Complete iodide trapping defect in two cases with congenital hypothyroidism: adaptation of thyroid to huge iodide supplementation.

abstract：:In man, HCl acidosis reduces blood and urinary urea with a concomitant rise in ammonium (NH4+) excretion. Significantly less urea is excreted following NH4Cl administration than following equimolar ingestion of NH4 HCO3. The results of these alterations in nitrogen excretion are interpreted in terms of bicarbonate uti...

journal_title：European journal of clinical investigation

authors： Fine A,Carlyle JE,Bourke E

更新日期：1977-12-01 00:00:00

abstract：:The retardation of gastric emptying induced by infusion of triglyceride into the small intestine is associated with suppression of antral pressure waves and stimulation of basal pyloric tone in combination with phasic pressure waves localized to the pylorus. The role of nitric oxide (NO) mechanisms in the control of p...

journal_title：European journal of clinical investigation

authors： Sun WM,Doran S,Lingenfelser T,Hebbard GS,Morley JE,Dent J,Horowitz M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated the presence of receptors for somatostatin, a neuropeptide with immunoregulatory properties, in the inflammatory lesions of patients suffering from sarcoidosis and other granulomatous diseases by in vivo somatostatin receptor scintigraphy and in vitro autoradiography. How...

journal_title：European journal of clinical investigation

authors： ten Bokum AM,Hofland LJ,de Jong G,Bouma J,Melief MJ,Kwekkeboom DJ,Schonbrunn A,Mooy CM,Laman JD,Lamberts SW,van Hagen PM

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Mortality from prostate cancer remains a significant problem with current treatment(s), with an expected 30 350 deaths from prostate cancer in 2005. Long-acting natriuretic peptide, vessel dilator, kaliuretic peptide and atrial natriuretic peptide have significant anticancer effects in breast and pancreatic ...

journal_title：European journal of clinical investigation

authors： Vesely BA,Alli AA,Song SJ,Gower WR Jr,Sanchez-Ramos J,Vesely DL

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation i...

journal_title：European journal of clinical investigation

authors： Schutte R,Whincup PH,Papacosta O,Lennon LT,Macfarlane PW,Wannamethee G

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Profilin-1 is a ubiquitous, actin-binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin-1 levels with fatal and nonfatal CVE in a coh...

journal_title：European journal of clinical investigation

authors： Eroglu E,Unal HU,Guclu A,Kocyigit I,Karaman M,Saglam M,Gezer M,Tas A,Zararsiz G,Eyileten T,Aydin İ,Oguz Y,Gungor O,Yilmaz MI

更新日期：2017-12-01 00:00:00

abstract：:Eur J Clin Invest 2012; 42 (6): 579-588 ABSTRACT: Glucose-based methods are currently gold standards for identifying individuals at risk of type 2 diabetes. Obviously, these methods only consider one of many pathologies of impaired glucose metabolism and they all suffer from a poor specificity as type 2 diabetes risk ...

journal_title：European journal of clinical investigation

authors： Gjesing AP,Pedersen O

更新日期：2012-06-01 00:00:00

abstract：:Basal cyclic AMP levels in blood mononuclear cells from healthy human donors has been studied. A great variation in cyclic AMP content ranging from below 2 to 20 pmol 10(-6) cells was seen. Incubation of the cells at 37 degrees C mostly showed a time-dependent decrease in basal cyclic AMP, levelling off after 16 h. Wh...

journal_title：European journal of clinical investigation

authors： Svenson M,Permin H,Wiik A

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Humming greatly increases nasal nitric oxide (NO) in healthy people by causing a rapid washout of NO from the sinuses. This increase is abolished in patients with complete sinus ostial obstruction. OBJECTIVE:Allergic rhinitis is a risk factor for development of sinusitis and we wanted to study whether nasal...

journal_title：European journal of clinical investigation

authors： Maniscalco M,Sofia M,Weitzberg E,De Laurentiis G,Stanziola A,Rossillo V,Lundberg JO

更新日期：2004-08-01 00:00:00

abstract：:Many diseases with a major public health impact are the result of complex interactions between environmental factors and multiple genes. In the past decade, methods for genome analysis, in particular quantitative trait locus (QTL) analysis in animal models, were developed to identify and localize the genes responsible...

journal_title：European journal of clinical investigation

authors： Hillebrandt S,Matern S,Lammert F

更新日期：2003-02-01 00:00:00

abstract：:Platelet aggregation, which plays an important role in acute myocardial infarction (AMI), is mediated by fibrinogen binding to the platelet membrane glycoprotein (GP)IIb-IIIa (CD41). This study measured the relative number of GPIIb-IIIa complexes on platelets from patients immediately following AMI (n = 14) compared w...

