialysis. However, the mechanisms, including signal transduction pathways, responsible for cardiac hypertrophy in re...

journal_title：European journal of clinical investigation

authors： Takahashi H,Takeishi Y,Miyamoto T,Shishido T,Arimoto T,Konta T,Miyashita T,Ito M,Kubota I

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:A total of 30 subjects with type 2 diabetes were incl...

journal_title：European journal of clinical investigation

authors： Heinisch BB,Francesconi M,Mittermayer F,Schaller G,Gouya G,Wolzt M,Pleiner J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. MATERIALS AND METHODS:Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. RESULTS:TP metabolism is...

journal_title：European journal of clinical investigation

authors： Dewit O,Starkel P,Roblin X

更新日期：2010-11-01 00:00:00

abstract：:The pathobiochemical mechanism of arteriosclerosis in hyperhomocysteinaemia has not yet been elucidated. In vitro studies have shown that the cytotoxic properties of homocysteine can be ascribed to its generation of reactive oxygen species. We studied lipid peroxidation, both in vivo and in vitro, in 10 homozygous cys...

journal_title：European journal of clinical investigation

authors： Blom HJ,Kleinveld HA,Boers GH,Demacker PN,Hak-Lemmers HL,Te Poele-Pothoff MT,Trijbels JM

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:The pleiotropic cytokine osteopontin (OPN) is thought to be involved in the pathogenesis of atherosclerosis. However, the relationship between OPN and renal function, a cardiovascular risk factor itself, is not known. Therefore, we assessed the relationship between OPN plasma levels and renal function in pat...

journal_title：European journal of clinical investigation

authors： Lorenzen J,Krämer R,Kliem V,Bode-Boeger SM,Veldink H,Haller H,Fliser D,Kielstein JT

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Alcohol may have a cardioprotective effect. One possible mechanism is by modifying insulin resistance/secretion. The aims of this study were: (i) to examine the effect of short-term alcohol consumption on the metabolic control of glucose tolerance; (ii) to study the influence of short-term alcohol consumptio...

journal_title：European journal of clinical investigation

authors： Flanagan DE,Pratt E,Murphy J,Vaile JC,Petley GW,Godsland IF,Kerr D

更新日期：2002-03-01 00:00:00

abstract：:The effect of propranolol 160-640 mg/day for 3 months on the accelerated loss of bone matrix and mineral in hyperthyroidism was studied in seventeen patients. A rise in serum thyroxine (P less than 0.01) during the first 3 weeks was followed by a fall (P less than 0.02). Serum triiodothyronine declined during the stud...

journal_title：European journal of clinical investigation

authors： Mosekilde L,Jastrup B,Melsen F,Lund B,Lund B,Sørensen OH,Nielsen HE,Yde H

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:The intestinal handling of dextran, an alpha-1,6-linked glucose polymer, is poor compared with starch, and some ingested dextran might therefore reach the lower small intestine. As luminal sugar up-regulates SGLT1 (sodium-dependent glucose transporter) locally, we report the effects of a dextran-enriched die...

journal_title：European journal of clinical investigation

authors： Debnam ES,Denholm EE,Grimble GK

更新日期：1998-08-01 00:00:00

abstract：:The clinical and physiological relevance of the relationship between gastrin and calcitonin has been investigated in normal subjects and in patients suffering from gastritis or duodenal ulcer. Basal plasma levels of calcitonin are increased in these patients but there is no significant relationship between calcitonin ...

journal_title：European journal of clinical investigation

authors： Heynen G,Brassine A,Daubresse JC,Ligny G,Kanis JA,Gaspar S,Franchimont P

更新日期：1981-08-01 00:00:00

abstract：:To study further the role of hepatic cholesterol synthesis in patients with gallstones, the activity of the rate-limiting step in cholesterogenesis, hydroxymethyl glutaryl co-enzyme A reductase (HMGCoAR), was measured in operative wedge liver biopsies from ten patients with untreated cholesterol gallstones, six with p...

journal_title：European journal of clinical investigation

authors： Maton PN,Ellis HJ,Higgins MJ,Dowling RH

更新日期：1980-08-01 00:00:00

abstract：:Metabolic alterations related to resting energy expenditure (REE) and fat metabolism have been noted during sepsis, and often depend on the causative agent and the stage and severity of the illness. We studied the effect of IL-1, the protein mediator of the 'acute phase' response during infection, on REE, respiratory ...

journal_title：European journal of clinical investigation

authors： Tocco-Bradley R,Georgieff M,Jones CT,Moldawer LL,Dinarello CA,Blackburn GL,Bistrian BR

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Age is one the factors associated with poor prognosis in acute coronary syndromes (ACS) and elderly patients are a high-risk collective with few parameters for mid-term cardiovascular stratification. We aimed to assess the predictive value of ankle-brachial index (ABI) in patients (> 75 years) for 1-year mor...

journal_title：European journal of clinical investigation

authors： Cordero A,Morillas P,Bertomeu-González V,Quiles J,Soria F,Guindo J,Mazón P,Anguita M,Rodríguez-Padial L,González-Juanatey JR,Bertomeu-Martínez V,en nombre de los investigadores del estudio PAMISCA.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Many chronic diseases are adversely affected by elevated iron levels. It has been speculated that this relationship is mediated by increased oxidative stress, due to the ability of iron to generate reactive oxygen species. The aim of this study was to assess the relationship between elevated iron levels and ...

journal_title：European journal of clinical investigation

authors： Aranda N,Fernandez-Cao JC,Tous M,Arija V

更新日期：2016-06-01 00:00:00