Abstract：
BACKGROUND:Cardiac resynchronization therapy (CRT) is an established therapy for advanced congestive heart failure, improving both survival and hospitalization. The mechanism beneath these improvements still needs to be defined as about one-third of the patients do not benefit from resynchronization. Restoration of sympatho-vagal function can play a significant role in the process, but available data are limited. In this scenario, positron emission tomography scans with (11) C-hydroxyephedrine, a noradrenaline analogous, has the potential to characterize the modifications of the sympathetic nervous system induced by CRT in decompensated patients. MATERIALS AND METHODS:Ten patients (six males, age 68 ± 10 years) with primary dilated cardiomyopathy were studied before and after resynchronization (acutely and after 3 months), from a clinical and echocardiographic point of view. Their cardiac sympathetic nerve activity was evaluated by (11) C-hydroxyephedrine positron emission tomography before resynchronization, at short and medium term after resynchronization. RESULTS:Responders to CRT (patients showing ≥ 15% decrease in left ventricular end-systolic volume) showed a higher level of left ventricular radiotracer uptake both at baseline and after resynchronization with respect to nonresponders. This was coupled with a progressive improvement in homogeneity in left ventricular tracer uptake mainly in responders. CONCLUSIONS:Cardiac resynchronization therapy improves cardiac sympathetic nerve activity in responders since its activation, while nonresponders do not show any significant change at any time of evaluation. CRT seems to be more effective in those patients with a still structurally preserved, yet functionally impaired, neuroautonomic system.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Martignani C,Diemberger I,Nanni C,Biffi M,Ziacchi M,Boschi S,Corzani A,Fanti S,Sambuceti G,Boriani Gdoi
10.1111/eci.12471subject
Has Abstractpub_date
2015-08-01 00:00:00pages
792-9issue
8eissn
0014-2972issn
1365-2362journal_volume
45pub_type
杂志文章abstract：:beta-Adrenoceptor binding on peripheral blood mononuclear cells (PBMC) of healthy adult volunteers was investigated using the radioligand 125iodo-cyanopindolol (ICYP). Saturation binding studies were performed with nine different concentrations of ICYP. Receptor density and affinity were calculated by Scatchard plots....
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1988.tb02416.x
更新日期：1988-04-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2362.1992.tb01448.x
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journal_title：European journal of clinical investigation
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doi：10.1111/j.1365-2362.1992.tb01503.x
更新日期：1992-08-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.2007.01746.x
更新日期：2007-01-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章
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更新日期：1985-12-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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更新日期：2000-12-01 00:00:00
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journal_title：European journal of clinical investigation
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更新日期：2006-02-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章,评审
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1989.tb00209.x
更新日期：1989-04-01 00:00:00
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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更新日期：1987-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1982.tb02236.x
更新日期：1982-08-01 00:00:00
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical investigation
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journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：BACKGROUND:The red cell distribution width (RDW) predicts mortality among many populations. RDW is calculated as the standard deviation (SD) of the red blood cell (RBC) volume divided by mean corpuscular volume (MCV). Because higher MCV also predicts mortality, we hypothesized that the RDW numerator (one SD of RBC volu...
journal_title：European journal of clinical investigation
pub_type： 杂志文章,多中心研究
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journal_title：European journal of clinical investigation
pub_type： 杂志文章,多中心研究
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更新日期：2018-08-01 00:00:00
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journal_title：European journal of clinical investigation
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
abstract：:The aim of this work is to evaluate whether type 2 diabetes mellitus, obesity and arterial hypertension, three conditions characterized by the presence of insulin resistance, share some common genetic markers. A potential candidate is the Na+/H+ antiporter, the increased activity of which is considered a marker of ess...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1994.tb00983.x
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis. It has been shown previously that this may result in a transient "oversaturation" of transferrin. METHODS:Ten stable haemodialysis patients on r-HuEPO treatment re...
journal_title：European journal of clinical investigation
pub_type： 临床试验,杂志文章
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更新日期：2002-03-01 00:00:00
abstract：:Factors affecting erythrocyte K+ content and plasma electrolytes during light exercise were examined in 8 normal subjects and 27 patients with chronic obstructive lung disease. The patients were classified into bronchitis, emphysema and intermediate groups. Arterial blood was obtained during rest, after 2, 5, and 7 mi...
journal_title：European journal of clinical investigation
pub_type： 杂志文章
doi：10.1111/j.1365-2362.1975.tb00469.x
更新日期：1975-09-12 00:00:00