journal_title：European journal of clinical investigation

authors： Giles H,Smith RE,Martin JF

更新日期：1994-01-01 00:00:00

abstract：:Deficient leucocyte sphingomyelinase activity has been demonstrated in a patient with the sea-blue histiocyte syndrome. Family studies revealed that two other cases previously diagnosed on clinical and histochemical criteria also had a pronounced diminution of sphingomyelinase activity. Both parents of the affected in...

journal_title：European journal of clinical investigation

authors： Fried K,Beer S,Krespin HI,Leiba H,Djaldetti M,Zitman D,Klibansky C

更新日期：1978-08-01 00:00:00

abstract：:We have reported that the disorder of lipoprotein metabolism in hyperalphalipoproteinaemic patients with a deficiency of cholesteryl ester transfer protein (CETP) is characterized by the polydisperse low density lipoprotein (LDL) particles and the accumulation of cholesteryl ester (CE) in high density lipoprotein (HDL...

journal_title：European journal of clinical investigation

authors： Sakai N,Yamashita S,Hirano K,Ishigami M,Arai T,Kobayashi K,Funahashi T,Matsuzawa Y

更新日期：1995-05-01 00:00:00

abstract：:The effect of marine n-3 polyunsaturated fatty acids on proliferation of human T-cells in vitro was compared to other polyunsaturated, monounsaturated and saturated fatty acids. Monoenes and saturated fatty acids had little effect on T-cell proliferation. Eicosapentaenoic acid and docosahexaenoic acid exerted a strong...

journal_title：European journal of clinical investigation

authors： Søyland E,Nenseter MS,Braathen L,Drevon CA

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:To date it is not known whether gastric juice vitamin C levels are influenced by Helicobacter pylori CagA(+) strains. The aim of the present study, therefore, was to study the impact of H. pylori CagA status on gastric juice vitamin C levels. MATERIALS AND METHODS:We studied 30 H. pylori(+) patients, and th...

journal_title：European journal of clinical investigation

authors： Rokkas T,Liatsos C,Petridou E,Papatheodorou G,Karameris A,Ladas SD,Raptis SA

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Four peptide hormones of a family of six hormones, i.e. atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-natriuretic peptide (CNP), long acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide, significantly decrease the number of adenocarcinoma cells in culture. The pres...

journal_title：European journal of clinical investigation

authors： Vesely BA,Song S,Sanchez-Ramos J,Fitz SR,Alli AA,Solivan SM,Gower WR Jr,Vesely DL

更新日期：2005-06-01 00:00:00

abstract：:The serum concentrations of collagen type IV,7S, collagen type IV,nc1, and aminoterminal type III procollagen peptide immunoreactive components were measured by means of specific radioimmunoassays during development of granulation tissue in rats. The results were compared with tissue deposition of basement membranes a...

journal_title：European journal of clinical investigation

authors： Hørslev-Petersen K,Pedersen LR,Bentsen KD,Brocks D,Garbarsch C,Kim KY,Hahn EG,Schuppan D,Lorenzen I

更新日期：1988-08-01 00:00:00

abstract：:The effects of percutaneous electrical stimulation (70 V, 300 microseconds pulses at 30 Hz) on muscle composition and rate of protein synthesis were studied in seven patients with quadriceps atrophy secondary to unilateral osteoarthritis of the knee (stimulated group). Quadriceps were stimulated on the affected side f...

journal_title：European journal of clinical investigation

authors： Gibson JN,Morrison WL,Scrimgeour CM,Smith K,Stoward PJ,Rennie MJ

更新日期：1989-04-01 00:00:00

abstract：:Efficient fragmentation is the most important prerequisite for successful treatment of gallstones by extracorporeally induced shock waves. No data are available on the amount of energy necessary for stone disintegration and on the threshold energy below which no further fragmentation occurs. We therefore performed an ...

journal_title：European journal of clinical investigation

authors： Neubrand M,Greinwald I,Lobentanzer H,Paumgartner G,Hermeking H,Sauerbruch T

更新日期：1997-03-01 00:00:00

abstract：:Infusion of ethanol (0.6 g/kg body wt) caused marked hypoglycaemia in subjects fasted for 36 h. Previous administration of the alcohol dehydrogenase (ADH) inhibitor 4-methylpyrazole (4-MP, 7 mg/kg body wt i.v.) strongly suppressed the ethanol-induced hypoglycaemia. The rate of ethanol elimination was 84.6 mg/kg per ho...

journal_title：European journal of clinical investigation

authors： Salaspuro MP,Pikkarainen P,Lindros K

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:After the Q fever outbreak in the Netherlands between 2007 and 2010, more than 300 patients with chronic Q fever have been identified. Some patients were also diagnosed with systemic sclerosis, a rare immune-mediated disease. We aimed to increase awareness of concomitant chronic Q fever infection and systemi...

journal_title：European journal of clinical investigation

authors： Jansen AFM,Raijmakers RPH,van Deuren M,Vonk MC,Bleeker-Rovers CP

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Improvement of renal concentration capacity was long ago shown to occur after surgery for primary hyperparathyroidism (pHPT). Study of concentration capacity is of interest, as it was also shown to be a predictive factor for the risk of death in patients with pHPT, and it affected the risk of death independe...

journal_title：European journal of clinical investigation

authors： Hedbäck G,Abrahamsson K,Odén A

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The Treating to New Targets (TNT) study has recently provided evidence that reduction in LDL-C levels below 2·6 mmol L⁻¹ lowers the risk of cerebrovascular events by an additional 20% to 25%, thereby confirming the value of statin therapy in preventing transient ischaemic attacks and stroke. Despite the prot...

journal_title：European journal of clinical investigation

authors： van den Bogaard B,van den Born BJ,Fayyad R,Waters DD,DeMicco DA,LaRosa JC,Kastelein JJ,Holme I,Treating to New Targets investigators.

更新日期：2011-02-01 00:00:00

abstract：:The cellular mechanisms controlling adaptive intestinal mucosal hypo- and hyperplasia are poorly understood but changes in tissue polyamine levels and in the activity of the key enzymes controlling their synthesis (ornithine decarboxylase: ODC) and degradation (diamine oxidase: DAO) have been implicated. Therefore, in...

journal_title：European journal of clinical investigation

authors： Hosomi M,Stace NH,Lirussi F,Smith SM,Murphy GM,Dowling RH

更新日期：1987-10-01 00:00:00

abstract：:Although in therapeutic use for more than a century, the mode of cellular action of organic nitrates remains incompletely understood. Despite ample experimental evidence from animal studies to show that nitrates are metabolized to NO in the vascular smooth muscle, direct demonstration of such an activity in human vasc...

journal_title：European journal of clinical investigation

authors： Feelisch M,Brands F,Kelm M

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:The ratio of serum C-reactive protein (CRP) to albumin has been proven to be a more accurate indicator than albumin and CRP levels alone in determining the prognosis of patients with cancer and critical illness. The aim of this study was to determine whether the CRP/albumin ratio (CAR) can be linked to imper...

journal_title：European journal of clinical investigation

authors： Karabağ Y,Çağdaş M,Rencuzogullari I,Karakoyun S,Artaç İ,İliş D,Yesin M,Çağdaş ÖS,Altıntaş B,Burak C,Tanboğa HI

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:In vitro fertilisation (IVF) has been widely used during the last decades. Recent studies demonstrated some alterations in IVF children's metabolic profile compared with controls. The recently reported lipocalins retinol-binding protein 4 (RBP-4) and neutrophil gelatinase-associated lipocalin (NGAL), as well...

journal_title：European journal of clinical investigation

authors： Sakka SD,Margeli A,Loutradis D,Chrousos GP,Papassotiriou I,Kanaka-Gantenbein C

更新日期：2013-05-01 00:00:00

abstract：:There is considerable information to indicate that when there is vessel injury, platelets can play a major role in the development of atherosclerosis and its thromboembolic complications in the non-diabetic population. Diabetes is a disease associated with an increased risk of vascular complications, but the nature of...

journal_title：European journal of clinical investigation

authors： Winocour PD

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:The DALI low-density lipoprotein (LDL) apheresis system is the first whole-blood apheresis system in regular clinical use. DALI stands for direct adsorption of lipoproteins, which describes the basic principle of operation of this newly developed LDL apheresis procedure. METHODS:The selective removal of LDL...

journal_title：European journal of clinical investigation

authors： Dräger LJ,Julius U,Kraenzle K,Schaper J,Toepfer M,Zygan K,Otto V,Steinhagen-Thiessen E

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Fat tissue is a common material for autologous transplantation in plastic and reconstructive surgery. Basic fibroblast growth factor (bFGF) ameliorates the fat graft survival. A transplantation model has shown the gene expression of matrix metalloproteinases (MMPs) to increase in adipocytes. The aim of this ...

journal_title：European journal of clinical investigation

authors： Kuramochi D,Unoki H,Bujo H,Kubota Y,Jiang M,Rikihisa N,Udagawa A,Yoshimoto S,Ichinose M,Saito Y

更新日期：2008-10-01 00:00:00